Umlawuli oyimfihlo olawula umfutho wegazi lethu: Konke mayelana neRenin!

Wake wazibuza ukuthi zingaki izinto ezimangalisayo ezenzeka emizimbeni yethu? Ngezinye izikhathi, ngaphandle kokuthi siqaphele, kunezindlela eziningi ezimangalisayo ezigcina imizimba yethu iphilile. Isibonelo, leyo esiza ekulawuleni umfutho wegazi wethu ibizwa ngokuthi i-Renin. Namuhla, ake sixoxe ngokuthi iyini i-Renin, ukuthi isebenza kanjani, nokuthi ibaluleke kangakanani empilweni yethu.

Uyini uRenin? Kalula nje...

Kulungile, manje ake sibone ukuthi iyini le renin. Kalula nje, i-renin iyi -enzyme eyenziwe ngamaseli akhethekile ezinso zakho. Ungesabi i-enzyme, iyiprotheni esiza ukusheshisa izinqubo ezahlukahlukene zamakhemikhali emizimbeni yethu.

Lo mfo obizwa ngokuthi i-renin akasebenzi yedwa. Uyingxenye yendlela enkulu ebizwa ngokuthi uhlelo lwe-renin-angiotensin-aldosterone (RAAS). Kufana nokusabela kweketanga. Inhloso eyinhloko yalolu hlelo lonke ukugcina umfutho wegazi wakho ulawulwa. Ngokukhethekile, i-renin ilawula i-hormone ebizwa ngokuthi i-aldosterone, ekhiqizwa yizindlala zethu ze-adrenal (izindlala ezincane ezitholakala ngaphezu kwezinso).

Ngakho-ke, le Renin isebenza kanjani?

Manje nansi ingxenye ebalulekile. Umsebenzi oyinhloko kaRenin ukulawula umfutho wegazi. Lokhu ukwenza kanye namanye ama-hormone amabili abalulekile abizwa ngokuthi i-angiotensin ne-aldosterone. Uma ehlangene, lawa mathathu asiza ukugcina amazinga e-sodium (usawoti) kanye ne-potassium emzimbeni wakho elawulwa.

Cabanga ngalokhu kwenzeka:

1. Okokuqala, i-renin iguqula i-angiotensinogen (isandulela se-angiotensin) ekhiqizwa yisibindi sakho ibe yi-angiotensin I ( i-angiotensin, i-hormone enciphisa imithambo yegazi yakho).

2. Bese, le angiotensin I iphenduka i- angiotensin II .

3. Manje le angiotensin II iyona ebaluleke kakhulu. Inciphisa imithambo yegazi yakho futhi isiza nokukhulula i-hormone i-aldosterone.

4. Okokugcina, le aldosterone isiza izinso zakho ukuthi zigcine amanzi nosawoti (i-sodium) emzimbeni wakho. Lokhu kwandisa inani loketshezi emzimbeni wakho. Yilokhu okwandisa umfutho wegazi lakho.

Kalula nje, lapho umfutho wegazi wehla, kufika umuntu okuthiwa i-renin, aqashe abanye abantu abambalwa, anciphise imithambo yegazi, agcine amanzi emzimbeni, futhi abuyisele umfutho wegazi esimweni esijwayelekile.

Ikhishwa kanjani i-renin? Ngasiphi isikhathi?

Kulungile, manje unombuzo: ingabe le renin yenziwa nje emzimbeni, noma ingabe ikhishwa ngezikhathi ezithile? I-Renin ikhishwa egazini lakho lapho umfutho wegazi wakho wehla kakhulu, noma uma ulahlekelwa yi-sodium (usawoti) eyanele emzimbeni wakho.

