Uma ubheka ukuhlolwa kwegazi, cishe unaka kakhulu i-cholesterol, ikakhulukazi i-cholesterol embi, i-LDL. Ngoba sonke siyazi ukuthi lapho amazinga e-LDL enyuka, amathuba okuthola izifo ezifana nokuhlaselwa yinhliziyo kanye nohlangothi ayanda. Kodwa indaba ayipheli lapho. Izifundo zithole ukuthi ama-50% abantu abake baba nokuhlaselwa yinhliziyo babengenawo amazinga aphezulu e-LDL. Ngakho-ke, odokotela basebenzisa olunye uhlolo ukuze bahlole ngokunembile ingozi. Yilokho esikubiza ngokuthi i-C-Reactive Protein, noma ukuhlolwa kwe-CRP.
Kuyini ngempela i-CRP?
Kalula nje, i-C-Reactive Protein (CRP) iyiprotheni ekhiqizwa yisibindi sethu. Uma kukhona ukuvuvukala , okungukuthi, ukuvuvukala okubangelwa umonakalo othile, endaweni ethile emzimbeni wakho, leli zinga le-CRP liyakhuphuka egazini.
Cabanga ngale ndlela. I-cholesterol embi (i-LDL) ayigcini nje ngokunamathela ezindongeni zemithambo yegazi yethu, kodwa futhi iyayilimaza. Lo monakalo yilokho esikubiza ngokuthi ukuvuvukala. Kufana nesilonda esincane. Lapho umzimba uzama ukwelapha lo monakalo, ukhiqiza amaprotheni akhethekile asebenza njenge "ithimba losizo." I-CRP ingenye yamaprotheni anjalo. Okusho ukuthi, uma kukhona ukuvuvukala endaweni ethile emzimbeni, singakubona kusukela ezingeni le-CRP. Kufana nokuthi uma sibona intuthu, sicabanga ukuthi kukhona umlilo endaweni ethile.
Kungani udokotela angancoma ukuhlolwa kwe-CRP?
Ukuhlolwa kwe-CRP kulinganisa inani le-C-Reactive Protein egazini lakho. Lokhu kunganikeza udokotela wakho umbono omuhle ngezinga lokuvuvukala emzimbeni wakho.
Ezinye izifundo zisikisela ukuthi i-CRP iyindlela engcono yokubikezela ingozi yesifo senhliziyo (CVD) kune-LDL cholesterol. Kodwa-ke, akuyona indlela ethile yokuhlola isifo senhliziyo. Ibonisa kuphela ukuthi kukhona yini ukuvuvukala emzimbeni. Ukuvuvukala kungabangelwa yisifo senhliziyo noma okunye.
Kunezinye izimo lapho kusetshenziswa khona lolu vivinyo:
- Izifo Ezivikela Umzimba: Lokhu kuhlolwa kwenziwa nakubantu abanezifo ezifana ne-Lupus noma i-Rheumatoid Arthritis. Ngoba lezi zifo zibangela nokuvuvukala emzimbeni. Lokhu kuhlolwa kusiza futhi ukubona ukuthi imithi enikezwayo iyanciphisa yini lokho kuvuvukala. Kodwa-ke, lokhu kuhlolwa akukwazi ukutshela ukuthi ukuvuvukala kukuphi emzimbeni.
- Ukutheleleka: Lokhu kuhlolwa kwenziwa uma kukhona izinsolo zokutheleleka okubangelwa yizifo ezifana ne-sepsis, ukutheleleka ngefungus, noma ukutheleleka ngamathambo.
- Ingozi yesibili yokuhlaselwa yinhliziyo: Iphinde isetshenziswe ukubona ukuthi iyini ingozi yokuba nokuhlaselwa yinhliziyo okunye kumuntu oseke waba nokuhlaselwa yinhliziyo kakade.
- Ezinye izifo:Lokhu kusiza futhi ekuxilongeni izimo ezifana nesifo samathumbu esivuvukalayo kanye nesifo samaphaphu.
Ungawaqonda kanjani amanani embikweni we-CRP?
Udokotela wakho angase akuyalele lokhu kuhlolwa kwe-CRP uma unezimpawu zokutheleleka, njengomkhuhlane, ukubanda, ukushaya kwenhliziyo okusheshayo, izinga lokuphefumula elikhuphukile, isicanucanu, nokuhlanza.
Lokhu ukuhlolwa kwegazi okulula kakhulu. Ngokuvamile, inani elincane legazi lithathwa emthanjeni osengalweni yakho. Akudingi ukulungiswa okukhethekile (njengokuzila ukudla). Akukho ubuhlungu ngaphandle kwendawo encane ebuhlungu lapho kufakwa khona inaliti. Kodwa-ke, eminye imithi oyithathayo ingathinta imiphumela yalolu vivinyo. Ngakho-ke qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyithathayo.
