Ingabe ngezinye izikhathi uzizwa sengathi amathambo akho abuthakathaka kancane futhi abuthakathaka kunamanye? Ingabe uyawaphula amathambo akho ngisho nangentfo encane? Noma ingabe amazinyo omntwana wakho aphuma ngaphambi kwesikhathi? Namuhla sizokhuluma ngesimo esingakhulumi kakhulu ngaso, kodwa okubaluleke kakhulu ukusiqaphela. Lokhu kubizwa ngokuthi i-Hypophosphatasia, noma i-HPP ngamafuphi.
Iyini ngempela i-Hypophosphatasia (HPP)?
Kalula nje, i-Hypophosphatasia (HPP) yisimo esingavamile, esizuzwe njengefa (sezakhi zofuzo) esithinta indlela amathambo namazinyo ethu akhula ngayo. Ukuze amathambo ethu aqine futhi amazinyo ethu asisize sihlafune futhi sihlafune ukudla kahle, adinga amaminerali afana ne-calcium ne-phosphorus ukuze engezwe kuwo. Le nqubo ibizwa ngokuthi "i-mineralization".
Ku-HPP, le nqubo ebizwa ngokuthi 'ukwenziwa kwamaminerali' ayenzeki kahle. Ngenxa yalokho, amathambo namazinyo awaqini ngokwanele, kodwa athambile futhi aqhekeke kalula. Nakuba lesi simo singathinta abantu abambalwa kuphela , singaba yisimo esibi nesisongela ukuphila kwabanye.
Yini ebangela i-HPP?
Lokhu kuyindaba yesayensi kancane, kodwa masiyiqonde kalula. Cabanga ukuthi imizimba yethu ifana nefektri enkulu. Konke kufanele kube ngendlela efanele. Ukuze amathambo aqine, sidinga amaminerali i-calcium ne-phosphorus esikhulume ngawo ngaphambili.
Kodwa inqubo 'yokwenza amaminerali' ibe ningi kakhulu nayo ayilungile. Isibonelo, akukuhle ukuthi la maminerali aqongeleleke egazini. Ngakho-ke sinamakhemikhali emizimbeni yethu okulawula lokhu.
Kodwa amathambo namazinyo kudingeka abe nenani elifanele lala maminerali. Kukhona i-enzyme ekhethekile emzimbeni wethu esiza kulo msebenzi obalulekile. Ibizwa ngokuthi i-alkaline phosphatase (ALP) . Le enzyme ivala amakhemikhali asemathanjeni nasemazinyweni avimbela ukunqwabelana kwalawo maminerali. Bese amaminerali adingekayo eqongelela emathanjeni nasemazinyweni, okwenza aqine.
Abantu abane-HPP banoguquko ku-gene ebizwa ngokuthi i-'ALPL', evimbela i-enzyme ye-ALP ukuthi ikhiqizwe kahle. Lokhu kubangela amakhemikhali avimbela ukuqongelela kwamaminerali ukuthi aqongelele emathanjeni, okuvimbela amathambo ekumunceni i-calcium ne-phosphorus ayidingayo. Ngenxa yalokho, amathambo aba buthakathaka futhi abe buthakathaka esikhundleni sokuba aqine.
Ziyini izimpawu ze-HPP?
Izimpawu ze-HPP ziyahlukahluka kakhulu. Ziya ngokuthi ingakanani i-enzyme ye-ALP emzimbeni. Njengoba amazinga e-enzyme ehla, izimpawu zivame ukuba zimbi kakhulu. Lesi simo singavela nganoma yisiphi isikhathi kusukela ekuzalweni kuya ebudaleni.
Uma abanye abantu abadala betholakala bene-HPP, bayakhumbula ukuthi babenezimpawu ezifanayo kusukela ebuntwaneni, kodwa azizange zitholakale kahle ngaleso sikhathi.
Ake sibone ukuthi yiziphi izimpawu eziyinhloko.
| Isibonakaliso | Incazelo |
|---|---|
| Izinkinga zamazinyo | Ukulahlekelwa amazinyo omntwana ngaphambi kweminyaka emi-5 noma ukulahlekelwa amazinyo ngokungalindelekile kunoma yimuphi ubudala. (Lena yindlela evame kakhulu - ifomu elithi "odonto") |
| Izinguquko emathanjeni | Izingalo nemilenze egobile, ubude obufushane, amathambo athambile, abuthakathaka noma akhubazekile, izihlakala ezibanzi kanye namalunga eqakala. |
| Izinkinga zezingane | Ukwehluleka ukukhulisa noma ukukhula kahle, ukuhlangana kwamathambo ekhanda ngaphambi kwesikhathi (okungaholela ekucindezelekeni okukhulu ebuchosheni), ubuthakathaka bemisipha (i-hypotonia) okwenza izingane zibukeke 'zithambile', kanye nobunzima bokuphefumula. |
| Ukuphuka kwamathambo | Amathambo aphuka kalula esemncane, ikakhulukazi ezinyaweni nasemilenzeni, futhi athatha isikhathi eside ukuphola. |
| Ezinye izici | Ubuhlungu emathanjeni nasemalungeni, ubunzima bokuhamba, amazinga e-calcium akhuphukile egazini (kungabangela ukuhlanza, ukuqunjelwa, izinkinga zezinso), ukuquleka, isifo samathambo esibi kakhulu esingazelelwe. |
Ungasithola kanjani lesi sifo?
