Ngezinye izikhathi, izinguquko ezincane ezakhiweni zethu zofuzo zingabangela izinkinga ezinkulu zempilo. I-hATTR amyloidosis ingenye yezifo ezingavamile, kodwa eziyingozi kakhulu zezakhi zofuzo. Kulokhu, iphrotheni ekhiqizwa yisibindi sethu iqoqana ngendlela engafanele futhi yonakalise imizwa. Lokhu kungabangela izinkinga eziningi ezifana nobunzima bokuhamba, ubuhlungu, kanye nokuba ndikindiki. Kodwa manje sekukhona ukwelashwa okusha kwalokhu. Namuhla, ake sixoxe ngalo muthi omusha obizwa ngokuthi i-Wainua.
Isebenza kanjani imithi iWainua?
Ukuze siqonde lokhu, ake siqale sibheke kalula isifo se-hATTR. Umzimba wethu uneprotheni ebizwa ngokuthi i-transthyretin (TTR). Lokhu kwenziwa yisibindi sethu. Ngenxa yoshintsho oluncane ku-gene ye-TTR kumuntu onesifo se-hATTR, le protheni igoqeka ngendlela engafanele, ihlangane ndawonye, bese isala emzimbeni njengeziqu ezibizwa ngokuthi 'i-amyloid'. Kufana nobisi olugoqekayo. La maqumqum e-amyloid ahlala kakhulu ohlelweni lwezinzwa. Bese imizwa yonakala futhi umsebenzi wayo uyaphazamiseka.
Manje ake sibheke ukuthi umuthi wokugomela i-Wainua wenzani. Umuthi i-Wainua uhlasela ngqo isakhi sofuzo esenza iphrotheni ye-TTR enephutha. Kalula nje, 'uyathulisa' isakhi sofuzo esinikeza imiyalelo engalungile.
Lokhu kunciphisa inani leprotheyini ye-TTR engajwayelekile ekhiqizwa yisibindi. Lokhu kunciphisa ukufakwa kwe-amyloid emithanjeni, okusiza ukulawula ukuqhubeka komonakalo wemizwa.
Lona umjovo wanyanga zonke ofakwa ngaphansi kwesikhumba. Okukhethekile ukuthi ufika 'kumshini wokujova ozenzakalelayo' owenzelwe isiguli noma umnakekeli waso ukuba awusebenzise ekhaya.
Ngingazi kanjani ukuthi lokhu kwelashwa kulungile kimi?
Udokotela wakho uzonquma ukuthi i-Wainua ikufanele yini. Lokhu kwelashwa kuvame ukufaneleka kubantu abalandelayo:
- Uma ungumuntu omdala okuqinisekisiwe ukuthi une -ATTR Amyloidosis .
- Uma lesi sifo sibangele ukulimala kwemizwa .
Udokotela wakho uzocabangela izici eziningana ngaphambi kokwenza lesi sinqumo.
- Umlando womndeni : Hlola ukuthi ukhona yini emndenini wakho oke waba nalesi sifo.
- Ukuhlolwa Kwezimpawu: Izimpawu zakho zizohlolwa ngokucophelela.
- Ukuhlolwa kwezakhi zofuzo: Kuhlolwa igazi ukuqinisekisa ukuguqulwa kwezakhi zofuzo ze-TTR.
- Ukuhlolwa kwezithombe: I-MRI scanUkuhlolwa okufana nalokhu kungahlola nokufakwa kwe-amyloid ezinzwa nakwezinye izitho zomzimba.
Impumelelo yomuthi waseWainua ihlolwe kanjani?
Ngaphambi kokuba noma yimuphi umuthi omusha ukhishwe emakethe, kwenziwa ucwaningo olunzulu ukuze kutholakale ikhwalithi yawo, ukuphepha kwawo, kanye nokusebenza kwawo. Umuthi waseWainua uphinde wahlolwa ngemithi ebizwa ngokuthi i-NEURO-TTTransform.
Lolu cwaningo lubheke kakhulu:
1. Umuthi we-Wainua ulishintsha kanjani izinga leprotheyini ye-TTR egazini?
2. Lokhu kuzozithinta kanjani izimpawu ezihlobene nokulimala kwemizwa ezigulini ze-hATTR?
Basebenzise izindlela ezikhethekile zokulinganisa lokhu.
- Isilinganiso Sokukhubazeka Kwe-Neuropathy (NIS): Lolu uhlelo olukhethekile lokulinganisa. Lulinganisa amandla emisipha, ukusabela, kanye nomuzwa. Uma isilinganiso siphansi, isimo sezinzwa siba ngcono.
- Ikhwalithi Yokuphila (QOL-DN): Lokhu kulinganisa ukukhathala kwesiguli, ikhono lokwenza imisebenzi yansuku zonke, kanye nesimo sengqondo. Nalapha futhi, amaphuzu aphansi abonisa ikhwalithi engcono yokuphila.
