Wake waba nenxeba elincane, loma ezinsukwini ezimbalwa, futhi laphola ngokuphelele njengokungathi akwenzekanga lutho? Kumelwe ukuba uke waphola, akunjalo? Ngaleso sikhathi, sicabanga ukuthi inxeba selipholile. Kodwa asikaze sicabange ngezinto ezimangalisayo ezenzeka emizimbeni yethu ukuze siphole lelo nxeba. Namuhla, sizokhuluma ngenqubo engavamile eyenzeka njalo emizimbeni yethu, ebalulekile ekusindeni kwethu, futhi ngezinye izikhathi isenza sihleke. Lokhu sikubiza ngokuthi i-angiogenesis.
Kalula nje, iyini i-angiogenesis?
Kulula kakhulu. I-Angiogenesis inqubo yokusebenzisa imithambo yegazi esivele isemizimbeni yethu ukudala imithambo yegazi emincane (ama-capillaries). Lokhu kuqala ngaphambi kokuba sizalwe, esibelethweni sikamama wethu, futhi kuqhubeke isikhathi eside sisaphila.
Manje ungase uzibuze ukuthi le mithambo yegazi emincane, ebizwa ngokuthi ama-capillary, yenzani. Eqinisweni, le mithambo yegazi emincane yenza omunye wemisebenzi ebaluleke kakhulu emizimbeni yethu. Isebenza 'njengesevisi yokulethwa' ethwala igazi, izakhamzimba, kanye nomoya-mpilo okudingwa yizitho zethu nezicubu.
Cabanga nje ukuthi endaweni ethile emzimbeni wethu, izicubu azitholi umoya-mpilo owanele. Lesi simo sibiza ngokuthi i-hypoxia. Uma kungekho umoya-mpilo owanele, amangqamuzana akuleyo ndawo ayasaba futhi aqale ukukhipha izimpawu zamakhemikhali athi, "Sisizeni! Akukho umoya-mpilo owanele lapha!" Kufana nokuthumela umlayezo 'we-SOS'. Lapho nje lo myalezo 'we-SOS' umukelwa, amangqamuzana akha udonga lwangaphakathi lwemithambo yethu yegazi, abizwa ngokuthi amangqamuzana e-endothelial, ayavuselelwa futhi aqale ukwenza imithambo yegazi emisha. Lokhu kungukuqala kwenqubo ye-angiogenesis.
Lezi mithambo yegazi emisha zakheka kanjani? Kunezindlela ezimbili eziyinhloko!
Umzimba wethu usebenzisa izindlela ezimbili eziyinhloko ukwakha imithambo yegazi emisha. Ake sibheke le mininingwane ukuze siqonde umehluko phakathi kwalokhu okubili.
| Igama lendlela | Kwenzeka kanjani | Kalula nje... |
|---|---|---|
| I-Angiogenesis Ehlumayo | Ihlumela elisha likhula emthanjeni wegazi okhona. Leli hlumela likhula kancane kancane liye esignalini yamakhemikhali (isib., ikhemikhali ebizwa ngokuthi i-VEGF) evela endaweni engenawo umoya-mpilo. Ekugcineni, iba umthambo wegazi omusha ngokuphelele. | Kufana negatsha elisha elihluma esiqwini somuthi. Kuvela elisha elivela kwelidala bese likhula. |
| I-Angiogenesis ye-Intussusceptive | Amahlumela amasha awahlumi lapha. Kunalokho, umthambo wegazi owodwa uyahlukana phakathi, ube imithambo yegazi emibili. Amaseli e-endothelial angena ngaphakathi komthambo wegazi bese akha amakholomu, awuhlukanise kabili. | Kufana nokwakha imigwaqo emibili ngokubeka umsele phakathi komgwaqo. Okuwukuphela kwawo okhona uhlukaniswe kabili. |
Ngakho-ke lokhu kufana yini ne-Vasculogenesis?
Cha. Nakuba la magama amabili engase azwakale efana, kunomehluko omncane kodwa obalulekile. Womabili ahilela ukwakheka kwemithambo yegazi emisha. Kodwa umehluko usehlotsheni lwamaseli ayiqalayo.
- I-Angiogenesis: Yilapho imithambo yegazi emisha yakheka khona emithanjeni yegazi ekhona kakade, ekhule ngokugcwele.
- I-Vasculogenesis: Yilapho kwakheka khona imithambo yegazi emisha ngohlobo oluthile lweseli olubizwa ngokuthi i-angioblast. Lawa amaseli angakakhuli ngokugcwele abe amaseli azungeze izindonga zemithambo yegazi.
Kalula nje, i-angiogenesis ifana nokwakha ikamelo elisha endlini endala. I-Vasculogenesis ifana nokwakha indlu kusukela ekuqaleni ngesisekelo esisha sha kanye nezitini ezintsha.
Ngakho-ke, ingabe lokhu kukhula kwe-angiogenesis kuyinto enhle noma embi?
Ngempela lena inkemba esika nhlangothi zombili. Ukuthi lokhu kuhle noma kubi kuncike ekutheni ubani ophakelwa yimithambo yegazi esanda kwakheka.
I-angiogenesis iba ngcono kanjani?
Emzimbeni ophilile, le nqubo ibalulekile ukuze siphile.
- Amanxeba ayaphola: Uma usika isandla sakho, kwakheka imithambo yegazi emisha ezungeze inxeba, elinikeza umoya-mpilo nezakhamzimba ezidingekayo. Yingakho amanxeba ephola ngokushesha.
- Ngesikhathi sokukhulelwa: Ingane ekhulayo esibelethweni sikanina ithola konke ukudla okunomsoco kanye nomoya-mpilo ekudingayo nge-placenta. Le placenta idinga imithambo yegazi emisha ukuze isebenze kahle.
