Kumelwe ukuba uke wezwa omama bethu, obaba, ogogo nomkhulu bethu bethi, "O, umzimba wami ubuthakathaka manje," nokuthi "Amathambo ami abuthakathaka." Eqinisweni, njengoba sikhula, amandla emizimba yethu ayancipha, futhi amandla amathambo ethu ayancipha kancane kancane. Ngezinye izikhathi, lapho lesi simo siba sibi kakhulu, ngisho nokuwa okuncane noma ngisho nokuvuka embhedeni kungaholela engcupheni enkulu kakhulu yokuphuka ingalo noma umlenze. Lesi simo lapho amathambo eba buthakathaka futhi ebuthakathaka sibizwa ngokuthi i-osteoporosis . Ngakho-ke, namuhla sizokhuluma ngeklasi elibaluleke kakhulu lemithi esetshenziswa odokotela ukulawula lolu hlobo lobuthakathaka bamathambo.
Kalula nje, ayini lawa ma-bisphosphonates?
Ama-bisphosphonates ayiqembu lemithi esetshenziselwa ukwelapha izimo ezifana ne-osteoporosis ezinciphisa ukuminyana kwamathambo namandla. Lokhu kusho ukuthi akukho muthi owodwa onaleli gama, kodwa inhlanganisela yemithi eminingana. Ngaphezu kwe-osteoporosis, odokotela banikeza lo muthi kwezinye izimo zamazinga aphezulu e-calcium egazini (i-hypercalcemia).
Ake sibheke izinhlobo eziyinhloko zemithi ngaphansi kwalesi sigaba. Lezi ziza ngezindlela ezimbili eziyinhloko. Eyodwa ingeyomlomo (amaphilisi athathwa ngomlomo), kanti enye ingeniswa ngemithambo yegazi (IV) (uketshezi olufakwa emthanjeni).
| Indlela yokunikeza umuthi | Izibonelo zemithi (evame ukusetshenziswa eSri Lanka) |
|---|---|
| Ama-Bisphosphonates Omlomo | I-Alendronate, i-Risedronate, i-Ibandronate |
| Ama-fluid angena emthanjeni (ama-IV Bisphosphonates) | I-Zoledronic acid, i-Pamidronate |
Lo muthi uwuthinta kanjani umzimba?
Ukuze siqonde lokhu, sidinga kuqala ukuqonda okuncane ngendlela amathambo ethu asebenza ngayo. Cabanga ngamathambo ethu njengesakhiwo esihlala silungiswa. Imizimba yethu iyaphuka ngokwemvelo futhi isuse amathambo amadala, abuthakathaka. Le nqubo ibizwa ngokuthi ukumuncwa kwamathambo.Ngesikhathi esifanayo, kwakheka ithambo elisha nelinamandla ezindaweni lapho lisuswe khona. Uma nje lezi zinqubo ezimbili zilingana, amathambo ethu ahlala eqinile.
Kodwa-ke, njengoba siguga, ikakhulukazi ngemva kokunqamuka kokuya esikhathini kwabesifazane, leli bhalansi liyalahleka. Okwenzekayo ukuthi ithambo elidala liphuka ngokushesha kakhulu kunamathambo amasha. Umphumela uba ukuthi amathambo kancane kancane aba mancane, abe nezimbobo eziningi, futhi abe buthakathaka.
Ngakho-ke, lokho okwenziwa yilawa ma-bisphosphonates ukulawula nokunciphisa izinga lokumuncwa kwamathambo. Ngemuva kwalokho, ngenxa yokuthi ithambo elidala liqinile ngenkathi kwakhiwa ithambo elisha, ukuqina kanye namandla amathambo kuyanda. Kalula nje, ayayeka ukulahleka kwamathambo.
Yiziphi izimo ezisetshenziswa ama-bisphosphonates?
Odokotela batusa kakhulu lo muthi kulezi zimo ezilandelayo:
- I-Osteoporosis yisimo esenzeka kwabesifazane ngemva kokunqamuka kokuya esikhathini.
- I-Osteoporosis emadodeni.
- Ukuvimbela ukwenzeka kwe-osteoporosis.
- I-Osteoporosis ebangelwa ukusetshenziswa okuqhubekayo kwemithi efana nama-steroids (ama-glucocorticoids).
- Isifo sikaPaget sethambo yisifo lapho amathambo ekhula khona ngendlela engavamile.
- Lawula izinkinga ezenzeka ngezinhlobo ezithile zomdlavuza (isib. i-Multiple Myeloma) kanye nalapho amangqamuzana omdlavuza esakazekela emathanjeni (i-Bone Metastasis).
- Ukulawula i-hypercalcemia ehlobene nomdlavuza (ukwanda kwamazinga e-calcium egazini ngenxa yomdlavuza).
Ngingawusebenzisa kanjani lo muthi? Lokhu kubaluleke kakhulu!
Kubalulekile ukulandela le miyalelo ngqo ukuze uthole izinzuzo ezigcwele zomuthi futhi unciphise imiphumela emibi.
Imithi Yomlomo
Indlela yokuphuza la maphilisi icacile kakhulu. Kumelwe ulandele imiyalelo kadokotela ngqo.
- Iphilisi kufanele liphuzwe ekuseni, ngaphambi kokudla noma ukuphuza noma yini (esiswini esingenalutho) .
- Iphilisi kufanele liphuzwe kuphela nengilazi egcwele yamanzi (amanzi alula) . Akuvunyelwe ngokuphelele ukuthatha lo muthi nezinto ezifana netiye, ikhofi, ubisi, noma iziphuzo zezithelo.
- Okubaluleke kakhulu: Ngemva kokuthatha umuthi, kufanele uhlale noma ume okungenani imizuzu engama-30 kuya kwengama-60 . Unganciki, ulale phansi, noma ulale nganoma yisiphi isizathu.
- Isizathu salokhu ukuthi lo muthi ungalimaza umphimbo. Leyo ngozi iyaphela uma usukuma ngoba umuthi udlula ngokushesha esiswini.
- Akuyona into enhle ukudla noma ukuphuza noma yini enye phakathi nalesi sikhathi semizuzu engama-30-60. Ngemva kokuba leso sikhathi sesiphelile, ungadla isidlo sasekuseni njengenjwayelo.
Imithi ye-IV
Awukwazi ukwenza lokhu ekhaya. Lokhu kwelashwa kunikezwa esibhedlela noma emtholampilo. Kuye ngesimo sakho, lo mjovo (i-infusion) uvame ukunikezwa kanye ngonyaka noma njalo ezinyangeni ezimbalwa.
Ngesikhathi uthatha lo muthi, udokotela wakho uvame ukuncoma ukuthi udle ukudla okucebile nge-calcium (ubisi, iyogathi, ushizi, inhlanzi encane) bese uthatha isithasiselo se-vitamin D , njengoba kokubili kubalulekile emathanjeni aqinile.
Yiziphi imiphumela emibi ye-bisphosphonates?
Njenganoma yimuphi umuthi, kungase kube nemiphumela emibi. Kodwa ungakhathazeki, eminingi yayo mincane.
| Uhlobo lomuthi | Imiphumela emibi engaba khona |
|---|---|
| Imithi yomlomo | Izinkinga zesisu ezifana nesilungulela, i-GERD, i-esophagitis, ubuhlungu besisu, kanye nezilonda. (Lokhu kungavinjelwa kakhulu ngokulandela indlela efanele yokuphuza imithi yakho.) |
| Imithi ye-Intravenous (IV) | Izimpawu ezifana nezomkhuhlane noma umkhuhlane, njengomkhuhlane, izinhlungu zomzimba, ikhanda elibuhlungu, kanye nobuhlungu bamalunga nemisipha, zingase zivele usuku noma ezimbili ngemva kokuthatha umuthi. Lokhu kuvame ukuphela zingakapheli izinsuku ezimbalwa. |
Imiphumela emibi engavamile kakhulu kodwa okufanele uyiqaphele
Nakuba lezi zingavamile kakhulu , kubalulekile ukuziqaphela.
- I-Osteonecrosis yomhlathi: Le ngozi incane kakhulu, ikakhulukazi ngemva kokuhlinzwa njengokukhishwa kwamazinyo. Ngakho-ke uma uthatha lo muthi, tshela udokotela wamazinyo njalo uma umbona.
- Ukuphuka kwe-femur okungavamile: Lokhu kuyinto engavamile kubantu abasebenzisa lo muthi isikhathi eside (ngaphezu kweminyaka engu-3-5).
- Izinkinga zamehlo: Ukuvuvukala (i-uveitis, i-scleritis) kwezingxenye ezahlukene zeso kungenzeka.
Into ebaluleke kakhulu ukuthi ingozi yokuphuka ithambo ngenxa ye-osteoporosis uma ungayithathi le mithi iphindwe kayinkulungwane kunengozi encane kakhulu yale miphumela emibi. Ngakho-ke, kubaluleke kakhulu ukulandela imiyalelo kadokotela wakho.
Ufuna ukuphinde ubonane nodokotela nini?
Uma uthatha lo muthi, kubalulekile ukubona udokotela wakho ngezikhathi ezithile ukuze ahlole ukuthi umuthi uyasebenza yini nokuthi kukhona yini imiphumela emibi. Ungathunyelwa futhi kuchwepheshe wamathambo (i-Endocrinologist noma i-Rheumatologist).
Udokotela wakho angase futhi ancome ukuthi kwenziwe i-DXA scan ukuze abone ukuthi amathambo akho aqine kangakanani.
Inothi Elikhethekile: Uma ususebenzise lo muthi iminyaka engaphezu kwemithathu futhi uzwa ubuhlungu obusha ethangeni noma esinqeni sakho, ungabunaki futhi wazise udokotela wakho ngokushesha.
Umlayezo Wokuya Nawe Ekhaya
- Ama-bisphosphonates ayimithi ephumelela kakhulu esiza ekuqiniseni amathambo abuthaka ngenxa ye-osteoporosis.
- Le mithi isebenza ngokunciphisa izinga lokulahlekelwa amathambo.
- Uma uthatha imithi yomlomo, kubalulekile ukuyiphuza esiswini esingenalutho, ngamanzi kuphela, futhi uhlale umile noma uhleli imizuzu engama-30-60 ngemva kokuthatha imithi.
- Nakuba kungase kube nemiphumela emibi emincane, imiphumela emibi emibi ayivamile kakhulu. Izinzuzo zomuthi zidlula kakhulu izingozi.
- Uma unemibuzo, ukukhathazeka, noma ukungabaza ngalo muthi, khuluma nodokotela wakho ngawo obala. Ungalokothi uyeke ukuthatha umuthi wakho ngaphandle kweseluleko sikadokotela.
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