Sonke sizizwa sididekile noma sinamahloni ngesikhathi esithile lapho sivuka esihlalweni noma embhedeni. Esikhathini esiningi, kuyaphela ngemizuzwana embalwa. Kodwa uma lokhu kwenzeka kuwe njalo, noma uma uzizwa sengathi usuzoquleka futhi uwe, kungase kungabi yinto evamile. Namuhla sizokhuluma ngesimo esingavamile esibangela lezi zimpawu. Lokho yi-Pure Autonomic Failure, noma i-PAF ngamafuphi.
Kalula nje, kuyini i-Pure Autonomic Failure (PAF)?
Cabanga ngakho, kunezinqubo eziningi emzimbeni wethu ezenzeka ngokuzenzakalelayo ngaphandle kokulawulwa yithi. Isibonelo, ukuphefumula, ukushaya kwenhliziyo, ukugaya ukudla, ukulawula izinga lokushisa lomzimba, kanye nokulawula umfutho wegazi. Konke lokhu kulawulwa yiSistimu yethu Yezinzwa Ezimele. Kufana nohlelo 'oluzenzakalelayo' emzimbeni wethu.
Ukwehluleka Okuzimele Okuhlanzekile (i-PAF) kuyisimo esingavamile sezinzwa esinciphisa kancane kancane ukusebenza kwesistimu yezinzwa ezizimele ngokuhamba kwesikhathi. Into eyinhloko eyenzekayo kulokhu ukuthi uma usukuma ngokuzumayo uhleli noma ulele, umfutho wegazi wakho wehla kakhulu . Ngokwezokwelapha, lokhu sikubiza ngokuthi i-orthostatic hypotension . Kodwa akuyona yodwa inkinga, i-PAF ingabangela ezinye izinkinga eziningi.
Lesi simo sivame ukubonakala kakhulu kubantu abadala abaneminyaka ephakathi kuka-40 no-60. Esikhathini esidlule, lesi sifo sasibizwa nangokuthi i-Bradbury-Eggleston syndrome.
Ziyini izimpawu zesifo se-PAF?
Njengoba sixoxile ngaphambili, uphawu oluvame kakhulu noluyinhloko isiyezi kanye nokuquleka lapho usukuma (i-orthostatic hypotension). Kodwa-ke, njengoba lesi simiso sezinzwa esizimele silawula izitho eziningi emzimbeni wethu, izimpawu azigcini nje kwesinye.
Into ebalulekile ukuthi lezi zimpawu azenzeki ngendlela efanayo noma ngokulandelana okufanayo kuwo wonke umuntu. Abanye abantu bangase babe nezinye izimpawu ngaphambi kokuba bazizwe benesiyezi lapho besukuma.
Ake sibone ukuthi yiziphi ezinye izimpawu ezingabangelwa yi-PAF.
| Uhlelo/inqubo ethintekile | Izimpawu ezingaba khona |
|---|---|
| Ukujuluka komzimba | Ngokuvamile kuba nokwehla kokujuluka (i-anhidrosis) noma ngezinye izikhathi ukujuluka ngokweqile (i-hyperhidrosis). |
| Amehlo | Umbono ofiphele ngenxa yokuthi abafundi abancane ngokwanele. |
| Uhlelo lomchamo | Ubunzima bokukhipha konke esinyini (ukugcinwa komchamo) noma ukungakwazi ukulawula ukuchama (ukungakwazi ukuzibamba komchamo). |
| Uhlelo lokugaya ukudla | Ukuqunjelwa noma ukungakwazi ukuzibamba indle. |
| Umsebenzi wocansi | Izinkinga ezinjengokungasebenzi kahle kwe-erectile noma i-anogasmia. |
Ngaphezu kwalokho, cishe ingxenye yabantu abane-PAF bangase babe ne-anemia encane.
Iyini imbangela yokwakheka kwe-PAF?
Imbangela eyinhloko yalokhu itholakale njengokuqongelela okungavamile kweprotheyini ebizwa ngokuthi i-alpha-synuclein kumaseli ethu ezinzwa azimele. Njengokungcola okuvala ipayipi, lapho le protheyini iqongelela kumaseli ezinzwa, ukusebenza kwawo kuyaphazamiseka.
