Isandla esisizayo ekulweni nomdlavuza: Ake sifunde ngamaphilisi e-Vemurafenib

Namuhla sizokhuluma ngomuthi okhethekile onikezwa umuntu olwa nomdlavuza. Wena noma othile omaziyo kungenzeka ukuthi unikezwe lo muthi, obizwa ngokuthi i-Vemurafenib , ngudokotela wakho. Ngakho-ke, namuhla sizokhuluma ngokuningiliziwe ngohlobo lomuthi, ukuthi usetshenziswa kanjani, nokuthi yini okudingeka siyiqaphele kakhulu.

Uyini lo muthi obizwa ngokuthi i-Vemurafenib?

Kalula nje, i-Vemurafenib umuthi ohlasela amaprotheni athile ngaphakathi kwamaseli omdlavuza futhi uwavimbele ukukhula. Uma sikhuluma iqiniso, isebenza njengokwelashwa okuqondisiwe . Isetshenziswa kakhulu ukwelapha uhlobo lomdlavuza wesikhumba olubizwa ngokuthi i-melanoma . Iphinde isetshenziswe ukwelapha isimo esingavamile esibizwa ngokuthi isifo se-Erdheim-Chester .

Khumbula, odokotela ngezinye izikhathi bangawusebenzisa lo muthi kwezinye izimo, ngakho-ke uma unemibuzo, kungcono ukubuza udokotela wakho noma usokhemisi.

Igama lomkhiqizo elivame kakhulu lalo muthi yiZelboraf .

Yiziphi izinto okudingeka ngizitshele udokotela ngaphambi kokuqala lo muthi?

Ngaphambi kokuthi uqale ukuthatha i-Vemurafenib, kubaluleke kakhulu ukutshela udokotela wakho ngomlando wempilo yakho. Kubaluleke kakhulu ukutshela udokotela wakho uma unezinye zezimo ezilandelayo:

• Uma unezifo zamehlo noma izinkinga zokubona
• Uma unesifo senhliziyo
• Uma uke waba nokushaya kwenhliziyo okungajwayelekile ngaphambili
• Uma uke watholakala unezinga eliphansi le-calcium, i-magnesium, noma i-potassium egazini
• Uma unesifo sezinso
• Uma unesifo sesibindi
• Uma usanda kwelashwa ngemisebe noma okwamanje uselashwa ngemisebe
• Uma uke waba nokusabela kokungezwani komzimba noma ukusabela okungavamile ku-Vemurafenib, eminye imithi, ukudla, udayi, noma izithasiselo.
• Uma uzama ukukhulelwa noma ukhulelwe njengamanje (lokhu kubaluleke kakhulu)
• Uma ungumama oncelisayo (lokhu kubalulekile futhi)

Udokotela uzokwazi ukunquma ukuthi lo muthi ukulungele yini noma cha, nokuthi yiziphi izinyathelo zokuphepha okudingeka uzithathe.

Ngiyisebenzisa kanjani ngempela le mithi?

Lo muthi uza ngesimo samaphilisi. Kufanele uwuphuze ngomlomo nengilazi yamanzi. Landela imiyalelo eselebula likadokotela onikezwe lona ngudokotela wakho noma usokhemisi.

• Ungawaphuli, uwachoboze, noma uwahlafune la maphilisi. Gwinya wonke.
• Ungayithatha lokhu nokudla noma ngaphandle kokudla. Kodwa-ke, uma uzizwa unesisu esibuhlungu, kungcono ukuyithatha nokudla.
• Thatha umuthi ngesikhathi esifanele, kuphela ngenani elinqunywe udokotela wakho. Ungathathi ngaphezu kwenani elinqunywe udokotela.
• Into ebaluleke kakhulu ukuthi, ungayeki ukuthatha lo muthi ngokuzumayo ngaphandle kweseluleko sikadokotela wakho.
• Esikhathini esiningi, le mithi ithathwa amahora ayi-12 ngokwehlukana. Lokho kusho ukuthi uma uyithatha ekuseni, kufanele uthathe umthamo olandelayo ebusuku.

