Ingabe uvame ukuzizwa ukhathele, ngezinye izikhathi unomuzwa wokucasuka, noma umane uzwe ukukhala ezindlebeni zakho? Nakuba lokhu kungase kubonakale njengezinto ezivamile, ngezinye izikhathi kungase kube nesinye isizathu ngemuva kwazo. Ngakho-ke, isifo esizokhuluma ngaso namuhla yi- Polycythemia Vera (PV) , okuyisimo esibangelwa ukukhiqizwa ngokweqile kwamaseli abomvu egazi emzimbeni wethu. Nakuba leli igama elide, masiliqonde kalula.

Kuyini i-Polycythemia Vera (PV)? Kalula nje...

Kalula nje, i-Polycythemia Vera (PV) yisimo lapho umzimba wakho, ikakhulukazi umongo wakho wamathambo (esiwubiza ngokuthi "i-Bone Marrow"), ukhiqiza amangqamuzana egazi abomvu amaningi kunalokho okufanele . Njengemijaho yezimoto, lapho kunezimoto eziningi kakhulu emgwaqweni, ukuhamba kwegazi kuyavimbeka. Lokhu kubangela ukuthi igazi lijiye futhi lihambe kancane. Lokhu kwandisa ingozi yokuqhekeka kwegazi. Lokhu kungaholela ezimweni ezimbi njengokuhlaselwa yinhliziyo kanye nohlangothi .

Akukhona lokhu kuphela, ngezinye izikhathi izimpawu ezifana nesikhumba esilumayo, ukukhala ezindlebeni (`(Tinnitus)`), ubuhlungu besisu, ukuphuma kwegazi ekhaleni, kanye nokungaboni kahle nakho kungase kube khona.

I-Polycythemia Vera (PV) yisifo esingamahlalakhona esingelapheki ngokuphelele. Kodwa ungakhathazeki. Ngokwelashwa okuhle kwezokwelapha, ungalawula izimpawu futhi unciphise ingozi yemiphumela emibi. Abanye abantu baphinde bakubize ngokuthi 'i-primary polycythemia', 'i-polycythemia rubra vera', 'i-erythema' kanye 'nesifo se-Osler-Vaquez'.

Ingabe i-Polycythemia Vera (PV) ingumdlavuza?

Yebo, lolu uhlobo lomdlavuza ngempela. Kodwa aluyona into embi kakhulu noma esakazeka ngokushesha njengoba singase sicabange lapho sizwa igama elithi umdlavuza. Lona umdlavuza wegazi ongoweqembu elibizwa ngokuthi i-`myeloproliferative neoplasm (MPN) . I-`MPN` ibhekisela eqenjini lezifo ezibangela ukukhiqizwa ngokweqile kwezinhlobo ezahlukene zamaseli egazi.

Imbangela eyinhloko ye-Polycythemia Vera (PV) ushintsho (ukuguquka kwezakhi zofuzo) emzimbeni wethu. Lokhu akuyona into esizalwa nayo, kodwa into eyenzeka empilweni yethu ngesizathu esingaziwa. Lesi sifo sikhula kancane kakhulu. Sivame ukutholakala ngemva kweminyaka engu-60. Lo mdlavuza awuvamile ukubangela ukufa okuqondile. Ingozi eyinhloko ivela ezinkingeni ezibangelwa ukuqhekeka kwegazi. Futhi, ngephesenti elincane kakhulu, ungaphenduka ezinye izinhlobo zomdlavuza wegazi ezingathi sína.

Ubani othinteka kakhulu yilesi simo?

I-Polycythemia Vera (PV) yisifo esingavamile kakhulu. Ezweni elifana ne-United States, sitholakala kubantu abangaba ngu-50 kwabayi-100,000. Sivame kakhulu kubantu abangaphezu kweminyaka engu-60.

Lesi sifo sithinta kanjani imizimba yethu?

