Ngaba uhlala ufumana izilonda zesisu okanye i-gastritis? Ngaba unesifo sesisu esingapheliyo esingaphucukiyo nangona unyango lukhona? Ngaba unesifo sorhudo? Ngamanye amaxesha sicinga ngezi zinto njengezinto eziqhelekileyo, kodwa namhlanje siza kuthetha ngemeko engaqhelekanga efihlakeleyo emva kwezi zinto, kodwa inokuba yingozi kancinci. Oku kubizwa ngokuba yiZollinger-Ellison Syndrome.
Ngamafutshane, yintoni iZollinger-Ellison Syndrome (ZES)?
Khawucinge ukuba kukho utshintsho esiswini sethu olulawula ukuveliswa kwe-asidi. I-hormone ebizwa ngokuba yi-gastrin isebenza ngolo tshintsho. Ngokwesiqhelo, xa sisitya, le hormone iyakhutshwa, nto leyo ebangela ukuba isisu sivelise i-asidi yokunceda ekugayeni ukutya. Xa umsebenzi ugqityiwe, ukuveliswa kwe-asidi kuyalawulwa.
Nangona kunjalo, kubantu abaneZollinger-Ellison Syndrome (ZES), uhlobo lwethumba olubizwa ngokuba yi-gastrinoma lukhula emzimbeni. Ezi thumba zihlala zikhula kwi-pancreas okanye kwinxalenye ephezulu yamathumbu amancinci (duodenum). Oko kwenziwa zezi thumba kukuvelisa i-hormone gastrin eninzi ngaphandle kolawulo. Kufana nokuba utshintsho luhlala 'luvuliwe'.
Xa sine-gastrin eninzi kakhulu, isisu sethu siqala ukuvelisa i-asidi eninzi kakhulu. Le asidi igqithisileyo yiyo ebangela izilonda zesisu eziqatha (izilonda zesisu) kunye norhudo olungapheliyo.
Malunga nama-60% ezi gastrinomas zinokuba ngumhlaza , ngoko ke kubaluleke kakhulu ukuzifumanisa nokuzinyanga kwangethuba.
Zithini iimpawu zesi sifo? Sizazi njani?
Ngamanye amaxesha, i-ZES isenokungabonakalisi zimpawu kwizigaba zokuqala. Kodwa xa iimpawu zibonakala, zinokuba nzima ngakumbi kune-gastritis eqhelekileyo. Ubunzima beempawu buyahluka ngokuxhomekeke kubukhulu kunye nenani leethumba emzimbeni wakho.
Masichaze oku ngakumbi kwitheyibhile engezantsi.
| Uphawu | Ingcaciso elula |
|---|---|
| Intlungu ebuhlungu yesisu okanye ukudumba | Le ntlungu yenzeka xa iindonga zesisu namathumbu zonakaliswa yi-asidi egqithisileyo esiswini. |
| Urhudo olungapheliyo | Xa i-asidi engaphezulu ingena emathunjini, iphazamisa ukusebenza kwee-enzymes apho, nto leyo ebangela ukuba urhudo kunye nokutya kungagaywa kakuhle. |
| Ukuhlanza okanye ukuphuma kwegazi esitulweni | Oku kunokwenzeka xa kuphuma igazi ngenxa yezilonda esiswini. Ukugabha kungaba mnyama njengekofu okanye indle ingaba mnyama njengetha. |
| Izitulo ezinamafutha, ezidadayo | Xa ukugaywa kwamafutha kuphazamiseka ngenxa ye-asidi eninzi, amafutha angagaywanga aphuma esitulweni. |
| Isitshiso sentliziyo esiqhelekileyo | Le meko yenzeka ngenxa yokuba i-asidi egqithisileyo esiswini ingena kwi-esophagus (i-acid reflux). |
| I-Anorexia kunye nokunciphisa umzimba | Intlungu engapheliyo kunye neengxaki zokugaya ukutya zinokubangela ukuncipha komnqweno wokutya kunye nokwehla kobunzima bomzimba. |
| Ukudinwa kunye nobuthathaka | Njengoko amanxeba esisu esopha kancinci kancinci, usenokuziva udiniwe ngenxa ye-anemia. |
Kwezinye iimeko, ukuba la mathumba asasazeka esibindini (i-metastasis) , anokubonisa neempawu zomhlaza wesibindi. Umzekelo, kunokubakho ukurhawuzelela, ukutyheli kwamehlo nolusu (i-jaundice).
