So wote nka sɛ wo nipadua no fi wo mu reko atia wo? Ebetumi ayɛ Antisynthetase Syndrome!

So ɛtɔ mmere bi a wote nka sɛ biribi rehaw wo fi wo mu? Ebetumi aba sɛ wo nkwaa reyɛ wo yaw kɛkɛ, ɛyɛ den ma wo sɛ wobɛhome, anaasɛ worehu nsakrae nketenkete bi wɔ wo honam ani kɛkɛ. Mma eyinom ngu kɛkɛ sɛ biribi a ɛrekɔ so. Ɛtɔ da bi a, asɛm bi a ɛyɛ den kɛse wɔ wɔn akyi. Ɛnnɛ yɛbɛka tebea bi a ɛntaa nsi nanso wotumi di ho dwuma a wɔfrɛ no Antisynthetase Syndrome ho asɛm.

Dɛn ne Antisynthetase Syndrome? Sɛ yɛbɛka no tiawa a...

Antisynthetase Syndrome yɛ tebea a ɛntaa nsi koraa. Nea ɛkɔ so wɔ eyi mu ne sɛ ɔfe wɔ yɛn nipadua nyinaa mu, kyerɛ sɛ, tebea bi te sɛ ɔfe. Eyi yɛ yare a nipadua no tumi ko tia nyarewa ankasa. Seesei worebisa nea ɛyɛ yare a nipadua no tumi ko tia nyarewa.

Fa no sɛ, yɛn nipadua no wɔ nipadua no mu tumi a ɛko tia nyarewa . Ɛte sɛ asraafo dɔm a wɔbɔ yɛn man ho ban. Nkwammoaa ne akwaa a ɛwɔ nhyehyɛe yi mu no bɔ yɛn ho ban fi mmoawa, mmoawa, ne mmoawa a wɔde nyarewa ba ho. Nanso, wɔ yare bi a nipadua no tumi ko tia nyarewa mu no, saa ahobammɔ nhyehyɛe yi nkɔ yiye. Ɛsusu sɛ yɛn ankasa nkwammoaa ne ntini a ɛwɔ apɔwmuden no yɛ "atamfo" na efi ase tow hyɛ wɔn so. Ɛte sɛ yɛn ankasa asraafo a wɔreto ahyɛ yɛn ankasa afie so. Nnuruyɛfo mpo da so ara ntumi nhu nea enti a eyi ba ankasa.

Wɔ Antisynthetase Syndrome mu no, yɛn nipadua mu ahoɔden a ɛko tia nyarewa no betumi aka yɛn nipadua no mmeae a edidi so yi:

• Ntini ahorow
• Nkwaa a ɛwɔ nipadua no mu
• Ahrawa
• Wedeɛ
• Mogya ntini ahorow

Ade a ɛho hia paa ne sɛ wobɛkɔ oduruyɛfo nkyɛn sɛ wuhu sɛ wo nkwaa mu yaw foforo biara, wo honam ani sesa, anaasɛ ɛyɛ den sɛ wobɛhome a, wummu w’ani ngu so.

Saa yare yi ho yɛ na dɛn?

Eyi (Antisynthetase Syndrome) yɛ yare a ɛntaa nsi koraa . Ɛyɛ den sɛ yɛbɛka nnipa dodow pɔtee a wɔwɔ bi. Efisɛ nnipa kakraa bi pɛ na wɔbɔ amanneɛ afe biara. Ɛtɔ da bi a, saa nsɛnkyerɛnne yi te sɛ nyarewa afoforo ho sɛnkyerɛnne, na ebetumi akɔ so a obiara nhu.

Dɛn ne Antisynthetase Syndrome ho sɛnkyerɛnne ahorow?

Nsɛnkyerɛnne a wubenya no begyina sɛnea wo nipadua mu tumi a ɛko tia nyarewa no reyɛ adwuma yiye wɔ wo nipadua mu ne sɛnea ɛresɛe no kɛse no so.

Mpɛn pii no, nnipa a wɔwɔ Antisynthetase Syndrome no nya tebea afoforo pii ho sɛnkyerɛnne ahorow bom. Momma yɛnhwɛ nea wɔyɛ:

• Myositis: Eyi yɛ ntini a ɛyɛ hyew bere tenten. Eyi ma ntini mu yaw na ɛyɛ mmerɛw.Ɛba. Fa no sɛ, wote nka sɛ woayɛ mmerɛw araa ma wuntumi mma wo nsa mpo so. Ɛtɔ mmere bi a, ntini a ɛwɔ wo menewam no yɛ mmerɛw, na ɛma ɛyɛ den sɛ wobɛmene aduan ne anonne. Yɛfrɛ saa (dysphagia) .

