Uma udokotela wakho ekutshela ukuthi unomdlavuza, unemibuzo eminingi engqondweni yakho, akunjalo? Sizwile nge-'chemo' kanye 'nemisebe', kodwa udokotela wakho kungenzeka ukuthi ukhuluma ngeqembu elisha lemithi elibizwa ngokuthi 'i-Angiogenesis Inhibitors'. Libizwa ngokuthini leli sidakamizwa esingajwayelekile? Lisebenza kanjani ngempela? Ungakhathazeki, ake sixoxe ngakho kalula.
Okokuqala, ake sibone, yiziphi lezi zithiyo ze-angiogenesis?
Kalula nje, lolu uhlobo lomuthi ovimba ukukhula kwemithambo yegazi emisha, okuyimithambo yegazi ehlinzeka ngamathumba. Amanye amagama alokhu yimithi yokulwa ne-angiogenic, imithi yokulwa ne-angiogenic, kanye nokwelashwa kwe-anti-angiogenic.
Cabanga ngakho, ukuze noma yini ikhule, idinga ukudla, ukudla okunomsoco, akunjalo? Amaseli omdlavuza anjalo nje. Adinga futhi ukuhlinzekwa okuqhubekayo kwegazi eligcwele izakhamzimba ukuze akhule futhi asakazeke. Uma iseli lomdlavuza lincane, lisinda ngokumunca igazi elithile ezicutshini ezinempilo ezizungezile. Kodwa lapho iseli likhula lize libe ngamamilimitha angu-1-2, kufanele lakhe uhlelo lwalo olusha lwemithambo yegazi. Ngaphandle kwalokho, alikwazi ukukhula libe likhulu.
Yilapho imithi ebizwa ngokuthi i-Angiogenesis Inhibitors ingena khona. Le mithi isebenza ngokuvimbela inqubo lapho amangqamuzana omdlavuza ekhulisa khona imithambo yegazi emisha. Kufana nokunqamula amanzi esihlahleni. Lokhu kunciphisa ukukhula komdlavuza, futhi ngezinye izikhathi isimila singancipha. Lokhu kwelashwa kungase kungelapheki ngokuphelele umdlavuza, kodwa kungalawula ukukhula kwesimila futhi kukuvumele ukuthi ube nabathandekayo bakho isikhathi eside.
Lo muthi usebenza kanjani emzimbeni?
Le mithi iphazamisa inqubo ebizwa ngokuthi i-angiogenesis . Empeleni lena inqubo evamile emizimbeni yethu. Cabanga uma usika isandla sakho, kudingeka imithambo yegazi emisha ikhule ukuze ipholise inxeba futhi ilethe igazi kuleyo ndawo. Lokho kubizwa ngokuthi i-angiogenesis. Amaseli alimele athumela isignali, njengokuthi "Sisize!" Lesi signali sibangela ukuba imithambo yegazi emisha ikhule.
Kodwa inkinga iwukuthi, amangqamuzana omdlavuza nawo asebenzisa le nqubo efanayo ukuze azuze. Amangqamuzana omdlavuza nawo athumela izimpawu ezifanayo futhi akhulise imithambo yegazi emisha. Le mithambo yegazi yiyo enikeza isimila izakhamzimba esizidingayo, esivumela ukuba sikhule futhi sisabalale kwezinye izingxenye zomzimba.
Ama-Angiogenesis Inhibitors asebenza ngokuphazamisa lolu hlelo lokubonisana oluvela kumdlavuza. Iningi lalawa maphilisi lisebenza ngokuvimbela iphrotheni ebizwa ngokuthi i-vascular endothelial growth factor (VEGF) . Cabanga nge-VEGF njengesignali "yosizo" eyinhloko ekhishwa amaseli omdlavuza. Lapho lesi signali se-VEGF sibopha kuma-receptor e-VEGF kumaseli omdlavuza, imithambo yegazi emisha iqala ukwakheka.
Manje ake sibone ukuthi lo muthi umisa kanjani lesi siginali.
- Ukuvimba isignali ye-VEGF ekubopheni kwi-receptor: Eminye imithi (isibonelo, ama-antibodies e-monoclonal njenge-Bevacizumab (Avastin®) aya ngqo kwiprotheni ye-VEGF bese enamathela kuyo. Ngemuva kwalokho ayikwazi ukuya kuleyo receptor bese inamathela kuyo. Kufana nokuvimba incwadi ngaphambi kokuba ifike kumuntu ohlosiwe.
