Kunzima ukuchaza ngamazwi ukuba kunjani ukufunyanwa unomhlaza weprostate. Kwakhona, umhlaza awunakulawulwa ngonyango oluqhelekileyo, kwaye kuyakhathaza nangakumbi ukwazi ukuba usasazeke kwamanye amalungu omzimba. Nangona kunjalo, ngokuhambela phambili kwesayensi yezonyango, ngoku kuye kwavela unyango olutsha noluphumelelayo kwiimeko ezinzima kangaka. Olunye unyango olutsha oluzisa ithemba elinjalo lunyango olujoliswe kwi-PSMA. Makhe sithethe ngale nto ngokulula namhlanje.
Yintoni i-PSMA-Targeted Therapy?
Ngamafutshane, olu lunyango oluphambili kakhulu olujolise kwaye lutshabalalise iiseli zomhlaza kuphela. I-PSMA kweli gama imele i -Prostate-Specific Membrane Antigen . Nangona oku kusenokuvakala kuyinkimbinkimbi ngokwegama, indlela esebenza ngayo ilula kakhulu.
Cinga ngeeseli zomhlaza weprostate njengomkhosi weentshaba. Ngamnye kula majoni otshaba unesibonakaliso esikhethekileyo, 'ibheji', kwiyunifomu yawo. Elo bheji yiPSMA. Le protein, ebizwa ngokuba yiPSMA, ikhona ngobuninzi kakhulu kumphezulu weeseli zomhlaza weprostate.
Ngoko ke into oyenzayo kolu nyango kukufaka iyeza emzimbeni elisebenza njenge-'missile ekrelekrele'. Eli yeza lihamba emzimbeni wonke, lifumana kuphela iiseli zomhlaza ezine-'bheji' ekhethekileyo ebizwa ngokuba yi-PSMA, kwaye lizincamathele kuzo. Emva koko, into ene-radioactive (`Lutetium-177`) kwiyeza itshabalalisa kuphela elo seli lomhlaza. Oku kukwabizwa ngokuba yi-`Lu177-PSMA` therapy. Ngamanye amaxesha uya kuva negama lophawu elithi `Pluvicto™`.
Eyona nzuzo inkulu yoku kukuba akufani nokudubula wonke umntu, kodwa kunoko kukuchonga utshaba oluchanekileyo nokulujolisa kubo, ngoko ke umonakalo kwiiseli ezisempilweni nezilungileyo emzimbeni wethu mncinci kakhulu.
Yintoni i-prostate gland?
Ngelixa sisesengxakini, masithethe kancinci nge-prostate gland. Oku kufumaneka kumadoda kuphela. Le gland ikwindawo engaphantsi kwesinyi, phambi kwe-anus. Ihlala ilingana ne-walnut enkulu ngobukhulu.
Kuxa kutheni apho olu nyango lusetyenziswa khona?
Olu asilonyango lwabo bonke abaguli abanomhlaza weprostate. Ludla ngokucetyiswa kwiimeko eziphucukileyo, oko kuthetha ukuba umhlaza usasazeke kakhulu ngaphaya kweprostate gland (umhlaza weprostate osasazekayo) . Oku kuthetha ukuba umhlaza usasazeke nakwamanye amalungu omzimba, njengamathambo okanye ii-lymph nodes.
Kwakhona, oogqirha bacinga ngolu hlobo lonyango xa umhlaza ungasalawulwa ngonyango oluqhelekileyo olufana notyando, imitha, kunye nonyango lweehomoni.
Ngaba olu nyango lungayinyanga ngokupheleleyo umhlaza?
Lo ngumbuzo obaluleke kakhulu. Ukuthetha inyani, hayi. Unyango olujoliswe kwi-PSMA alulonyango lomhlaza.
Ngoko ke kwenzeka ntoni ngale nto? Iinjongo eziphambili zolu nyango zezi:
- Ukunciphisa okanye ukwenza amathumba abe mancinci.
- Ukucothisa izinga lokukhula komhlaza ngakumbi.
- Ukunciphisa iimpawu ezifana neentlungu ezibangelwa ngumhlaza.
- Ukwandisa ubomi besigulana kunye nokuphucula umgangatho wobomi.
Ngamafutshane, inceda ekulweni nomhlaza kwaye iwugcine uphantsi kolawulo. Emva kolu nyango, unokuba nexesha "lokuxolelwa" xa ungenazo iimpawu zomhlaza kwaye isifo singasebenzi. Nangona kunjalo, kubalulekile ukuqhubeka nokulandela ugqirha wakho.
Kwenzeka ntoni ngaphambi kokuba unyango luqale?
Ngokwesiqhelo, ngaphambi kokuba ufumane olu nyango, kusenokwenzeka ukuba sele ufumene ezinye iindlela zonyango, ezifana ne-chemotherapy okanye unyango lwe-hormone. Ugqirha wakho uza kuxoxa nawe ngolu khetho kuphela ukuba azizange zibe neziphumo ezinqwenelekayo.