• "Mechanic nsa": So eyi nyɛ din a ɛyɛ nwonwa kakra? Eyi ne baabi a nsateaa no nsateaa ne n’afã ho were no yɛ den na ɛpaapae. Ɛte sɛ mfiridwumayɛfo bi a ɔde srade ne ngo yɛ adwuma da mũ nyinaa nsa.

• Interstitial lung disease (ILD): Eyi ne bere a ntini a ɛda mframa kotoku nketenkete (alveoli) a ɛwɔ yɛn ahurututu mu ne mogya ntini a atwa ho ahyia no ntam no sɛe. Eyi betumi ama obi home ayɛ tiaa (ahome a ɛyɛ den) , ɔfe a ɛyɛ kusuu , ɔbrɛ , na ne koko ayɛ no yaw . Ɛte sɛ nea woahwe ase wɔ antweri bi so.

• Polyarthritis: Eyi ne bere a nkwaa anum anaa nea ɛboro saa nya bere koro mu. Eyi ma nkwaa no yɛ yaw, ɛyɛ den, na ɛho ahonhon . Ebia wobɛte nka sɛ wo ho yɛ den bere a wosɔre anɔpa no.

• Raynaud adeyɛ (Raynaud yare a ɛto so abien): Wɔ eyi mu no, nsateaa ano ne nansoaa no kɔla sesa (ɛdan kɔla, afei ɛyɛ bruu, afei ɛyɛ kɔkɔɔ) na ɛyɛ mmerɛw, titiriw bere a awɔw wom no. Ɛte sɛ nea wo nsateaa ayɛ mmerɛw bere a woayi nsukyenee afi frigye mu awie no.

• Atiridii: Nnipa binom tumi nya atiridii kɛkɛ a ɔyare mmoawa biara nni wɔn nipadua mu. Eyi kyerɛ sɛ nipadua no hyew kɔ soro esiane saa nipadua no mu tumi a ɛko tia nyarewa no dwumadi yi nti.

Dɛn na ɛde Antisynthetase Syndrome ba?

Wonnya nhuu nea ɛde yare yi ba ankasa . Nanso nnuruyɛfo ahu sɛ nnipa pii a wɔwɔ saa yare yi wɔ nnuru soronko bi a ɛko tia nyarewa wɔ wɔn mogya mu. Saa nnuru a ɛko tia nyarewa yi kyerɛ sɛ wɔn nipadua mu tumi a ɛko tia nyarewa no reto ahyɛ wɔn ankasa nipadua so mmom sen sɛ ɛbɛbɔ wɔn ho ban. Yɛfrɛ eyinom (autoantibodies) , a ɛkyerɛ "ankasa-antibody".

Afei, hwɛ, antibodies yɛ protein ahorow a ɛbɔ yɛn ho ban bere a biribi bɔne hyɛn yɛn nipadua mu no. Wɔte sɛ nnuru a ɛkyerɛ sɛnea yɛn nipadua no mu tumi a ɛko tia nyarewa no de di dwuma. Saa nnuru a ɛko tia nyarewa yi hyɛ ntuafo a wopira te sɛ mmoawa ne mmoawa agyirae sɛ "asiane." Nanso sɛ wowɔ yare bi a nipadua no tumi ko tia nyarewa a, wo nipadua no mu tumi a ɛko tia nyarewa no di mfomso yɛ nnuru a ɛko tia nyarewa a ɛtow hyɛ ntini a ɛte apɔw so na eyi fi mu.

Nnipa a wɔwɔ Antisynthetase Syndrome taa nya autoantibodies a ɛtow hyɛ enzyme ahorow a wɔfrɛ no tRNA synthetases so . Saa tRNA synthetases yi yɛ enzymes a ɛho hia na mfaso wɔ so a yɛn nipadua hia na ama ayɛ adwuma yiye.

Ɛda so ara yɛ ahintasɛm nea enti a yɛn nipadua mu ahoɔden a ɛko tia nyarewa no fi ase yɛ saa autoantibodies yi. Nanso, sɛ wowɔ adanse a ɛkyerɛ sɛ saa autoantibodies yi wɔ wo mogya mu a, ɛda adi kɛse sɛ wowɔ Antisynthetase Syndrome.

