Ingabe inkumbulo yakho kanye nokunyakaza kwakho kuyawohloka kancane kancane? Ake sifunde ngalokhu (Ukuwohloka kwe-Corticobasal)!

Ingabe ngezinye izikhathi uyakhohlwa izinto? Noma ukuthola kunzima ukuhambisa izingalo nemilenze yakho? Ingabe uyawasho amazwi akho uma ukhuluma? Uma lezi zinto zibonakala zikhula, mhlawumbe kubalulekile ukuthi uqaphele lesi simo esikhuluma ngaso namuhla esibizwa ngokuthi `(Corticobasal Degeneration)`. Ungakhathazeki, ake sixoxe ngalokhu kalula.

Kuyini "Ukonakala kwe-Corticobasal"?

Kalula nje, `(Corticobasal Degeneration)` yisimo sezinzwa esithinta ubuchopho bethu. Abanye abantu basibiza nangokuthi `(Corticobasal Syndrome).` Okwenzekayo kulokhu ukuthi amanye amangqamuzana ebuchosheni bethu ayalimala futhi abhujiswe kancane kancane. Njengoba nje eminye imishini iwohloka ngokuhamba kwesikhathi. Ngenxa yalokhu, ikhono lethu lokukhuluma, ukugwinya ukudla, ukuhambisa imizimba yethu, nokukhumbula izinto lingancipha kancane kancane. Into edabukisayo ukuthi lezi zimpawu ziyanda kancane kancane (intuthuko) ngokuhamba kwesikhathi.

Igama elithi "corticobasal" egameni libhekisela ezingxenyeni ezimbili zobuchopho ezilinyazwe kakhulu yilesi sifo:

• I-cerebral cortex: Lena ungqimba olungaphandle kakhulu lwezicubu zezinzwa ebuchosheni bethu. Le ngxenye ibaluleke kakhulu ekukhumbuleni kwethu, ekufundeni, ekunyakazeni ngokuzithandela, kanye nasezinzweni.
• I-basal ganglia: Leli iqoqo lamaseli ezinzwa atholakala ngaphakathi ebuchosheni. Libalulekile ekufundeni nasekusebenzeni kwemisipha.

Igama elithi "ukonakala" lisho "ukuwohloka" noma "ukulahlekelwa ukusebenza kahle." Ngakho-ke okwenzekayo kulesi sifo ukuthi ukusebenza kwalezi zingxenye ezimbili zobuchopho kwehla kancane kancane.

Lesi simo, "i-Corticobasal Degeneration"`, singanciphisa isikhathi sokuphila komuntu futhi sibangele izinkinga ezisongela ukuphila. Njengoba izimpawu zisakazeka emzimbeni wonke, kungaba nzima ukusebenza ngokuzimela.

Yiziphi izimpawu `(Ukonakala kwe-Corticobasal)`?

Izimpawu zalesi simo zingahluka kumuntu nomuntu, kodwa amakhono angathinteka ngokujwayelekile yile:

• Ubunzima bokunyakaza (`Apraxia`): Lokhu kusho ukuthi izinto ezinjengokuchofoza inkinobho noma ukubamba isipuni ukuze udle ziba nzima. Ngisho noma ubuchopho buthumela imiyalezo ezandleni, abukwazi ukuyenza kahle.
• Ukukhubazeka kwenkumbulo: Kuba nzima ukukhumbula izinto ezintsha, futhi izinto ezindala ziyalibaleka kancane kancane.
• Ukukhubazeka kokubona: Abanye abantu bangase babe nezinkinga zokubona.
• Ubunzima bokukhuluma (`Aphasia`): Ubunzima bokuthola amagama, ukungaqondi kahle lokho ofuna ukukusho, futhi ngezinye izikhathi ukulahlekelwa yinkulumo ngokuphelele.
• Ubunzima bokugwinya: Ungase uzizwe sengathi uyaminyana lapho ugwinya ukudla neziphuzo.

