Mhlawumbi wawukhe wavavanywa igazi ngenxa yesinye isifo. Okanye mhlawumbi yayiluvavanyo lwezonyango oluqhelekileyo lonyaka. Ngelo xesha, ugqirha wayekuxelela athi, "Uneproteni engaqhelekanga egazini lakho ebizwa ngokuba yi-'M protein', kwaye le meko siyibiza ngokuba yi-MGUS." Xa nabani na esiva into efana nale, uyothuka kancinci kwaye uyoyika. Kuqhelekile ukuba kuvele imibuzo emininzi engqondweni, efana nokuthi 'Ngaba ngumhlaza lo?', 'Kuza kwenzeka ntoni kum ngoku?', 'Ngaba kukho unyango lwale nto?' Kodwa ungakhathazeki. Namhlanje, siza kuthetha ngokuba yintoni i-MGUS, ingaba iyingozi ngokwenene, kunye nento esifanele siyenze ngale meko ngendlela elula kakhulu onokuyiqonda.
Yintoni kanye kanye iMGUS?
Ngamafutshane, i-MGUS (i-Monoclonal Gammopathy of Undetermined Significance) yimeko apho igazi lakho livelisa iproteni engaqhelekanga. Le protein engaqhelekanga siyibiza ngokuba yiproteni ye-M . Oku kunokubonwa ngovavanyo lwegazi okanye ngamanye amaxesha uvavanyo lomchamo.
Kulungile, masingene nzulu kancinci sibone ukuba oku kwenzeka njani.
Khawucinge ukuba sinomkhosi wokhuselo ngaphakathi emizimbeni yethu. Uhlobo olulodwa lwamajoni kulo mkhosi ziiseli zeplasma . Ezi ngokwenene luhlobo lweeseli ezimhlophe zegazi. Umsebenzi wazo ophambili kukwenza izixhobo ezikhethekileyo zeproteni ezibizwa ngokuba zii-antibodies zokulwa neentsholongwane ezibangela izifo (iibhaktheriya, iintsholongwane, njl.njl.) ezingena emizimbeni yethu. Ezi antibodies zezona zisikhusela kwizifo ngokubamba nokutshabalalisa iintsholongwane.
Kodwa kumntu one-MGUS, ezinye zezi seli zeplasma ziyaphazama kancinci. Oko kukuthi, endaweni yokwenza ii-antibodies eziqhelekileyo nezisempilweni, ezi seli ziqala ukwenza inani elikhulu leproteni efanayo, engenamsebenzi, nengaqhelekanga. Yiloo nto siyibiza ngokuba yiproteni ye-M.
Into ebalulekileyo kukuba i-MGUS ayingomhlaza . Kodwa oogqirha bayijonga njengesiqalo esingenabungozi somhlaza . Oko kukuthi, inokuba sisiqalo somhlaza. Kodwa musani ukoyika la mazwi. Uninzi lwabantu abane-MGUS alusoze lufumane naluphi na ukugula okunzulu ebomini babo.
Ngaba kukho iimpawu ze-MGUS?
Nantsi into emangalisayo. Abantu abaninzi abane-MGUS abanazo iimpawu . Yiyo loo nto le meko idla ngokufunyanwa ngengozi, ngexesha lovavanyo lwegazi olwenziwe ngesinye isizathu. Usenokungaziva mahluko. Ngoko ke kuqhelekile ukucinga, "Ndiphilile," xa ufumanisa ukuba une-MGUS. Kungenxa yokuba ezi proteni ze-M zihlala zikhona egazini, ngaphandle kokubangela monakalo emzimbeni.
Kutheni i-MGUS ikhula? Zithini izinto ezibangela umngcipheko?
Enyanisweni, oogqirha abakayazi kakuhle ukuba kutheni ezi seli zeplasma ziqala ukuziphatha ngale ndlela ingaqhelekanga. Kuseyimfihlakalo. Kodwa uphando lufumanise ukuba abanye abantu basengozini enkulu yokuhlaselwa yile meko.
Izinto ezonyusa umngcipheko wokuphuhlisa i-MGUS
- Ubudala: I-MGUS iba yinto eqhelekileyo njengoko ukhula. Ixhaphake kakhulu emva kweminyaka engama-50. Xa uneminyaka engama-70, malunga nabantu aba-5 kwabayi-100 banokuba nale meko.
- Isini: Amadoda anamathuba amaninzi okufumana i-MGUS kunabafazi.
- Uhlanga: Le meko ixhaphake kakhulu kwiintlanga ezithile, ingakumbi abantu abamnyama .
- Imbali yosapho: Ukuba isalamane esisondeleyo (umama, utata, umntakwenu) sinomhlaza wegazi ofana ne-MGUS okanye i-multiple myeloma , usemngciphekweni omkhulu wokufumana esi sifo.
