Ngaba wakha weva nge "Waldenström Macroglobulinemia"? Mhlawumbi akunjalo. Ligama elide, elinzima ukulibiza, akunjalo? Kodwa ungakhathazeki. Luhlobo lomhlaza wegazi olungaqhelekanga, kodwa oluqhelekileyo. Namhlanje, siza kuthetha ngale meko ngolwimi olulula onokuluqonda, njengokuthetha nomhlobo. Makhe sibone ukuba yintoni kanye kanye, zithini iimpawu, kwaye inyangwa njani.
Yintoni kanye kanye iWaldenström Macroglobulinemia (WM)?
Ngamafutshane, lo ngumhlaza ochaphazela igazi lakho. Ngokuchanekileyo, ungoweqela leemhlaza ezibizwa ngokuba yiLymphoma, kwaye luhlobo lwe-non-Hodgkin lymphoma. Ukwabizwa ngokuba yi-lymphoplasmacytic lymphoma. Unqabile kakhulu. Kwanakwilizwe elifana neMelika, uchaphazela abantu abathathu ukuya kwabane kuphela kwisigidi. Ngoko ungacinga ukuba unqabile kangakanani.
Ngoku makhe sibone ukuba oku kwakheka njani ngaphakathi emzimbeni.
Enye yezona ntlobo zibalulekileyo zeeseli kwinkqubo yethu yokuzikhusela komzimba ibizwa ngokuba yi-"B cells." Ezi ziveliswa kumongo wethu wethambo. Uyazi ukuba umongo yindawo engaphakathi emathanjeni ethu efana nomzi-mveliso ovelisa iiseli zegazi.
Ngoko ke, kwi-WM, ezi seli ze-B eziphilileyo zijika zibe ziiseli zomhlaza kwaye ziqala ukwahlukana nokwanda ngokungalawulekiyo. Xa ezi seli zomhlaza zizalisa umongo wethambo, zikhupha iiseli zethu zegazi eziphilileyo.
Ngoko ke, iintlobo ezintathu eziphambili zeeseli zegazi zinokuncitshiswa:
- Iiseli eziBomvu eziNciphisiweyo: Oku kubizwa ngokuba yi-"anemia". Yiyo le nto ikwenza uzive udiniwe kakhulu kwaye ungenabomi .
- Ukuncipha kweeSeli zeGazi ezimhlophe: Oku kubizwa ngokuba yi-"neutropenia." IiSeli zegazi ezimhlophe zifana namajoni emzimbeni wethu. Ezi seli zisikhusela kwizifo. Ngoko ke xa ezi seli zincipha , usulelo lunokubakho rhoqo .
- Iiplatelets ezinciphileyo: Oku kubizwa ngokuba yi-`(thrombocytopenia).` Ezi zezona zinceda ekuqhekekeni kwegazi. Zezona zithintela ukopha nokuba kukwinxeba elincinci. Ngoko ke xa iiplatelets ziphantsi, nenxeba elincinci alinakukuthintela ukopha, kwaye unokufumana imivumbo emzimbeni wakho .
Ukongeza, ezi seli zomhlaza zivelisa inani elikhulu leproteni engaqhelekanga ebizwa ngokuba yi-`(immunoglobulin M)` okanye `(IgM)`. Xa le proteni ye-`(IgM)` iqokelelana egazini, igazi lethu liyaqina. Khawuthelekelele ukuba igazi, elifanele ukuba lifana namanzi, liyaqina njengesiraphu. Oku kubizwa ngokuba yi-`(hyperviscosity syndrome)` kwisayensi yezonyango.
Xa igazi likhula ngolu hlobo, kuba nzima ukuhamba ngemithambo yegazi emincinci necolekileyo emizimbeni yethu. Oku kunokubangela iimpawu ezinzulu ezifana nesiyezi kunye nokopha empumlweni.
Akukho nyango lwe-WM okwangoku. Nangona kunjalo, kuba ixhaphake kakhulu, ngonyango olufanelekileyo, iimpawu zinokulawulwa, kwaye ngamanye amaxesha zipheliswe ngokupheleleyo, kwaye abantu banokuphila kakuhle iminyaka.
Ziziphi iimpawu ezinokubakho zesifo se-WM?
Into emangalisayo kukuba malunga nomntu omnye kwabane abanesi sifo akabonisi zimpawu. Bafunyanwa ngengozi ngexesha lovavanyo xa besiya kugqirha ngenxa yesinye isifo. Ukuba iimpawu ziyavela, ziza kancinci kancinci.