Ngokuqondile, izici ezilandelayo zithinta ukukhiqizwa kwe-renin:

• Ama-baroreceptor (lawa angama-receptor azwela ukucindezeleka) emithanjeni yakho yegazi azwa umfutho wegazi ophansi.
• Uma izinso zakho zibona amazinga aphansi kasawoti (i-sodium) emzimbeni wakho.
• Ama-receptor e-Beta 1 adrenergic, alawula ukushaya kwenhliziyo yakho, azwe umsebenzi ohlelweni lwakho lwezinzwa oluzwelanayo (lokhu kwenzeka lapho sikhathazekile noma sesaba).

Ingabe i-renin yodwa iyakwandisa umfutho wegazi?

Cha, akunjalo ngempela. I-Renin iyodwa ayithinti umfutho wegazi lakho. Kunalokho, njengoba eshilo ngaphambili, isebenza ngokubambisana ne-angiotensin kanye ne-aldosterone. I-Angiotensin inciphisa imithambo yegazi yakho, kanti i-aldosterone isiza izinso zakho ukuthi zigcine amanzi nosawoti. Yilokhu okwenza umzimba wakho ugcine uketshezi oluningi futhi uphakamise umfutho wegazi lakho.

Ikhiqizwa kuphi i-renin?

Cishe usuyazi lokhu manje. I-Renin ikhiqizwa ezinso zakho. Lapho umfutho wegazi wakho we-systolic (inani eliphezulu lapho ulinganisa umfutho wegazi) wehla, noma lapho izinso zakho zizwa ukuthi umzimba wakho unciphile ngoketshezi, zikhipha i-renin egazini lakho.

Yenziwe ngani i-renin? (Lokhu kungokwesayensi kancane, kodwa kufanelekile ukukwazi.)

Lokhu kuyindaba ejulile kancane, kodwa uma sikubeka kalula, i-renin inama-amino acid residues angaba ngu-340. Ama-amino acid afana namabhulokhi amancane amaprotheni. Lawa ayahlangana ukuze akhe i-enzyme i-renin. Kufana nezitini eziningi ezihlangana ukuze zakhe udonga.

Yiziphi izimo zezokwelapha ezingase zihlotshaniswe nokukhiqizwa kwe-renin?

Ngezinye izikhathi amazinga e-renin angakhuphuka emzimbeni. Izinto ezinjengalezi zingayibangela:

• Umfutho wegazi ophansi (i-Hypotension) .
• Uma ulahlekelwe igazi eliningi (isib. ngenxa yengozi).
• Uma izinso zakho zinciphise ukugeleza kwegazi .
• Ukuncipha komthamo (isib., ukuphelelwa amanzi emzimbeni ngenxa yokuhlanza noma ukuphazamiseka kwesisu).
• Umsebenzi owandisiwe wesimiso sezinzwa esinozwela (ukuvuselelwa kwemizwa enesihawu) (kulokhu, ukushaya kwenhliziyo, ukuphefumula, umfutho wegazi uyakhuphuka, kanye nezindilinga ezimnyama emehlweni ziba zinkulu).

Ingabe kukhona ukuhlolwa kokuhlola amazinga e-renin?

Yebo, impela. Udokotela wakho angenza ukuhlolwa kokusebenza kwe-renin kanye nokuhlolwa kwezinga le-aldosterone. Lokhu kuzomtshela ukuthi ingakanani i-aldosterone ekhiqizwa yizindlala zakho ze-adrenal.

Uma unomfutho wegazi ophakeme, ikakhulukazi uma ungalawulwa yimithi yakho evamile, udokotela wakho angase akuyalele lokhu kuhlolwa.Ungase ube nesimo esibizwa ngokuthi i-primary aldosteronism (PA) (ebizwa nangokuthi i-Conn's syndrome) . Kulesi simo, kukhiqizwa i-aldosterone eningi kakhulu, okubangela umfutho wegazi ophakeme. Ukuhlolwa kwe-renin kungasiza ekunqumeni ukuthi i-PA iyimbangela yomfutho wegazi ophezulu yini.

Ilinganiswa kanjani i-renin?