- Ukuvimba izimpawu ezivela kuma-receptor e-VEGF: Ezinye izidakamizwa (isibonelo, ama-tyrosine kinase inhibitors afana ne-sorafenib (Nexavar®) kanye ne-sunitinib (Sutent®)) zivimba i-receptor ekuthumeleni umlayezo emuva, noma ngabe ithola isignali.
- Ukuvimba ezinye izinhlelo zokubonisa izimpawu: Eminye imithi (isibonelo, ama-immunomodulators afana ne-thalidomide kanye ne-lenalidomide (Revlimid®)) iphazamisa ezinye izinhlelo zokubonisa izimpawu ezihilelekile kule nqubo.
Lo muthi usetshenziselwa ziphi izinhlobo zomdlavuza?
Odokotela bavame ukunikeza lezi zithibi ze-angiogenesis kumdlavuza osuthuthukile noma ophindaphindayo . Ezinye zezinhlobo zomdlavuza okunconywa ngazo lokhu kwelashwa yilezi:
- Umdlavuza wobuchopho
- Umdlavuza webele
- Umdlavuza wesibeletho
- Umdlavuza wamathumbu amakhulu
- Umdlavuza we-Fallopian tube
- Umdlavuza wezinso
- Umdlavuza wesibindi
- Umdlavuza wamaphaphu
- I-Lymphoma
- I-myeloma eminingi
- Umdlavuza we-pancreatic
- Umdlavuza we-peritoneal
- Umdlavuza wesisu
- Umdlavuza we-thyroid
- Umdlavuza wesibeletho/we-endometrial
Ngaphezu kwalokho, le mithi (i-VEGF inhibitors) isetshenziselwa ukwelapha izifo ezithile zamehlo lapho imithambo yegazi ikhula khona ngendlela engavamile esweni.
Kwenzekani ngesikhathi sokwelashwa?
Odokotela abavamile ukunikeza le mithi yodwa. Ivame ukunikezwa kanye nezinye izindlela zokwelapha umdlavuza, njengokwelashwa nge-immunotherapy kanye ne-chemotherapy .
Cabanga ngakho njengempi. Ama-Angiogenesis Inhibitors anquma ukudla nezinhlamvu (igazi) ezitholwa yisitha (umdlavuza). Ezinye izindlela zokwelapha (njenge-chemotherapy) ziya ngqo esitheni (amangqamuzana omdlavuza) bese ziwahlasela. Uma lezi zindlela ezimbili zisebenza ndawonye, imiphumela ingaba yimpumelelo enkulu.
Kuye ngohlobo lomuthi owunikezwayo, kungadingeka uwuthathe njengephilisi kanye noma kabili ngosuku, noma kungadingeka uwuthathe njenge-IV (njenge -saline ) emthanjeni ngezikhathi ezithile.
Kuthatha isikhathi esingakanani lokhu kwelashwa?
Ubude bokwelashwa kwakho buxhomeke ezintweni eziningi, okuhlanganisa uhlobo lomuthi owunikezwayo kanye nohlobo lomdlavuza onawo. Iningi labantu liyaqhubeka nokuphuza le mithi uma nje isebenza. Ngezinye izikhathi, ukwelashwa kungase kumiswe uma imiphumela emibi iba nzima kakhulu ukuyithwala. Udokotela wakho uzoxoxa nawe ngezinzuzo nemiphumela emibi yokwelashwa futhi enze isinqumo esingcono kakhulu.
Yiziphi imiphumela emibi kanye nezingozi?
Njenganoma yimuphi umuthi, lokhu kwelashwa kungaba nemiphumela emibi kanye nezingozi. Iningi lalokhu izinkinga zokopha (ukopha) kanye nokujiya kwegazi. Ezimweni ezingavamile, le miphumela emibi ingaba yingozi empilweni. Ngakho-ke kubalulekile ukuqaphela lokhu.
Udokotela wakho uzoqapha impilo yakho njalo ukuze anciphise lezi zingozi.