Njengoba sishilo ngaphambili, i-Polycythemia Vera (PV) ibangela ukuthi umzimba ukhiqize amangqamuzana egazi abomvu amaningi kakhulu. Lokhu kunqwabelana kwamangqamuzana kwandisa ingozi yokopha, ukuklwebheka, kanye nokuqhekeka kwegazi. Ngenxa yokuthi igazi liyaqina futhi lihamba kancane, izicubu nezitho zomzimba wethu azitholi umoya-mpilo eziwudingayo.

Lokhu futhi kubeka umsebenzi omningi embotsheni yomzimba wethu. Omunye wemisebenzi eyinhloko yembotshana ukuhlunga igazi nokususa amaseli egazi amadala. Lapho amaseli abomvu egazi ekhula, imbotshana nayo iba nomsebenzi omningi, okungabangela ukuvuvukala nobuhlungu. Lokhu kubizwa ngokuthi `(Splenomegaly)`. Ngokuhamba kwesikhathi, lesi simo singadala izimpawu ezahlukene ezingakhululekile. Futhi, i-PV ingabangela ezinye izimo zesibili.

Yiziphi izingozi nezinkinga ze-Polycythemia Vera (PV)?

Nakuba i-PV iyisifo esiqhubekayo, kunengozi yokuqhekeka kwegazi okungazelelwe ngenxa yokukhiqizwa ngokweqile kwamaseli egazi. Ngokuhamba kwesikhathi, i-PV ingadala nezinye izimo zesibili. Akuvamile kakhulu, ingaba umdlavuza onzima.

Amahlule egazi

Lena ingozi enkulu nesheshayo ye-PV. Uma ihlule legazi lakha futhi liya enhliziyweni noma ebuchosheni, lingabangela ukuhlaselwa yinhliziyo noma isifo sohlangothi . Uma liya emaphashini (i-Pulmonary Embolism - PE), lingabangela umfutho wegazi ophezulu emaphashini (i-pulmonary hypertension) kanye nokwehluleka kwenhliziyo. Uma ihlule legazi libhajwa emthanjeni (i-Venous Thromboembolism - VTE), lingabangela ukufa kwezicubu noma ukungasebenzi kahle kwemithambo yegazi okungapheli. Uma ihlule legazi libhajwa emthanjeni wegazi oyinhloko oya esibindini (i-hepatic vein thrombosis), lingabangela amahlule egazi esibindini (i-Budd-Chiari syndrome), i-jaundice kanye nokwehluleka kwesibindi.

Izimo zesibili

Uma amangqamuzana abomvu ekhiqizwa ngokweqile futhi ehlakazeka, izinga le-'uric acid' emzimbeni liyakhuphuka. Lokhu kungabangela izinkinga eziningana:

• Amatshe ezinso: Uma i-uric acid ifakwa ezinso.
• I-Gout: Isimo esibuhlungu samathambo esenzeka lapho i-uric acid inqwabelana emalungeni.
• Izilonda zesisu: Amaseli abomvu egazi angeziwe andisa nenani le-asidi yesisu. Amaseli abomvu egazi angeziwe abangela ukuthi umzimba ukhiphe ikhemikhali ebizwa ngokuthi i-histamine, okubangela ukuthi isisu sikhiqize i-asidi eyengeziwe ukulwa nokutheleleka. Abantu abane-PV banamathuba aphindwe kane okuthola izilonda zesisu (isifo sesilonda se-peptic).

Ukuphendukela ku-Leukemia

I-Polycythemia Vera ingumdlavuza womnkantsha wamathambo, kodwa ngokuvamile akuyona inkinga esongela ukuphila. Ngokwelashwa okufanele, ingaphathwa kahle iminyaka eminingi. Kodwa-ke, kwabanye abantu, i-PV ingakwazi, nakuba ingavamile,Kungaba umdlavuza wegazi ongathi sína njenge-'Acute Leukemia'.