Kutheni kusenzeka into enje?
Uninzi lwexesha, i-ZES yenzeka ngamaxesha athile , oko kuthetha ukuba iyenzeka nje.
Kodwa malunga nama-25% ezigulana ziba nale meko ibizwa ngokuba yi -MEN Type 1 (Multiple Endocrine Neoplasia Type 1).Ngemeko yemfuza ebizwa ngokuba yi-ZES. Ngamafutshane, le yimeko yemfuza engaqhelekanga. Kule meko, kukho umngcipheko wokukhula kweethumba kwiigland ezininzi ezivelisa iihomoni emzimbeni wethu ngaxeshanye. I-ZES yinxalenye enye yayo.
Zeziphi iimvavanyo ezenziwayo ukufumanisa oku?
Ukuba uneempawu ezichazwe apha ngasentla, ugqirha wakho usenokuyalela iimvavanyo ezininzi ukuba ukrokrela ukuba une-ZES.
Uvavanyo lokuqala
- Uvavanyo lweGazi: Olu vavanyo lujonga inqanaba le-gastrin egazini lakho. Ukuba une-ZES, eli nqanaba liza kuba phezulu ngendlela engaqhelekanga . Oku kubizwa ngokuba yi-hypergastrinemia.
- Ukuvavanya amanqanaba e-asidi esiswini: Ityhubhu ifakwa ngempumlo esiswini kwaye kuthathwa isampuli ye-asidi ize ivavanywe. Kwi-ZES, eli nqanaba le-asidi liphezulu kakhulu.
- Uvavanyo lweMifanekiso: I-CT scan okanye i-MRI scan yenziwa ukujonga iithumba kwi-pancreas okanye emathunjini.
Uvavanyo olongezelelweyo ukuba iithumba ziyaqinisekiswa
Kusenziwa olunye uvavanyo ukuze kuchongwe ukuba ezi thumba ziphi kanye kanye, ubungakanani bazo, nokuba zinomhlaza okanye azinawo.
- I-Endoscopy: Kufakwa ityhubhu encinci enekhamera ngomlomo ukuze kuhlolwe isisu kunye nenxalenye ephezulu yamathumbu amancinci. Oku kunokunceda ukubona ukuba kukho izilonda zesisu.
- I-Endoscopic Ultrasound: Le yindibaniselwano ye-endoscopy kunye ne-ultrasound scan. Iyakwazi ukubona neethumba ezincinci kakhulu kwi-pancreas.
- I-ERCP: Le ikwayi-scan ekhethekileyo.
- I-Biopsy (Ukufunxwa kwenaliti encinci): Iqhekeza elincinci kakhulu lesicubu lithathwa kwithumba lize lihlolwe phantsi kwemakroskopu ukuze kubonwe ukuba linazo na iiseli zomhlaza.
Zithini iindlela zonyango zoku?
Iindlela zonyango zixhomekeke kubukhali beempawu zakho kunye nokuba iqhuma linomhlaza okanye akunjalo. Kukho iindlela ezintathu eziphambili zonyango.
| Indlela yonyango | Inkcazo |
|---|---|
| Amayeza | Ezona zisetyenziswa kakhulu zii -proton pump inhibitors (ii-PPI).La ngamayeza alawula ukuveliswa kwe-asidi esiswini. Kusenokufuneka uwasebenzise la mayeza ubomi bakho bonke. |
| Utyando | Ukuba ithumba linokususwa, kuyacetyiswa utyando. Uhlobo lotyando luyahluka ngokuxhomekeke kwindawo elikuyo ithumba (umz., iPancreatectomy - ukususwa kwenxalenye yepancreas, iDuodenectomy - ukususwa kwenxalenye yamathumbu amancinci). |
| Unyango lomhlaza | Ukuba iithumba zingumhlaza kwaye zisasazeke kwamanye amalungu omzimba, unyango olufana ne -chemotherapy luyanikwa. Oku kusebenza ukulawula ukukhula kweeseli zomhlaza kunye nokunciphisa iimpawu. |
Liza kuba njani ikamva lam kule meko?
Lo ngumbuzo abantu abaninzi abanawo. Ikamva lakho lixhomekeke kuhlobo lomhlaza onawo.
- Izimila ezingezizo umhlaza: Ezi azisongeli ubomi, kodwa kuya kufuneka uqhubeke nokusela amayeza okulawula i-asidi yesisu.
- Iithumba ezinomhlaza: Imeko yahlukile kancinci apha. Ukuba zonke iiseli zomhlaza emzimbeni zinokususwa ngotyando, esi sifo sinokunyangeka ngokupheleleyo. Nangona kunjalo, kuya kufuneka uqhubeke novavanyo lwezonyango ukuze ubone ukuba esi sifo siyabuya na.
Ngokwezibalo zeengcali, ngaphezulu kwama-90% ezigulana ezisuswe zonke iithumba ngotyando ziphila iminyaka emi-5 ukuya kweli-10. Ukuba utyando alukwazi ukususa zonke iithumba, izinga lokusinda kweminyaka emi-5 limalunga nama-43%.
Kodwa khumbula oku: Ezi zibalo ziyi-avareji nje esekelwe kwidatha evela kumawaka ezigulane. Imeko yakho isenokuba yahlukile kakhulu. Ke ngoko, umntu ongcono ukwazi kakuhle imeko yakho ngugqirha wakho onyangayo.
Ndingazinyamekela njani?
Ukuba ufunyaniswe une-ZES, kuya kufuneka wenze utshintsho oluthile ebomini bakho.
- Sela amayeza akho ngokuchanekileyo: Kubalulekile ukuthatha amayeza okunciphisa i-asidi (ii-PPI) ngexesha elifanelekileyo, njengoko ugqirha wakho ekuyalele.
- Ukuhlolwa rhoqo kwezonyango: Ingakumbi ukuba ukhe waba neethumba ezinomhlaza, kufuneka uye kuhlolwa rhoqo ngamaxesha athile njengoko ugqirha wakho eyalele ukuze abone ukuba isifo siphinde savela na.
- Lumka ngeempawu: Ukuba iimpawu ezifana nentlungu yesisu kunye norhudo ziphinda zibuye emva konyango, yazisa ugqirha wakho ngoko nangoko .
Kuqhelekile ukuba nexhala kwaye woyike xa ufumanisa ukuba unesifo esingaqhelekanga esifana nesi. Unemibuzo emininzi. Thetha nogqirha wakho ngokukhululekileyo ngayo yonke loo nto. Mamela ngononophelo iziphumo zovavanyo lwakho kunye nezicwangciso zonyango. Bakulungele kwaye bazimisele ukukunceda.
Umyalezo Wokuya Ekhaya
- I-Zollinger-Ellison Syndrome (ZES) sisifo esingaqhelekanga esibangelwa ziithumba ezibizwa ngokuba yi-gastrinomas ezivelisa i-asidi egqithisileyo esiswini.
- Iimpawu eziphambili zizilonda zesisu ezihlala zisenzeka ezingaphenduliyo kunyango kunye norhudo oluhlala ixesha elide.
- Ezi thumba zisenokuba zingumhlaza okanye azinazo, ngoko ke ukubonwa kwangethuba kubaluleke kakhulu.
- Esi sifo sinokulawulwa ngempumelelo ngamayeza afanelekileyo, utyando, kwaye, ukuba kuyimfuneko, unyango lomhlaza.
- Ukuba unezi mpawu, ungoyiki kwaye ngoko nangoko qhagamshelana nogqirha ofanelekileyo ukuze akunike ingcebiso.
💬 Comments (0)
Akukho zimvo zithunyelweyo okwangoku. Faka uluvo lwakho apha okokuqala.
Faka uluvo lwakho