Ingabe othile emndenini wakho, mhlawumbe umama wakho othandekayo, ubaba, noma umlingani wakho wokuphila, unesifo i-Alzheimer's? Khona-ke cishe uyazi kahle ukuthi kunzima futhi kubuhlungu kangakanani kuwo wonke umuntu emndenini. Akulula ukubuka lesi sifo lapho ulahlekelwa khona inkumbulo yakho usuku nosuku bese ukhohlwa ukuthi ungubani. Ngakho-ke lapho kufika izindaba mayelana nomuthi omusha walesi sifo, kuletha ithemba elikhulu nemibuzo eminingi engqondweni. "Ingabe lokhu kuyasebenza ngempela? Ingabe ikhona imiphumela emibi? Ubani ongakusebenzisa lokhu?" Kumelwe ukuba kunemibuzo eminingi engqondweni yakho. Ngakho ake sixoxe ngakho konke ngokucacile nangokulula namuhla.
Uyini lo muthi omusha okhulumayo?
Igama lalo muthi omusha yiLecanemab, futhi uzothengiswa ngaphansi kwegama elithi Leqembi. Okokuqala, into ebaluleke kakhulu okudingeka siyiqonde sonke ukuthi lokhu akulona ikhambi lesifo i-Alzheimer's. Kodwa-ke, kwenza okuthile okukhulu. Okusho ukuthi, kunciphisa ijubane lokuqhubeka kwalesi sifo ezigabeni zokuqala . Kalula nje, kubambezela ukuwohloka kwenkumbulo kanye nekhono lokucabanga lesiguli.
Lokhu kunikezwa njengokufakwa ngemithambo yegazi njalo emavikini amabili. Umuthi ufakwa kancane kancane emzimbeni, njengosawoti.
Lomuthi usebenza kanjani?
Cabanga nje, lapho sithola isifo i-Alzheimer's, into enamathelayo nefana nodoti iyanda phakathi kwamangqamuzana ethu obuchopho. Lokhu sikubiza ngokuthi i-amyloid. Le phrotheni ebizwa ngokuthi i-amyloid iyimbangela eyinhloko yokulimala kwamangqamuzana obuchopho nokulahlekelwa yinkumbulo. Ngakho-ke lokho okwenziwa yilesi sidakamizwa esisha ukuthi sihlasela le phrotheni ye-amyloid engafuneki ebuchosheni bese siyisusa. Ngamanye amazwi, lesi sidakamizwa sihlasela imbangela yesifo.
Lesi yisinyathelo esikhulu esiqhubekela phambili emkhakheni wethu wezokwelapha. Ngoba imithi eminingi ebilokhu ikhona isikhathi eside ikwazile ukulawula ezinye zezimpawu kuphela. Kodwa lo muthi uzama ukushintsha indlela isifo esiqhubeka ngayo.
Iyini imiphumela kanye nezingozi zalokhu?
Njenganoma yimuphi umuthi, lo unezinzuzo nezinkinga zawo. Kubalulekile ukuthi sizazi zombili.
Ucwaningo lukhombisile ukuthi iziguli ezithathe lo muthi izinyanga ezingu-18 zazinokwehla okungu-27% kwenkumbulo nekhono lokucabanga uma kuqhathaniswa neqembu le-placebo. Inani le-amyloid ebuchosheni nalo lehlisiwe kakhulu. Nakuba lokhu kungase kubonakale njengephesenti elincane, kuyinto enkulu ukuthi isiguli sisengabona abathandekayo baso futhi senze umsebenzi waso izinyanga ezimbalwa ezengeziwe.
Kodwa, siyazazi nezingozi.
Ingozi enkulu yalo muthi yisimo esibizwa ngokuthi i-ARIA (i-amyloid-related imaging abnormalities). Kalula nje, lokhu kungabangela ukuvuvukala okuncane noma ukuphuma kwegazi okuncane ebuchosheni.Kungenzeka. Ocwaningweni, lesi simo sibikwe kubantu abangaba ngu-14% abathathe umuthi. Kodwa-ke, kubantu abaningi, lokhu akubangeli izimpawu ezinkulu. Kodwa-ke, akuvamile ukuba kubi kakhulu.
Le ngozi iphezulu kakhulu ezigulini ezithatha imithi yokunciphisa igazi . Ngakho-ke, kubalulekile ukuthi isiguli sitshele udokotela ngayo yonke eminye imithi esiyithathayo ngaphambi kokuqala lo muthi.