| Umphumela/ingozi engaba khona | Incazelo elula |
|---|---|
| Umfutho wegazi ophakeme | Umfutho wegazi ophakeme. Lokhu kufanele kuhlolwe futhi kulawulwe njalo. |
| Ukopha kwangaphakathi | Ukopha ngaphakathi emzimbeni. |
| Ukuphola kancane kwenxeba | Ngenxa yokuthi iphazamisa ukwakheka kwemithambo yegazi emisha, ingandisa isikhathi esithathwayo ukuze amanxeba aphole. |
| Ukubhoboza kwamathumbu | Akuvamile kakhulu ukuthi kube nengozi yokubhoboka kwesisu noma amathumbu. |
| Ukwehla komsebenzi we-thyroid | Ukunciphisa ijubane le-thyroid gland, elawula ama-hormone omzimba. |
| Ukulimala kwesibindi | Ngezinye izikhathi ukusebenza kwesibindi kungathinteka. |
| Amahlule egazi | Kukhona ingozi yokuthi kube namahlule egazi ayingozi emithanjeni yegazi. Lokhu kungabangela izimo ezifana nokuhlaselwa yinhliziyo noma isifo sohlangothi. |
Into ebaluleke kakhulu ongayenza ukuqonda le miphumela emibi kanye nezingozi ngaphambi kokuba uqale ukwelashwa. Uma wazi ukuthi yini ongayilindela, ungaqaphela kakhudlwana izinguquko emzimbeni wakho. Uma ubona noma yini engavamile, yazisa udokotela wakho ngokushesha. Angabe esekufundisa indlela yokuphatha imiphumela emibi noma ukulungisa umthamo wemithi yakho.
Ingabe zikhona izinto ezingamisa le nqubo ngokwemvelo?
Lona umbuzo abantu abaningi abawubuzayo. Okunye ukudla kuqukethe ama-compounds avimba izimpawu ezithile ezihilelekile enkambisweni ye-angiogenesis. Okuningi kwalokhu kudla kutholakala ekudleni kwaseMedithera. Isibonelo:
- I-asparagus
- Impande ye-Dandelion
- Itiye eliluhlaza
- Amafutha omnqumo
- Amantongomane
- Iwayini elibomvu
- Amagilebhusi abomvu
Abacwaningi bezokwelapha bazama ukusebenzisa la makhemikhali ukudala imithi emisha, kodwa lolo cwaningo lusesesigabeni salo sokuqala.
Kodwa into ebaluleke kakhulu okufanele uyikhumbule lapha ukuthi lokhu kudla ngeke kube yinto ethatha indawo yemithi yomdlavuza. Ngamanye amazwi, ukudla amagilebhisi abomvu amaningi nokuphuza itiye eliluhlaza ngeke kuvimbele ukwakheka komdlavuza. Lowo ngumbono ongalungile nhlobo.
Kodwa-ke, ukudla ukudla okunomsoco kubaluleke kakhulu ukuze umzimba wakho uhlale uqinile. Kubalulekile ukunikeza umzimba ukudla okunempilo ngesikhathi nangemva kokwelashwa komdlavuza.
Kunini lapho udinga ukukhuluma nodokotela?
Uma uhlangabezana nanoma yiziphi izimpawu ezingalindelekile ngesikhathi sokwelashwa, xhumana nodokotela wakho ngokushesha.
Ikakhulukazi uma ubona izimpawu zesimo esisongela ukuphila, njengokuhlaselwa yinhliziyo noma isifo sohlangothi, hamba uye eMnyangweni Wezimo Eziphuthumayo (ETU) ngokushesha.
Ama-angiogenesis inhibitors ayindlela yokwelapha ebaluleke kakhulu evimba ikhono lamaseli omdlavuza lokuphatha inqubo yokuphulukisa yomzimba wethu. Angase angayelaphi ngokuphelele umdlavuza, kodwa angasiza ekulawuleni ukusabalala kwawo futhi akunike isikhathi esengeziwe sokuphila. Uma udokotela wakho encoma lo muthi, qiniseka ukuthi ukhuluma nodokotela wakho ngendima yawo ohlelweni lwakho lokwelashwa oluphelele.
Umlayezo Wokuya Nawe Ekhaya
- Ama-Angiogenesis Inhibitors uhlobo lomuthi ovimba ukwakheka kwemithambo yegazi emisha enikeza amangqamuzana omdlavuza ngegazi. Lokhu kuvimbela amangqamuzana omdlavuza ekutholeni izakhamzimba azidingayo futhi kulawula ukukhula kwawo.
- Nakuba lokhu kungelaphi ngokuphelele umdlavuza, kungalawula ukusabalala kwalesi sifo futhi kuqhubeke isikhathi eside.
- Lokhu kwelashwa kuvame ukunikezwa kanye nezinye izindlela zokwelapha, njenge-chemotherapy.
- Kubalulekile ukuqaphela imiphumela emibi efana nomfutho wegazi ophakeme, ukujiya kwegazi, kanye nokuphola kwenxeba okulibazisekile, nokwazisa udokotela wakho uma uhlangabezana nanoma yikuphi ukukhubazeka.
- Nakuba okunye ukudla kwemvelo kuqukethe izinto eziphazamisa le nqubo, akufanele zisetshenziswe esikhundleni sokwelashwa.
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