Cishe uke wezwa nge-hormone i-insulin. Leli gama livela kakhulu, ikakhulukazi uma kukhulunywa ngesifo sikashukela. Kodwa wake wezwa nge-hormone i-insulin-like growth factor-1, noma i-IGF-1 ngamafuphi? Yi-hormone ehlobene ne-insulin, futhi isebenza njenge-insulin. Namuhla, ake sixoxe ngokuthi iyini i-IGF-1 nokuthi ihlobene kanjani nesifo sikashukela.
Kalula nje, iyini i-IGF-1?
I-'Insulin-like Growth Factor-1' noma i-'IGF-1' iyi-hormone ebaluleke kakhulu ekhiqizwa yisibindi sethu. Omunye wemisebenzi yayo eyinhloko ukukhombisa amathambo nemisipha yethu ukuthi "ikhule kahle." Lokho kusho ukuthi ibaluleke kakhulu ekukhuleni kwemizimba yethu.
Le hormone ifana kakhulu ne-insulin. Iphinde ithinte indlela amangqamuzana ethu asebenzisa ngayo ushukela, noma i-glucose, egazini lethu. Ngakho-ke manje uyabona ukuthi kukhona ukuxhumana okukhulu phakathi kwalokhu okubili.
Ubudlelwano nesifo sikashukela sohlobo 2
Okokuqala, masikhumbule ukuthi isifo sikashukela siqala kanjani. I-hormone i-insulin isiza i-glucose esiyithola ekudleni esikudlayo ukuthi ingene emaselini ethu futhi yenze amandla. Cabanga ngayo njengokuthi i-insulin ifana nesihluthulelo, iseli lifana negumbi, kanti umnyango weseli uyilokhi. Ngakho-ke, uma lesi sihluthulelo (i-insulin) sifakwa futhi ilokhi ivuliwe, i-glucose ingangena esiseleni.
Kodwa ngezinye izikhathi imizimba yethu ayiphenduli kahle kule insulin. Sikubiza ngokuthi ukumelana ne-insulin . Kufana nokukhiya okugqwalile okungenakuphendulwa yikhiye. Ngemuva kwalokho ama-pancreas ethu azama ukwenza i-insulin eyengeziwe ukuze enze umsebenzi. Kodwa ngesinye isikhathi, nawo awakwazi ukukwenza. Umphumela uba ukuthi i-glucose ayikwazi ukungena emaseli futhi iqongeleleke egazini. Ekugcineni, lesi simo siba yisifo sikashukela sohlobo 2 .
Manje yilapho i-'IGF-1' ingena khona. Ucwaningo luthole ukuthi abantu abanamazinga aphansi e-'IGF-1' basengozini enkulu yokuthola inqwaba yezimo ezibizwa ngokuthi 'i-Metabolic Syndrome'.
I-Metabolic Syndrome ayisona isifo esisodwa. Iyinhlanganisela yezinkinga eziningana zempilo, njengomfutho wegazi ophakeme, i-cholesterol ephezulu, namafutha esiswini. Uma zonke lezi zinto zihlangana, ingozi yokuthola isifo senhliziyo nesifo sikashukela iyanda kakhulu.
Lokhu kusho ukuthi uma amazinga akho e-IGF-1 ephansi, kungenzeka kakhulu ukuthi ube nezinye izinkinga ezingaholela kushukela.
Ngakho-ke i-IGF-1 ingayelapha yini isifo sikashukela?
Lona umbuzo abacwaningi abazama ukuwuphendula kulezi zinsuku. Inkomba eyodwa yalokhu umuthi obizwa ngokuthi i-`mecasermin (Increlex).` Lona umuthi wokwenziwa, okungukuthi, i-`IGF-1' hormone eyenziwe elebhu. Odokotela basebenzisa lo muthi ukwelapha izingane ezincane ezingakhuli kahle.
Kodwa omunye wemiphumela emibi yalo muthi ukwehla kwamazinga kashukela egazini, okungukuthi, ukwenzeka kwesimo esibizwa ngokuthi 'i-Hypoglycemia'. Lokhu kwadonsa ukunaka kwabacwaningi. Ezifundweni zakamuva, lapho abantu abadala abanesifo sikashukela sohlobo 2 benikwa le 'IGF-1', babona nokuthi amazinga abo kashukela egazini ehla. Ngaphezu kwalokho, ukumelana kwabo ne-insulin kwathuthuka kakhulu.
