Uma udokotela ekutshela noma othandekayo wakho ukuthi "unomdlavuza webele ," kuvamile ukuzizwa sengathi umhlaba wakho wonke uwile. Kanye nokwesaba nokukhathazeka okufika engqondweni, unemibuzo eyinkulungwane mayelana nokwelashwa kanye nemithi udokotela ayinikezayo. "Ingabe lo muthi ulungele umzimba?", "Ingabe uzodala imiphumela emibi ?", "Ingabe lokhu kuzosebenza ngempela?" Izinto ezinjalo cishe zidlula ekhanda lakho. Yileyo ndlela esizokhuluma ngayo ngeTamoxifen, umuthi obaluleke kakhulu osetshenziswa kabanzi ekwelapheni umdlavuza webele, ngendlela elula nenobungane namuhla.
Kalula nje, iyini iTamoxifen?
I-Tamoxifen umuthi osetshenziselwa ukwelapha umdlavuza webele one- hormone receptor . Uza njengephilisi (Nolvadex®) noma uketshezi (Soltamox®).
Manje ungase ucabange, "Uyini lo mdlavuza oxhomeke kuma-hormone?" Kulula kakhulu. Amanye amangqamuzana omdlavuza emzimbeni wethu afana nesitshalo esincane. Njengoba nje isitshalo sidinga amanzi nokudla okunomsoco ukuze sikhule futhi sikhule, lawa maseli omdlavuza adinga ama-hormone abizwa ngokuthi i-estrogen noma i-progesterone ukuze akhule futhi asakazeke. Yilokho esikubiza ngokuthi 'umdlavuza oxhomeke kuma-hormone.'
Lokho okwenziwa umuthi i-tamoxifen ukuvimba isenzo se-hormone ye-estrogen edingwa amangqamuzana omdlavuza. Kufana nokuvala umpompi wamanzi wesitshalo. Khona-ke amangqamuzana omdlavuza awawutholi umyalezo awudingayo ukuze akhule.
Futhi, odokotela ngezinye izikhathi batusa lo muthi ukuvimbela umdlavuza kubantu abasengozini enkulu yokuthola umdlavuza webele (isibonelo, uma othile emndenini eke waba nomdlavuza ).
Lo muthi unconyelwa bani?
I-Tamoxifen ayinikezwa bonke abantu abanomdlavuza webele. Udokotela wakho uzocabangela izici eziningi, okuhlanganisa umlando wakho wezokwelapha kanye nohlobo lomdlavuza, ukuze anqume ukuthi lo muthi ukulungele yini. Usetshenziswa kakhulu ezimweni ezilandelayo:
- Labo abanomlando womndeni womdlavuza noma izinguquko zezakhi zofuzo ze-BRCANjengesinyathelo sokuvimbela umdlavuza kulabo abasengozini enkulu yokuba nomdlavuza webele ngenxa yezici ezifana nalezi:
- Vimbela ukuphinda umdlavuza kumuntu oseke waba nomdlavuza webele futhi oke welashwa njengokuhlinzwa , ukwelashwa ngamakhemikhali , noma ukwelashwa ngemisebe .
- Vimbela umdlavuza kwelinye ibele elinempilo kumuntu onomdlavuza kwelinye ibele.
- Kumuntu onesigaba sokuqala somdlavuza, njenge -DCIS (ductal carcinoma in situ) , vimbela ukuthi ungasabalali kakhulu futhi ube umdlavuza oyingozi kakhulu.
Into ebaluleke kakhulu ukuthi isinqumo sokuthi uzowuthatha lo muthi noma cha, nokuthi uzowuthatha isikhathi esingakanani, kufanele senziwe ngudokotela wakho ngokuphelele. Ngakho-ke ungesabi ukuxoxa nganoma yimiphi imibuzo onayo ngalokhu nodokotela wakho.
Yiziphi izinzuzo eziyinhloko zeTamoxifen?
I-Tamoxifen umuthi osize ekusindiseni izimpilo zezigidi zabesifazane emhlabeni wonke amashumi eminyaka. Izinzuzo zalokhu azibalulekile.
