Isifo seSickle Cell sisifo esinokuba ngumceli mngeni wokwenene ebomini. Ngabo banamava aso kuphela abaziyo ukuba kunzima kangakanani ukuphila nentlungu engapheliyo, ukudinwa, kunye nezinye iingxaki. Nangona kunjalo, ngokuhambela phambili kwesayensi yezonyango, amayeza amatsha afunyenwe elawula ezo zifo. Olunye unyango olutsha noluphumelelayo yiVoxeletor. Ngoko ke ukuba ugqirha wakho ukunike eli yeza, kubaluleke kakhulu ukuba nolwazi olupheleleyo ngalo. Namhlanje, masithethe ngezi pilisi zeVoxeletor.
Luhlobo luni lonyango iVoxeletor?
Ngamafutshane, iVoxeletor luhlobo olukhethekileyo lwamayeza asetyenziselwa ukunyanga isifo se-sickle cell . Ngokwezonyango, ikwiqela lamayeza abizwa ngokuba yi-'hemoglobin S polymerization inhibitors'.
Ngoku usenokuba uzibuza ukuba yintoni leyo. Kulula kakhulu. Umntu onesifo se-sickle cell uneproteni ebizwa ngokuba yi-hemoglobin kwiiseli zakhe ezibomvu zegazi eyahlukileyo kancinci. Xa amanqanaba eoksijini ephantsi, ezi molekyuli ze-hemoglobin ziyanamathelana, zenze imixokelelwane emide etshintsha imo yeeseli ezibomvu zegazi. Iiseli ezibomvu zegazi eziqhelekileyo zigoba zibe yimo yesike. Ezi seli zesike yizo ezinamathela kwimithambo yegazi emincinci, zibangela iingxaki ezifana neentlungu kunye nomonakalo wamalungu omzimba.
Ngoko ke, into eyenziwa yiVoxeletor kukuthintela iimolekyuli zehemoglobin ukuba zingadibani (polymerization). Oku kunciphisa iiseli ezibomvu zegazi ezimile okwesikela kwaye kuzinceda zigcine imo yazo efanelekileyo. Oku kuvumela igazi ukuba lihambe kakuhle kwaye kunciphisa iingxaki zesifo kakhulu.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale eli yeza
Ngaphambi kokuba uqale unyango lweVoxeletor, kubalulekile ukunika ugqirha wakho inkcazo epheleleyo yempilo yakho. Qiniseka ukuba uzikhankanya ezi zinto ngokukodwa.
- Ukuba uneengxaki zesibindi: Ukuba ukusebenza kwesibindi sakho akusebenzi kakuhle, oku kunokuchaphazela indlela elisuswa ngayo iyeza emzimbeni wakho. Ke ngoko, ugqirha wakho unokufuna ukutshintsha umthamo.
- Ukuba ukhe waba ne-allergy kwiVoxeletor okanye nakweyiphi na enye iyeza okanye ukutya: Abanye abantu bane-allergy kumayeza athile. Ngoko ke qiniseka ukuba uyasixelela ukuba ukhe waba namava ngaphambili.
- Ukuba ukhulelwe okanye uceba ukukhulelwa: Kufuneka ulumke kakhulu malunga nokusebenzisa amayeza ngexesha lokukhulelwa. Ngoko ke qiniseka ukuba uthetha nogqirha wakho ngale nto.
- Ukuba ungumama oncancisayo: Amanye amayeza anokudluliselwa kumntwana wakho ngobisi lwebele. Ngoko ke, yazisa ugqirha wakho ngale nto.
Ndingazisebenzisa njani ezi pilisi?
Ukuze ufumane unyango olungcono kakhulu, kubaluleke kakhulu ukulusebenzisa ngokuchanekileyo.
- Ginya le pilisi yonke ngeglasi yamanzi. Ungaze uyiqhekeze, uyityumze, okanye uyihlafune. Ginya ipilisi yonke. Ukungaphumeleli ukwenza njalo kunokutshintsha indlela amayeza angena ngayo emzimbeni, nto leyo enciphisa ukusebenza kwawo.
- Ungalithatha eli yeza nokuba utye okanye ungenalo. Nangona kunjalo, ukuba uziva uphazamisekile esiswini okanye unesicaphucaphu, kungcono ukulithatha emva kokutya.
- Sela amayeza akho yonke imihla, njengoko ugqirha wakho ekuyalele. Musa ukuwasela ngenye imini uze udlule kolandelayo.
- Nokuba uzive ungcono, ungayeki ukuthatha amayeza ngaphandle kwengcebiso kagqirha wakho.
Kubalulekile: Eli yeza limiselwe wena wedwa. Musa ukunika eli yeza nabani na oneempawu ezifanayo nezakho. Lisenokuba yingozi.
Ukuba unika abantwana eli yeza...
Oogqirha bakwanika abantwana abaneminyaka engaphezu kwe-12 eli yeza kwiimeko ezithile ezikhethekileyo. Nangona kunjalo, ugqirha wabantwana kufuneka enze isigqibo. Ke ngoko, ukuba unika umntwana wakho eli yeza, thetha nogqirha wakho ngononophelo kwaye ufumane ingcebiso.