- Izinto ezibangela imeko-bume: Abantu abanembali yokuchatshazelwa zizibulali-zinambuzane okanye izibulali-zinambuzane banokuba semngciphekweni omkhulu.
- Ezinye izifo: Abantu abanezifo ezithile zokuzikhusela komzimba nabo basenokuba semngciphekweni.
- Ukuvezwa kwimitha: Ukuvezwa kwimitha egqithisileyo nako kunokuba yingozi.
Ziziphi iingxaki ezinokubakho ze-MGUS?
Le yinto ecingwa kakhulu ngumntu wonke kwaye uyoyika kakhulu. Njengoko bekutshiwo ngaphambili, i-MGUS ayingomhlaza. Nangona kunjalo, kubantu abambalwa, le meko inokuba sisifo esibi ngakumbi ngokuhamba kwexesha.
Abantu abamalunga nama-20 ukuya kuma-25 kwi-100 abane-MGUS ekugqibeleni baya kuba nesifo esinzulu esinxulumene negazi. Oko kuthetha ukuba abantu abangama-75 ukuya kuma-80 kwi-100 abayi kuba nangxaki.
Izifo eziphambili ezinokukhula njengoko i-MGUS iqhubeka zezi:
- I-Multiple Myeloma: Le yeyona ngxaki ixhaphakileyo. Ngumhlaza weeseli zeplasma.
- I-Amyloidosis: Isifo apho iiproteni ze-M zigcinwa kwiindawo ezahlukeneyo zomzimba kwaye ziwonakalise.
- I-Waldenstrom macroglobulinemia: Olu luhlobo olungaqhelekanga lomhlaza wegazi.
- I-chronic lymphocytic leukemia: Olunye uhlobo lomhlaza wegazi.
Into ebalulekileyo kukuba ayinguye wonke umntu ofumana i-multiple myeloma ofumana i-MGUS kuqala. Kodwa ayinguye wonke umntu ofumana i-MGUS ofumana i-multiple myeloma.
Ukongeza, i-MGUS inokunyusa kancinci umngcipheko wezinye iingxaki zempilo:
- Amahlwili egazi
- Ukulahlekelwa ngamathambo okanye ukwaphuka kwawo
- Usulelo oluqhelekileyo
- Iingxaki zezintso
- Ukonakala kwemithambo-luvo (peripheral neuropathy): Oku kunokubangela ukungaziva mnandi nokurhawuzelelwa kwamalungu.
Ugqirha uxilonga njani i-MGUS?
Ugqirha wakho uza kwenza uvavanyo lwegazi nomchamo ukujonga ukuba kukho iproteni ye-M na. Nje ukuba oko kuqinisekiswe, baza kuvavanya umngcipheko wokuba le meko ibe ngumhlaza. Oku kuza kujonga izinto ezintathu eziphambili:
1. Ubungakanani beprotheyini ye-M egazini: Ukuba inqanaba leprotheyini ye-M lingaphezulu kwe-1.5 g/dL (iigram nge-deciliter nganye), umngcipheko uphezulu kancinci.
2. Uhlobo lweproteni ye-M: Kukho iintlobo ezahlukeneyo zeproteni ye-M (ebizwa ngokuba ziintlobo ze- Immunoglobulin (Ig) . Ezinye iintlobo zinokubangela izifo ezinzulu kunezinye.
3. Amanqanaba okukhanya angena-serum (FLC): Le yenye iproteni eveliswa ziiseli zeplasma. Uvavanyo lwegazi olukhethekileyo ( uvavanyo lokukhanya olungena-serum (FLC) ) lunokufumanisa amanqanaba angaqhelekanga kwezi.
Umntu oneenkalo ezintathu usemngciphekweni omkhulu wokuba nomhlaza. Kodwa umntu ongenazo naziphi na kwezi zinto usemngciphekweni omncinci kakhulu. Ugqirha wakho uza kukuchazela ukuba ukuliphi iqela elisemngciphekweni ngokusekelwe kwiziphumo zolu vavanyo.
Ngaba kukho unyango lwe-MGUS?
Nazi iindaba ezimnandi: Uninzi lwabantu abane-MGUS aludingi naluphi na unyango.
Ngoko ke wenza ntoni? Ugqirha wenza into ebizwa ngokuba "kukulinda ngononophelo" okanye "ukugada okusebenzayo." Ngamafutshane, "ukulinda ngononophelo."
Oko kuthetha ukuba, ngaphandle kokukunika amayeza, amanqanaba eeprotheyini zakho ze-M egazini kunye nezinye izinto zihlala zijongwa ngokweshedyuli emiselweyo.
- Ngokwesiqhelo, uvavanyo lwegazi luyalelwa rhoqo kwiinyanga ezi-3 ukuya kwezi-6 kunyaka wokuqala.
