Uma umuntu osekhulile endlini yethu, okungukuthi, umama, ubaba, ugogo noma umkhulu, eqala ukukhohlwa izinto kancane kancane, futhi lapho ebuza into efanayo ngokuphindaphindiwe, ukwesaba okuncane kufika ezinhliziyweni zethu, akunjalo? Umbuzo othi "Ingabe lokhu kuyisiqalo seSifo se-Alzheimer?" usenza sikhathazeke. Eqinisweni, lapho sizwa isifo se-Alzheimer, okufika engqondweni yethu yisimo esidabukisayo lapho silahlekelwa khona inkumbulo yethu kancane kancane, singakwazi ukwenza ngisho nemisebenzi esijwayele, futhi ekugcineni sikhohlwe ukuthi singobani. Kuyiqiniso lokho. Kodwa bewazi ukuthi kunezinhlobo eziningana eziyinhloko zalesi sifo, kuye ngendlela esikhula ngayo, okungukuthi, iminyaka lapho lesi sifo siqala khona kanye nezimbangela? Ake sixoxe ngalokhu namuhla nje.
Nakuba izinhlobo zesifo zihluka, izimpawu ezivamile ziyafana.
Okokuqala, ake sikuqonde lokhu. Kungakhathaliseki uhlobo lwesifo i-Alzheimer's, izimpawu cishe zonke iziguli ezibhekana nazo ngokuhamba kwesikhathi zifana kakhulu.
- Ukulahlekelwa yinkumbulo: Ukukhohlwa izinto, ikakhulukazi ezakamuva.
- Ukudideka: Ukudideka ngezinto ezifana nesikhathi, indawo, nezinsuku.
- Ubunzima bokwenza imisebenzi ejwayelekile: Ubunzima bokwenza ngisho nemisebenzi elula njengokwenza itiye noma ukugqoka izingubo wedwa.
- Ubunzima bokwenza izinqumo: Ukuzizwa ulahlekile, ungakwazi ngisho nokwenza isinqumo esilula.
Imbangela eyinhloko yakho konke lokhu ukunqwabelana kohlobo lweprotheyini olubizwa ngokuthi i-'amyloid beta peptides' emangqamuzaneni ezinzwa zobuchopho bethu. Kalula nje, lokhu kufana nohlobo "lwemfucumfucu" oluqongelela ebuchosheni. Ngokuvamile, ubuchopho bethu bususa lolu hlobo lwezinto ezingadingekile. Kodwa esifweni i-Alzheimer's, le nqubo ayenzeki kahle. Khona-ke lawa maprotheni ayaqongelela futhi akhe ama-plaque nama -tangles ebuchosheni. Ngenxa yalokhu, ukugeleza kolwazi phakathi kwamangqamuzana obuchopho kuyama, futhi amaseli ayafa kancane kancane. Kungakhathaliseki uhlobo lwesifo, le nqubo ivamile.
Izinhlobo ezimbili eziyinhloko zesifo i-Alzheimer's
Siyihlukanisa ibe izinhlobo ezimbili eziyinhloko, ngokusekelwe eminyakeni yokuqala. Bheka ithebula elingezansi ukuze uqonde umehluko phakathi kwalezi zinhlobo ezimbili.
