Dɛn ne calcitonin? Momma yensua ho ade kɛkɛ!

So woate asɛmfua calcitonin pɛn? Ebia wotee fii oduruyɛfo bi hɔ, anaasɛ ebia wokenkanee wɔ baabi. Eyi yɛ hormone titiriw bi a ɛwɔ yɛn nipadua mu ankasa. Nanso yebetumi aka nso sɛ ɛyɛ ahintasɛm mu hormone kakra. Momma yɛnhwɛ nea saa calcitonin yi yɛ ne nea ɛyɛ yɛn nipadua wɔ ɔkwan a ɛnyɛ den so.

Dɛn ne calcitonin? Ɛhe na efi?

Sɛ yɛbɛka no tiawa a, calcitonin yɛ hormone a yɛn thyroid ntini no yɛ. Wunim sɛ thyroid ntini no yɛ ntini ketewaa bi a ɛte sɛ ntontom a ɛwɔ yɛn kɔn anim, wɔ honam ani pɛɛ. Nkwammoaa soronko bi a ɛwɔ thyroid gland no mu, a wɔfrɛ no C-cells anaa parafollicular cells, na ɛyɛ saa calcitonin hormone yi na ɛma ɛkɔ yɛn mogya mu.

Nanso nea ɛyɛ nwonwa ne sɛ, nyansahufo da so ara nte dwumadi pɔtee a saa hormone yi, calcitonin, yɛ no ase yiye. Ɛne sɛ, yenim nea ɛyɛ, nanso yennim nea enti a yɛwɔ bi ankasa. Sɛ nneɛma bi a ɛnteɛ wɔ calcitonin dodow mu mpo a, ɛntaa mma yare no ho sɛnkyerɛnne atitiriw biara, anaasɛ ɛtɔ mmere bi a ɛnyɛ koraa.

Bere bi a atwam no, na nnuruyɛfo de calcitonin a wɔayɛ no foforo di dwuma de sa tebea horow bi. Sɛ nhwɛso no, sɛ wɔbɛsa tebea horow te sɛ Paget yare a ɛwɔ dompe mu, anaa hypercalcemia, tebea a ɛma calcium a ɛwɔ mogya mu dɔɔso dodo. Nanso seesei, esiane nnuru foforo, titiriw bisphosphonates, aba nti, wɔntaa mfa calcitonin nni dwuma sɛ aduru.

Dɛn na calcitonin yɛ yɛn nipadua?

Adwuma titiriw a hormone calcitonin yɛ ne sɛ ɛbɛma calcium dodow a ɛwɔ yɛn mogya mu no so atew. Kae sɛ eyi fa calcium a ɛwɔ mogya no mu ho, na ɛnyɛ calcium a ɛwɔ nnompe mu no. Ɛyɛ eyi wɔ akwan titiriw abien so:

1. Ɛma nkwammoaa a ɛsan twetwe nnompe no dwumadi gyae: Nkwammoaa bi a wɔfrɛ no osteoclasts wɔ yɛn nnompe mu. Saa nkwammoaa yi bubu yɛn nnompe mu na ɛde calcium no ka mogya no ho. Hormone a wɔfrɛ no calcitonin no ma nnompe mu nkwaadɔm yi gyae adwumayɛ bere tiaa bi. Eyi ma calcium dodow a wɔde ka mogya no ho no so tew.

2. Ɛtew calcium a ɛsan twetwe fi asaabo no mu kɔ mogya no mu no so: Wɔde nsu a yɛn asaabo yiyi no na ɛma calcium fi mu. Nanso, asaabo no san twe calcium bi kɔ mogya no mu. Hormone calcitonin brɛ calcium a ɛsan kɔ asaabo no mu kɔ mogya no mu no ase wɔ saa kwan yi so. Esiane eyi nti, calcium dodow a ɛwɔ mogya no mu no so tew.

Susuw ho saa kwan yi so: calcium dodow a ɛwɔ yɛn mogya mu no te sɛ nsu dodow a ɛwɔ nsukorabea mu. Calcitonin te sɛ obi a ɔboa ma saa nsu no so tew bere a ɛkɔ soro no.

Dɛn nti na yɛn thyroid no ma calcitonin ba?

Yɛn thyroid ntini no gyina calcium dodow a ɛwɔ yɛn mogya mu so na ɛyɛ calcitonin. Sɛ calcium dodow a ɛwɔ mogya no mu kɔ soro a, thyroid ntini no ma calcitonin pii ba. Saa ara na sɛ calcium dodow a ɛwɔ mogya mu no so tew a, calcitonin dodow a thyroid ntini no yɛ no nso so tew. Eyi te sɛ afiri a wɔde di dwuma ankasa.