- Emva koko, ukuba yonke into izinzile, ungacela ukuhlolwa rhoqo emva kweenyanga ezi-6 okanye kube kanye ngonyaka .
Injongo ephambili yokuhlolwa rhoqo ngolu hlobo kukubona iimpawu zokuqala ze-MGUS eziguquka zibe yimeko embi kakhulu. Ukuba kukho utshintsho olubonakalayo, unyango lunokuqaliswa kwangethuba. Elo lithuba elikhulu.
Ukuba unenye ingxaki ukongeza kwi-MGUS, njengobuthathaka bamathambo, ugqirha wakho uya kukunika unyango olwahlukileyo lwaloo nto.
Ndifanele ndibonane nogqirha nini?
Ukuba une-MGUS, ugqirha wakho uza kukunika imihla ethile yokuhlolwa kwakho. Qiniseka ukuba uyaya ngaloo mihla. Ukongeza, ukuba ufumana naziphi na iimpawu ezingaqhelekanga, bona ugqirha wakho ngoko nangoko, endaweni yokulinda idinga lakho elilandelayo leklinikhi. Ezi mpawu zinokuba luphawu lokuba imeko yakho iya isiba mandundu.
Nika ingqalelo ekhethekileyo kwiimpawu ezidweliswe ngezantsi.
| Iimpawu ekufuneka uziqaphele | Inkcazo kunye nesizathu esinokwenzeka |
|---|---|
| Ukudinwa kakhulu ngaphandle kwesizathu | Ukudinwa okwahlukileyo kokudinwa okuqhelekileyo kwaye akupheli nokuba ulala kangakanani. Kusenokuba kungenxa ye-anemia (ukungabikho kwegazi). |
| Intlungu yethambo | Intlungu, ingakumbi esifubeni, emqolo, okanye ezimbanjeni. Olu luphawu oluphambili lwe-multiple myeloma. |
| Ukunciphisa umzimba ngendlela engachazekiyo | Ukuba ngequbuliso wehla umzimba ngaphandle kokuzama. |
| Usulelo oluqhelekileyo | Ukuba uhlala ufumana umkhuhlane kunye nomkhuhlane ngenxa yobuthathaka benkqubo yomzimba yokuzikhusela. |
| Ukurhawuzelela okanye ukudumba okulula | Ukopha ngenxa yokwenzakala okuncinci okanye ukubonakala kwamabala aluhlaza okwesibhakabhaka (imivumbo) phantsi kolusu. |
| Ukurhawuzelela okanye ukungakhululeki kwamalungu | Ukonakala kwemithambo-luvo (peripheral neuropathy) kunokubangela iimpawu ezifana nezi ezandleni nasezinyaweni. |
| Intloko ebuhlungu, isiyezi, utshintsho embonweni | Iimpawu ezinje zinokwenzeka ngenxa yokuqina kwegazi okubangelwa yi-M protein. |
Ukuxilongwa kwe-MGUS kunokuba yinto ephazamisayo kancinci. Amagama athi "unedetermined value" akuyo akuxelela ukuba kusekho okuninzi esingakwaziyo ngayo. Uphando lusaqhubeka ukuze kufunyaniswe ukuba kutheni ibaluleke kangaka kwabanye abantu, kungekhona kwabanye.
Kodwa eyona nto ilungileyo kukuba, ngokuqhubela phambili kwesayensi yezonyango namhlanje, ungawuvavanya umngcipheko wakho kwangaphambili. Kwaye ngenxa yokuba uhlala ujongiwe, naluphi na utshintsho lunokubonwa kwasekuqaleni. Ngoko ke eyona nto ingcono onokuyenza kukunciphisa uloyiko lwakho kwaye ulandele imiyalelo kagqirha ngokuchanekileyo.
Umyalezo Wokuya Ekhaya
- I-MGUS ayingomhlaza, kodwa yimeko engaphambi komhlaza enokuthi iguquke ibe ngumhlaza.
- Uninzi lwabantu abane-MGUS alunazo naziphi na iimpawu kwaye alubi neengxaki ezinzulu ebomini babo bonke.
- Eyona nto ibalulekileyo kukwenza uvavanyo lwegazi nomchamo wakho ngamaxesha amiselweyo, njengoko ugqirha wakho ecebisa. Oku kubizwa ngokuba 'kukulinda ngononophelo'.
- Ukuba ufumana iimpawu ezintsha nezingaqhelekanga (ingakumbi iintlungu zamathambo, ukudinwa kakhulu, ukwehla kobunzima bomzimba), bona ugqirha wakho ngoko nangoko, ngaphandle kokulinda idinga elilandelayo leklinikhi.
- Musa ukoyika ngokungeyomfuneko le meko. Eyona nto ibalulekileyo kukuba phantsi kweliso elifanelekileyo lezonyango. Thetha nogqirha wakho ngayo nayiphi na imibuzo okanye uloyiko onalo.
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