Kodwa... lokhu kusesesigabeni socwaningo. Ngenxa yokuthi i-IGF-1 iyi-hormone eyenza izinto eziningi emzimbeni, kusekuningi okufanele kufundwe ngendlela esebenza ngayo. Okwamanje, i-IGF-1 ivunyelwe kuphela ezinkingeni zokukhula ezinganeni. Ayikavunyelwa njengokwelashwa kwesifo sikashukela.
Masiqaphele nemiphumela emibi eyingozi.
I-'IGF-1' akuyona into yokudlala ngayo. Ingabangela imiphumela emibi kakhulu. Kubaluleke kakhulu ukuqaphela lokhu.
| Umphumela ongemuhle | Incazelo elula |
|---|---|
| Ukuvuvukala ku-Retina | I-retina ungqimba olungaphakathi kweso oluthumela lokho esikubonayo ebuchosheni. Lokhu kuvuvukala kungabangela umonakalo omkhulu ekuboneni. |
| Ubuhlungu obukhulu bemisipha namalunga | Kungase kube nobuhlungu obungabekezeleleki emisipheni nasemalungeni omzimba. |
| Ukukhubazeka kukaBell | Lokhu kwenzeka lapho uhlangothi olulodwa lobuso luba buthakathaka ngokuzumayo bese luwela phansi, lufane nohlangothi. |
| Ingozi yomdlavuza | (Kubaluleke kakhulu) Kutholakale ukuthi i-IGF-1 ihlotshaniswa nokukhula komdlavuza webele, wamathumbu amakhulu, wamaphaphu kanye nowendlala yesinye. |
Iqiniso mayelana nezithasiselo
Lesi yisihloko esibalulekile kubantu abaningi. Abanye abakhi bomzimba kanye nabasubathi basebenzisa izithasiselo ze-IGF-1, kungaba ezithengiswa ngaphandle kwemithi kadokotela noma ezitholakala ngomuthi kadokotela, ukuze bandise imizimba yabo futhi bandise amandla abo.
Kodwa khumbula, i-World Anti-Doping Agency (WADA) ivimbele zonke izinhlobo ze-hormone i-IGF-1, okuhlanganisa nezithasiselo.
I-WADA ithi ngisho ne-'IGF-1' enikezwe udokotela ingabangela umonakalo ohlala njalo emalungeni akho, esibindini, nasenhliziyweni uma isetshenziswa ngendlela engafanele. Ngakho-ke kuthiwani ngezithasiselo ezithengiswa ngaphandle kwemithetho? Akekho kithi owaziyo ukuthi ziquketheni ngempela.
Abanye bawasebenzisela izinzuzo zokulwa nokuguga noma impilo jikelele. Kuyiqiniso ukuthi njengoba siguga, imizimba yethu ikhiqiza i-IGF-1 encane. Kodwa-ke, abukho ubufakazi besayensi bokuthi ukuthatha izithasiselo ze-IGF-1 kuzokusiza ukuthi uhlale usemncane.
Lo mbono uvela ocwaningweni ngomuthi wesifo sikashukela i-metformin. Kulezo zifundo, izimpethu namagundane aphila isikhathi eside uma enikezwa i-metformin. Kodwa akukaziwa ukuthi izothinta kanjani abantu.
Ngakho-ke, uma ucabanga ukuthatha isithasiselo se-`IGF-1`, sicela ungacabangi ngisho nakancane ngakho. Qiniseka ukuthi ukhuluma nodokotela wakho ngaphambi kokwenza kanjalo. Ukujova izinto ezinamandla kangaka emzimbeni wakho ngaphandle kweseluleko sikadokotela kungabangela umonakalo ongacabangeki.
Umlayezo Wokuya Nawe Ekhaya
- I-'IGF-1' iyi-hormone yemvelo efana ne-insulin ebalulekile ekukhuleni kwemizimba yethu.
- Amazinga aphansi e-IGF-1 emzimbeni ahlotshaniswa nesifo i-Metabolic Syndrome, esanda ingozi yesifo sikashukela nesifo senhliziyo.
- Nakuba kukhona ucwaningo mayelana nokusetshenziswa kwe-IGF-1 njengokwelashwa kwesifo sikashukela, akukabi ukwelashwa okuvunyelwe okwamanje.
- Le hormone ingabangela imiphumela emibi kakhulu njengokulimala kwamehlo, ubuhlungu bamalunga, kanye nengozi yomdlavuza.
- Ukusetshenziswa kwezithasiselo ze-'IGF-1' emakethe kuyingozi kakhulu. Zifakiwe futhi ohlwini lwe-World Anti-Doping Agency.
- Njalo xhumana nodokotela wakho ngaphambi kokusebenzisa noma yisiphi isithasiselo noma imithi.
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