Ingabe wena noma othile omaziyo unikezwe i-Tamoxifen ngudokotela wakho ngenxa yomdlavuza webele? Noma ingabe unikezwe yona ngoba usengozini enkulu yokuba nomdlavuza? Kuvamile ukuzizwa wesaba kancane, unelukuluku, futhi unemibuzo eminingi uma uzwa igama lalo muthi. "Ingabe lokhu kuzowuphulukisa ngempela umdlavuza? Iyini imiphumela emibi?" Cishe uyazibuza. Ngakho-ke, namuhla sizoxoxa ngokuthi iyini i-Tamoxifen, ukuthi yenzani emzimbeni, nokuthi yini okudingeka siyiqaphele, kalula nje, njengokungathi sikhuluma nomngane.
Kalula nje, iyini iTamoxifen?
I-Tamoxifen umuthi ovame kakhulu osetshenziswa ekwelapheni umdlavuza webele. Kodwa-ke, awunikezwa zonke izinhlobo zomdlavuza webele. Inikezwa ikakhulukazi abantu abanomdlavuza webele one-hormone receptor .
Kusho ukuthini lokho? Cabanga ngakho, amanye amangqamuzana omdlavuza webele afana nezingane ezilambile. Adinga ama-hormone amabili akhiqizwa yimizimba yethu ngokwemvelo ukuze akhule futhi asakazeke. Angama -estrogen nama -progesterone . Lokho okwenziwa umuthi i-tamoxifen ukuthi uvimba lawo maseli omdlavuza ekutholeni "ukudla" akudingayo, okuyi-hormone i-estrogen.
Ngaphezu kwalokho, odokotela batusa futhi lo muthi ukuvimbela umdlavuza kulabo abasengozini enkulu yokuba nomdlavuza webele (isibonelo, uma othile emndenini eke waba nomdlavuza, noma uma enezinguquko zofuzo ezifana ``(BRCA)```).
Yiziphi izinzuzo eziyinhloko zokwelashwa nge-tamoxifen?
Lo muthi usize ekusindiseni izimpilo zezigidi zabesifazane emhlabeni jikelele. Ezinye zezinzuzo zawo eziyinhloko yilezi:
- Ukuvimbela ukuphinda komdlavuza: Ingozi yokubuya komdlavuza ngemva kokuhlinzwa, ukwelashwa ngamakhemikhali, noma ukwelashwa ngemisebe yehliswa ngo-30% kuya ku-50%.
- Ukuvikela elinye ibele: Kumuntu onomdlavuza kwelinye ibele, ingozi yokuba nomdlavuza kwelinye ibele eliphilile incishiswa cishe ngo-50%.
- Ukuvimbela umdlavuza ohlaselayo: Kumuntu onomdlavuza osesigabeni sokuqala (i-Ductal Carcinoma in Situ noma i-DCIS), ovalelwe emigudwini yobisi yebele, kunciphisa ingozi yokuba umdlavuza ohlaselayo cishe ngo-50%.
- Ukuqinisa amathambo: Lo muthi usiza futhi ekuvimbeleni i-osteoporosis nokuqinisa amathambo, okungenzeka ngemva kokunqamuka kokuya esikhathini.
- Ukwehlisa i-cholesterol: Futhi kusiza ngezinga elithile ekunciphiseni izinga le-cholesterol embi egazini.
Ake sifunde nokuthi ungawuthatha kanjani umuthi kanye nemiphumela yawo emibi.
Udokotela wakho uzokutshela ukuthi uthathe i-tamoxifen njengephilisi (`Nolvadex®`) noma njengoketshezi (`Soltamox®`) ngesikhathi esifanayo nsuku zonke. Isikhathi sokwelashwa singaba iminyaka emi-5 noma eyi-10. Lokhu kuzonqunywa udokotela wakho kuye ngesimo sakho.
Njenganoma yimuphi umuthi, i-tamoxifen ingabangela eminye imiphumela emibi. Iningi lale miphumela ayibi kakhulu, futhi akuwona wonke umuntu oyitholayo. Kodwa kubalulekile ukuqaphela.