Ɛte sɛ eyi, fa no sɛ obi reto ogyaframa wɔ wo fie anim. Sɛ wohwɛ ade kyee anɔpa a, ogyaframa asinasin ne akwan a wɔahyew apete fam nyinaa. Ebia wunnim onii ko a wɔtow ogyaframa no, bere a wɔtow, anaa nea enti a wɔtow no ankasa. Nanso adanse wɔ hɔ a ɛkyerɛ sɛ ɛbaa saa. Wɔ Antisynthetase Syndrome mu no, sɛ́ anka dede a wote bere a woto ogyaframa na akraman no suro no, wunya sɛnkyerɛnne ahorow a yɛadi kan aka ho asɛm no.

Hena na ɔwɔ asiane kɛse sɛ obenya saa yare yi?

Obiara betumi anya Antisynthetase Syndrome. Nanso, ɛda adi sɛ mmea ne nnipa a wɔadi boro mfe 50 benya saa yare yi. Mmea betumi anya saa yare yi bɛyɛ mmɔho abien sen mmarima.

Ɔkwan bɛn so na wohu sɛ obi anya Antisynthetase Syndrome?

Oduruyɛfo gyina wo yare no ho sɛnkyerɛnne, wo nipadua mu nhwehwɛmu, ne nhwehwɛmu afoforo pii so hu yare yi.

Ebia ɛho behia sɛ wokɔ oduruyɛfo bi a ne ho akokwaw wɔ nyarewa a nipadua no tumi ko tia nyarewa mu, a wɔfrɛ no akisikuru ho ɔbenfo . Ɔbɛhwehwɛ wo mu na wabisa wo wo yareɛ no ho sɛnkyerɛnne. Ɛho behia sɛ woka nea wo yare no ho sɛnkyerɛnne te, bere a edi kan a wuhui, ne sɛ ebia biribi ma ɛyɛ kɛse kyerɛ oduruyɛfo no.

Bio nso, ɛho behia sɛ woyɛ nhwehwɛmu pii de si so dua sɛ wowɔ Antisynthetase Syndrome na woyi tebea afoforo a ebetumi de sɛnkyerɛnne a ɛte saa ara aba no afi hɔ.

Nhwehwɛmu bɛn na wɔde hu yare no?

Sɔhwɛ biako biara nni hɔ a ebetumi asi eyi so dua koraa. Mpɛn pii no eyi a wobehu no yɛ adeyɛ bi a wɔfrɛ no differential diagnosis no fã . Eyi kyerɛ sɛ wo duruyɛfo no bɛyɛ nhwehwɛmu pii de ahu nea ɛde wo sɛnkyerɛnne ahorow no ba, ayi tebea afoforo afi hɔ, na awiei koraa no wahu sɛ wowɔ Antisynthetase Syndrome. Sɔhwɛ ahorow a ebia wowɔ no bi ne:

• Mogya mu nhwehwɛmu: Sɛnea ɛbɛyɛ a wobɛhwɛ sɛnea wo nipadua mu tumi a ɛko tia nyarewa no reyɛ adwuma na woahu sɛ wowɔ autoantibodies, a ɛyɛ Antisynthetase Syndrome ho sɛnkyerɛnne. Mogya mu nhwehwɛmu nso betumi ahwɛ sɛ enzyme ahorow bi a ɛkɔ mogya no mu bere a ntini ahorow asɛe no dodow akɔ soro anaa.
• Nsuo mu nhwehwɛmu: Sɛ wɔbɛhwɛ sɛnea asaabo no yɛ adwuma na wɔahwɛ sɛ ɔyare mmoawa anaa ɔhaw afoforo bi wɔ nsu no mu a ebetumi de wo sɛnkyerɛnne ahorow no aba anaa.
• Ahurututu mu dwumadi ho nhwehwɛmu: Hwɛ sɛ ebia w’ahurututu anaa wo home nhyehyɛe no aka wo anaa.
• Computed tomography (CT) scan anaa mfoninitwa nhwehwɛmu afoforo: Twa ntini ne akwaa ahorow a ɛwɔ nipadua no mu no mfonini.
• (Electromyography - EMG) a wɔde yɛ adwuma:Hwɛ sɛnea ntini ahorow no yɛ adwuma.
• Magnetic resonance imaging (MRI) scan a wɔde hwɛ ntini a ɛka no: de hwɛ sɛ ɛyɛ ɔfe anaa.
• Biopsy yɛ sɔhwɛ a ɛfa ntini anaa ahurututu mu ntini ketewaa bi a wɔfa ho.