Uma uthola imithi yakho, ikhemisi lizokunikeza incwajana ekhethekile yomhlahlandlela (i-MedGuide) . Funda le ncwajana ngokucophelela njalo uma uthola imithi emisha. Iqukethe ulwazi oluningi olubalulekile kuwe.

Uma unikeza izingane lo muthi, kufanele ukhulume nodokotela wezingane ngakho futhi uzinakekele ngokukhethekile.

Yini okufanele uyenze uma uthatha umuthi omningi kakhulu?

Uma ucabanga ukuthi uphuze kakhulu lo muthi ngephutha, shayela isikhungo sokulawula ubuthi noma igumbi lezimo eziphuthumayo eliseduze ngokushesha.

Lo muthi unikezwe wena kuphela. Ungawunikezi omunye umuntu.

Yini okufanele uyenze uma uphuthelwa umthamo wemithi?

Uma uphuthelwa umthamo, thatha ngokushesha nje lapho ukhumbula. Kodwa-ke, uma kungaphansi kwamahora ama-4 ngaphambi komthamo wakho olandelayo ohleliwe, yeqa umthamo ophuthelwe. Kunalokho, thatha umthamo wakho olandelayo ngesikhathi esihleliwe. Ungalokothi uthathe umthamo ophindwe kabili.

Yiziphi ezinye izinto ezingasebenzisana nalo muthi?

Leli iphuzu elibaluleke kakhulu. I-Vemurafenib ingasebenzisana neminye imithi oyithathayo. Uma lokhu kwenzeka, imiphumela emibi inganda noma ukusebenza kahle komuthi kungancipha.

Ungayithathi i-Vemurafenib kanye nemithi elandelayo:

• I-Cisapride
• I-Dronedarone
• I-Fluconazole
• I-Pimozide
• I-Posaconazole
• I-Saquinavir
• I-Thioridazine

Ngaphezu kwalokho, imithi elandelayo ingasebenzisana ne-Vemurafenib:

• Imithi yokulwa negciwane lengculazi noma ingculazi
• Izinto eziqukethe i-caffeine (buza udokotela wakho ngalokhu)
• Amanye ama-antibiotic, isibonelo: i-clarithromycin, i-erythromycin, i-telithromycin
• Eminye imithi yokwelapha izifo zesikhunta, isibonelo: i-itraconazole, i-ketoconazole, i-voriconazole
• Eminye imithi yokwelapha izinkinga zesigqi senhliziyo
• Eminye imithi esetshenziselwa ukwelapha izimo ezifana nokuquleka (ukuquleka), isibonelo: i-carbamazepine, i-phenobarbital, i-phenytoin
• Eminye imithi evimbela noma elapha amahlule egazi, isibonelo: i-warfarin
• I-Dextromethorphan
• I-Digoxin
• I-Nefazodone
• I-Midazolam
• Eminye imithi engabangela ukushaya kwenhliziyo okungajwayelekile, okungukuthi ukwandisa isikhathi se-QT , isibonelo: i-dofetilide, i-ziprasidone
• I-Rifabutin
• I-Rifampin
• I-Rifapentine
• Isithasiselo semithi ye-St. John's wort (i-Hypericum perforatum)
• I-Tizanidine

Lolu hlu alufaki konke ukusebenzisana. Ngakho-ke, tshela udokotela wakho ngayo yonke imithi (ebhalwe ngudokotela kanye nethengiswa ngaphandle kwemithi kadokotela), imikhiqizo yamakhambi, amavithamini, kanye nezithasiselo zokudla ozithathayo. Qiniseka ukuthi utshela udokotela wakho uma ubhema, uphuza utshwala, noma usebenzisa izidakamizwa ezingekho emthethweni. Lokhu kungathintana nemithi yakho.

Yiziphi izinto okudingeka uziqaphele kakhulu lapho uthatha lo muthi?

Kubaluleke kakhulu ukunaka impilo yakho njalo ngenkathi uthatha i-Vemurafenib.