Izigaba Zesifo Se-Polycythemia Vera (PV)

Isifo se-PV siqhubeka kanje:

• Isigaba sokuqala (`I-PV Yasekuqaleni`): Phakathi nalesi sigaba, kunezimpawu ezimbalwa noma azikho nhlobo.
• Ukuqhubekela phambili kwe-PV: Njengoba i-PV iba nzima kakhulu, ungase uqale ukuzwa izimpawu ezingakhululekile, noma izimo zesibili zingase zivele.
• Isigaba sokuchitha: Lokhu kubizwa ngokuthi “isigaba sokuchitha.” Kuleli qophelo, amangqamuzana egazi angajwayelekile abangela lesi sifo ayanda ngaphandle kokulawulwa futhi avimbe ngokuphelele umongo wamathambo, okwenza amangqamuzana egazi. Lapho lawa mangqamuzana angajwayelekile efa, kwakheka izicubu zesibazi endaweni yawo. Lapho iningi lomnkantsha wamathambo ligcwele lezi zicubu zesibazi, awukwazi ukwenza amangqamuzana egazi anempilo. Ngokumangalisayo, lokhu kubangela i-anemia - ukuntuleka kwamangqamuzana egazi abomvu anempilo. Kuphinde kwandise ingozi yokopha.

Ezinye izifo zegazi ezingase zenzeke ngemva kwe-PV

Uma i-PV iba yimbi kakhulu, ingaholela kwezinye izifo zegazi.

• I-Myelofibrosis (MF): Akukho mehluko omkhulu phakathi kwe-"spent phase" ye-PV kanye ne-"Myelofibrosis (MF)" , olunye uhlobo lomdlavuza wegazi. Abanye odokotela bacabanga ukuthi ziyafana. I-"Myelofibrosis" yilapho amangqamuzana angajwayelekile akha izicubu zesibazi emnkantsheni wamathambo bese ewugcwalisa. Lawa maseli angajwayelekile angasakazeka ngaphandle komnkantsheni wamathambo aye kwezinye izingxenye zomzimba. I-"MF" nayo "iyisifo se-myeloproliferative." Cishe u-10% weziguli ze-"MF" uba ne-"Acute Myeloid Leukemia."
• I-Myelodysplastic Syndrome (MDS): Akuvamile kakhulu ukuthi i-PV ikhule ibe yisimo esibizwa ngokuthi i-Myelodysplastic Syndrome (MDS) . Lesi yisimo lapho amangqamuzana egazi engavuthwa kahle, akhule ngendlela engavamile, futhi afe ngokushesha. Umzimba awukwazi ukwenza amangqamuzana aphilile, avuthiwe, okuholela ekunciphiseni inani lezinhlobo ezahlukene zamangqamuzana egazi. I-MDS inzima kakhulu kune-PV noma i-MF, futhi inengozi engu-30% yokuthola i-Acute Myeloid Leukemia (AML).
• I-Acute Myeloid Leukemia (AML): Cishe abantu abangu-3% abane-Polycythemia Vera bathola i-Acute Myeloid Leukemia (AML) zingakapheli iminyaka eyi-10 bexilongiwe. I-AML ingumdlavuza wegazi ongathi sína oqala emnkantsheni wamathambo futhi ungasakazeka ngokushesha uye egazini bese uya kwezinye izingxenye zomzimba. Idinga ukwelashwa okusheshayo, kodwa amathuba okusinda aphezulu.

Ziyini izimpawu ze-Polycythemia Vera (PV)?

Izimpawu zivame ukubonakala kancane kakhulu, futhi ngezinye izikhathi kungase kungabi nazimpawu nhlobo. Okokuqala, izimpawu ezingacacile ezivamile ezifweni eziningi:

• Ikhanda elibuhlungu.
• Isiyezi.
• Ukukhathala.
• Umfutho wegazi ophezulu.
• Umbono ofiphele noma umbono ophindwe kabili.
• Ukuzwa ukukhala ezindlebeni (`(Tinnitus)`).