Ɔkwan bɛn so na wɔsa Antisynthetase Syndrome?

Aduru biara nni hɔ a wɔde sa Antisynthetase Syndrome. Nanso, wo duruyɛfo betumi aboa wo ma woanya ayaresa ahorow a wɔaka abom a ebetumi aboa ma woadi wo sɛnkyerɛnne ahorow no so, atew nkɛntɛnso a enya wɔ wo da biara da asetra so no so, na ama w’akwaa ahorow asɛe no kakraa bi.

Ayaresa ko a wuhia no begyina baabi a wo yare no ho sɛnkyerɛnne no wɔ ne sɛnea emu yɛ den no so. Ayaresa a wɔtaa de di dwuma no bi ni:

• Corticosteroids: Eyinom yɛ nnuru a wɔkyerɛw ma obi a ɛtew ɛyaw ne ɔfe so. Nnuruyɛfo taa kyerɛw nnuru a wɔfrɛ no corticosteroids ka nnuru a wɔfrɛ no immunosuppressants ho.
• Nnuru a ɛma nipadua no tumi ko tia nyarewa: Nnuru yi yɛ adwuma denam wo nipadua mu tumi a ɛko tia nyarewa a ɛma wogyae sɛ ɛbɛtow ahyɛ nkwammoaa ne ntini a ɛwɔ apɔwmuden so no so. Aduru ko a wuhia no begyina akwaa ahorow a ɛka wo no so. Nnuru a wɔtaa de siw nipadua no mu tumi a ɛko tia nyarewa ano ne methotrexate, azathioprine, ne mycophenolate . Ebia wubehia cyclophosphamide, rituximab, anaa tacrolimus nso .
• Ahurututu mu Yare a Ɛwɔ Interstitial Lung Disease (ILD) Ayaresa: Wobetumi ama wo nnuru a ɛbɛma ayɛ mmerɛw sɛ wobɛhome, anaasɛ oxygen ayaresa sɛ wuhia oxygen foforo a. Ɛho behia sɛ wo ne ahurututu ho oduruyɛfo yɛ adwuma na ama woadi wo home mu haw ahorow ho dwuma.
• Apɔw-mu-teɛteɛ: Apɔw-mu-teɛteɛ ho ɔbenfo betumi aboa wo ma wo nipadua no atu mpɔn. Wobetumi aboa ma woadi sɛnkyerɛnne ahorow a ɛfa ntini ahorow ho no ho dwuma anaasɛ wɔhyɛ nyansa sɛ fa ahomegye apɔw-mu-teɛteɛ ahyɛ w’ahurututu mu den. Ebia wubehia ahurututu mu ayaresa nso .

Sɛ mewɔ Antisynthetase Syndrome a, dɛn na ɛba?

Wo duruyɛfo betumi aboa wo ma woanya ayaresa ahorow a wɔaka abom a ebetumi adi wo sɛnkyerɛnne ahorow no so.

Antisynthetase Syndrome yɛ yare a enni sabea . Eyi kyerɛ sɛ ɛsɛ sɛ wudi sɛnkyerɛnne ahorow no ho dwuma bere tenten (ebia w’asetra nyinaa).

So (Antisynthetase Syndrome) no di awu?

Antisynthetase Syndrome ntaa nkum obi . Mpɛn pii no, ennya nnipa a wɔte saa yare yi nkwa nna so nkɛntɛnso kɛse. Nnipa pii de saa yare yi tra ase wɔn nkwa nna nyinaa, nanso wobetumi de ayaresa adi wɔn sɛnkyerɛnne ahorow no so.

Nanso, sɛ wowɔ ahurututu mu yare a emu yɛ den anaa ɔhaw foforo a ɛka wo home nhyehyɛe a, ebetumi akum wo. Nanso ɛntaa nsi koraa. Wo duruyɛfo bɛkyerɛ wo nea ɛsɛ sɛ wohwɛ kwan, ne sɛnkyerɛnne ahorow a ɛsakra a ebetumi ayɛ ɔhome mu nsɛnnennen a emu yɛ den ho sɛnkyerɛnne a edi kan.