• Bona udokotela wakho njalo: Qhubeka uyohlolwa njengoba udokotela wakho ekutshela. Kungase kudingeke futhi ukuthi kwenziwe umsebenzi wegazi ngenkathi uthatha lo muthi.
• Ukusabela okukhulu kwesikhumba: Lo muthi ngezinye izikhathi ungabangela ukusabela okukhulu kwesikhumba. Lokhu kungase kwenzeke emavikini noma ezinyangeni ngemuva kokuqala ukuthatha umuthi. Tshela udokotela wakho ngokushesha uma uthola ukuqhuma okunezimpawu ezifana nomkhuhlane noma ukubanda. Ukuqhuma kungase kube bomvu noma kube nsomi, bese kuba amabala futhi isikhumba singase siqhekeke. Noma ungase uthole ukuqhuma okubomvu okunokuvuvukala kobuso noma izindebe, noma ama-lymph node avuvukele entanyeni noma emakhwapheni. Uma ubona into efana nale , tshela udokotela wakho ngokushesha.
• Khuluma ngengozi yomdlavuza: Uma uthatha lo muthi, ungase ube sengozini enkulu yokuthola ezinye izinhlobo zomdlavuza. Khuluma nodokotela wakho ngalokhu.
• Izinguquko zombono: Uma ubona noma yiziphi izinguquko embonweni wakho, njengokubona okufiphele noma ukubona izinto ngendlela ehlukile kunejwayelekile, kufanele utshele udokotela wakho ngokushesha.
• Ukuzwela kwelanga: Lokhu nakho kuyinkinga ebaluleke kakhulu. Uma uthatha i-Vemurafenib, isikhumba sakho siba nomuzwa omkhulu elangeni. Lokhu kusho ukuthi ngisho nesikhathi esifushane elangeni singabangela isikhumba sakho sishise, sibe bomvu, futhi sibe namabala.
• Ngakho-ke, gwema ilanga ngangokunokwenzeka.
• Uma kufanele uye elangeni,Gqoka izingubo ezimboza isikhumba sakho kahle, gqoka isigqoko esibanzi, bese usebenzisa isithako esihle sokuvikela ilanga esinconywe udokotela wakho.
• Ungasebenzisi izibani zelanga noma imibhede/amadokodo okushiswa kwesikhumba.
• Ukukhulelwa kanye nokuncelisa:
• Ungakhulelwa ngenkathi uthatha lo muthi futhi amasonto amabili ngemuva kokuyeka umuthi.
• Uma uhlela ukukhulelwa noma ucabanga ukuthi ukhulelwe, tshela udokotela wakho ngokushesha. Lo muthi ungabangela umonakalo omkhulu enganeni engakazalwa. Cela udokotela wakho noma usokhemisi ukuthola ulwazi olwengeziwe.
• Ungamncelisi umntwana wakho ibele ngesikhathi uthatha lo muthi futhi amasonto amabili ngemva kokuyeka umuthi.

Yimiphi imiphumela emibi engaba khona?

Njenganoma yimuphi umuthi, i-Vemurafenib ingabangela imiphumela emibi. Eminye iyingozi, eminye ayibi kakhulu.

Imiphumela emibi okufanele ibikwe kudokotela wakho noma kuchwepheshe wezempilo ngokushesha okukhulu:

Uma uhlangabezana nanoma yiziphi zalezi zimpawu, tshela udokotela wakho ngokushesha:

