Uyazi nge-Renal Medullary Carcinoma (RMC), umdlavuza ongavamile kodwa oyingozi okhula ezinso?

Wake wezwa ngohlobo lomdlavuza olungavamile kakhulu nolubi kakhulu oluvela ezinso, ikakhulukazi kubantu abasha? Mhlawumbe akunjalo. Lokhu yi-Renal Medullary Carcinoma, noma i-RMC ngamafuphi. Nakuba kungavamile kakhulu, kungaba kubaluleke kakhulu ukukuqaphela, ikakhulukazi kwabanye abantu. Nakuba lokhu kuyindaba engathi sína, ungesabi. Ake sixoxe ngakho ngendlela elula neqondakalayo namuhla.

Iyini ngempela i-RMC?

Kalula nje, i-Renal Medullary Carcinoma (RMC) uhlobo lomdlavuza wezinso. Kodwa aluvamile, lunolaka kakhulu, futhi lusakazeka ngokushesha. Luvame kakhulu kubantu abasha, ikakhulukazi labo abanesimo segazi esibizwa ngokuthi 'isifo se-sickle cell' noma 'isici se-sickle cell'.

Uma sikhuluma ngomdlavuza wezinso, uhlobo oluvame kakhulu yi-'renal cell carcinoma'. I-RMC nayo iwuhlobo lwe-'renal cell carcinoma'. Kodwa akekho ngisho noyedwa kwabayi-100 abane-renal cancer aba nalesi simo se-RMC. Kuyinto engavamile kangako.

Yini ebangela lo mdlavuza?

Ososayensi nodokotela abakayitholi imbangela eqondile eyi-100% yalokhu, kodwa kukhona into eyodwa eyinhloko esitholiwe.

Izinso zethu zinengxenye ebizwa ngokuthi i-'renal medulla'. Umuntu onesifo se-'sickle cell' ngezinye izikhathi uba namaseli abomvu egazi aguquka abe yisimo se-sickle. Uma lokhu kwenzeka, amaseli anganamathelana futhi avimbe imithambo yegazi engxenyeni ye-'renal medulla' yezinso.

Lokhu kuvinjelwa kokunikezwa kwegazi kulimaza amaseli kuleyo ndawo. Ikakhulukazi, i-gene ebizwa ngokuthi `INI1` (ebizwa nangokuthi `SMARCB1`) kulawo maseli yonakele. Le gene `INI1` isebenza njengomqaphi ovimba amaseli ekubeni umdlavuza. Lapho kuhlolwa amaseli omdlavuza we-RMC, le gene `INI1` ayitholakali kuwo. Ngakho odokotela bahlola ukuba khona kwale gene `INI1` ukuqinisekisa ukuthi isimila siyi-RMC noma cha.

Ingabe nami ngisengozini yokuthola i-RMC?

Kunzima ukusho ngqo ukuthi ubani ozokwakha lokhu. Ukuba nomuntu emndenini wakho one-RMC akukukhulisi ingozi yokuba nakho. Lokho kusho ukuthi akuyona into eyenzeka emindenini.

Isici esiyinhloko sengozi ukuphazamiseka kwegazi okubizwa ngokuthi i-'sickle hemoglobinopathy'. Okusho ukuthi, ukuba nesifo se-sickle cell noma i-'sickle cell trait'. Kodwa akuvamile kakhulu , abantu abangenazo lezi zimo bangaba ne-RMC. Ibizwa ngokuthi “i-renal cell carcinoma, engahlukaniswanga nge-medullary phenotype” (RCCU-MP).

Uma ubheka izibalo:

• Kuvame kakhulu kwabesilisa kunabesifazane.
• Ngokuvamile kuthinta izinso ezifanele.
• Lesi sifo sivame ukutholakala sisebancane, siphakathi kweminyaka eyi-11 nengama-39 ubudala.

Ziyini izimpawu ze-RMC?

Kunezimpawu eziningana ezivamile zalesi sifo. Uma unesinye noma ngaphezulu kwalezi, kungcono ukufuna iseluleko sezokwelapha ngokushesha okukhulu.

Udokotela uhlonza kanjani lokhu?

Uma usitshela ngezimpawu zakho, into yokuqala udokotela azokwenza ukukuhlola. Ngemuva kwalokho ungalandela lezi zinyathelo.

1.Ukuskena nge-ultrasound: Lokhu kunganikeza umbono oqondile wokuthi kukhona yini into efana nesimila ezinso.

2. I-CT noma i-MRI scan: Uma kusolwa ukuthi kukhona isimila, i-CT scan noma i-MRI ingayalwa ukuze kutholakale isithombe esicacile salesi simila. Ngokusekelwe kulezi zithombe, udokotela anganquma ukuthi kungenzeka kangakanani ukuthi sibe nomdlavuza.

3. I-Biopsy: Uma kusolwa kakhulu ukuthi umdlavuza ukhona, lokhu kuhlolwa kwenziwa ukuze kuqinisekiswe. Lokhu kuhilela ukufaka inalithi encane endaweni yesimila sezinso, ukuthatha ingxenye encane kakhulu yezicubu bese uyihlola ngaphansi kwesibonakhulu.

4. Ukuhlolwa kwezakhi zofuzo: Amaseli athathwe ku-biopsy ahlolwa ukuthi akhona yini i-gene ethi `INI1` elwa nomdlavuza esikhulume ngayo ngaphambili.

• Uma i-gene ethi `INI1` ingekho , ibizwa ngokuthi yi-RMC.
• Uma i-gene ethi `INI1` ingekho futhi isiguli singenaso isimo se-`sickle cell`, sitholakala njenge-`RCCU-MP`.
• Uma i-gene ethi `INI1` ikhona , akuyona i-RMC, kodwa uhlobo oluhlukile lwesimila.

Yiziphi izindlela zokwelapha lokhu?

Ngenxa yokuthi i-RMC ingumdlavuza osakazeka ngokushesha futhi onolaka, ukwelashwa kumele kube okusheshayo futhi okunolaka ngokulinganayo.

• Ukwelashwa ngamakhemikhali: Lokhu kuyindlela yokuqala yokwelapha evame kakhulu. Kuhilela ukunikeza umzimba imithi ebulala amangqamuzana omdlavuza.
• Ukuhlinzwa: Ukususwa kwesimila esinomdlavuza kanye nezinso ezithintekile.
• Ukwelashwa Ngemisebe: Ukubhubhisa amangqamuzana omdlavuza kusetshenziswa imisebe enamandla yemisebe.

Ngenxa yokuthi lesi sifo asivamile, ucwaningo lusaqhubeka. Ososayensi bahlala befuna izindlela zokwelapha ezintsha nezisebenza kahle ze-RMC.

Ingabe ikhona indlela yokuvimbela i-RMC?

Ngeshwa, okwamanje ayikho indlela eyaziwayo yokuvimbela i-RMC ukuthi ingakhuli, futhi azikho izivivinyo zokuyithola ngaphambi kokuba kuvele izimpawu.

Into engcono kakhulu ongayenza ukuqaphela . Uma wazi ukuthi unesifo se-sickle cell noma uphawu lwe-sickle cell, qaphela izimpawu ezibalwe ngenhla. Uma unenkinga, bona udokotela wakho ngokushesha.

Ngokuvamile, ngesikhathi lesi sifo sitholakala, umdlavuza usuvele usakazekele kuma-lymph node noma kwezinye izitho ezifana namaphaphu, isibindi, namathambo. Ngakho-ke, ukutholwa kusenesikhathi kuyindlela engcono kakhulu yokuthola imiphumela emihle kakhulu.