Ngaphezu kwalokhu, ezinye izimpawu ezifana nalezi zingabonakala:

• Ukuqaqamba kwemisipha, ukudikiza, imisipha eqinile, noma ukuthuthumela.
• Ubunzima bokwenza imisebenzi emincane nebucayi (isib., ukunamathisela izinkinobho zehembe, ukubhala ngepeni).
• I-Alien hand syndrome: Ukungakwazi ukulawula ingalo noma umlenze owodwa njengoba ufisa (`i-Alien hand syndrome`). Cabanga ukuthi enye yezingalo zakho yenza izinto ongafuni ukuthi izenze, futhi uzizwa sengathi awukwazi ukuzilawula.
• Umuzwa wokuba ndikindiki kolunye uhlangothi lomzimba.
• Ukunyakaza okuhamba kancane kakhulu (`Bradykinesia`) noma ukungakwazi ukuhambisa izitho zomzimba (`Akinesia`) kwenzeka.
• Ukwehla kokusebenza kwengqondo, okungukuthi, ukwehla kobuhlakani (i-Dementia).
• Ubunzima bokuhamba ngaphandle kosizo.
• Izinguquko esimweni sengqondo nasekuziphatheni (ukunganaki, intukuthelo engazelelwe, ukunganaki).

Lesi sifo asibathinti bonke ngendlela efanayo. Sivame ukuqhubeka kancane kancane. Ngezinye izikhathi izimpawu ziqala engalweni eyodwa, bese zisakazekela kwenye ingalo nasemilenzeni. Ungase uqale ukuzizwa sengathi uyakhubeka lapho uhamba, bese ungase ungakwazi ukuhamba ngaphandle kosizo. Ungase uqale ukuthukuthela lapho ukhuluma, futhi ngokuhamba kwesikhathi, ungase ungakwazi ukukhuluma umusho owodwa onenjongo.

Njengoba lesi sifo sithinta izingxenye eziningi zobuchopho, izimpawu ziya ziba zimbi kancane kancane. Lokhu kwenzeka kancane kancane.

Ziqala nini izimpawu ze-`(Corticobasal Degeneration)`?

Izimpawu zivame ukuqala phakathi kweminyaka engama-50 nengama-70. Iningi labantu liba nezimpawu zabo cishe eminyakeni engama-64. Nakuba kungavamile ukuqala ekuqaleni kweminyaka engama-40, akukaze kube nemibiko yokuthi lesi sifo siqala ebuntwaneni.

Yiziphi izimbangela `(Ukuwohloka kwe-Corticobasal)`?

Isizathu esiyinhloko salokhu ukuthi amangqamuzana obuchopho nezicubu ziyawohloka kancane kancane futhi ziyafa. Isikhathi esiningi, lo monakalo uqala ezindaweni esikhulume ngazo ngaphambilini ezibizwa ngokuthi i-cerebral cortex kanye ne-basal ganglia. Njengoba lesi sifo siqhubeka, singathinta nezinye izingxenye zobuchopho.

Abacwaningi bakholelwa ukuthi iphrotheni ebizwa ngokuthi "i-Tau" ihilelekile kulesi sifo. Le phrotheni ivame ukutholakala emangqamuzaneni obuchopho. Kodwa kulesi sifo, le phrotheni ihlangana ngokungajwayelekile futhi yakhe amaqhubu. La maqhubu abizwa ngokuthi "ama-neurofibrillar tangles." La maqhubu abangela ukuba amangqamuzana obuchopho awohloke futhi afe. ​​Ngenxa yalokho, kuvela izinkinga ngokunyakaza, inkulumo kanye nenkumbulo.

Isizathu esiqondile sokuthi kungani iprotheni ye-Tau ihlangana ndawonye asikaziwa okwamanje. Kutholakale ukuthi abantu abaningi abane-Corticobasal Degeneration bane-genetic variant (mutation) ebizwa ngokuthi i-H1 haplotype ku-chromosome 17. Lokhu kuhlukahluka kwezakhi zofuzo kungabangela ukuthi iprotheni ye-Tau ikhiqizwe ngokweqile futhi ihlangane ndawonye, ​​noma kungenzeka ukuthi iqembu le-methyl linamathele ku-Tau gene, okuthinta ukusebenza kwayo.