Ngokuhamba kwesikhathi, izimpawu ezithile zingase zivele:

• Ukujuluka, ikakhulukazi ebusuku.
• Ubunzima bokuphefumula, ikakhulukazi uma ulele phansi.
• Isikhumba esilumayo, ikakhulukazi ngemva kokugeza ngamanzi ashisayo. (Lolu uphawu oluthile lwe-PV)
• Ubomvu, ukushisa, ukungazweli, noma ukusha ezithweni.
• Ukopha ngokweqile noma ukuklwebheka.
• Ukopha okuvela ekhaleni nasezinsinini.
• Ukuba mncane ngaphandle kwesizathu.

Uma i-PV iba yimbi kakhulu futhi iqhubekela ezimweni zesibili, kungase kube nezimpawu ezihlobene nayo. Isibonelo:

Izimpawu ze-splenomegaly:

• Ubuhlungu obufana nokuthile bunamathele engxenyeni engenhla kwesobunxele yesisu.
• Okuhlangenwe nakho okugcwalisa isisu.
• Ngisho nangemva kokudla kancane, ngizizwa ngisuthi.

Izimpawu zezilonda zesisu (`Isifo sesilonda se-Peptic`):

• Ubuhlungu obuhambisana nobuhlungu besisu.
• Isilungulela.
• Ukuvuvukala kwe-asidi.

Izimpawu ze-Gout:

• Ukuvuvukala okubuhlungu kwamalunga.
• Ukuqina kwamalunga.
• Ukuvuvukala kozwane olukhulu.

Izimpawu zamatshe ezinso:

• Ubuhlungu esiswini esingezansi noma ohlangothini.
• Ubuhlungu lapho uchama.
• Isidingo sokuchama njalo.

Izimpawu ze-Budd-Chiari syndrome:

• Ukuvuvukala kwesibindi, ubuhlungu engxenyeni ephezulu kwesokudla yesisu, kanye nokuvuvukala.
• Ukuphuzi kwamehlo nesikhumba (i-jaundice).
• Ama-Ascites kanye ne-Edema.

Izimpawu ze-Deep Vein Thrombosis (DVT):

• Ukuvuvukala engalweni noma emlenzeni kanye nobuhlungu uma kuthintwa.
• Kukhona ukubomvu noma ukushisa kuleyo ndawo.
• Ukubonakala kwemithambo yegazi evuvukele ebusweni besikhumba.

Izimpawu zokuqhekeka kwegazi emaphashini (i-Pulmonary Embolism - PE):

• Ubuhlungu besifuba obungazelelwe.
• Ukuphelelwa umoya.
• Isilinganiso senhliziyo siyanda.

Izimpawu ze-Anemia (ezigabeni zokugcina zesifo se-PV):

• Isiyezi (vertigo).
• Isikhumba esimpunga.
• Ukukhathala.

Yini ebangela i-Polycythemia Vera (PV)?

I-Polycythemia Vera (PV) iqala engxenyeni ethambile, ethambile yamathambo ethu ebizwa ngokuthi umongo wamathambo. Yilapho kwakheka khona amangqamuzana amasha egazi. I-PV iqala ngokuguqulwa kwezakhi zofuzo okukodwa esiseleni esisodwa esisemongo wamathambo. Ngaphezu kwama-90% esikhathi, lokhu kuguqulwa kwezakhi zofuzo kubizwa ngokuthi i-JAK2.

Lesi sakhi sofuzo esiguquliwe sitshela iseli lesitho ukuba liqhubeke lizala. Wonke amaseli akhiqizwayo ayaqhubeka nokuziphindaphinda. Ekugcineni, la maseli angajwayelekile agcwalisa umongo wamathambo, angashiyi ndawo yamaseli avamile.