Ɔkwan bɛn so na wobɛhwɛ sɛnea calcitonin dodow te? Dɛn nti na wɔyɛ sɔhwɛ yi?

Wo duruyɛfo betumi ayɛ wo mogya mu nhwehwɛmu de ahwɛ sɛnea calcitonin dɔɔso wɔ wo mu.

Nanso esiane sɛ calcitonin dodow a ɛnteɛ ntaa mma obi nnya yare no ho sɛnkyerɛnne atitiriw nti, mpɛn pii no nnuruyɛfo kra nhwehwɛmu yi esiane nneɛma pɔtee kakraa bi nti. Eyinom bi ne:

• Sɛnea ɛbɛyɛ a ɛbɛboa ma wɔahu tebea horow te sɛ Medullary Thyroid Cancer (MTC) anaa C-cell hyperplasia .
• Hwɛ sɛnea ayaresa a wɔde sa medullary thyroid cancer (MTC) no di yiye.
• Sɛ obi wɔ w’abusua mu wɔ yare bi a wɔfrɛ no Multiple Endocrine Neoplasia (MEN type 2) a .

Dɛn ne calcitonin dodow a ɛfata?

Mpɛn pii no, calcitonin dodow a ɛfata ne nea edidi so yi:

• Wɔ mmarima fam no: Ennu picogram 25 wɔ mililita biara mu (Ennu 25 pg/mL) .
• Wɔ mmea fam no: Ennu picogram 20 wɔ mililita biara mu (Ennu 20 pg/mL) .

Nanso ade biako a ɛsɛ sɛ yɛma ɛtra yɛn adwenem ne sɛ saa gyinapɛn ahorow a ɛfata yi betumi ayɛ soronko kakra wɔ lab biara mu. Enti, ɛsɛ sɛ wohwɛ gyinapɛn ahorow a ɛfata ma lab no bere nyinaa wɔ wo mogya amanneɛbɔ so.

Sɛ woyɛ calcitonin nhwehwɛmu a, wo duruyɛfo bɛkyerɛkyerɛ nea ebefi mu aba no mu akyerɛ wo na wakyerɛ wo sɛ ebia ɛho hia sɛ woyɛ nhwehwɛmu foforo anaa.

Sɛ calcitonin dodow kɔ soro a, dɛn na ɛba?

Ɛte sɛ nea calcitonin a ɛdɔɔso a yebenya no nni nkɛntɛnso bɔne kɛse biara wɔ yɛn nipadua so. Na ɛmfa sɛnkyerɛnne atitiriw biara mma. Nanso, calcitonin dodow a ɛkɔ soro no betumi ayɛ tebea abien a ɛntaa nsi koraa ho sɛnkyerɛnne. Dɛn ne wɔn?

1. Medullary Thyroid Cancer (MTC): Eyi yɛ kokoram a ɛntaa nsi a ɛba thyroid ntini no mu. Efi ase wɔ C-nkwaboaa a ɛma calcitonin no mu. Saa kokoram yi ma saa nkwammoaa yi yɛ calcitonin pii.

2. C-nkwaboaa a ɛdɔɔso dodo:Eyi nyɛ kokoram (a ɛnyɛ kokoram). Nanso nea ɛba wɔ eyi mu ne sɛ C-nkwaboaa no nyin wɔ ɔkwan a ɛnteɛ so. Saa ntini a ayɛ kɛse yi betumi ama calcitonin pii aba. Ɛtɔ mmere bi a, saa tebea yi a wɔfrɛ no C-cell hyperplasia no betumi adan akyiri yi abɛyɛ medullary thyroid cancer (MTC).

Sɛ wowɔ tebea horow yi mu biara ho sɛnkyerɛnne a, ebia wo duruyɛfo bɛkamfo akyerɛ sɛ wɔnyɛ calcitonin nhwehwɛmu.

Sɛ calcitonin dodow so tew a, dɛn na ɛba?

Ɛte sɛ nea calcitonin a ɛba fam no nnya yɛn nipadua so nkɛntɛnso kɛse. Nnipa a wɔayi wɔn thyroid koraa, na enti calcitonin dodow a wontumi nhu mpo nnya sɛnkyerɛnne biara a ɛfa wɔn mogya mu calcium dodow ho. Eyi ne ade a ɛyɛ nwonwa wɔ saa hormone yi ho.

Nsonsonoe bɛn na ɛda Parathyroid Hormone ne Calcitonin ntam?

Parathyroid Hormone (PTH) ne Calcitonin nyinaa boa ma yɛhwɛ calcium dodow a ɛwɔ yