Iqhawe elincane lomzimba wethu: Konke mayelana ne-Erythropoietin!

Wake wezwa ngento ebizwa ngokuthi 'i-Erythropoietin' noma 'i-EPO'? Mhlawumbe udokotela wakho uke wakhuluma ngayo, noma uma unesifo esifana ne-anemia, igama lingase lijwayelene nawe kancane. Lena ngempela i-hormone emangalisayo futhi ebaluleke kakhulu emizimbeni yethu. Namuhla, sizokhuluma ngayo ngendlela elula ongayiqonda.

Kuyini i-Erythropoietin?

Kalula nje, i-Erythropoietin iyi-hormone ekhiqizwa kakhulu yizinso zakho. Siyibiza nangokuthi i-EPO ngamafuphi. Umsebenzi oyinhloko wale-EPO ukusiza ukugcina izinga elinempilo lamaseli abomvu egazi, okungukuthi, amaseli abomvu egazi (ama-erythrocyte) . Le-EPO isebenza njengomphathi otshela ifektri yamaseli abomvu egazi emzimbeni wethu ukuthi 'yenze okwengeziwe!'

Ngezinye izikhathi, odokotela basebenzisa uhlobo lokwenziwa lwe-erythropoietin, ikakhulukazi ukwelapha i-anemia ebangelwa yisifo sezinso esingamahlalakhona (CKD) . Cabanga nje, ngoba izinso zabanye abantu azisebenzi kahle, azikhiqizi ngokwanele le hormone ye-EPO. Bese ziba ne-anemia. Yilapho-ke le EPO yokwenziwa isiza khona.

Kodwa-ke, abanye abasubathi bayayisebenzisa kabi ukuze bathuthukise ukusebenza kwabo. Isizathu ukuthi i-EPO yandisa inani lomoya-mpilo ofinyelela emisipheni yabo. Lokho akuyona into enhle nhlobo, ngoba kungabangela izinkinga ezinkulu zempilo.

I-Erythropoietin yaziwa nangamanye amagama, njenge-erythropoietin, i-hematopoietin, kanye ne-hemopoietin. Kodwa-ke, amagama asetshenziswa kakhulu yi-Erythropoietin kanye ne-EPO.

Yini eyenziwa yi-erythropoietin (EPO) emizimbeni yethu?

Lona umbuzo obaluleke kakhulu. I-EPO iyi-hormone enkulu esiza imizimba yethu ukuthi yenze amangqamuzana abomvu egazi . Manje, kungani sidinga amangqamuzana abomvu egazi? Uma uphefumula, ubani othwala umoya-mpilo oza emaphashini akho uye kuzo zonke izingxenye zomzimba wakho, kuwo wonke amangqamuzana? Yilokho okwenziwa amangqamuzana abomvu egazi. Cabanga ngakho njengamaloli amancane athwala umoya-mpilo kuwo wonke umzimba wakho. I-EPO itshela lawa maloli ukuthi awadale.

Uma umoya-mpilo ufika emaselini ethu, uphenduka amandla. Lawa mandla abalulekile kuwo wonke umsebenzi wethu. Bese kuthi lawa maseli abomvu egazi athwale i-carbon dioxide eshiya amangqamuzana ethu emuva emaphashini. Ukusuka lapho, siyawukhipha umoya.

Okuvame ukwenzeka yilokhu: Amaseli akhethekile ezinso zakho azwa ukuthi izinga lomoya-mpilo egazini lakho liphansi. Uma ezwa lokho, andisa ukukhiqizwa kwawo kwe-EPO. Le EPO ibe isiya engxenyeni ethambile yamathambo ethu, umnkantsha , bese ithi, 'Kulungile, manje yenza amaseli egazi abomvu engeziwe!'

Kodwa-ke, uma amangqamuzana asezinso ezwa ukuthi kunomoya-mpilo owanele egazini, anciphisa ukukhiqizwa kwe-EPO. Lokhu kufana nohlelo lokufunwa kokunikezwa. Akhiqiza okuningi uma umzimba ukudinga, futhi akhiqiza okuncane uma isidingo siphansi.

Akumangalisi yini ukuthi izinto ezinje zenzeka kanjani emizimbeni yethu? Konke kuhlelwe kahle!

Ezinye izimo zezokwelapha zingathinta inani le-EPO elikhiqizwa yizinso. Lokhu kungabangela ukuthi kukhiqizwe i-EPO eningi kakhulu, noma kunganele. Zombili lezi zingabangela ukungalingani kwamazinga amangqamuzana abomvu egazi.

Kwenzekani uma amazinga e-erythropoietin (EPO) ekhuphuka?

Uma amazinga e-EPO enyuka ngokungadingekile, okungukuthi, uma umzimba ukhiqiza i-EPO eningi kunalokho okudingayo ngempela, inani lamaseli abomvu egazi nalo lizokhula. Lokhu sikubiza ngokuthi i -polycythemia . Kalula nje, kunamaseli abomvu egazi amaningi kakhulu egazini. Lokhu futhi kuyinkinga, ngoba igazi liyaqina futhi igazi lingaqhekeka.

Kungani amazinga e-erythropoietin (EPO) ekhuphuka?

Kunezizathu eziningana zokuthi kungani amazinga e-EPO engaba phezulu ngokungadingekile:

• Ukuhlala endaweni enamazinga aphansi omoya-mpilo isikhathi eside: Cabanga nje, uma umuntu eqhubeka nokubhema, inani lomoya-mpilo elifinyelela emzimbeni wakhe liphansi. Khona-ke izinso zicabanga ukuthi, 'O, awukho umoya-mpilo owanele, sidinga ukwenza amangqamuzana abomvu engeziwe,' bese zikhiqiza i-EPO eningi. Ngokufanayo, uma umuntu ehlala endaweni ephakeme kakhulu njengeNuwara Eliya isikhathi eside, izinga le-EPO lingakhuphuka ngenxa yezinga eliphansi lomoya-mpilo emoyeni lapho. Kodwa kuvamile ukuthi i-EPO ikhuphuke kulokhu kuphakama, kuyindlela yokuzivumelanisa nomzimba.
• I-anemia ayibangelwa yisifo sezinso: Ngezinye izikhathi i-anemia ayibangelwa inkinga yezinso. Kodwa ngenxa yokuthi amangqamuzana abomvu egazi ambalwa kakhulu noma amangqamuzana abomvu egazi angasebenzi kahle, izinso zizwa ukuthi azitholi umoya-mpilo owanele. Ngisho nalapho, zikhiqiza i-EPO eyengeziwe ukusiza ekwakheni amangqamuzana abomvu egazi. Lokhu empeleni kuyindlela evamile yokusabela komzimba.
• Izinhlobo ezithile zezimila: Nakuba zingavamile kakhulu, ezinye izinhlobo zezimila zingabangela izinso ukuba zikhiphe inani elikhulu le-EPO.

Kwenzekani uma amazinga e-erythropoietin (EPO) ehla?

Imbangela eyinhloko yamazinga aphansi e-EPO yisifo sezinso esingamahlalakhona (CKD) . Njengoba kushiwo ngaphambili, lapho izinso zonakele, azikwazi ukukhiqiza i-EPO ngendlela efanele. Lokhu kuphumela emazingeni aphansi e-EPO. Lesi simo, i-CKD, kanye namazinga aphansi e-EPO kungaholela ekulahlekelweni yigazi. Lokhu kusho ukuthi ungase uzizwe ukhathele, uphaphathekile, futhi ube nenkinga yokuphefumula.

Kungani amazinga e-erythropoietin (EPO) ehla?

Nakuba imbangela eyinhloko kuyi-CKD, kukhona enye imbangela. Leso yisimo esibizwa ngokuthi i-Polycythemia Vera . Lolu uhlobo lomdlavuza oluvela egazini. Ngenxa yokuguquka kwezakhi zofuzo, umongo wamathambo wenza amangqamuzana egazi abomvu amaningi kakhulu. Khona-ke izinso zizwa, 'O, kunamangqamuzana egazi abomvu amaningi kakhulu egazini, asisadingi ukwenza i-EPO.' Ngakho-ke zinciphisa ukukhiqizwa kwe-EPO. Lokhu futhi kuyimbangela ye-EPO ephansi.

Yikuphi ukwelashwa okungenziwa uma amazinga e-EPO ephansi?

Uma amazinga e-EPO ephansi, yelashwa ngokwelapha imbangela eyisisekelo . Okusho ukuthi, uma kuyisifo sezinso, yelashwa, uma kuyimbangela ehlukile, yelashwa.

Kodwa-ke, ukwelashwa okuyinhloko kwe-anemia okubangelwa amazinga aphansi e-EPO yi- recombinant erythropoietin . Lawa abizwa nangokuthi ama-erythropoietin-stimulating agents (ESAs) . Lawa yizinguqulo zokwenziwa ze-hormone ye-EPO ezenziwe elebhu. Odokotela bahlanganisa i-gene ye-EPO bese bekunika yona njengomjovo. Bese ingena emzimbeni wakho futhi ivuselele umongo wakho wethambo ukuze uqale ukwenza amaseli egazi abomvu engeziwe.

Lokhu kwelashwa kunikezwa ikakhulukazi ukwelapha i-anemia ebangelwa ukwehluleka kwezinso okungapheli. Kunikezwa nabantu abanezinhlobo ezithile zomdlavuza ezingavamile.

Kodwa lawa ma-ESA angabangela imiphumela emibi:

• Umfutho wegazi ophakeme
• Imfiva
• Isiyezi
• Isicanucanu
• Ubuhlungu endaweni yokujova

Ngakho-ke, kubaluleke kakhulu ukuthatha lolu hlobo lokwelashwa ngesilinganiso esiqondile, njengoba kuceliwe udokotela.

Amazinga e-erythropoietin (EPO) alinganiswa kanjani?