Le phrotheni ifakwa ezinqwabeni zemizwa (i-autonomic ganglia) kuzo zombili izinhlangothi zomgogodla noma eduze kwezitho zomzimba. Ngokuhamba kwesikhathi, inani lala maseli emizwa liyancipha, futhi umsebenzi wesistimu yokuzimela uyaphazamiseka. Kodwa into ebaluleke kakhulu ukuthi ku-PAF, ubuchopho noma umgogodla akulimali . Ngakho-ke, ayithinti izinto ezifana nenkumbulo kanye nekhono lokucabanga.
Abacwaningi abakaqondi kahle ukuthi kungani le phrotheni ibekwa kanje.
Ubudlelwano nezinye izifo
Nakhu okubalulekile okufanele ukwazi. Le phrotheni efanayo, i-alpha-synuclein, yiyo enqwabelana ebuchosheni ezifweni ezifana nesifo sikaParkinson, i-Multiple System Atrophy, kanye ne-Lewy Body Dementia. Ngakho-ke, abanye abantu abane-PAF (hhayi bonke) banethuba lokuthola esinye salezi zifo ngokuhamba kwesikhathi. Udokotela wakho uzokwazisa ngalokhu.
Ungasithola kanjani lesi sifo?
Ukuxilonga i-PAF kuyinqubo eyinkimbinkimbi, njengoba odokotela bezoqala bakhiphe ezinye izimo ezingase zibangele izimpawu zakho, ikakhulukazi ukwehla komfutho wegazi uma usukuma.
Inqubo yokuxilonga ingafaka:
- Ukubuza imibuzo ngokucophelela mayelana nezimpawu zakho kanye nomlando wezokwelapha.
- Ukuhlolwa okuphelele ngokomzimba kanye nokuhlolwa kwezinzwa.
Ngemva kwalokho, kungase kunconywe ukuhlolwa okukhethekile okuningana ukuqinisekisa lesi sifo.
| Ukuhlolwa | Mane nje wenze lokhu... |
|---|---|
| Ukuhlolwa Kwethebula Elithambekile | Uzobekwa embhedeni okhethekile bese uthuthelwa endaweni yokuma ngokuzumayo. Umfutho wegazi lakho kanye nokushaya kwenhliziyo yakho kuzoqashwa. |
| I-QSART (ukuhlolwa kokujuluka) | Lokhu kubheka indlela izinzwa ezilawula ukujuluka ezisebenza ngayo. Lokhu kusiza ekuboneni izinkinga ohlelweni lwezinzwa oluzimele. |
| Ukuhlolwa kwezithombe (njenge-MRI) | Izinto ezifana nokuskena kwe-MRI yobuchopho zenziwa ukuqinisekisa ukuthi azikho ezinye izimo zezokwelapha ezingase zibangele izimpawu. |
| Ukuhlolwa Kwelebhu (Igazi Nomchamo) | Amazinga ekhemikhali ebizwa ngokuthi i-norepinephrine egazini nasemchameni alinganiswa ngenkathi elele phansi nangemva kokuma. Ku-PAF, kukhona ushintsho oluphawulekayo kula mazinga. |
Kungaba nzima kakhulu ukuba nezivivinyo eziningi kangaka, kodwa kuphela ngokuhlonza lesi sifo ngokunembile lapho singakha khona uhlelo lokwelapha olungcono kakhulu kuwe.
Yiziphi izindlela zokwelapha i-PAF?
Akukho ukwelashwa kwalokhu okwamanje. Kodwa ungakhathazeki. Kunezinto eziningi ongazenza ukusiza ekulawuleni izimpawu zakho futhi uphile impilo evamile. Udokotela wakho kanye nethimba lezokwelapha bazosebenzisana nawe ukuthuthukisa uhlelo lokwelapha oluqondene nawe ngqo.
Ukulawulwa kwe-Orthostatic Hypotension (umfutho wegazi ophansi uma umile)
Lena inkinga enkulu. Kukhona kokubili ukwelashwa okungewona okwemithi kanye nemithi yalokhu.