Uma usuthole imiphumela yakho, ithebula elingezansi lizokusiza ukuthi uqonde amanani. Kodwa khumbula, la manani angahluka kancane kuye ngelabhorethri. Ngakho-ke qiniseka ukuthi ubonisa udokotela wakho umbiko wakho futhi uthole iseluleko.
| Izinga Lokuvuvukala | Inani le-CRP (mg/dL) | Incazelo/izizathu ezingaba khona |
|---|---|---|
| Ukuphakama Okumaphakathi | 1.0 - 10.0 mg/dL | Izifo ezizenzakalelayo ezifana ne-rheumatoid arthritis, i-lupus, ukuhlaselwa yinhliziyo, i-pancreatitis, i-bronchitis. |
| Ukuphakama Okuphawuliwe | 10.0 - 50.0 mg/dL | Ukutheleleka okubangelwa amagciwane noma amagciwane, ukuvuvukala kwemithambo yegazi (i-Systemic Vasculitis), ingozi noma ukulimala okukhulu. |
| Ukuphakama Okukhulu | Kungaphezu kuka-50.0 mg/dL | Ngokuvamile (90%) kubangelwa ukutheleleka okubangelwa amagciwane. Izimo ezifana ne-dengue, i-malaria, kanye ne-hepatitis C nazo zingayibangela. |
Izinga le-CRP elingaphezu kuka-10 mg/dL ngokuvamile libhekwa njengophawu lokuvuvukala okukhulu. Kodwa-ke, lokhu kuhlolwa kukodwa akukwazi ukusho ukuthi yini ebangela lokhu. Udokotela wakho kuzodingeka enze ukuhlolwa okwengeziwe ukuze athole imbangela.
Ukuhlolwa okukhethekile kwe-CRP (hs-CRP) okubheka ingozi yesifo senhliziyo
Kukhona ukuhlolwa okuzwela kakhulu kunokuhlolwa kwe-CRP okujwayelekile, okusetshenziselwa ukuhlola ingozi yesifo senhliziyo (i-CVD). Kubizwa ngokuthi i-High-Sensitivity CRP (hs-CRP) .
Lokhu kuhlolwa kuwusizo kakhulu kubantu abasengozini engu-10%-20% yokuhlaselwa yinhliziyo eminyakeni eyi-10 ezayo. Amazinga e-CRP, njengamazinga e-cholesterol, angasiza ekubikezeleni ingozi yesifo senhliziyo. Ucwaningo olulodwa luthole ukuthi ukuba namazinga aphezulu e-CRP kwandise kathathu ingozi yokuhlaselwa yinhliziyo.
Nansi indlela yokuhumusha imiphumela ye-hs-CRP:
| Inani le-hs-CRP (mg/L) | Ingozi yesifo senhliziyo (CVD) |
|---|---|
| Ngaphansi kuka-1.0 mg/L | Ingozi ephansi |
| 1.0 mg/L kuya ku-3.0 mg/L | Ingozi emaphakathi |
| Ngaphezu kuka-3.0 mg/L | Ingozi ephezulu |
Ngenxa yokuthi amazinga e-CRP angahluka kancane usuku nosuku, kungcono ukwenza lokhu kuhlolwa kabili, amasonto amabili ahlukene, ukuze uhlole ngokunembile ingozi yakho yesifo senhliziyo. Futhi, ukuba nezinga eliphezulu le-hs-CRP akusho ukuthi unesifo senhliziyo. Ngakho-ke kubalulekile ukuliqhathanisa nezinga lakho le-cholesterol ye-LDL ukuze uthole isithombe esigcwele.
Yini okufanele uyenze uma izinga lakho le-CRP liphezulu?
Uma izinga lakho le-CRP liphezulu, ukwelashwa kuzoncika esibangweni. Uma izinga lakho le-CRP liphakeme ngenxa yesici esiyingozi sesifo senhliziyo, kunezinto eziningana ongazenza ukuze unciphise leyo ngozi:
- Yamukela ukudla okunempilo kwenhliziyo: Yidla ukudla okunamafutha amancane, usawoti, noshukela, kanye nezithelo nemifino eminingi.
- Lawula i-cholesterol.
- Gcina isisindo somzimba esifanele.
- Vivinya umzimba njalo.
- Uma unesifo sikashukela noma umfutho wegazi ophakeme, balawule kahle.
- Uma ubhema, yeka ngokushesha.
- Nciphisa ukusetshenziswa kotshwala.
Ama-statin, uhlobo lomuthi okwehlisa i-cholesterol, angasiza ekunciphiseni ingozi yesifo senhliziyo kubantu abanamazinga aphezulu e-CRP. Kodwa-ke, uma amazinga akho e-cholesterol ejwayelekile, ama-statin angase angabi yimpendulo efanele yamazinga aphezulu e-CRP. Kungcono ukukhuluma nodokotela wakho mayelana nokuthi iyiphi indlela yokwelapha engcono kakhulu kuwe.
Umlayezo Wokuya Nawe Ekhaya
- Ukuhlolwa kwe-CRP kulinganisa ukuvuvukala emzimbeni, hhayi isifo esithile.
- Lokhu kuwusizo kakhulu ekuhloleni izimo ezifana nobungozi besifo senhliziyo, izifo ezithathelwanayo, kanye nezifo ezizimele.
- Uma izinga lakho le-CRP liphezulu, udokotela wakho kungadingeka enze izivivinyo ezengeziwe ukuthola imbangela.
- Ukuhlolwa okubucayi kakhulu okubizwa nge-hs-CRP kusetshenziselwa ukuhlola ngqo ingozi yesifo senhliziyo.
- Izinguquko zendlela yokuphila zibalulekile ekuphatheni amazinga aphezulu e-CRP, kodwa qiniseka ukuthi uthintana nodokotela wakho nganoma yiluphi ukwelashwa.
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