Kodwa abacwaningi bayazi ukuthi lesi sakhi sofuzo akusona sodwa imbangela yalokhu. Ngenxa yokuthi abantu abaningi emphakathini jikelele banalesi sakhi sofuzo, ababi nezimpawu "zokonakala kwe-corticobasal." Ngakho-ke ucwaningo lusaqhubeka ukuze kutholakale imbangela eqondile yalesi simo.

Ingabe `(Ukonakala kwe-Corticobasal)` kuyifa?

Ochwepheshe bezokwelapha abasazi ukuthi kungani abanye abantu beba ne-Corticobasal Degeneration. Akuvamile kakhulu ukuthi amalungu omndeni ofanayo athole lesi sifo. Lokho kusho ukuthi kunzima ukusho ukuthi yisifo esizuzwe njengefa.

Yiziphi izinkinga ezingaba khona?

Njengoba lesi sifo siqhubeka, ingozi yokuthola izinkinga ezisongela impilo njenge:

• Ukutheleleka ngamagciwane
• Amahlule egazi kanye ne-pulmonary embolisms
• Izingozi zomzimba (njengokuwa)
• Inyumoniya
• I-Sepsis (ukutheleleka okukhulu okubangelwa amagciwane angena egazini)

Odokotela basithola kanjani lesi sifo? (`Ukuxilongwa`)

Isici esingavamile sokuxilonga `(Corticobasal Degeneration)` ukuthi kungaqinisekiswa kuphela ngokuhlola ubuchopho ngemva kokufa. Kulapho-ke kuphela lapho udokotela noma isazi sezifo singanquma ngokunembile izinga lokuwohloka kobuchopho.

Kodwa-ke, ngesikhathi sokuphila kwakho, udokotela wakho angase abize lesi simo ngokuthi "i-Corticobasal Syndrome" ngokusekelwe ezimpawini zakho.

Ukuze ahlole isifo, udokotela wakho uzoqala ngokukuhlola ngokomzimba. Uzohlola izimpawu zakho ngokucophelela.

Ngenxa yokuthi izifo eziningi zinezimpawu ezifanayo, udokotela wakho angenza izivivinyo ezahlukahlukene ukuze athole imbangela eqondile. Lokhu kungafaka:

• Ukuhlolwa kwegazi
• Ukuhlolwa kwezithombe zobuchopho (`Ukuskena kwezithombe`) - isibonelo `(MRI)` noma `(CT scan`)
• Ukuhlolwa kwe-neuropsychological ukuhlola ukusebenza kobuchopho kanye nenkumbulo

Ngaphezu kwalokho, udokotela angase futhi a-ode ukuskena kwemithi yenuzi njenge-`(FDG-PET (Fluorodeoxyglucose Positron Emission Tomography))` kanye ne-`(DAT (Dopamine Transporter))`. Ngezinye izikhathi, i-`skin biopsy` ingasiza ekuxilongweni.

Yiziphi izindlela zokwelapha `(Ukuwohloka kwe-Corticobasal)`?

Udokotela wakho angase akunikeze imithi ehlukene yokulawula izimpawu ezahlukene zalesi sifo.

Khumbula, okwamanje akukho ukwelashwa kwalesi sifo noma ikhambi lokuvimba ukuqhubeka kwezimpawu. Kodwa-ke, kunezinto ezingasiza ekunciphiseni ukungakhululeki okubangelwa yizimpawu.

Imithi yezimpawu ezihlobene nemisipha ingafaka:

• Ukunyakaza okuhamba kancane noma ukuqina kwemisipha: `(Levodopa)`
• Ukwelapha ukuqaqamba kwemisipha: I-Clonazepam (i-Benzodiazepines)
• Ukuqina kwemisipha noma ukulawula ukunyakaza: `(Ubuthi be-Botulinum)` (Imijovo ye-Botox)
• Ngokuqina kwemisipha: `(Cyclobenzaprine)`, `(Levetiracetam)` noma `(Baclofen)`

Uma unezinkinga zokukhumbula, udokotela wakho angase akunike olunye lwalezi zinhlobo zemithi ebizwa ngokuthi "i-Cholinesterase inhibitors":

• `(I-Donepezil)`
• `(I-Rivastigmine)`
• `(Galantamine)`

Eminye imithi ayisebenzi kahle ngokulinganayo ezimpawini zawo wonke umuntu, ngakho udokotela wakho angase azame izinhlobo ezahlukene ukuthola okusebenzela kahle kakhulu wena.

Futhi, njengayo yonke imithi, kunemiphumela emibi engaba khona. Udokotela wakho uzokhuluma nawe ngalokhu. Bazokuhlola njalo ukuqinisekisa ukuthi umuthi usebenza kahle nokuthi uma kukhona izinkinga. Uma uhlangabezana nanoma yimiphi imiphumela emibi, kufanele utshele udokotela wakho ngokushesha.

Into ebaluleke kakhulu ukuthi okwamanje akukho ukwelashwa okuzovimba ukuqhubeka kwalezi zimpawu noma ukwelapha lesi sifo ngokuphelele.

Ungazilawula kanjani izimpawu?

Uma uphila nezimpawu ze-"Corticobasal Syndrome," izindlela zokwelapha ezilandelayo zingasiza ekuzilawuleni:

• Ukwelashwa Komsebenzi: Lokhu kungakusiza ufunde izindlela ezintsha zokwenza imisebenzi yansuku zonke futhi ugcine ukuzimela kwakho isikhathi eside ngangokunokwenzeka. Uma kudingeka, ungafunda nokuthi ungasebenzisa kanjani amadivayisi okusiza ukuhamba.
• Ukwelashwa ngokomzimba: Lokhu kusiza ukugcina ukunyakaza komzimba futhi kunciphise ukungakhululeki okubangelwa izimpawu ezihlobene nemisipha. Ukuzivocavoca kungasiza ekuqiniseni imisipha futhi kulondoloze ukuguquguquka.
• Ukwelapha ngenkulumo: Lokhu kusiza ngobunzima bokukhuluma nokugwinya. Kungasiza ngezinto ezifana nendlela yokuveza imibono, indlela yokuphimisela amagama, kanye nendlela yokugwinya ukudla ngokuphephile.

Udokotela wakho uzosebenza nawe ukuthola amasu okuphatha angcono kakhulu ezimpawu zakho. Lawa masu angahluka kumuntu nomuntu, futhi kungadingeka alungiswe njengoba isimo sakho sishintsha ngokuhamba kwesikhathi.

Kufanele ubonane nini nodokotela?

Uma wena noma othandekayo wakho enezimpawu zalezi zimpawu (zokonakala kwe-corticobasal)`, xhumana nodokotela ngokushesha:

• Uma unenkinga yokuhamba noma ukulawula izitho zakho.
• Uma ubhekene nezinkinga zokukhumbula noma izimpawu ze-dementia.
• Uma unenkinga yokukhuluma, yokugwinya, noma yokuphefumula.
• Uma kukhona ukuthuthumela.

Iyini iphrojekthi `(Ukonakala kwe-Corticobasal)`?

Uma ngikhuluma iqiniso, umbono wokwehla kwe-Corticobasal awuthembisi kangako. Kuyisifo esiqhubekayo, okusho ukuthi izimpawu ziya ziba zimbi kakhulu ngokuhamba kwesikhathi.Kodwa lokhu kuvame ukwenzeka kancane kancane, eminyakeni edlule. Udokotela wakho uzokunikeza ukwelashwa okuzokusiza ukuthi ubhekane nokuphatha izimpawu zakho. Nakuba lokhu kwelashwa kunganciphisa ubukhulu bezimpawu zakho, akukwazi ukuzivimba ukuthi zingabi zimbi kakhulu. Njengoba izimpawu zakho ziba zimbi kakhulu, kungaba nzima kakhulu ukuzilawula wedwa.

Ngenxa yokuthi lesi sifo siqhubeka kancane, unesikhathi sokuhlela ikusasa lakho. Akudingeki wenze lezi zinto ngokushesha lapho uthola ukuxilongwa. Udinga ukuzinika isikhathi sokucabanga ngalokho okukulungele. Udinga ukusebenzisana nodokotela bakho nabantu obathembayo ukuhlela izifiso zakho kanye nokunakekelwa okudingayo.