Makhe sijonge iimpawu eziqhelekileyo ezinje.
| Uphawu | Kalula nje... |
|---|---|
| Ubuthathaka kunye nokudinwa kakhulu | Ukudinwa nokuba ulala kangakanani na, okubangelwa kukungabikho kweeseli ezibomvu zegazi (i-anemia). |
| Umkhuhlane ngaphandle kwesizathu | Umkhuhlane ongenalo naluphi na usulelo. |
| Ukulahlekelwa ngumdla wokutya kunye nokunciphisa umzimba | Ukunciphisa umzimba ngaphandle komzamo, ngaphandle kokuqaphela. |
| Ukubila kakhulu ebusuku | Ubila kakhulu kangangokuba awukwazi ukulala, amashiti amanzi kakhulu. |
| Ukuphazamiseka kwenkumbulo kunye nokuqonda (Ukudideka) | Istroke sinokwenzeka ngenxa yokuphazamiseka kokuhamba kwegazi ukuya engqondweni ngenxa yokugabha kwegazi. |
| Ukudumba kwesibindi, ipleyini, okanye ii-lymph nodes | Iiseli zomhlaza ziyaqokelelana kwezi zitho, nto leyo ebangela ukuba zikhule. |
| Ukungaziva zimpawu kwamalungu omzimba (i-Peripheral Neuropathy) | Ukuziva ukurhawuzelela kwiminwe nakwiinzwane, ngokungathi iimbovane zibaleka zijikeleza. |
| Iimpawu zokuqunjelwa kwegazi | Ukopha empumlweni, ukopha kweentsini xa uhlamba amazinyo, isiyezi, iintloko ezibuhlungu rhoqo, ukubona izinto ezingaqondakaliyo. |
Kutheni olu hlobo lwesifo lusenzeka?
Eyona sizathu siphambili soku kukuguquka kwezakhi zofuzo. Oko kukuthi, utshintsho kwizakhi zofuzo zethu. Abantu abalithoba kwabalishumi abane-WM banotshintsho kwizakhi zofuzo ezibizwa ngokuba yi-``MYD88```. Kwaye malunga nabantu abane kwabalishumi banotshintsho kwizakhi zofuzo ezibizwa ngokuba yi-``CXCR4```. Utshintsho kuzo zombini ezi zakhi zofuzo lunceda iiseli zomhlaza ezingaqhelekanga ukuba zahlukane kwaye zikhule ngokukhawuleza.
Kodwa eyona nto ibalulekileyo neqinisekisayo apha kukuba olu tshintsho lwemfuza aluzuzwa njengelifa.
Oko kuthetha ukuba, le asiyonto uyifumene kumama okanye kutata wakho. Kwaye asiyonto oyidlulisela kubantwana bakho. Ezi ziinguqu ezintsha ezenzeka emzimbeni ngexesha lobomi.
Kodwa abaphandi abakakwazi ukufumana isizathu esithile sokuba kwenzeke olu tshintsho lwemfuza.
Ziziphi izinto ezibangela umngcipheko wokufumana esi sifo?
Kukho izinto ezithile ezinyusa kancinci amathuba okufumana esi sifo. Nangona kunjalo, ukubakho kwale nto akuthethi ukuba esi sifo siza kuvela.
| Into enobungozi | Inkcazo |
|---|---|
| Ubudala | Esi sifo sidla ngokufunyanwa kubantu abaneminyaka engaphezu kwama-65 ubudala. |
| Isizwe | Kuqhelekile ukubonwa phakathi kwabantu abamhlophe. |
| Isini | Amadoda anamathuba amaninzi okuba nayo le ngxaki kunabafazi. |
| Ezinye iimeko zonyango | Abantu abanezifo ezifana neHepatitis C, iAIDS, kunye neSjögren's Syndrome basengozini enkulu. Imeko ebizwa ngokuba yi-``(MGUS)`` inokuba sisiseko se-WM. Nangona kunjalo, ayinguye wonke umntu one-MGUS oza kuba ne-WM. |
| Imbali yezonyango yosapho | Umngcipheko unokwanda kancinci ukuba isalamane segazi sibe ne-WM okanye olunye uhlobo lwe-lymphoma. |
Ugqirha usifumanisa njani esi sifo?
Ukuba uneempawu, ugqirha wakho uza kwenza iimvavanyo ezininzi ukuqinisekisa ukuba unesifo na. Uvavanyo oluphambili kukujonga iiseli zomhlaza kunye neproteni engaqhelekanga ``(IgM)`` egazini lakho.
- Uvavanyo lwegazi nomchamo: Olu vavanyo lujonga ukuba iiseli zegazi ziphantsi na (iiseli ezibomvu, iiseli ezimhlophe, iiplatelets) kunye namanqanaba aphezulu ngokungaqhelekanga eproteni ``(IgM)''.
- Uvavanyo lwemifanekiso: Uvavanyo olufana ne-"CT scan" okanye "PET scan" lunokusetyenziswa ukujonga ukuba akukho lymph nodes zidumbileyo na kunye namalungu omzimba akhulisiweyo anjengesibindi kunye ne-spleen.
- Uvavanyo lwamehlo: Ngamanye amaxesha, ukopha okuncinci kunokwenzeka ngaphakathi kweliso, ngasemva kwebhola yeliso, ngenxa yokuqhekeka kwegazi. Ingcali yamehlo ingakujonga oku.
- I-Bone Marrow Biopsy: Olu lolona vavanyo lubalulekileyo lokuqinisekisa esi sifo. Kule meko, kuthathwa isampulu encinci kakhulu yomongo wethambo kwindawo efana nethambo lesinqe ize ihlolwe nge-microscope. Oku kungasetyenziselwa ukufumanisa ukuba kukho iiseli zomhlaza na kuwo.
