Ingaba une-vitamin B12 enganelanga? Fumana ulwazi ngolu vavanyo lweMethylmalonic Acid (MMA)!

Namhlanje siza kuthetha ngovavanyo olunegama elithile lezonyango, kodwa lubaluleke kakhulu kwimpilo yemizimba yethu. Luvavanyo lweMethylmalonic Acid ( MMA ), okanye njengoko silubiza ngokufutshane. Usenokuba awuzange uve ngeli gama ngaphambili. Kodwa cinga ngako, olu vavanyo lweMMA luluncedo kakhulu ekufumaneni ukuba unayo na i-vitamin B12 eyaneleyo (elinye igama le-vitamin B12 yi-cobalamin) emzimbeni wakho, okanye ukuba umzimba wakho unokulufunxa ngokufanelekileyo na. Ngoko ke, masithethe ngale nto ngokweenkcukacha ezithe vetshe, akunjalo?

Yintoni le MMA test?

Ngamafutshane, uvavanyo lwe-methylmalonic acid (MMA) yindlela yokufumanisa ukuba unesiphene se-vitamin B12 . Ugqirha wakho uza kuthatha isampuli yegazi okanye umchamo wakho aze ajonge inqanaba le-methylmalonic acid (MMA).

Cinga ngale ndlela. Xa amanqanaba ethu evithamini B12 ephantsi, okanye xa singayifunxi kakuhle i-B12 esiyithathayo, imizimba yethu iqala ukuvelisa ikhemikhali ebizwa ngokuba yi-MMA. Ngokuchanekileyo, i-MMA yimveliso yenkqubo ye-metabolism yevithamini B12. Xa i-B12 iphantsi, le nkqubo ayenzeki kakuhle, ngoko ke i-MMA iyaqokelelana. Ngoko ke, ukuba amanqanaba akho e-MMA aphezulu, kuthetha ukuba kunokubakho ingxaki nge-B12.

Kutheni ufuna ukwenza uvavanyo lwe-MMA?

Ngoku usenokuba ucinga, "Kutheni ndithatha olu vavanyo lwe-MMA?" Kunokubakho izizathu ezimbalwa:

• Ukuba uneempawu zokunqongophala kwe-vitamin B12:
• Ngaba uhlala uziva udiniwe kwaye ungenabomi ?
• Ngaba kukho naziphi na iingxaki zenkqubo yokugaya ukutya, ezifana norhudo okanye iintlungu zesisu?
• Ngaba uziva ungenazimvakalelo okanye ukurhawuzelelwa kwimilenze yakho?
• Ngaba unomdla wokutya?

Ukuba unale mpawu, ugqirha wakho unokucebisa uvavanyo lwe-MMA, njengoko ezi zinokuba ziimpawu zokunqongophala kwe-B12.

• Ukuhlola iintsana ezisandul’ ukuzalwa: Ngamanye amaxesha, umntwana unikwa uvavanyo lwe-MMA emva nje kokuzalwa ukuze kuhlolwe imeko engaqhelekanga yemfuza ebizwa ngokuba yi-methylmalonic acidemia okanye i-methylmalonic aciduria . Oku kudla ngokwenziwa njengovavanyo lwe-MMA lomchamo ukuze kujongwe imeko.

Kubalulekile ukufumanisa ngokuchanekileyo ukungabikho kwevithamini B12, njengoko kunokuba luphawu lweemeko ezininzi zempilo ezinobungozi ezinokonakalisa imithambo-luvo . Imizekelo ibandakanya i-anemia enobungozi (uhlobo lwe-anemia olubangelwa kukungakwazi ukufunxa i-B12) kunye ne-neuropathy enxulumene nesifo seswekile .

Kutheni ujonge i-MMA endaweni yokujonga amanqanaba e-B12 ngqo?

Lo ngumbuzo olungileyo. Unokucinga ukuba ukujonga nje inqanaba le-B12 egazini kuya kuyisombulula ingxaki. Nangona kunjalo, kukho iingenelo ezikhethekileyo zokujonga inqanaba le-B12 kunye nenqanaba le-MMA. Ukujonga inqanaba le-MMA kunika ugqirha ulwazi oluthe kratya kwaye kuvumela ukuxilongwa ngokuchanekileyo .

Cinga ngale ndlela. Amanqanaba e-B12 egazini lakho asenokuba aqhelekileyo xa uwavavanya. Kodwa umzimba wakho usenokungakwazi ukusebenzisa i-B12 ngokufanelekileyo. Oku kubizwa ngokuba yi -bioavailability ephantsi. Khumbula, i-MMA yenziwa xa amanqanaba e-B12 ephantsi. Ngoko ke, nokuba amanqanaba e-B12 egazini lakho aqhelekile, ukuba amanqanaba e-MMA akho aphezulu, inokuxelela ugqirha wakho ukuba umzimba wakho awusebenzisi i-B12 ngokufanelekileyo, kwaye kukho into engalunganga. Kwakhona, amanqanaba aphezulu e-MMA anokunceda ekuxilongeni nasekunyangeni ezinye iimeko zempilo kwangethuba .

