Ɛyɛ den sɛ wobɛka awerɛhow a wote bere a wuhu sɛ w’abusua muni anaa w’adamfo paa bi werɛ fi biribiara nkakrankakra na wɔn ankasa ntumi nyɛ da biara da nnwuma mpo no ho asɛm. Alzheimer yare yɛ tebea a ɛyɛ awerɛhow saa. Ɛde besi nnɛ no, nnuru a ɛhyɛ yare no ho sɛnkyerɛnne so nkutoo na ɛwɔ hɔ, nanso seesei wiase no reka ayaresa foforo a ɛde n’ani si nea ɛde yare yi ba so tẽẽ ho asɛm. Ɛnnɛ yɛreka anidasoɔ foforɔ yi ho asɛm, a ɛyɛ Anti-Amyloid therapy.
Sɛ yɛbɛka no tiawa a, dɛn ne saa Anti-Amyloid aduru yi?
Wɔ obi a ɔwɔ Alzheimer yare amemene mu no, protein bi a wɔfrɛ no `beta-amyloid` boaboa ano a ɛho nhia. Fa no sɛ anyinam ahoɔden a ɛfa anyinam ahoɔden hama bi mu, na ɛno ne sɛnea nsɛm fa ntini ahorow a ɛwɔ yɛn amemene mu no ntam. Saa `beta-amyloid` protein no boaboa ano na ɛyɛ `plaques` a ɛte sɛ nkannare wɔ saa ntini nkwammoaa yi ntam. Afei eyi sɛe nsɛm a ɛkɔ so no. Eyi ne ade titiriw a ɛma obi nkae ade na ontumi nsusuw nneɛma ho yiye.
Saa nnuru kuw foforo yi a wɔfrɛ no anti-amyloid no yɛ adwuma denam `beta-amyloid` ntini a aboaboa ano a woyi fi amemene no mu no so. Ɛno kyerɛ sɛ ɛtow hyɛ nea ɛde yare no ba no so sen sɛ ebesiw sɛnkyerɛnne ahorow no ano kɛkɛ. Anidaso no ne sɛ, sɛ woyi saa nsensanee yi fi hɔ a, amemene mu nkwammoaa betumi ayɛ adwuma yiye akyɛ.
Eyinom ka ayaresa ahorow bi a wɔfrɛ no `immunotherapy` ho ankasa. Sɛ yɛbɛka no pɛpɛɛpɛ a, wɔde nnuru yi ma sɛ antibody (monoclonal antibody) bi a wɔayɛ no titiriw wɔ aduruyɛdan mu. Sɛ saa nnuru a ɛko tia nyarewa yi hyɛn yɛn nipadua mu a, ehu saa `beta-amyloid` protein ahorow a epira no, ɛbata ho, na ɛsɛe.
Nnuru titiriw abien a ɛko tia amyloid a wɔapene so mprempren ne `donanemab (Kisunla)` ne `lecanemab-irmb (Leqembi)`. Aduru bi nso wɔ hɔ a wɔfrɛ no `aducanumab (Aduhelm),` nanso mprempren adwumakuw a ɛyɛɛ no ayi afi gua so.
Mɛyɛ dɛn anya saa ayaresa yi? So nsunsuanso bɔne bi wɔ hɔ?
Wɔnam nkyene aduru (IV infusion) so de saa aduru yi ma kɔ ntini bi mu. Eyi gye bɛyɛ dɔnhwerew biako. Wɔtaa de `Leqembi` ma adapɛn abien biara, na wɔtaa de `Kisunla` ma adapɛn anan biara. Wode dodow ketewaa bi na efi ase na wode nkakrankakra ma ɛkɔ soro kodu dodow a wo duruyɛfo akyerɛ wo no so.
Nanso ɛsɛ sɛ wuhu asiane a emu yɛ den sen biara a ɛde saa ayaresa yi ba no. Wɔfrɛ no `ARIA (Amyloid-Related Imaging Abnormalities)`.
Sɛ yɛbɛka no tiawa a, eyi betumi ama amemene no ahonhon kakra anaasɛ mogya atɔ ntini nketenkete bi wɔ amemene no mu. Ɛwom sɛ mpɛn pii no eyi ankasa siesie de, nanso ɛho hia sɛ yɛma yɛn ani si eyi so. Ɛno nti na ɛsɛ sɛ woyɛ amemene no MRI mfonini daa wɔ ayaresa yi nyinaa mu no.
| Nsunsuanso bɔne no su | Nkyerɛmu |
|---|---|
| ARIA (asiane kɛse) . | Amemene no a ɛho ahonhon anaa mogya ketewaa bi a ɛba amemene no mu. Eyi betumi ama obi ti ayɛ no yaw, ne ho ayɛ no yaw, ne ho ayɛ no yaw, adwene atu afra, na wahwɛ ade yiye. |
| Nneɛma afoforo a ɛde ba | - a ɛma obi ho yɛ no yaw - a wohwe ase - Ayamtuo |
| Adwene titiriw bi | Nyansahufo susuw sɛ saa ayaresa yi betumi ama asiane a ɛwɔ hɔ sɛ amemene mu mogya bɛtu no ayɛ kɛse sɛ wɔde ma obi a ɔnom nnuru a ɛma mogya tu a. Akyinnye biara nni ho sɛ ɛsɛ sɛ wo ne wo duruyɛfo kasa fa eyi ho. |
Aduru yi tu mpɔn dɛn ankasa?