| Uhlobo lomphumela ongemuhle | Incazelo kanye nezimpawu |
|---|---|
| Imiphumela emibi evamile | |
| Izimpawu ezifana nokunqamuka kokuya esikhathini | Ukushisa, ukujuluka ebusuku, kanye nokoma kwesitho sangasese sowesifazane. |
| Ukwanda kwesisindo/ukuvuvukala | Abanye abantu bangase bakhuluphale noma bavuvuke (bavuvuke) ezindaweni ezifana nemilenze. |
| Ukuya esikhathini okungajwayelekile | Ukuya esikhathini okungajwayelekile noma ukuyeka ngokuphelele. |
| Ezinye izifo ezincane | Ukuvuvukala kwemilenze, isicanucanu, ukuphuma koketshezi esithweni sangasese sowesifazane, ukuqubuka kwesikhumba, ukukhathala, ikhanda elibuhlungu. Kwabesilisa, ukungasebenzi kahle kwenduku yobulili kungase kwenzeke. |
| Izingozi ezinkulu kodwa ezingavamile ezidinga ukunakekelwa kwezokwelapha ngokushesha | |
| Amahlule egazi | Izimo ezinjengokuqhekeka kwegazi emithanjeni yemilenze (i-Deep Vein Thrombosis - DVT) noma isifo sohlangothi. |
| Ama-cataract | Izinkinga zamehlo ezifana nokungaboni kahle. |
| Umdlavuza wesibeletho | Kukhona ingozi encane kakhulu yokuba nomdlavuza we-endometrial. |
Lezi zingozi ezinkulu azivamile, kodwa kubalulekile ukuziqaphela. Udokotela wakho unikeza lo muthi ngoba izinzuzo zomuthi zidlula kakhulu izingozi.
Uma udinga ukubona udokotela ngokushesha!
Uma uthatha i-tamoxifen futhi uhlangabezana nanoma yiziphi izimpawu ezilandelayo, tshela udokotela wakho ngokushesha noma uye eMnyangweni Wezimo Eziphuthumayo (ETU) wesibhedlela ngokushesha.
- Ubuhlungu besifuba obungazelelwe noma ubunzima bokuphefumula .
- Imfiva .
- Izimpawu zesifo sohlangothi zifaka phakathi ukukhuluma okungacacile , ukubona okufiphele , kanye nokuba ndikindiki ngokuzumayo kolunye uhlangothi lwengalo, umlenze, noma ubuso .
- Ukuvuvukala okukhulu emilenzeni, emaqakaleni, noma ezinyaweni .
- Ukuhlanza okungenakunqandeka.
Qaphela lezi zinto uma uthatha umuthi.
Ngingawuthatha lo muthi ngesikhathi sokukhulelwa?
Cha. Lutho neze. Uma ukhulelwa ngenkathi uthatha i-tamoxifen, ingane yakho ingase ibe nezinkinga ezinkulu zokuzalwa. Ngakho-ke, kufanele ugweme ukukhulelwa ngenkathi uthatha lo muthi futhi izinyanga ezimbili ngemva kokuyeka umuthi. Khuluma nodokotela wakho mayelana nokusebenzisa indlela yokuvimbela inzalo engeyona eye-hormone (njengekhondomu).
Ingabe i-tamoxifen iyi-chemotherapy?
Cha. Lezi yizinto ezimbili ezihlukene. I-Tamoxifen iwukwelashwa ngama-hormone . Ngokukhethekile, ingeyesigaba semithi ebizwa ngokuthi "Selective Estrogen Receptor Modulators - SERMs." I-Chemotherapy iwukwelashwa okubulala amaseli ahlukana ngokushesha (amangqamuzana omdlavuza kanye namaseli anempilo). Kodwa i-tamoxifen ihlose kuphela umsebenzi wama-hormone.
Ingabe kukhona ukudla noma iziphuzo okufanele ngizigweme ngenkathi ngithatha lo muthi?
Yebo. Ukudla neziphuzo ezithile kunganciphisa ukusebenza kahle kwe-tamoxifen, ngakho-ke kuwukuhlakanipha ukuzigwema.
- Isithelo segilebhisi
- Ama-tangerine
- Noma yisiphi isiphuzo esiqukethe utshwala
Umlayezo Wokuya Nawe Ekhaya
- I-Tamoxifen iyindlela yokwelapha ephumelela kakhulu nesindisa impilo yomdlavuza webele oxhomeke kuma-hormone.
- Kubalulekile ukuphuza imithi yakho njengoba nje udokotela wakho ekuyalele, ngesikhathi esifanele, nangesikhathi esifanele.
- Ungesabi imiphumela emibi, kodwa qaphela. Qaphela kakhulu izimpawu zokuqhekeka kwegazi noma isifo sohlangothi (ukuvuvukala emilenzeni, ubuhlungu besifuba, ukukhuluma okungacacile). Uma uhlangabezana nanoma yikuphi kwalokhu, funa iseluleko sezokwelapha ngokushesha.
- Ungakhulelwa ngenkathi uthatha lo muthi futhi izinyanga ezimbili ngemuva kokuyeka. Khuluma nodokotela wakho mayelana nokusebenzisa indlela yokuvimbela inzalo ephephile.
- Khuluma nodokotela wakho ngokukhululekile nganoma yimiphi imibuzo, ukwesaba, noma ukungabaza ongase ube nakho. Bahlala bekulungele ukukusiza.
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