Udokotela wakho angalinganisa amazinga akho e-EPO ngokuhlolwa kwegazi okulula. Lokhu kuhlolwa kwegazi kungathola izinguquko kumaseli akho egazi ezithinta ukukhishwa kwe-EPO. Lokhu kungasiza ekunqumeni ukuthi une-polycythemia, i-anemia, noma ezinye izimo zomnkantsha wamathambo.

Udokotela noma umhlengikazi uzokhetha umthambo ongalweni yakho bese ehlanza isikhumba lapho ngento efana ne-iodine noma i-isopropyl alcohol. Ngemuva kwalokho, inaliti encane kakhulu (inaliti engu-21 gauge - encane kancane kunesihloko se-earring) izothatha isampula encane yegazi emthanjeni wakho. Isampula yegazi izothunyelwa elabhorethri ukuze ihlaziywe.

Uma imiphumela yelabhorethri isifikile, udokotela wakho uzokhuluma nawe ngayo futhi aphendule noma yimiphi imibuzo ongase ube nayo. Khumbula, noma ngabe amazinga akho e-EPO angaphakathi kwesilinganiso esijwayelekile, ungase udinge ezinye izindlela zokwelapha. Lokho kuzoba kudokotela wakho ukuthi anqume.

Liyini izinga elijwayelekile le-erythropoietin (EPO)?

Odokotela balinganisa i-EPO ngama -milliyunithi nge-milliliter (mU/mL) . Izinga le-EPO lomuntu ophilile lingasukela ku-4 kuya ku-26 mU/mL.

Kodwa lezi zindinganiso zingezakho:

• Ubudala
• Ubulili
• Isimo sempilo sisonke

Kungahluka kuye ngezici eziningana, njengokuthi: Ngakho-ke, udokotela wakho kuphela ongachaza imiphumela yakho ngokunembile futhi akutshele ukuthi ingaphakathi kwebanga elinempilo noma ngaphandle kwayo. Ngakho-ke, ungazihlolisisi ngokwakho ngokusekelwe kulokho okutholakala ku-inthanethi.

Kungenzeka yini ukwandisa amazinga e-erythropoietin (EPO) ngokwemvelo?

Uma unesifo sezinso esingamahlalakhona (i-CKD) noma i-anemia enamazinga aphansi e-EPO, ezinye izinguquko zokudla nendlela yokuphila zingasiza ekwandiseni amazinga akho e-EPO kancane. Kodwa-ke, lokhu kufanele kwenziwe ngaphezu kweseluleko sezokwelapha hhayi njengokufaka esikhundleni sokwelashwa.

• Ukuzivocavoca: Ucwaningo lubonisa ukuthi uma uzivocavoca njalo, ngamandla aphakathi, umzimba wakho usebenzisa umoya-mpilo owengeziwe. Ubuchopho bakho bube sebutshela umzimba wakho ukuthi 'wenze i-EPO eyengeziwe.' Izinto ezifana nokugibela ibhayisikili, ukugijima, nokubhukuda ziyizibonelo ezinhle zalolu hlobo lokuzivocavoca.
• Insimbi yokudla: Insimbi iyingxenye ebalulekile ye -hemoglobin emangqamuzaneni ethu abomvu egazi. Le hemoglobin yiyo ethwala umoya-mpilo. Uma sikhuluma ngokudla okucebile ngensimbi, sisho inyama ebomvu, izikhupha zamaqanda, ubhontshisi, ngisho nemifino eluhlaza njengesipinashi esinazo edolobhaneni lakithi. I-Tofu, okusanhlamvu okuqiniswe ngensimbi, ufulawa, kanye nesinkwa nakho kuqukethe insimbi.

Ngaphezu kwalezi zinto, izinto ezifana nokudla ukudla okulinganiselayo, ukuphuza amanzi anele, nokugwema ukubhema nazo zinhle empilweni yakho iyonke, futhi ngokungaqondile, amazinga akho e-EPO.

Okokugcina, izinto okudingeka uzikhumbule

I-Erythropoietin (EPO) iyi-hormone ebaluleke kakhulu etshela umnkantsha wethu ukuthi 'wenze amangqamuzana egazi abomvu engeziwe'.

Ngezinye izikhathi, imizimba yethu yenza amangqamuzana egazi abomvu amaningi kakhulu, noma anganele. Zombili lezi zinto zingabangela izinkinga zempilo. Udokotela wakho angahlola inani le-EPO egazini lakho ngokuhlolwa kwegazi futhi, uma kudingeka, akunikeze ukwelashwa okufanele. Ngakho-ke, uma unezimpawu ze-anemia (ukukhathala, ukuphaphatheka, ukuphelelwa umoya), noma uma unezinkinga zezinso, qiniseka ukuthi ufuna iseluleko sezokwelapha. Bazokusiza ngendlela efanele. Hlala uphilile!

I- Erythropoietin, i-EPO, amaseli abomvu egazi, i-anemia, izinso, ama-hormone, umnkantsha wamathambo