Ziziphi iindlela zonyango ze-WM?
Njengoko besitshilo ngaphambili, nangona esi sifo singenakunyangwa ngokupheleleyo, kukho unyango olusebenzayo kakhulu lokulawula iimpawu. Ugqirha wakho uza kuvavanya imeko yakho aze enze isicwangciso sonyango esifanelekileyo kuwe kwaye sineziphumo ebezingalindelekanga ezimbalwa.
| Indlela yonyango | Kwenzeka ntoni kuyo? |
|---|---|
| Ukulinda Ngokucothayo | Ukuba awunazo iimpawu, ugqirha wakho uza kukujonga nje ngaphandle kokusebenzisa amayeza. Abanye abantu baphila kakuhle iminyaka emininzi ngaphandle konyango. |
| I-Plasmapheresis (utshintshiselwano lwe-plasma) | Oku kwenziwa ukuba uneempawu zokuxinana kwegazi. Umatshini wahlula inxalenye yolwelo ebizwa ngokuba yiplasma egazini lakho, ususa iproteni ye-IgM eyingozi, uze ubuyisele iplasma ecocekileyo emzimbeni wakho. |
| Unyango lwe-immunotherapy | Oku kuquka ukusebenzisa amajoni akho omzimba ukutshabalalisa iiseli zomhlaza. Iyeza elithi ``Rituximab`` lisetyenziswa kakhulu koku. |
| Unyango ngamakhemikhali | Ukunika amayeza abulala iiseli zomhlaza. Ngamanye amaxesha oku kudityaniswa ne-immunotherapy. |
| Unyango olujoliswe kulo | Olu luhlobo olutsha lonyango. La mayeza ajolise kwiiproteni ezithile ezinceda iiseli zomhlaza zahlukane kwaye zikhule, ziyeke ukusebenza kwazo. `(Ibrutinib)` kunye `(Zabrutinib)` zezo ziyobisi. |
| Ukufakelwa kweeStem Cell | Olu lunyango olungaqhelekanga kakhulu, lwenziwa kuphela kwizigulana ezikhethiweyo. Kule meko, umongo wethambo owonakaliswe ngumhlaza uthatyathelwa indawo ngumongo wethambo ophilileyo. |
Buza kuba njani ubomi ngesi sifo?
Ngenxa yokuba sisifo esiqhubekela phambili kakhulu, amava abantu abaninzi awafani. Uphando lubonise ukuba abantu abangama-66 kwabayi-100 (oko kukuthi abangaphezu kwaba-2 kwaba-3) basaphila emva kweminyaka eli-10 emva kokufunyaniswa kwesi sifo. Nangona kunjalo, oku kuyahluka ngokweminyaka. Kwiimeko ezininzi, abantu abafunyaniswa emva kweminyaka engama-65 abafi ngenxa ye-WM, kodwa ngenxa yezinye iimeko ezikhula njengoko bekhula.
Indlela oqhubeka ngayo ixhomekeke kwizinto ezininzi:
- iminyaka yakho
- Iziphumo zeengxelo zovavanyo lwakho lwegazi
- Uhlobo lotshintsho lwemfuza onalo
Ukuba unemibuzo malunga noku, thetha nogqirha wakho. Uyakwazi wena nayo yonke into echaphazela impilo yakho.
Yintoni onokuyenza ukuze uhlale usempilweni?
Ukuphila nesigulo esifana ne-WM ixesha elide kunokuthetha ukwenza utshintsho olukhulu ebomini bakho, kodwa zininzi izinto onokuzenza ukunceda.
- Buza ugqirha wakho: Zeziphi ukutya neziselo ezifanelekileyo kuwe, zeziphi imithambo efanelekileyo kuwe, kunye nezinto ekufuneka uzenze ukuze uhlale uphilile engqondweni.
- Qhagamshelana nabanye: Xa unesifo esingaqhelekanga esifana nesi, unokuziva unesizungu, njengokuthi "Ndim ndedwa emhlabeni onesi sifo." Kodwa awuwedwa. Kukho amaqela enkxaso kubantu abanesifo esi. Cela ugqirha wakho ukuba akudibanise nesinye. Ukuthetha nabantu abaye badlula kwizinto ezifanayo nawe kunokuba ngumthombo omkhulu wamandla.
Umyalezo Wokuya Ekhaya
- I-Waldenström Macroglobulinemia (WM) ngumhlaza wegazi oqhelekileyo nolawulekayo.
- Abantu abaninzi abafunyaniswe benesifo ekuqaleni abanazo iimpawu, ngoko ke banokuphila iminyaka emininzi ngaphandle konyango.
- Esi asisosifo esizuzwa njengelifa, ngoko ke ungakhathazeki ngokusidlulisela kubantwana bakho.
- Injongo ephambili yonyango ayikuko ukunyanga esi sifo, kodwa kukulawula iimpawu nokugcina umgangatho wobomi bakho.
- Thetha ngokukhululekileyo nogqirha wakho onyangayo malunga nemibuzo, uloyiko, okanye amathandabuzo onokuba nawo. Uza kukunceda.
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