I-Renin ivame ukulinganiswa ngento ebizwa ngokuthi umsebenzi we-plasma renin (PRA) . Lokhu kulinganisa ukuthi i-renin iyakha kahle kangakanani i-angiotensin I (isandulela se-angiotensin II). Ingalinganiswa futhi njenge -renin eqondile .

Kusho ukuthini uma izinga lakho le-renin liphezulu?

Uma izinga lakho le-renin liphezulu, kungenzeka ukuthi kungenxa yalokhu okulandelayo:

• Isifo sika-Addison (lapho izindlala zakho ze-adrenal zingakhiqizi ama-hormone anele) - ikakhulukazi uma uketshezi lomzimba lunciphile.
• Ukuphelelwa amanzi emzimbeni (ukuntuleka kwamanzi emzimbeni).
• Amazinga aphansi e-potassium egazini (i-hypokalemia) .
• Ukopha (igazi eliningi eligeleza ngaphakathi noma ngaphandle kwesitho).
• Izimila zezinso ezikhiqiza i-renin .
• Umfutho wegazi ophezulu wezinso (umfutho wegazi ophezulu obangelwa ukucinana kwemithambo yegazi okuholela ezinso).
• Umfutho wegazi ophakeme oyingozi (lokhu umfutho wegazi ophezulu ofika ngokuzumayo, ngaphandle kwesixwayiso ).
• Umfutho wegazi ophakeme oyinhloko (lokhu umfutho wegazi ophakeme ongewona umphumela wesinye isimo sezokwelapha).
• Ukwehluleka kwenhliziyo noma ukuqina kwesibindi (lapho umthamo wegazi osebenzayo womzimba wehla ngenxa yalezi zimo).

Kuthiwani uma izinga le-renin liphansi?

Kukhona futhi izizathu zokuthi kungani amazinga e-renin engaba phansi. Isibonelo:

• I-aldosteronism eyinhloko (PA)
• Uma usebenzisa imithi yama-steroid ebangela ukugcinwa kosawoti emzimbeni.
• Umfutho wegazi ophakeme ozwela usawoti (abanye abantu banomfutho wegazi ophakeme ngisho noma bedla usawoti omningi kakhulu, lokho kuyisimo).

Ngingawagcina kanjani amazinga ami e-renin ephilile?

Uma izinga lakho le-renin liphezulu noma liphansi ngendlela engavamile, udokotela wakho uzonquma imbangela eyisisekelo bese esungula uhlelo lokwelashwa. Ngeke nje akunikeze imithi yokwehlisa noma yokuphakamisa i-renin yakho.

Isibonelo, uma unezinga eliphezulu le-renin kanye nomfutho wegazi ophakeme, udokotela wakho angase akunike imithi yokwehlisa umfutho wegazi efana nama -beta-blockers kanye ne-clonidine .

Okokugcina, okufanele ukukhumbule (Umyalezo Wokuya Ekhaya)

Ngakho-ke, i-renin akuyona nje i-enzyme. Iyingxenye ebaluleke kakhulu yesistimu ye-renin-angiotensin-aldosterone (RAAS). Idlala indima enkulu ekugcineni umfutho wegazi wakho ulawulwa.

Kungaba nezizathu ezahlukahlukene zokuthi kungani amazinga akho e-renin engajwayelekile. Ngakho-ke uma unokungabaza, into engcono kakhulu ongayenza ukubona udokotela, uthole imbangela eqondile, bese uthola ukwelashwa okudingekayo. Ungagcini nje ngokuzizwa ugula, ngoba lezi zinto ziyinkimbinkimbi kancane.

Udokotela wakho angakusiza ngqo. Hlala uphilile!

` I-Renin, Umfutho Wegazi, Izinso, i-Aldosterone, i-Angiotensin, Umfutho Wegazi Ophakeme, Umfutho Wegazi Ophansi, i-Renin, Umfutho Wegazi, Izinso, i-Aldosterone, i-Angiotensin, i-RAAS