Ɔfã a ɛyɛ anifere no ni. Nhwehwɛmu ada no adi sɛ saa nnuru yi tumi yi `beta-amyloid` a ɛwɔ amemene no mu no fi hɔ. Ɛno yɛ ade pa.
Nanso, adwene a ɛsonsonoe da so ara wɔ sɛnea ɔyarefo no nkae ne sɛnea otumi yɛ da biara da nnwuma no bɛtu mpɔn ankasa bere a wɔayi saa nsensanee no afi hɔ akyi no ho. Nhwehwɛmu ahorow bi ada no adi sɛ eyinom tumi ma yare no kɔ so brɛoo kakra. Ɛno nkyerɛ sɛ wɔasa yare no koraa, na mmom ɛma yare no brɛ ase na ansɛe.
Nyansahufo gye di sɛ sɛ wofi saa ayaresa yi ase wɔ yare no mfiase , ansa na amemene no asɛe kɛse a, wobetumi ahwɛ kwan sɛ nea ebefi mu aba kɛse.
Henanom na wobetumi anya saa ayaresa yi?
Eyi nyɛ ayaresa a wobetumi de ama Alzheimer ɔyarefo biara. Mprempren, wɔkamfo eyinom kyerɛ nnipa kakraa bi pɛ.
- Wɔ nnipa a yareɛ no mfitiaseɛ no fam: Ɛne sɛ, wɔn a wɔwɔ Alzheimer yareɛ a ɛfiri aseɛ ntɛm anaa wɔn a wɔwɔ tebea bi a wɔfrɛ no ‘adwene mu yareɛ a ɛnyɛ den’. Wonnya nnim sɛ ebia eyi so bɛba mfaso ama nnipa a yare a emu yɛ den kɛse no.
- Wɔn a wɔagye atom sɛ wɔwɔ amyloid plaques no fam no:Ansa na wo duruyɛfo bɛkyerɛw saa aduru yi ama wo no, ɛsɛ sɛ wohu sɛ ebia saa nsensanee yi wɔ w’amemene mu ankasa anaa. Ebia eyi bɛhwehwɛ sɛ wɔyɛ PET scan anaasɛ akyi berɛmo mu tap.
Henanom na wontumi nnya saa ayaresa yi?
Wɔnyɛɛ saa aduru yi ho nhwehwɛmu wɔ nnuruyɛ mu sɔhwɛ pii mu, enti ebia asiane wom sɛ wɔde saa aduru yi bɛma nnipa a wɔwɔ akwahosan ho haw ahorow a edidi so yi:
- Nnipa a wɔnom nnuru a ɛmma mogya ntumi nkɔ (gye aspirin).
- Wɔn a wɔadi kan anya komayare anaa akisikuru.
- Nnipa a mogya tu ho haw.
- Nnipa a wɔwɔ asaabo anaa mmerɛbo mu yare.
Ade foforo ne sɛ, saa ayaresa ahorow yi bo yɛ den yiye . Wɔ ɔman te sɛ Sri Lanka mu no, ebetumi ayɛ den ama nnipa pii sɛ wobenya eyinom. Eyinom ntaa mma saa mpo mprempren.
Nkrasɛm a Wɔde Kɔ Fie
- Anti-amyloid yɛ aduru foforɔ a ɛyi `beta-amyloid' plaques a ɛboaboa ano wɔ amemene no mu na ɛtumi de Alzheimer yareɛ ba.
- Eyi botae ne sɛ wɔbɛsa nea ɛde yare no ba titiriw mmom sen sɛ wɔbɛsa yare no ho sɛnkyerɛnne ahorow.
- Wobetumi de eyi ama ayarefo a yare no mfiase na wɔakyerɛ sɛ wɔwɔ amemene no mu nsensanee nkutoo.
- Esiane asiane a ɛwɔ hɔ sɛ amemene no bɛhohoro anaasɛ mogya atu wɔ ARIA mu nti, ɛho hia sɛ wɔde MRI mfonini hwɛ no daa bere a wɔreyɛ ayaresa no.
- Te ase sɛ saa ayaresa yi da so ara wɔ nhwehwɛmu fã, ne bo yɛ den yiye, na nnipa kakraa bi pɛ na wobetumi anya .
- Sɛ wo dɔfo bi wɔ Alzheimer yare ho sɛnkyerɛnne a, ade a eye sen biara a wobɛyɛ ne sɛ wo ne wo duruyɛfo bɛkasa afa nsɛm pii ne ayaresa a ɛfata wo ho.
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