Ezimweni eziningi, lokhu kuguqulwa kwezakhi zofuzo ze-`JAK2` akuyona into esiyizuza njengefa. Kuyinto eyenzeka ngesikhathi sokuphila, ngezizathu ezingaziwa. Kodwa-ke, akuvamile kakhulu, kube nemibiko yamalungu amaningana omndeni athola i-PV.

I-Polycythemia Vera (PV) itholakala kanjani?

I-World Health Organization (WHO) iphakamise izindlela ezintathu eziyinhloko zokuxilonga i-Polycythemia Vera (PV). Udokotela kumele aqinisekise zonke izindlela ezintathu.

Isici 1: Ukuhlolwa kwegazi okubonisa inani eliphezulu lamaseli abomvu egazi:

Amaseli abomvu egazi angalinganiswa:

• Amazinga aphezulu e-hemoglobin (iphrotheni etholakala kumaseli abomvu egazi).
• Izinga eliphezulu le-hematocrit (iphesenti lamaseli abomvu egazini).
• Umthamo wegazi ophezulu (isisindo samangqamuzana abomvu).

Isigaba 2: Ukuhlolwa kwe-bone marrow biopsy okubonisa okunye kwalokhu okulandelayo:

• Amaseli egazi amaningi kakhulu emnkantsheni wethambo, noma
• Ukuba khona ngokweqile kwama-megakaryocyte avuthiwe (amangqamuzana enza ama-platelet egazi).

Isigaba 3: Isigaba sesithathu singafezwa ngokubonisa noma yikuphi kwalokhu okubili:

• Ukuqinisekiswa kokuba khona kokuguqulwa kwezakhi zofuzo ze-JAK2 ngokuhlolwa kwama-molecule, noma
• Ukuhlolwa kwegazi kuqinisekisa ukuthi izinga le -`erythropoietin' (i-hormone ekhuthaza ukukhiqizwa kwamaseli abomvu egazi yizinso) egazini liphansi kakhulu.

"Udokotela uzobheka konke lokhu ukuze akutshele kahle ukuthi une-Polycythemia Vera noma cha. Ngakho-ke uma unezimpawu, kungcono ukubona udokotela bese uthola iseluleko."

Iphathwa kanjani i-Polycythemia Vera (PV)?

Ezigabeni zokuqala ze-PV, ukwelashwa kulula kakhulu. Ukwelashwa okuvamile kuhlanganisa:

I-Phlebotomy (ukukhipha igazi)

Lokhu kuyindlela yokwelapha eyinhloko nevame kakhulu ye-PV. Kwenziwa ngendlela efanayo naleyo obunganikela ngayo ngegazi. Umhlinzeki wezempilo ufaka inaliti emthanjeni osengalweni yakho bese esusa inani elincane legazi (ngokuvamile cishe iphayinti, kodwa inani lingahluka kuye ngesimo sakho). Lokhu kunciphisa inani legazi lakho eliphelele kanye nenani lamaseli egazi engeziwe.

I-aspirin enomthamo ophansi

Lona umuthi ongawuthenga ekhemisi. Ngokuvamile unikezwa ukuze kuncishiswe ingozi yokuqhekeka kwegazi. Uma uthathwa ngomthamo ophansi kanye ngosuku, i-aspirin ivimbela ama-platelet egazi ukuthi anganamatheli ndawonye. Iphinde isize ekunciphiseni izimpawu ezifana nokuvuvukala ezithweni. Kodwa-ke, inzima kancane esiswini futhi yandisa ukopha. Ngakho-ke lokhu akuwona umqondo omuhle uma unezilonda esiswini.