Ngaphambi kokuba uqale unyango, ugqirha wakho uza kukuxilonga kakuhle. Ufanele uxoxe naye ngembali yakho epheleleyo yezonyango, unyango lwangaphambili, kunye namayeza angoku. Eli lixesha elifanelekileyo lokubuza nayiphi na imibuzo onokuba unayo.
Ukongeza, kuye kulandelwe uvavanyo lwegazi oluninzi kunye neeskeni ezikhethekileyo. Ezi skeni zisetyenziselwa ukufumana ngqo apho iiseli zomhlaza zikhoyo emzimbeni.
| Skena | Kalula nje, kwenzeka ntoni ngale nto? |
|---|---|
| I-CT Scan (i-Computed Tomography) | Oku kuvelisa umfanekiso onemilinganiselo emithathu (3D) wamathambo kunye nezicubu ezithambileyo ngaphakathi emzimbeni. Oku kunceda ukubona apho iithumba ezinomhlaza zikhoyo kunye nobukhulu bazo. |
| Iskeni se-MRI (Umfanekiso weMagnetic Resonance) | Kusetyenziswa iimagnethi ezinkulu kunye namaza erediyo, kufunyanwa imifanekiso ecacileyo neneenkcukacha zezicubu ezithambileyo zomzimba. |
| Iskeni ye-PSMA PET | Olu lolona vavanyo lubalulekileyo kolu nyango. Kulo, njengakwindlela yangaphambili yonyango, kufakwa into ene-radioactive ebona i-PSMA emzimbeni. Nangona kunjalo, injongo yoku ayikokutshabalalisa iiseli zomhlaza, kodwa kukuphawula apho zikhoyo kwi-scan. Oku kunokufumana ngokuchanekileyo kwaneseli yomhlaza encinci. |
Ngokudibanisa zonke ezi scan, oogqirha benza imephu epheleleyo yendlela umhlaza osasazeke ngayo emzimbeni wakho.
Kwenzeka ntoni ngexesha lonyango?
Ukunika olu nyango akunzima njengoko unokucinga.
- Ngokwesiqhelo, i-cannula encinci ifakwa emthanjeni osengalweni yakho, kwaye iyeza linikwa emzimbeni wakho ngayo, njengesicombululo setyuwa.
- Le injection iqulethe into ene-radioactive ethi "Lutetium-177" esithethe ngayo.
- Inkqubo yokugonya ithatha imizuzu embalwa kuphela.
- Usenokunikwa amayeza kwangaphambili ukuze ulawule izinto ezifana nokucaphuka nokuhlanza.
- Le yinkqubo yokulaliswa ngaphandle . Oku kuthetha ukuba akufuneki uhlale esibhedlele. Uza kuhlolwa iiyure ezimbalwa emva konyango uze emva koko ugoduke xa imeko yakho izinzile.
Ithatha ixesha elingakanani le nyango?
Olu nyango ludla ngokucwangciswa rhoqo emva kweeveki ezintandathu . Kufuneka kugqitywe imijikelo yonyango emithandathu. Oku kuthetha ukuba ixesha lonyango lilonke limalunga neenyanga ezisi-8 (iiveki ezingama-36).
Emva komjikelo omnye wonyango nangaphambi kolandelayo, ugqirha wakho uya kwenza uvavanyo lwegazi ukuze abone ukuba umzimba wakho usabela njani kunyango aze ajonge iziphumo ebezingalindelekanga.
Zithini iingenelo zolu nyango?
Eyona nzuzo iphambili yolu nyango kukuba lunokulawula umhlaza weprostate oqhubekileyo ongaphenduliyo kwezinye iindlela zonyango, lunciphise iimpawu, kwaye lunciphise ukusasazeka kwesi sifo.
Enye inzuzo enkulu yoku kukuba ijolise kwaye itshabalalise iproteni ye-PSMA kwiiseli zomhlaza, ngoko ke akukho monakalo mkhulu kwiiseli eziphilileyo emzimbeni. Oku kufana nohlaselo olujoliswe kakhulu.
Ngaba kukho naziphi na iziphumo ebezingalindelekanga? Zithini iingozi?
Njengakwezinye iindlela zonyango lomhlaza, kukho iziphumo ebezingalindelekanga ezinokubakho. Nangona kunjalo, ayinguye wonke umntu ozifumana ngendlela efanayo. Abanye abantu basenokuzifumana rhoqo.
| Iziphumo ebezingalindelekanga eziqhelekileyo | Ingcaciso encinci ngaloo nto |
|---|---|
| Umlomo owomileyo | Eli yeza linokuba nefuthe elithile kwi-salivary glands, ngoko ke ungaziva ngathi umlomo wakho uzele ngamathe. |
| Amehlo omileyo | Ukuveliswa kweenyembezi emehlweni kunokuchaphazeleka, nto leyo ebangela ukuba amehlo azive omile kwaye erhabaxa. |
| Ukudinwa | Ukuziva udiniwe kakhulu. Oku kuqhelekile kwiindlela ezininzi zonyango lomhlaza. |
| Isicaphucaphu nokuhlanza | Ugqirha uza kukunika amayeza okulawula le meko. |
| Umnqweno wokutya | Umnqweno wokutya kunye nomdla wokutya unokuncipha. |
| Ukuncipha kweeseli zegazi | Amanqanaba e-hemoglobin kunye neeplatelets egazini asenokuba aphantsi kancinci. Yiyo loo nto uvavanyo lwegazi lwenziwa rhoqo. |
Musa ukukhathazeka ngezi ziphumo ebezingalindelekanga. Uninzi lwazo lunokulawulwa. Kubalulekile ukuthetha nogqirha wakho malunga nokungonwabi okuvayo.