- Qaphela lapho ushintsha izikhundla: Uma uvuka ulele noma uhleli, kwenze kancane kakhulu . Ungavuki ngokuzumayo.
- Amanzi nosawoti: Udokotela wakho angase akuncome ukuthi uphuze amalitha amanzi angaba ngu-3 ngosuku. Angase akutshele nokuthi wengeze usawoti omncane ekudleni kwakho.
- Ukulungiselela umbhede: Lala ikhanda lombhede liphakanyisiwe cishe ngamasentimitha angu-4-6. Ngaleyo ndlela, ngeke uzizwe umehluko omkhulu ekucindezelweni kwegazi uma uvuka.
- Izingubo Zokucindezela: Ukugqoka amasokisi aqinile akhethekile (izingubo zokucindezela) afika okhalweni noma emathangeni kusiza ekunciphiseni ukuhlangana kwegazi emilenzeni nokugcina umfutho wegazi uzinzile.
- Ngaphezu kwalokhu, udokotela uncoma nemithi ethile ekhulisa umfutho wegazi.
Izinkinga zokukhipha indle kanye nokuchama
- Ngokuqunjelwa: Ungenza izinto ezifana nokudla ukudla okune-fiber eningi (imifino, izithelo, ilayisi le-bran) bese usebenzisa izithambisi zendle.
- Ngezinkinga zomchamo: Uma unenkinga yokuchama, kungadingeka usebenzise i-catheter. Uma ungakwazi ukulawula umchamo wakho, kunemithi ekhethekile (njenge-Oxybutynin, i-Mirabegron).
Ukuziphatha okubi ngokocansi
Nakuba kunemithi efana ne-sildenafil noma i-tadalafil yalokhu, le mithi ingandisa ingozi yokwehla kwengcindezi yegazi okubangelwa yi-orthostatic. Ngakho-ke, kufanele uxoxe ngalokhu ngokukhululekile nodokotela wakho futhi uyisebenzise kuphela ngaphansi kweseluleko sakhe.
Kuzokwenzekani esikhathini esizayo kumuntu onalesi sifo?
Kunzima ukunikeza impendulo eyodwa mayelana nekusasa lomuntu ophila nalesi sifo, ngoba siyahlukahluka kuye ngomuntu.
I-PAF iyisifo esiqhubekayo. Kodwa kubantu abaningi, kwenzeka kancane kakhulu, eminyakeni eminingi, ngisho namashumi eminyaka. Ezinye izifundo zibonise ukuthi isilinganiso sobude bokuphila ngemva kokuxilongwa kwe-PAF siyiminyaka engaba ngu-12.5. Kodwa lokhu kuyisilinganiso nje, futhi kungahluka kakhulu kuye ngezimpawu zakho kanye nempilo yakho. Ngakho-ke ungalibali kakhulu ngalezo zinombolo.
Uma une-PAF, kubalulekile ukubona udokotela wakho njalo ukuqinisekisa ukuthi ukwelashwa kwakho kuyasebenza nokuthi isimo sakho siqhubeka kanjani. Uma uba nezimpawu zesifo sikaParkinson (njengokuthuthumela, ubunzima bokuhamba), kufanele utshele udokotela wakho ngokushesha.
Umlayezo Wokuya Nawe Ekhaya
- Ukwehluleka Okuzimele Okuhlanzekile (i-PAF) yisifo esingavamile esithinta uhlelo lwezinzwa olulawula izinqubo ezizenzakalelayo emzimbeni wethu.
- Uphawu oluyinhloko isiyezi kanye nokuquleka lapho uvuka endaweni yokuhlala noma yokulala ngenxa yokwehla komfutho wegazi.
- Nakuba lesi sifo singelapheki ngokuphelele, izimpawu zingalawulwa kahle futhi impilo esezingeni eliphezulu ingagcinwa.
- Ayikho indlela yokuvimbela lokhu, futhi akulona iphutha lakho ukuthi kwenzeke.
- Kubaluleke kakhulu ukuhlala uxhumana nodokotela wakho njalo futhi ulandele uhlelo lwakho lokwelashwa ngqo. Ungesabi ukukhuluma ngokukhululekile ngemibuzo nezinto ezikukhathazayo.
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