- Ngesikhathi sokuzivocavoca: Uma sizivocavoca, imisipha yethu idinga umoya-mpilo owengeziwe. Le nqubo iyasiza ekuhlangabezaneni naleso sidingo.
- Ngesikhathi somjikelezo wokuya esikhathini kwabesifazane: Le nqubo ibalulekile futhi ukuze izindonga zesibeletho zakhe kabusha.
Ngezikhathi ezinjengalezi, i-angiogenesis ifana neqhawe elisiza ekusindiseni izimpilo zethu futhi lisigcine siphilile.
Uhlangothi olumnyama lwale nqubo - indlela yokusiza umdlavuza
Le nqubo ngokwayo ingaba yisitha sethu. Okusho ukuthi, uma isiza amangqamuzana omdlavuza ukuba akhule.
Sonke siyazi ukuthi umdlavuza ulapho amangqamuzana emzimbeni wethu eqala ukuhlukana ngokungalawuleki, njengokuhlanya. Lawa mangqamuzana ahlukanisayo ahlangana ndawonye ukuze akhe amathumba. Njengazo zonke ezinye izicubu emzimbeni wethu, lawa mathumba adinga ukudla, amanzi, kanye nokunikezwa kwegazi ukuze aphile, akhule, futhi asakazeke emzimbeni wonke.
Okwenzekayo lapha kuhlakaniphe kakhulu. Amaseli omdlavuza, njengezicubu ezinempilo, aqala ukukhulula lezi zimpawu zamakhemikhali 'ze-SOS' (njenge-VEGF). Lezi zimpawu zithi, "Asitholi igazi elanele, thumela imithambo yegazi emisha lapha ngokushesha!"
Lapho sithola lesi siginali, inqubo ye-angiogenesis yomzimba wethu iqala ukusebenza futhi iqale ukukhulisa imithambo yegazi emisha iye esigaxeni. Ngamanye amazwi, umdlavuza 'uyayintshontsha' inqubo yemvelo emzimbeni wethu.
Le mithambo yegazi emisha inikeza lesi simila umoya-mpilo kanye nezakhamzimba okuqhubekayo. Ngenxa yalokho, lesi simila sikhula ngokushesha nangokushesha. Okuyingozi nakakhulu ukuthi amangqamuzana omdlavuza angahamba ngale mithambo yegazi emisha futhi aqale ukusabalala aye kwezinye izingxenye zomzimba.
Yingakho sithi inqubo ebizwa ngokuthi i-angiogenesis ingaba yingozi kumdlavuza. Kufana nokondla isitha sethu, ukusondla.
Lokhu akukwazi yini ukumiswa? Ake sixoxe ngama-Angiogenesis Inhibitors
Lapho ososayensi sebeqonda ukuthi lezi zimila ziyingozi kangakanani, baqala ukufuna ikhambi. Omunye wemiphumela yalolo cwaningo kwaba uhlobo lwemithi ebizwa ngokuthi i-Angiogenesis Inhibitors .
Into eyinhloko eyenziwa yile mithi ukuvala igazi eliya kumdlavuza. Kufana nokubulala isitha ngendlala.
Le mithi isebenza ngezindlela eziningana. Enye indlela enkulu ukuvimba ukuxhumana phakathi kwesignali yamakhemikhali 'ye-SOS' yomdlavuza kanye nemithambo yegazi eyitholayo. Njengoba nje i-static iphazamisa ucingo, le mithi ivimba umyalezo womdlavuza ekufinyeleleni emithanjeni yegazi. Lokhu kuvimbela ukwakheka kwemithambo yegazi emisha, kuncishe umdlavuza izakhamzimba ozidingayo, futhi kunciphise ukukhula kwawo.
Namuhla, imithi eminingi yokuvimbela i-angiogenesis ivunyelwe yizikhungo ezifana ne-US Food and Drug Administration (FDA) yokwelapha umdlavuza. Sekuyiyona ngxenye ebaluleke kakhulu yokwelapha umdlavuza.
Uma wena noma othile omaziyo enomdlavuza futhi enemibuzo mayelana nalokhu kwelashwa, umuntu ongcono kakhulu nofaneleke kakhulu ongakhuluma naye udokotela wakho okwelaphayo . Kubaluleke kakhulu ukufuna iseluleko kudokotela osazi kangcono isimo sakho, kunokuthembela ku-inthanethi noma kweminye imithombo.
I-Angiogenesis inqubo encane kakhulu esingenakuyibona ngamehlo ethu, kodwa iyisibonelo esihle sendlela imizimba yethu esebenza kahle ngayo. Ukwazi lokhu ngemizimba yethu, izifo kanye nokwelashwa kungasisiza senze izinqumo ezingcono ngempilo yethu.
Umlayezo Wokuya Nawe Ekhaya
- I-Angiogenesis inqubo yemvelo yokwakha imithambo yegazi emisha ngemithambo yegazi ekhona emzimbeni wethu.
- Le nqubo ibalulekile ekusebenzeni kahle komzimba ngezikhathi ezifana nokuphola kwamanxeba nokukhulelwa.
- Kodwa-ke, le nqubo ingaba yingozi ngoba inikeza amangqamuzana omdlavuza ukudla okunomsoco nomoya-mpilo, okuwasiza ukuba akhule futhi asakazeke emzimbeni wonke.
- Ama-Angiogenesis inhibitors ayiqembu elisha lemithi elapha umdlavuza ngokuvimbela ukutholakala kwegazi ezimila.
- Ukuqaphela indlela umzimba wakho osebenza ngayo kungakusiza ukuthi uqonde kangcono impilo yakho. Uma unenkinga nganoma yisiphi isimo sezokwelapha noma ukwelashwa, khuluma nodokotela wakho.
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