Ngaphezu kwalokho, imiphumela emibi efana nomkhuhlane, izinhlungu zomzimba, isicanucanu, ukuhlanza, kanye nezinguquko ekucindezelweni kwegazi kungenzeka ngesikhathi somjovo.
| Ochwepheshe | Izingozi kanye Nezinkinga |
|---|---|
| Kunciphisa ukulahlekelwa yinkumbulo ezigabeni zokuqala zesifo. | Ingozi yokuvuvukala nokopha kobuchopho (ARIA). |
| Isusa amaprotheni e-amyloid ayingozi ebuchosheni. | Kumele ifakwe emthanjeni njalo emavikini amabili. |
| Kuletha ithemba elisha lokwelapha lesi sifo. | Kubiza kakhulu emhlabeni jikelele. |
| Kunika isiguli nomndeni isikhathi esengeziwe. | Imiphumela emibi efana nomkhuhlane kanye nesicanucanu ingase ivele. |
Ubani ngempela lo muthi ofanelekela lona?
Leli yiphuzu elibaluleke kakhulu. Lo muthi awufanele wonke umuntu one-Alzheimer's.
- Kuphela kweziguli ezisesigabeni sokuqala: Lo muthi usebenza kahle kakhulu ezigulini ezisesigabeni sokuqala salesi sifo, okusho ukuthi zisanda kuqala ukukhombisa izimpawu. Amathuba amancane okusebenza kahle ezigulini ezisesigabeni sokugcina salesi sifo, lapho lesi sifo sibi kakhulu.
- I-Amyloid kumele iqinisekiswe: Kuyadingeka ukuqinisekisa ukuthi isiguli sinama-amyloid deposits ebuchosheni ngokuhlolwa okukhethekile (i-PET scan noma i-lumbar puncture).
- Akuyona eyezinye izinhlobo ze-dementia: Lo muthi awufaneleki kwezinye izinhlobo zokulahlekelwa yinkumbulo, ngaphandle kwe-Alzheimer's (isb. i-vascular dementia).
Ngakho-ke, udokotela wezinzwa kuphela onganquma ukuthi lo muthi uyafaneleka yini esigulini.
Intengo nesimo eSri Lanka
Intengo yalo muthi iphakeme kakhulu. Izindleko zonyaka e-United States zingama-$26,500 (imali engaphezu kwezigidi ezingu-8 zaseSri Lanka). Kungathatha isikhathi ukuthi umuthi omusha, okhethekile nobizayo kangaka ubhaliswe ezweni lethu futhi utholakale ezigulini ezivamile. Futhi, ngenxa yentengo ephezulu, kungaba nzima cishe kuwo wonke umuntu ukuwuthola.
Nokho, leli yithemba elikhulu ngekusasa. Ngokuthuthuka kwesayensi, sithemba ukuthi ngolunye usuku, imithi enjalo izothuthukiswa kakhulu futhi ingabizi futhi itholakale kalula kuwo wonke umuntu.
Umlayezo Wokuya Nawe Ekhaya
- I-Lecanemab ayilona ikhambi lesifo i-Alzheimer's, kodwa iwumuthi onciphisa ukuqhubeka kwalesi sifo ezigabeni zokuqala .
- Lokhu kususa amaprotheni e-amyloid ayingozi ebuchosheni, kodwa futhi kunemiphumela emibi eyingozi njengokuvuvukala kobuchopho kanye nokopha kwegazi.
- Lo muthi awufanele wonke umuntu, ikakhulukazi ezigulini ezisesigabeni sokuqala salesi sifo futhi okuqinisekisiwe ukuthi zine-amyloid ebuchosheni.
- Lokhu kubiza kakhulu, futhi ukutholakala kwayo eSri Lanka okwamanje akukaqiniseki.
- Uma othile emndenini wakho enesifo i-Alzheimer's, bonana nodokotela wakho ukuze nixoxe nganoma yiziphi izindlela zokwelapha ezintsha noma izimo zezokwelapha. Ungenzi izinqumo ngokusekelwe kulokho okubonayo ku-inthanethi.
💬 Comments (0)
Awekho amazwana athunyelwe okwamanje. Faka amazwana akho lapha okokuqala ngqa.
Engeza amazwana akho