Uma wena noma ingane yakho ninalezi zimpawu, udokotela wakho uzobuza ngomlando wezokwelapha womndeni wakho futhi enze ukuhlolwa okuphelele ngokomzimba. Ngaphezu kwalokho, bazo-oda ama-X-ray kanye nokuhlolwa kwegazi.
Ukuhlolwa okubaluleke kakhulu lapha ukukala izinga le-enzyme ye-ALP egazini.Uma kwenzeka i-HPP, leli zinga livame ukuba phansi.
Ngezinye izikhathi, ukuhlolwa kofuzo kungenziwa ukuqinisekisa ukuthi une-HPP. Kodwa-ke, lokhu kuhlolwa akutholakali yonke indawo futhi kungabiza kakhulu. Kodwa-ke, ezimweni eziningi, udokotela wakho angaxilonga lesi sifo ngezinye izivivinyo.
Ngenxa yokuthi lesi yisifo esingavamile, ngezinye izikhathi kungathatha isikhathi ukuthola ukuxilongwa. Ngakho-ke uma wena noma ingane yakho ninalezi zimpawu, kubalulekile ukuba nolwazi oluphelele futhi nikhulume ngokukhululekile nodokotela wakho .
Yiziphi izindlela zokwelapha i-HPP?
Ngenhlanhla, manje sekukhona ukwelashwa kwe-HPP. Ku-HPP, ikakhulukazi labo abatholakale besebancane noma besebancane, kusetshenziswa umuthi obizwa ngokuthi i-asfotase alfa (Strensiq) . Lona umjovo onikezwa ngaphansi kwesikhumba. Usebenza ngokufaka esikhundleni se-enzyme ye-ALP engekho emzimbeni (ukwelashwa kokufaka esikhundleni se-enzyme).
Ngaphezu kwalokhu kwelashwa okuyinhloko, kwenziwa ezinye izinto eziningana ukulawula izimpawu.
- Ukunikeza imithi yobuhlungu (ama-NSAID) njenge-paracetamol noma i-ibuprofen ngenxa yobuhlungu bamathambo noma bamalunga.
- Uma ingcindezi ekhanda iphezulu, kufanele kwenziwe ukuhlinzwa ukuze incishiswe.
- Ukunikeza i-vitamin B6 ukulawula ukuxhuzula kwabanye abantu.
- Ukulawula ukudla noma imithi yokulawula amazinga e-calcium egazini.
- Njalo nakekela impilo yakho yamazinyo futhi ufune iseluleko samazinyo.
- Ukwelashwa ngokomzimba kuqinisa imisipha futhi kuthuthukisa ukunyakaza.
- Ukufaka izinduku zensimbi emathanjeni avame ukuphuka.
- Into eyodwa okufanele uyikhumbule ikakhulukazi ukuthi imithi yohlobo lwe-bisphosphonate, esetshenziselwa ukwelapha ezinye izifo zamathambo, njenge-osteoporosis, ingenza i-HPP ibe yimbi kakhulu. Ngakho-ke, kufanele igwenywe.
Lokhu kwelashwa kungabiza kakhulu, ngakho-ke kubalulekile ukukhuluma nodokotela wakho ngezinzuzo, izinkinga kanye nezindleko zokwelashwa.
Ukuthola ukwesekwa uma uhlala ne-HPP
Ukuphuka kwamathambo, ubuhlungu, nezinye izimpawu kungenza impilo yansuku zonke ibe nzima. Ukuphila nesifo esingavamile kusho ukuba nolwazi oluphelele ngesimo sakho nokuzikhulumela. Lokhu kungasebenza kuwe noma enganeni yakho.
Qonda futhi uhloniphe ukulinganiselwa kwakho ngokomzimba. Phumula uma kudingeka. Ukwelapha i-HPP ngokuvamile kudinga ithimba elinolwazi oluhlukahlukene. Lokhu kungafaka phakathi udokotela wezingane, udokotela ohlinzayo wamathambo, udokotela wamazinyo, kanye nodokotela wezokwelapha ngokomzimba.
Kunezinye izifo ezivamile ezinezimpawu ezifana neze-HPP, ngakho-ke uma ungaqiniseki ngokutholakala kwesifo kudokotela wakho, ungesabi ukuthola umbono wesibili komunye uchwepheshe.Kuyilungelo lakho.
Nakuba ukwelashwa kungathatha iminyaka, izimpawu zingalawulwa kakhulu ngokuhamba kwesikhathi.
Umlayezo Wokuya Nawe Ekhaya
- I-Hypophosphatasia (HPP) yisifo esingavamile, esidluliselwa ngofuzo esibuthakathaka amathambo namazinyo.
- Izimpawu zingahluka kakhulu kumuntu nomuntu, kusukela ekulahlekelweni kwamazinyo ngaphambi kwesikhathi ezinganeni ezincane kuya ekukhubazekeni okukhulu kwamathambo.
- Ukuhlolwa kwegazi ukuhlola amazinga aphansi e-enzyme ye-ALP egazini kubaluleke kakhulu ekuxilongweni.
- Njengamanje, kunezindlela zokwelapha ezisebenzayo ezilawula izimpawu, okuhlanganisa nokwelashwa kokufaka esikhundleni sama-enzyme.
- Uma wena noma ingane yakho ninalezi zimpawu, ningesabi futhi nikhulume nodokotela wakho ngokushesha. Ukuthola ukuxilongwa okufanele kanye nokwelashwa kubaluleke kakhulu.
💬 Comments (0)
Awekho amazwana athunyelwe okwamanje. Faka amazwana akho lapha okokuqala ngqa.
Engeza amazwana akho