Izinto onokuzenza ukuze unyango lwakho lube lula
Ukuphila nomhlaza kunye nokunyangwa akulula. Ezi zinto ziya kukunceda wenze eli xesha libe lula kancinci kuwe.
Phumla kakuhle.
Xa ufumanisa ukuba unomhlaza, uxinzelelo lokucinga ngonyango lunokwenza kube nzima ukulala. Kodwa umzimba wakho udinga ukuphumla ngokwenene. Ukungalali ngokwaneleyo akunakuchaphazela nje kuphela indlela ovakalelwa ngayo, kodwa kunokwenza kube nzima nokujongana noxinzelelo lonyango.
- Kuphephe ukutya ukutya okugqithisileyo, ikofu, kunye notywala ngaphambi kokulala.
- Izinto ezinje ngokucamngca kunye nokubhala iijenali zinokukunceda ukhulule iingcinga zakho kwaye uphumze ingqondo yakho.
- Phumla xa umzimba wakho ukuxelela ukuba wenze njalo, hayi xa unako.
Shukumisa umzimba wakho kancinci xa unako.
Ukuba uziva udiniwe, licebo elihle ukwenza umthambo omncinci. Nokuba yinto efana nokuhamba inokunceda ukugcina intliziyo yakho kunye nemiphunga isebenza kakuhle, iqinise izihlunu zakho, incede amajoni akho omzimba, kwaye inciphise ukudinwa kunye noxinzelelo.
Kodwa khumbula, ngaphambi kokuba uqale naluphi na umthambo, kubaluleke kakhulu ukubonisana nogqirha wakho.
Yitya ukutya okunesondlo.
Ukucaphuka kunye nokuphelelwa ngumdla wokutya kunokunciphisa umdla wakho wokutya, kodwa kubaluleke kakhulu ukunika umzimba ukutya okufunekayo ngeli xesha.
- Iiproteni ezinamafutha aphantsi (intlanzi, inkukhu)
- Imifuno neziqhamo
- Amazimba
- Ukutya kobisi okunamafutha aphantsi
Yongeza izinto ezinjalo ekutyeni kwakho. Thetha nogqirha wakho ngale nto. Angakuthumela kwingcali yokutya eqinisekisiweyo yi-oncology.
Fumana inkxaso oyifunayo.
Awuwedwa kolu hambo. Ukuthetha ngoloyiko lwakho, intlungu yakho, kunye neenkxalabo zakho nelungu losapho okanye umhlobo osondeleyo kunokuba ngumthombo omkhulu wentuthuzelo. Ungabuza ugqirha wakho malunga namaqela enkxaso apho abanye abaye baba namava afanayo banokuya khona, okanye malunga nomcebisi wezempilo yengqondo.
Ingaba olu nyango lufumaneka eSri Lanka?
Unyango olujoliswe kwi-PSMA yindlela yonyango evunyiweyo kwaye yamkelwe zizikhungo zamazwe ngamazwe ezifana ne-FDA eMelika. ESri Lanka, izibhedlele ezinkulu ezinyanga umhlaza nazo ziyakwazi ukufumana iindlela zonyango eziphucukileyo.
Nangona kunjalo, eyona ndlela ilungileyo nekuphela kwayo yokufumana ulwazi oluchanekileyo nolucacileyo malunga nokuba oku kulungile na kuwe, apho ungalufumana khona olu nyango eSri Lanka, kunye nokuba lubiza malini kukuthetha ngqo nogqirha wakho we-oncologist. Uza kufunda imeko yakho kakuhle aze akukhokele kunyango olufanelekileyo kuwe.
Umyalezo Wokuya Ekhaya
- Unyango olujoliswe kwi-PSMA lunyango oluphambili lomhlaza weprostate olusasazeke emzimbeni wonke kwaye alulawulwa zezinye iindlela zonyango.
- Nangona olu nyango lungeyonyango oluphilisa umhlaza ngokupheleleyo, luluncedo kakhulu ekulawuleni esi sifo, ekunciphiseni iimpawu, nasekuphuculeni umgangatho wobomi.
- Enye yezona nzuzo zinkulu zoku kukuba ijolise kuphela kwiiseli zomhlaza, nto leyo enciphisa umonakalo kwiiseli ezisempilweni.
- Iziphumo ezingalindelekanga ezifana nomlomo owomileyo kunye nokudinwa zinokubakho, kodwa kukho iindlela zokuzilawula.
- Kubalulekile ukuthetha ngokukhululekileyo nogqirha wakho malunga nolu nyango okanye naluphi na uhlobo lokungonwabi onokuba unalo. Hlala ukhumbula ukuba awuwedwa kolu hambo.
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