Ingakanani iminyaka yokuphila yomuntu onokukhubazeka kwe-corticobasal?

Ngokwesilinganiso, abantu abaningi baphila iminyaka eyisithupha kuya kweyisishiyagalombili ngemva kokuvela kwezimpawu zokuqala ze-Corticobasal Degeneration. Kodwa-ke, lokhu akufani kuwo wonke umuntu, futhi abanye abantu baphila isikhathi eside kakhulu. Isimo sakho singase singahambisani nezibalo, ngakho-ke umuntu ongcono kakhulu ongakhuluma naye ngalokhu udokotela wakho.

Yiziphi ezinye izimo ezinezimpawu ezifanayo?

Ezinye zezimpawu `(Ukonakala kwe-Corticobasal)` zingase zifane nezimpawu zezinye izifo, njenge:

• Umdlavuza wobuchopho (`Umdlavuza wobuchopho / isimila sobuchopho`)
• `(Ukuwohloka komqondo kwangaphambili)`
• Isifo sika-Alzheimer
• `(Ukuwohloka kwesistimu okuningi)`
• Isifo sikaParkinson
• `(I-Progressive supranuclear palsy)`
• Isifo sohlangothi

Ngakho-ke, kubaluleke kakhulu ukubonana nodokotela ngokushesha uma uhlangabezana nanoma yiziphi izimpawu, njengoba ukwelashwa kusenesikhathi kungasindisa impilo, ikakhulukazi ezimweni ezifana nokukhubazeka.

Kungaba nzima ukulawula imizwa ehambisana nokuxilongwa okufana nokuthi `(Corticobasal Degeneration)`. Ungase uzizwe wesaba futhi ukhathazekile ngekusasa. Njengoba izimpawu zikhula eminyakeni edlule, ungase uzibuze ukuthi ungayisebenzisa kanjani yonke imizuzu. Kungaba nzima ukubhekana nakho konke lokhu ngesikhathi esisodwa. Ungase ufune nokukhuluma nochwepheshe wezempilo yengqondo ukuze akusekele phakathi nalesi sikhathi esinzima.

Khumbula, awuwedwa kukho konke lokhu. Uma udinga usizo, ungalokothi unqikaze ukuxhumana nethimba lakho lezokwelapha.

Okokugcina, izinto okufanele uzikhumbule

Kulungile, nansi ezinye zezinto esikhulume ngazo `(Corticobasal Degeneration)` engicabanga ukuthi zizoba zibalulekile kuwe:

• Lesi yisimo esithinta ubuchopho futhi izimpawu ziyanda kancane kancane ngokuhamba kwesikhathi.
• Imbangela eqondile yalokhu ayikatholakali okwamanje, kodwa kucatshangwa ukuthi ihlobene nephrotheni ebizwa ngokuthi `(Tau)`.
• Okwamanje akukho ukwelashwa kokwelapha lesi sifo ngokuphelele.
• Kodwa-ke, kunezindlela zokwelapha zokulawula izimpawu nokwenza impilo ibe lula.(Njengomuthi, ukwelashwa ngokomzimba, ukwelashwa ngokomsebenzi, ukwelashwa ngenkulumo).
• Kubalulekile ukufuna iseluleko sezokwelapha ngokushesha.
• Hlela ikusasa bese uthola ukwesekwa okudingayo.
• Awuwedwa. Kubaluleke kakhulu futhi ukuhlala uqinile engqondweni. Thola usizo kodokotela, emndenini nakubangani.

Ngiyethemba ukuthi lolu lwazi luzokusiza. Uma unemibuzo, ungangabazi ukukhuluma nodokotela wakho.

Ukuwohloka kwe- Corticobasal, Izifo Zobuchopho, Izifo Zezinzwa, Ukuphazamiseka Kokunyakaza, Ukukhubazeka Kwenkumbulo, Ukuphazamiseka Kwenkulumo, I-Tau Protein, i-CBS, Ukuwohloka Kobuchopho, i-Apraxia, i-Aphasia, i-Dementia