- Kunciphisa ukuphinda kuvele umdlavuza: Lo muthi unganciphisa ingozi yokuphinda kuvele umdlavuza ngemva kokwelashwa ngo- 30% kuya ku-50% .
- Kuvikela elinye ibele: Kumuntu oke waba nomdlavuza kwelinye ibele, ingozi yokuba nomdlavuza kwelinye ibele incishiswa cishe ngo-50% .
- Kuvimbela umdlavuza: Kumuntu osengozini enkulu, ingozi yokuba nomdlavuza ingancishiswa cishe ngo-40% .
- Uqinisa amathambo: Lo muthi usiza ekuvimbeleni i-osteoporosis , isifo sokuncipha kwamathambo esiba khona ikakhulukazi ngemva kokunqamuka kokuya esikhathini.
- Yehlisa i-cholesterol: I-Tamoxifen inekhono lokunciphisa izinga le-cholesterol embi emzimbeni.
Yiziphi imiphumela emibi engaba khona yokusebenzisa i-Tamoxifen?
Njenganoma yimuphi umuthi, i-Tamoxifen ingabangela imiphumela emibi. Kodwa lokhu akusho ukuthi uzobhekana nayo yonke. Abanye abantu bangase bangezwa nhlobo. Abanye bangase babe noyedwa noma emibili. Ukwazi lezi zinto kusengaphambili kuzokusiza ukubhekana nazo.
Ake sihlukanise le miphumela emibi ibe izingxenye ezimbili.
| Uhlobo lomphumela ongemuhle | Incazelo |
|---|---|
| Imiphumela emibi evamile, engemibi kangako | |
| Izimpawu Zokunqamuka Kwesikhathi | Ukushisa komzimba, ukujuluka ebusuku, kanye nokomisa kwesitho sangasese sowesifazane kungenye yezinto ezibangela ukungakhululeki okukhulu abantu abaningi ababhekana nakho. |
| Izinguquko esikhathini sanyanga zonke | Umjikelezo wokuya esikhathini ungase ungabi njalo noma ume ngokuphelele. |
| Ukwanda kwesisindo noma ukuvuvukala | Abanye abantu bangase bakhuluphale kancane. Abanye bangase bavuvuke (bavuvuke) njengokungathi imizimba yabo igcwele amanzi. |
| Ezinye izinkinga ezincane | Ukuphuma koketshezi esithweni sangasese sowesifazane, isicanucanu, ukuqubuka kwesikhumba, ukukhathala, ikhanda elibuhlungu, ukuvuvukala kwemilenze, kanye nokungasebenzi kahle kokuchama kwabesilisa kungenzeka. |
| Izingozi ezingavamile kodwa ezinkulu | |
| Amahlule egazi | Kukhona ingozi encane kakhulu yokuthuthukisa izimo ezifana nokuqhekeka kwegazi emithanjeni yemilenze (i-deep vein thrombosis - DVT) noma isifo sohlangothi. |
| Umdlavuza wesibeletho | I-Tamoxifen iyandisa kancane ingozi yomdlavuza we-endometrial, okuyi-layer yesibeletho. Yingakho kufanele utshele udokotela wakho ngokushesha uma uzwa ukopha okungajwayelekile kwesitho sangasese sowesifazane. |
| Izinkinga zamehlo | Ingozi yokuba ne-cataract inganda kancane. |
Kubalulekile ukukhumbula ukuthi le miphumela emibi kakhulu ayivamile , kodwa kuwukuhlakanipha ukuqaphela futhi wazise udokotela wakho ngokushesha uma kuvela noma yiziphi zalezi zimpawu.
Kunini lapho kudingeka ushayele udokotela ucingo ngokushesha?
Uma uthatha i-Tamoxifen futhi uhlangabezana nanoma yiziphi izimpawu ezilandelayo, kufanele wazise udokotela wakho ngokushesha noma uye eMnyangweni Wezimo Eziphuthumayo (ETU) esibhedlela esiseduze nawe.
- Uma uzwa ubuhlungu esifubeni noma ubunzima bokuphefumula .