Ungenza njani uvavanyo lwe-MMA?

Ukuze wenze uvavanyo lwe-MMA, ugqirha wakho uya kukucela ukuba uthathe isampuli yegazi (ukutsalwa kwegazi) okanye isampuli yomchamo (uvavanyo lomchamo).

• Isampuli yegazi ingathathwa elabhoratri, esibhedlele, okanye eofisini kagqirha.
• Ukuba yisampulu yomchamo , ungacelwa ukuba uyithathe ekhaya uze uyiyise kwilebhu, okanye ungacelwa ukuba uyinike ugqirha.

Inqanaba le-MMA kweli sampuli lijongwa kwilebhu ye-pathology, apho kuvavanywa khona ulwelo lomzimba kunye nezicubu zomzimba.

Ngamanye amaxesha, ugqirha wakho angacela uvavanyo lwe-homocysteine . Emva koko, ukuxilongwa kwenziwa ngokusekelwe kuloo ngxelo kunye nengxelo ye-MMA.

Ulungiselela njani olu vavanyo?

Inkqubo yokulungiselela ingahluka kancinci ngokuxhomekeke ekubeni uvavanyo lwakho lwe-MMA lwenziwa ngegazi okanye ngomchamo. Ngoko ke, soloko ubuza ugqirha wakho ukuba kukho nayiphi na imiyalelo ekhethekileyo.

• Ngokwesiqhelo, ukuba luvavanyo lwegazi , uya kucelwa ukuba uzile ukutya , oko kuthetha ukuba ungatyi okanye usele nantoni na, kangangeeyure ezimbalwa ngaphambi kovavanyo.
• Ukuba kuthathwa isampuli yomchamo iiyure ezingama-24 , unokucelwa ukuba uyeke ukuthatha ukutya okuthile kunye namayeza ngosuku olungaphambi kovavanyo.

Kwenzeka ntoni ngexesha lovavanyo?

Oku kuyahluka ngokuxhomekeke kwisampulu ofuna ukuyinika.

• Uvavanyo lwegazi: Uhlala esitulweni uze wolule ingalo enye. Emva koko, ingcali ye-phlebotomist, umntu oqeqeshwe ukutsala igazi, ifaka inaliti emthanjeni osengalweni yakho kufutshane nengqiniba yakho ize itsale igazi elincinci. Xa inaliti isusiwe, uya kucelwa ukuba ubambe indawo ngeqhekeza le-gauze. Emva koko, kufakwa ibhandeji elincinci. Ungakhathazeki, uya kuziva intlungu encinci, kodwa iya kuphela ngokukhawuleza.

• Uvavanyo lomchamo lweeyure ezingama-24: Uqokelela umchamo wakho kwixesha leeyure ezingama-24 kwibhotile ekhethekileyo ecocekileyo. Ugqirha okanye umongikazi wakho uza kukubonisa indlela yokwenza oku. Xa ixesha liphelile, kufuneka uyise ibhotile kwilebhu.

• Isampulu yomchamo eqhelekileyo (uvavanyo lomchamo): Oku kuquka ukuqokelela umchamo omncinci kwikomityi ecocekileyo, nokuba usekhaya okanye eofisini kagqirha wakho. Uza kufundiswa indlela yokwenza oku.

• Uvavanyo losana olusandul’ ukuzalwa luvavanyo olubandakanya umboneleli wezempilo ethatha amathontsi ambalwa egazi kwindawo encinci esithendeni somntwana wakho ngenaliti. Oku kudla ngokwenziwa esibhedlele, kungekapheli usuku okanye ezimbini emva kokuzalwa.

Kwenzeka ntoni emva kovavanyo?

Emva kokuba kwenziwe uvavanyo lwegazi okanye uvavanyo lomchamo, akukho nto ikhethekileyo onokuyenza. Ilebhu iya kuhlola isampuli ize ithumele ingxelo kugqirha wakho. Isenokubonakala nakwiirekhodi zakho zonyango ze-elektroniki.

Ngaba kukho naziphi na iingozi ngolu vavanyo?

Njengakwezinye iimvavanyo zegazi, kukho umngcipheko omncinci wokosuleleka kwindawo yokufaka inaliti, kodwa uphantsi kakhulu.