| Isici | Isifo i-Alzheimer's esiqala ekuqaleni | Isifo i-Alzheimer's esiqala sekwephuzile |
|---|---|---|
| Ubudala bokuqala kwalesi sifo | Abangaphansi kweminyaka engama-65 ubudala. Ngokuvamile baseminyakeni yabo engama-40 kuya kwengama-50. | Iminyaka engama-65 noma ngaphezulu. |
| Ukufana | Akuvamile kakhulu, kwenzeka ngaphansi kuka-5% wabo bonke abaguli. | Lolu uhlobo oluvame kakhulu. |
| Amathuba okudlulisela izizukulwane | Ngokuvamile kuba nokuxhumana okuqinile kwezakhi zofuzo. | Kungakhula noma ngabe othile emndenini unaso noma cha. I-gene ethile ayikakatholakali. |
| Izinguquko zobuchopho | Ama-plaque amaningi kanye nama-tangles angabonakala ebuchosheni. Kukhona ukuncishiswa kobuchopho okwengeziwe. | Ngisho noma kwenzeka izinguquko zobuchopho, zingase zibe zincane kakhulu. |
| Ezinye izici | Kungabonakala ukudikiza/ukugxuma kwemisipha ngokuzumayo (i-myoclonus) . | Ukulahlekelwa yinkumbulo kuvela njengophawu oluyinhloko. |
Isifo i-Alzheimer's esiqala ekuqaleni
Lokhu kungase kuzwakale kumangalisa kancane. Kodwa yebo, abanye abantu bangaba nesifo i-Alzheimer's bebancane kakhulu eminyakeni engu-40 noma engu-50 ubudala. Lesi yisimo esingavamile kakhulu. Sibangelwa kakhulu ukukhubazeka kwezakhi zofuzo . Ngokukhethekile, kutholakale ukuthi lesi simo sibangelwa ukukhubazeka kuma-chromosome 1, 14, kanye no-21, aqukethe ulwazi lwezakhi zofuzo emizimbeni yethu. Futhi, abantu abane-Down syndrome basengozini enkulu yokuthola lolu hlobo lwesifo i-Alzheimer's.
Isifo i-Alzheimer's esiqala sekwephuzile
Lolu uhlobo oluvame kakhulu lwe-Alzheimer esilwaziyo sonke. Izimpawu zivame ukuqala ukuvela ngemva kweminyaka engu-65. Ngezinye izikhathi zingase zivele emindenini. Lokhu kusho ukuthi uma umama enaso, ingane yakhe ingaba sengozini. Kodwa i-gene ethile, njengohlobo olukhula esemncane,Imbangela eqondile yalesi simo ayikatholakali. Ngakho-ke, odokotela nososayensi basacwaninga ukuthi kungani abanye abantu beyihlakulela kanti abanye bengayithuthukisi.
Iyini i-Familial Alzheimer's Disease (FAD)?
Kukhona into abantu abaningi abadideka ngayo lapha. "Othile emndenini wayenayo" kanye nethi "Familial Autism Spectrum Disorder (FAD)" yizinto ezimbili ezihlukene.
Isifo i-Familial Alzheimer's Disease (FAD) yisimo odokotela abaqiniseka ngaso ngokuphelele ukuthi sibangelwa izici zofuzo. Ukuze kutholakale ukuthi sinaso, okungenani izizukulwane ezimbili zomndeni (isibonelo, ugogo nomama) kumele ukuthi zazinaso lesi sifo. Singavamile kakhulu, sibalwa ngaphansi kuka-1% wabo bonke abaguli abane-Alzheimer's. Iningi labantu abathola i-Alzheimer's besebancane banalolu hlobo lwe-FAD.
Uma wena noma othile emndenini wakho enezinkinga zokukhumbula, ungacabangi nje ukuthi, "Lokhu kuyinto yakudala" noma "kungumlando womndeni nje." Kungaba yisimo esingelapheka. Ngakho into engcono kakhulu ongayenza ukubonana nodokotela wakho ngokushesha okukhulu bese uthola ukuxilongwa okufanele.
Umlayezo Wokuya Nawe Ekhaya
- Isifo i-Alzheimer's singaba ngezindlela eziningana. Lokhu kuhlukaniswa kusekelwe kakhulu eminyakeni lapho lesi sifo siqala khona (ekuqaleni kokuqala kanye nasekugcineni kwesikhathi).
- Uhlobo lokuqala kwasekuqaleni, oluvela kubantu abangaphansi kweminyaka engu-65, aluvamile kakhulu. Lunesixhumanisi esiqinile sezakhi zofuzo.
- Imbangela ethile yezakhi zofuzo ayikatholakali yohlobo lokuqala kwesifo esivame ukulubona, oluvela ngemva kweminyaka engu-65.
- Ungacabangi ukuthi ngoba nje othile emndenini wakho une-Alzheimer's, nawe uzoyithola. Kodwa kubalulekile ukuqaphela ingozi.
- Uma kwenzeka noma iyiphi inkinga ehlobene nokukhumbula, ukufuna iseluleko sezokwelapha ngokushesha kunokusishaya indiva kuwusizo olukhulu kokubili isiguli nomndeni.
💬 Comments (0)
Awekho amazwana athunyelwe okwamanje. Faka amazwana akho lapha okokuqala ngqa.
Engeza amazwana akho