Impumelelo yeWainua yaqinisekiswa ngokuqhathanisa imiphumela yalolu cwaningo nemiphumela yeziguli kolunye ucwaningo ezanikwa i-placebo engenawo umuthi.
| Indlela abahlanganyeli ocwaningweni abakhethwe ngayo | |
|---|---|
| Izindlela Zokufaka | Izindlela Zokungabandakanyi |
| - Iminyaka engu-18-82 - Abantu abanesigaba 1 (abahamba ngaphandle kosizo) noma isigaba 2 (abahamba ngosizo) abanomonakalo wezinzwa ngenxa ye-hATTR - Labo abanokuguqulwa okuqinisekisiwe ku-gene ye-TTR | - Abantu abanezinye izinhlobo ze-Amyloidosis - Abantu abanomonakalo wezinzwa ngenxa yezinye izimbangela ezifana nesifo sikashukela - Labo abake bafakelwa noma abazofakelwa isibindi - Abantu abathola ezinye izindlela zokwelapha ze-hATTR |
Yayiyini imiphumela eyinhloko yocwaningo?
Imiphumela yocwaningo yayikhuthaza kakhulu. Labo abathola ukwelashwa kweWainua amasonto angu-66 babe nemiphumela engcono kakhulu kunalabo abathola i-placebo.
- Amazinga eprotheyini ye-TTR eyingozi egazini labo ayenciphe kakhulu.
- Izimpawu ze-neurological (amaphuzu e-NIS) zalawulwa kakhulu.
- Futhi, izinga labo lokuphila lalithuthukile ngokusobala.
Yimiphi imiphumela emibi ye-Wainua nokuthi ungayiphatha kanjani?
Njenganoma yimuphi umuthi, i-Wainua ingabangela imiphumela emibi emincane. Evame kakhulu yile:
| Umphumela ongemuhle | Indlela yokuphatha |
|---|---|
| Amazinga e-vitamin A anciphile | Thatha isithasiselo sevithamini A njengoba nje udokotela wakho ekuyalele. Ungalokothi uthathe okungaphezu kwalokho udokotela wakho akuyalele kona. Uma ubona noma yiziphi izinguquko ekuboneni kwakho, njengokuncipha kokubona ebusuku noma amehlo omile, tshela udokotela wakho ngokushesha. |
| Ukuhlanza | Phuza amanzi amaningi kanye noketshezi. Gwema ukudla okunamafutha nokudla okunzima. Yidla kancane. Uma ukuhlanza kungapheli ngemva kwezinsuku ezimbalwa, khuluma nodokotela wakho nakanjani. |
Lena yimiphumela emibi eyinhloko. Ngaphezu kwalokho, khuluma nodokotela wakho nganoma yiziphi izimpawu ezikukhathazayo.
Wazi kanjani ukuthi ukwelashwa kuphumelele?
Udokotela wakho uzoqapha impilo yakho njalo. Lokhu kuzofaka phakathi ukuhlolwa kwegazi ukuhlola amazinga akho e-TTR. Bazohlola futhi ukubona ukuthi izimpawu zakho zezinzwa ziyathuthuka kangakanani. Ngokuhamba kwesikhathi, ungase uqale ukuqaphela ukuthuthuka emandleni emisipha yakho, ikhono lokwenza imisebenzi yansuku zonke, kanye nesimo sengqondo.
Into ebaluleke kakhulu ukuthi, ungayeki ukugoma nganoma yisiphi isizathu noma ushintshe isimiso sokugoma ngaphandle kweseluleko sikadokotela.
Ingabe zikhona izinkinga ngeminye imithi noma ukudla?
Ngokusho kocwaningo lwamanje, akukho ukusebenzisana okubi okutholiwe phakathi kweWainua neminye imithi noma ukudla. Kodwa-ke, ulwazi olusha lungase luvele esikhathini esizayo.
Ngakho-ke, ngaphambi kokuthi uqale lokhu kwelashwa nangesikhathi sakho, nikeza udokotela wakho incazelo ephelele yayo yonke eminye imithi, amavithamini, izithasiselo, kanye nemikhiqizo ye-Ayurvedic oyisebenzisayo. Lokhu kubaluleke kakhulu ekuphepheni kwakho.
Umlayezo Wokuya Nawe Ekhaya
- I-Wainua iyindlela entsha yokwelapha ngomuthi wokugomela yanyanga zonke evunyelwe isifo esingavamile sofuzo i-hATTR Amyloidosis.
- Lokhu kunciphisa ukukhiqizwa komzimba kweprotheni engavamile elimaza imizwa.
- Lokhu kusiza ukulawula umonakalo wezinzwa obangelwa yilesi sifo futhi kuthuthukise ikhwalithi yokuphila kweziguli.
- Njengoba ukwehla kwamazinga e-vitamin A kuyimbangela enkulu yemiphumela emibi, kubalulekile ukuthatha isithasiselo se-vitamin A esinikezwe udokotela wakho njengoba kunqunywe.
- Khuluma nodokotela wakho njalo ngaphambi kokuqala noma ukuyeka noma yikuphi ukwelashwa, futhi uma kuvela imiphumela emibi.
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