• Ukusabela kokungezwani komzimba: ukuqubuka kwesikhumba, ukulunywa noma ukuqubuka, ukuvuvukala kobuso, izindebe noma ulimi
• Ubunzima bokuphefumula
• Izinguquko zombono
• Umchamo onombala omnyama
• Ubuhlungu noma ukuvuvukala kwamehlo
• Ukushaya kwenhliziyo okusheshayo noma okungajwayelekile
• Ukuquleka, isiyezi, kanye nokuwa
• Izimpawu ezivamile zokungakhululeki noma ezifana nokubanda
• Izitulo ezinombala okhanyayo
• Isifiso sokudla
• Kuvela insumpa entsha; iqhubu elibuhlungu esikhumbeni noma elibomvu eliphuma igazi noma elingapholi; ushintsho ngobukhulu noma umbala wensumpa noma ibala
• Ubuhlungu, ukungazweli, noma ukulahlekelwa umuzwa ezithweni
• Ukuqubuka, umkhuhlane, kanye nokuvuvukala kwezinqe
• Ukubomvu kwesikhumba, ukuqubuka, ukuqhekeka kwesikhumba (kufaka phakathi ukuqhekeka kwesikhumba ngaphakathi emlonyeni)
• Ubuhlungu ohlangothini oluphezulu kwesokudla lwesisu
• Ukuzwela kwelanga noma ukushiswa yilanga
• Ukuqina kwesikhumba ezintendeni nasezinyaweni
• Iminwe igobile ngaphakathi futhi iqinile
• Ukuzizwa ubuthakathaka noma ukhathele ngendlela engavamile
• Ukuhlanza
• Ukuphuzi kwamehlo noma isikhumba

Imiphumela emibi evame ukungadingi ukunakekelwa kwezokwelapha (tshela udokotela wakho uma lokhu kuqhubeka noma kukhathaza):

• Izinguquko zokunambitha
• Ukulahlekelwa yisifiso sokudla
• Uhudo (ubuhlungu besisu)
• Isiyezi
• Isikhumba esomile
• Ukulahlekelwa izinwele
• Ikhanda elibuhlungu
• Ubuhlungu bamalunga
• Ubuhlungu bemisipha
• Isicanucanu (ukuzizwa ugula)
• Ukuvuvukala kwamaqakala, izinyawo, izandla
• Ukukhathala

Lolu hlu alufaki yonke imiphumela emibi engaba khona. Uma uhlangabezana nanoma yiziphi ezinye izimpawu ezingavamile, xhumana nodokotela wakho. Uma ufisa, ungabika nemiphumela emibi ku- FDA (Food and Drug Administration) ngokushayela ku-1-800-FDA-1088.

Ngingawagcina kanjani la maphilisi?

• Gcina kude nezingane. Lokhu kubaluleke kakhulu.
• Gcina ekamelweni lokushisa (phakathi kwama-degree Celsius angu-20 no-25 / 68 no-77 degrees Fahrenheit).
• Gcina umuthi ebhodleleni lokuqala owafika kulo, uvalwe kahle.
• Lahla imithi ephelelwe yisikhathi ngaphandle kokuyisebenzisa.

Okokugcina, izinto okudingeka uzikhumbule (Umyalezo Wokuya Ekhaya)

I-Vemurafenib umuthi odlala indima ebalulekile ekwelapheni umdlavuza. Kunezinto ezimbalwa okufanele uziqaphele uma usebenzisa wona.

• Landela imiyalelo kadokotela ngqo. Yenza konke njengoba ekutshela, okuhlanganisa nokuthi uwuthatha nini umuthi, inani, nokuthi ungawuyeka kanjani.
• Tshela udokotela wakho ngayo yonke eminye imithi oyithathayo kanye nanoma yiziphi ezinye izifo onazo. Lokhu kuzosiza ekuvimbeleni imiphumela emibi.
• Uma ubona noma yiziphi izimpawu ezintsha, ikakhulukazi izinguquko zesikhumba noma izinguquko embonweni, tshela udokotela wakho ngokushesha.
• Qaphela ilanga. Ungakhohlwa lokhu.
• Uma ukhulelwe, uhlela ukukhulelwa, noma uncelisa, qiniseka ukuthi utshela udokotela wakho ngaphambi kokuthatha lo muthi.

Lesi sihloko siyisifinyezo nje esijwayelekile. Uma uneminye imibuzo mayelana nalo muthi, sicela ungangabazi ukubuza udokotela wakho, usokhemisi, noma omunye umhlinzeki wezempilo. Bazokwazi ukukusiza.

Sikufisela konke okuhle ohambweni lwakho lwezempilo!

I- Vemurafenib, i-Zelboraf, umuthi womdlavuza, umdlavuza wesikhumba, i-melanoma, imiphumela emibi, umuthi, ukwelashwa komdlavuza