- Uma uthola umkhuhlane .
- Uma unezimpawu zesifo sohlangothi - isibonelo, ukukhuluma okungacacile, ukubona okufiphele, noma ukungazweli ngokuzumayo kolunye uhlangothi lomzimba (ingalo, umlenze, noma ubuso).
- Uma imilenze yakho, amaqakala, noma izinyawo zakho zivuvukala ngokuzumayo (ikakhulukazi umlenze owodwa nje).
- Uma ungakwazi ukuyeka ukuhlanza .
- Uma unesifo sokuphuma kwegazi esingavamile esithweni sangasese sowesifazane .
Eminye imibuzo evamile mayelana ne-Tamoxifen
Ingabe i-Tamoxifen iyi-chemotherapy?
Cha. Yilapho abantu abaningi bedideka khona. I-Tamoxifen iwukwelashwa ngama-hormone . Ingokwesigaba semithi ebizwa ngokuthi i-Selective Estrogen Receptor Modulators (SERMs) . I-Chemotherapy iwukwelashwa okubulala amaseli ahlukana ngokushesha (amangqamuzana omdlavuza kanye namaseli anempilo). Kodwa i-Tamoxifen isebenza ngendlela ehlukile, ezingeni lama-hormone.
Ingabe kuphephile ukuthatha i-Tamoxifen ngesikhathi sokukhulelwa?
Lutho neze. Ukukhulelwa ngenkathi uthatha i-tamoxifen kungabangela ukukhubazeka okukhulu kokuzalwa . Ngakho-ke uma uthatha lo muthi, kufanele ugweme ukukhulelwa . Ukulawula ukuzalwa ngama-hormone (njengamaphilisi okulawula ukuzalwa) akufaneleki ngalesi sikhathi, ngakho-ke khuluma nodokotela wakho ngokusebenzisa indlela yokulawula ukuzalwa engeyona eye-hormone (njengamakhondomu noma ama-IUD). Kubalulekile ukusebenzisa ukuvimbela ukuzalwa okungenani izinyanga ezimbili ngemva kokuyeka umuthi.
Yikuphi ukudla neziphuzo okufanele uzigweme lapho usebenzisa i-Tamoxifen?
Yebo. Ukudla neziphuzo ezithile kunganciphisa ukusebenza kwe-Tamoxifen. Ngakho-ke, kungcono ukugwema lokhu:
- Isithelo segilebhisi
- Ama-tangerine
- Utshwala banoma yiluphi uhlobo
Ingabe imiphumela emibi iyenzeka ngokushesha ngemva kokuqala ukuthatha umuthi?
Lokhu kuyahlukahluka kuye ngomuntu nomuntu. Abanye abantu bangase baqale ukubona izinguquko ezincane kusukela ngosuku abathatha ngalo iphilisi lokuqala. Abanye bangase bangaboni lutho izinyanga eziningi.
Umuthi uhlala isikhathi esingakanani emzimbeni ngemva kokuyeka?
I-Tamoxifen ihlala isebenza emzimbeni cishe amasonto amabili ngemuva kokuthatha iphilisi lokugcina, kodwa kungathatha cishe izinyanga ezintathu ukuthi iphume ngokuphelele emzimbeni wakho.
Umlayezo Wokuya Nawe Ekhaya
- I-Tamoxifen iyindlela yokwelapha yama-hormone ephumelela kakhulu yomdlavuza webele oxhomeke kuma-hormone.
- Lomuthi unciphisa kakhulu ingozi yokuphinda umdlavuza kanye nokukhula okusha.
- Ungakhathazeki ngemiphumela emibi yokuphuza imithi. Iningi layo lingalawuleka. Kodwa qaphela izimpawu ezingathi sína bese utshela udokotela wakho ngokushesha uma zivela.
- Kubaluleke kakhulu ukuqhubeka nokuthatha lo muthi isikhathi sonke esinqunywe udokotela wakho.
- Zizwe ukhululekile ukuxoxa nganoma yimiphi imibuzo noma ukukhathazeka onakho nodokotela wakho. Kuyilungelo lakho.
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