Uma izimpawu zakho zinzima, noma uma unomlando wamahlule egazi ngaphambilini (i-thrombosis), ungase ubekwe eqenjini elisengozini enkulu futhi kungase kuphakanyiswe ezinye izindlela zokwelapha. Ezinye zalezi zindlela zifaka:

Izindlela zokwelapha ukunciphisa ukulunywa:

Uma i-PV iba nzima, udokotela angase anikeze imithi efana nale yokwelapha ukulunywa:

• Ama-Antihistamine: Lena imithi evamile enikezwayo yokungezwani komzimba.
• Ukwelashwa nge-Phototherapy: Ukwelashwa okuhlanganisa ukukhanya kwe-ultraviolet (UVA) nekhemikhali ebizwa ngokuthi i-psoralen (ikhemikhali ephilayo ezwela isikhumba ekwelashweni ngokukhanya).
• Ama-SSRI (ama-Selective Serotonin Reuptake Inhibitors): Lawa uhlobo lwemithi evame ukunqunyelwa ukucindezeleka. Kodwa-ke, uma inikezwa ngemithamo ephansi kakhulu, itholakale isebenza kahle ezimpawini zomzimba eziqhubekayo njengokulunywa.

Imithi enciphisa inani lamaseli abomvu egazi:

Lezi zingasetshenziswa zodwa noma zihlanganiswe ndawonye. Izibonelo:

• `I-Hydroxyurea`
• I-Interferon alfa
• `Ruxolitinib`
• `Busulfan`

Izivivinyo zemitholampilo

Lokhu kunikeza abantu ithuba lokuzama izindlela zokwelapha zakamuva kanye nokufaka isandla ocwaningweni lwezokwelapha. Eminye yemithi esesigabeni socwaningo njengamanje yile:

• `I-Peginterferon alfa-2a`
• `I-Givinostat`
• `Idasanutlin`

Ukufakelwa umnkantsha wethambo

Kwezinye izimo, kunganconywa ukufakelwa umnkantsha. Udokotela uzothatha lesi sinqumo ngokusekelwe ezicini eziningana, njengobunzima besifo sakho kanye nekhono lomzimba wakho lokuphulukisa.

Ukunakekelwa okusekelayo

Uma i-PV yakho iqhubeka nokuba yimbi naphezu kokwelashwa, udokotela wakho uzogxila ekuphatheni izimpawu zakho. Ezigabeni zakamuva ze-PV, ungase ube ne-anemia kanye ne-spleen ekhulisiwe. Unganikezwa ukwelashwa okufana nalokhu:

• Izibulali-zinhlungu.
• Ukumpontshelwa igazi.
• Ukwelashwa ngemisebe ngesilinganiso esiphansi ku-spleen.

Ingakanani iminyaka yokuphila komuntu one-Polycythemia Vera (PV)?

Ucwaningo lwamuva nje lubonisa ukuthi isilinganiso sobude bokuphila ngemva kokuxilongwa kwe-Polycythemia Vera (PV) siyiminyaka engaba ngu-20. Isilinganiso sobudala bokufa siyiminyaka engaba ngu-77. Imbangela ehamba phambili yokufa yizinkinga ezibangelwa ukuqhekeka kwegazi (cishe u-33%). Imbangela yesibili ehamba phambili umdlavuza (cishe u-15%).

"Ungesabi ngalezi zinombolo. Lezi yizindinganiso ezijwayelekile. Uma uthola ukwelashwa okufanele futhi wenza ushintsho endleleni yokuphila, ungahlala uphilile isikhathi eside."

Ngingazinakekela kanjani futhi ngiphathe izimpawu zami?

Uma uphila ne-Polycythemia Vera (PV), kubalulekile ukuhlala uxhumana nodokotela wakho njalo. Lokhu kuzosiza udokotela wakho ukuthi aqaphele ukuthi isimo sakho siqhubeka kanjani. Ungatshela nodokotela wakho ukuthi usabela kanjani ekwelashweni nokuthi ngabe ubhekene nanoma yimiphi imiphumela emibi. Ungaphila isikhathi eside ngaphandle kwezimpawu ezinkulu.