Iingozi zovavanyo lomchamo kukuba isampuli isenokungaqokelelwa kakuhle (ingakumbi xa kuqokelelwa umchamo ohlala iiyure ezingama-24) kwaye isampuli isenokuba ingcolisiwe - umzekelo, ukuba into efana nebhaktheriya evela kwindle ingena emchameni - nto leyo enokubangela iziphumo ezingachanekanga kwingxelo.

Injani inqanaba eliqhelekileyo le-MMA?

Amanqanaba aqhelekileyo e-MMA egazini nasemchameni anokwahluka kancinci kwilabhoratri nganye.

• Inqanaba eliqhelekileyo le-MMA kwi-serum yi- 0.40 µmol/L (i-micromole ngelitha) , ngamanye amaxesha libhalwa njenge-umol/L okanye i-mcmol/L, kwaye kufuneka libe ngaphantsi kwelo nqanaba.
• Amanqanaba e-MMA kumchamo anokuba yinto eqhelekileyo, nokuba aphezulu njenge- 4.0 mmol/mol crt (i-millimole nge-mole ye-creatinine) . Apha i-crt ibhekisa kwikhemikhali ebizwa ngokuba yi-creatinine.

Ngoko ke, ngokuqinisekileyo kufuneka ujonge uluhlu lwereferensi olunikiweyo kwingxelo yakho.

Kuthatha ixesha elingakanani ukuba ingxelo ifike?

Kungathatha naphi na ukusuka kusuku ukuya kwiveki okanye ezimbini ukuba ingxelo ibuye emva kovavanyo lwe-MMA. Iyahluka ngokuxhomekeke kwilabhoratri. Ungabuza ugqirha wakho ukuba ungayilindela nini ingxelo.

Kuza kwenzeka ntoni ukuba inqanaba le-MMA liphezulu kakhulu?

Ukuba ingxelo yakho ye-MMA ibonisa ukuba amanqanaba akho aphezulu, unokufuna uvavanyo olongezelelweyo okanye unyango lokunqongophala kwe-vitamin B12. Ugqirha wakho usenokuthelekisa ingxelo yakho ye-MMA nezinye iziphumo zovavanyo, njengengxelo yakho ye-B12 kwaye mhlawumbi nengxelo yakho ye-homocysteine , ukuze enze isigqibo.

• Ukuba usana olusandul’ ukuzalwa lunamanqanaba aphezulu e-MMA, lusenokuba ne-methylmalonic acidemia.Kusenokubakho. Ugqirha usenokuyalela iimvavanyo ezongezelelweyo ukuqinisekisa ukuxilongwa. Unyango lwale meko luquka izongezo zeevithamini, ukutya okuneproteni ephantsi, kunye nokunciphisa ukutya okune -amino acids ezithile.

Kuthekani ukuba i-B12 iqhelekile kodwa i-MMA iphezulu?

Umzekelo, amanqanaba akho e-B12 aqhelekile, kodwa amanqanaba akho e-MMA aphezulu. Nangona kunjalo, usenokuba nokungabikho kwe-B12 - ingakumbi ukuba uneempawu. Isenokuba kukungabikho kwangoko okanye ukungabikho kancinci . Oku akuthethi ukuba uza kuba mandundu. Ugqirha wakho uya kugqiba ukuba ufuna unyango okanye akunjalo.

Ndifanele ndimbone nini ugqirha?

Ukuba uneempawu zokunqongophala kwevithamini B12, okanye ukuba unemibuzo malunga neziphumo zovavanyo lwakho, qiniseka ukuba ubona ugqirha. Ungoyiki, ugqirha uza kukuchazela yonke into.

Okokugqibela, izinto ekufuneka uzikhumbule

Uyabona, ngamanye amaxesha uvavanyo olwenziwe kwelinye ilungu lomzimba wethu lungasixelela indlela elisebenza ngayo elinye ilungu. Olu vavanyo lwe-MMA lunjalo. Inqanaba eliphezulu le-MMA linokuxelela ugqirha wakho ukuba amanqanaba akho e-B12 aphantsi, okanye ukuba umzimba wakho awuyifunxi kakuhle.

Olu lwazi lubaluleke kakhulu, ingakumbi ukuchonga iimeko ezonakalisa imithambo-luvo yethu nokuqala unyango ngokukhawuleza.

Ngoko ke, ukuba unemibuzo okanye iinkxalabo malunga nolu vavanyo lwe-MMA okanye ingxelo yalo, ungathandabuzi ukuthetha nogqirha wakho ngalo. Uza kukunika zonke iingcaciso ozifunayo. Hlala usempilweni!

` I-Vitamin B12, Uvavanyo lwe-MMA, i-Methylmalonic Acid, Ukunqongophala kwe-B12, Uvavanyo lweGazi, Uvavanyo lomchamo, Uvavanyo lwezeMpilo