Yintoni omawuyenze ukuba uphoswe yidosi yeyeza?
Ukuba ulibele ukuthatha idosi, ungakhathazeki. Yitsibe idosi ephosiweyo uze uthathe idosi elandelayo ngexesha eliqhelekileyo. Ungaze uthathe idosi ephindwe kabini ukuze ubuyisele idosi ekhohliweyo.
Kuthekani ukuba ndithatha amayeza amaninzi kakhulu?
Ukuba ucinga ukuba uthathe ngaphezu kwedosi emiselweyo, fowunela iZiko loLwazi lweePoisons kwiSibhedlele sikaZwelonke saseColombo ngoko nangoko. Ngaphandle koko, yiya kwiYunithi yoNyango oluNgxamisekileyo (ETU) yesibhedlele esikufutshane ngaphandle kokulibazisa.
Amanye amayeza anokusebenzisana neVoxeletor
Amanye amayeza owasebenzisayo anokuchaphazela indlela esebenza ngayo iVoxeletor. IVoxeletor inokutshintsha nendlela esebenza ngayo amanye amayeza. Ngoko ke, xelela ugqirha wakho ngawo onke amayeza owasebenzisayo (kuquka iivithamini, amayeza esintu, kunye nezongezo) .
| Uhlobo lweyeza | Phawula |
|---|---|
| Ii-Antifungal (umz. i-fluconazole, i-ketoconazole) | Ezi zinokunyusa izinga leVoxeletor emzimbeni. |
| Amayeza esifo sephepha (umz. `rifampin`) | Oku kunokunciphisa ukusebenza kakuhle kweVoxeletor. |
| Unyango lwe-HIV (umz. i-efavirenz) | Iziphumo zeVoxeletor zinokuchaphazeleka. |
| Ezinye izinto zokuthomalalisa (umz. i-midazolam) | I-Voxeletor inokutshintsha imiphumo yala mayeza. |
Olu luhlu aluphelelanga. Ngoko ke xelela ugqirha wakho ngazo zonke iziyobisi ozisebenzisayo, ukuba uyatshaya, nokuba usela utywala.
Iziphumo ebezingalindelekanga ezinokubakho ngenxa yale yeza
Njengalo naliphi na iyeza, iVoxeletor inokubangela iziphumo ebezingalindelekanga kwabanye abantu. Ezinye zezi zinokuba yingozi, ngoko ke kubalulekile ukuba uzazi.
| Iziphumo ebezingalindelekanga ezinzulu ekufuneka zixelwe kugqirha ngoko nangoko | |
|---|---|
| Iimpendulo ze-Allergic | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kwemilebe, ulwimi okanye ubuso, ubunzima bokuphefumla. |
| Iimpawu zeClot yegazi | Intlungu yesifuba ngequbuliso, ubunzima bokuphefumla, intlungu ngequbuliso, ukudumba, okanye ukuba bomvu emlenzeni. |
| Iziphumo ebezingalindelekanga ezihlala zingeyongozi, kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka | |
| Iingxaki zenkqubo yokugaya ukutya | Intlungu yesisu, urhudo, isicaphucaphu. |
| Ezinye iingxaki ezincinci | Intloko ebuhlungu, ukudinwa, umkhuhlane. |
Ukuba ufumana naziphi na ezinye iimpawu ezingaqhelekanga ezingakhankanywanga kolu luhlu, thetha nogqirha wakho ngazo.
Ndingaligcina njani iyeza?
- Yigcine kude nabantwana abancinci .
- Gcina kubushushu begumbi, ngaphantsi kwama-30 degrees Celsius (86 degrees Fahrenheit). Khusela kubushushu obugqithisileyo kunye nokufuma.
- Lahla amayeza aphelelwe lixesha ngaphandle kokuwasebenzisa.
Umyalezo Wokuya Ekhaya
- I-Voxeletor liyeza elibalulekileyo elithintela iiseli ezibomvu zegazi ekutshintsheni imilo kwisifo se-sickle cell kwaye linciphisa iingxaki zesifo.
- Ngaphambi kokuba uqalise eli yeza, xelela ugqirha wakho ngalo lonke ulwazi lwakho lwempilo kunye nawo onke amanye amayeza owasebenzisayo.
- Ginya ipilisi yonke, ungayiqhekezi, ungayityumzi, okanye ungayihlafuni. Thatha idosi emiselweyo ngexesha elimiselweyo.
- Ukuba ufumana naziphi na iziphumo ebezingalindelekanga ezinje ngokudumba kobuso, ubunzima bokuphefumla, okanye iintlungu zesifuba, funa ingcebiso kagqirha ngokukhawuleza.
- Eli yeza lelakho kuphela. Ungaze wabelane ngalo nabanye. Ukuba uneengxaki, thetha nogqirha wakho rhoqo.
💬 Comments (0)
Akukho zimvo zithunyelweyo okwangoku. Faka uluvo lwakho apha okokuqala.
Faka uluvo lwakho