Ngaphezu kokuhlolwa okuvamile kanye nokwelashwa, udokotela wakho uzophinde asikisele izinguquko ezilula zendlela yokuphila ezingasiza ekuvimbeleni ukuqhekeka kwegazi kanye nezinye izinkinga. Isibonelo:

• Ukuzivocavoca. Ngisho nokuzivocavoca okuncane kungasiza ekuthuthukiseni ukujikeleza kwegazi.
• Gwema ukubhema. Ukubhema kunciphisa imithambo yegazi yakho.
• Gwema izindawo ezinezinga eliphansi lomoya-mpilo. Izindawo eziphakeme kakhulu zingabangela amazinga aphansi omoya-mpilo egazini.
• Lawula umfutho wegazi lakho. Ukugcina isisindo esinempilo kuzosiza kulokhu.

Nakuba i-Polycythemia Vera (PV) iwuhlobo lomdlavuza, abantu abaningi baphila kahle amashumi eminyaka ngemva kokuxilongwa ukuthi banalesi sifo. Lo mdlavuza uvela ngoba amangqamuzana akhiqizwa ngaphandle kokulawulwa. Kodwa-ke, kuthatha isikhathi eside ukuthi ukukhiqizwa okungalawulwa kwamangqamuzana abomvu egazi kuqale ukukuthinta. Ngisho noma wenza kanjalo, ungasiphatha lesi simo isikhathi eside ngokususa elinye legazi lakho eliningi.

Ingozi enkulu evela ku-Polycythemia Vera (PV) akuyona umdlavuza ngokwawo, kodwa ingozi yokuqhekeka kwegazi. Uma uphila ne-PV, qiniseka ukuthi ubona udokotela wakho njalo. Futhi ungakhohlwa ukuzinakekela "ngezinto ezincane" - okungukuthi, imikhuba yokuphila enempilo. Lokhu kusiza ekugcineni impilo ejwayelekile yesimiso sakho senhliziyo nemithambo yegazi, okungaba kubaluleke kakhulu kunanoma yiluphi ukwelashwa kwe-Polycythemia Vera.

Yimuphi umyalezo esifuna ukuwuthatha ekhaya kule ndaba?

Kulungile, ngakho-ke sesikhulume kakhulu nge-Polycythemia Vera (PV). Nazi ezinye zezinto ezibaluleke kakhulu okufanele uzikhumbule:

• I-PV yisifo segazi lapho umzimba ukhiqiza khona amangqamuzana egazi abomvu amaningi kakhulu futhi ukhula ngendlela engavamile. Ingeqembu lomdlavuza elibizwa ngokuthi i-`myeloproliferative neoplasm (MPN)`.
• Ingozi enkulu ivela ekuqineni kwegazi kanye nokujiya kwegazi, okungaholela ezimweni ezimbi njengokuhlaselwa yinhliziyo kanye nohlangothi.
• Izimpawu zingase zihlanganise isikhumba esilumayo (ikakhulukazi ngemva kokugeza), ukuzizwa ukhathele, ikhanda elibuhlungu kanye nesiyezi.
• Nakuba ingelapheki ngokuphelele, ingaphathwa kahle ngokwelashwa okufanele, izinguquko zendlela yokuphila, kanye nemithi. I-Phlebotomy (ukukhipha igazi) kanye ne-aspirin ephansi yizona zindlela zokwelapha eziyinhloko.
• Ukuguquka kwezakhi zofuzo ze-`JAK2` kuvame ukuba imbangela yalokhu.
• Uma unezinye zalezi zimpawu, qiniseka ukuthi ubona udokotela ukuze akunike iseluleko. Ukutholwa kusenesikhathi kwandisa amathuba akho okugwema izinkinga nokuphila impilo enempilo.

Ungesabi, kodwa ungakuthathi kalula. Nakekela impilo yakho. Khuluma nodokotela wakho njalo, uthole izivivinyo ezidingekayo kanye nokwelashwa ngesikhathi. Khona-ke ungahlala uphilile ngisho noma unalesi simo!

I- Polycythemia Vera, Amaseli Egazi Abomvu, Amahlule Egazi, i-MPN, i-JAK2, i-Phlebotomy, umdlavuza