So metumi asiw Antisynthetase Syndrome a menya no ano?

Ɔkwan biara nni hɔ a wɔbɛfa so asiw Antisynthetase Syndrome ano, efisɛ abenfo nnim nea ɛde ba anaa nea ɛma asiane no yɛ kɛse no ankasa.

Bere bɛn na ɛsɛ sɛ mekɔ oduruyɛfo nkyɛn?

Sɛ wunya sɛnkyerɛnne foforo, titiriw sɛ ɛyɛ kɛse a, kɔ oduruyɛfo nkyɛn . Sɛ wote nka sɛ wɔrentumi nni wo yare no ho sɛnkyerɛnne so yiye sɛnea na wɔyɛ wɔ w’ayaresa no ho, anaasɛ wo sɛnkyerɛnne no rema ayɛ den sɛ wobɛyɛ wo da biara da dwumadi ahorow a, wo ne wo duruyɛfo nkasa.

Bere bɛn na ɛsɛ sɛ mekɔ baabi a wɔhwɛ wɔn a egye ntɛmpɛ?

Sɛ wowɔ saa sɛnkyerɛnne yi bi a, kɔ baabi a wɔhwɛ wɔn a wɔwɔ yare a egye ntɛmpɛ ntɛm ara anaa frɛ 911 (anaa wo mpɔtam hɔ nɔma a egye ntɛmpɛ) :

• Ɔhome a ɛyɛ den mpofirim.
• Ahome tiaa a emu yɛ den (te nka sɛ wuntumi nhome).
• Kɔla a ɛyɛ bruu a ɛwɔ honam ani, anofafa, anaa nsateaa nnadewa (cyanosis).
• Koko mu yaw anaasɛ emu yɛ duru.

Nsɛm bɛn na ɛsɛ sɛ mibisa me duruyɛfo?

• So mewɔ Antisynthetase Syndrome anaa yare foforo a nipadua no tumi ko tia nyarewa?
• Sɔhwɛ ahorow bɛn na ɛsɛ sɛ meyɛ?
• Dɛn ne ayaresa a eye sen biara a mede bedi me yare no ho sɛnkyerɛnne ahorow so?
• So mehia apɔw-mu-teɛteɛ anaasɛ ɔhome a wɔbɛsan asiesie?
• Ɔkwan bɛn so na mewɔ asiane mu sɛ menya ahurututu mu nsɛnnennen a emu yɛ den?

Dɛn ne edin afoforo a wɔde frɛ Antisynthetase Syndrome?

Ɛtɔ mmere bi a nnuruyɛfo de din afoforo frɛ Antisynthetase Syndrome. Nhwɛsoɔ:

• (Antisynthetase a enni nipadua mu) .
• (AS syndrome) .
• (Anti-Jo1 yare no) .

Eyinom nyinaa yɛ din ahorow a wɔde frɛ tebea koro no ara.

Awiei koraa no, nea ɛsɛ sɛ wokae (Take-Home Message) .

Antisynthetase Syndrome yɛ tebea a ɛntaa nsi a wo nipadua mu tumi a ɛko tia nyarewa no tow hyɛ wo nipadua so sen sɛ ɛbɛbɔ wo ho ban. Wo ne wo duruyɛfo nkasa mfa ayaresa ahorow a ebetumi aboa ma nkɛntɛnso a wo sɛnkyerɛnne ahorow no nya wɔ wo da biara da asetra so no so atew ho.

Sɛ wo ne autoimmune yareɛ bɛtra ase a , ɛbɛtumi ayɛ abasamtuo kɛseɛ – ɛbɛtumi ate nka sɛ wo nipadua no resisi wo. Sɛ wuhia mmoa a wode bɛyɛ nsakrae wɔ nsakrae a aba w’asetra mu anaasɛ wubegyina tebea no ano a, bisa wo duruyɛfo akwan a wobɛfa so anya adwenemyare ho afotu. Awerɛhow ne adwenemhaw a wobɛte nka no yɛ ade a ɛfata, nanso ɛnsɛ sɛ wo nkutoo fa mu.

`Antisynthetase Syndrome, autoimmune yare, myositis, interstitial ahurututu mu yare, Raynaud adeyɛ, autoantibodies, nkwaa mu yaw, ntini mu mmerɛwyɛ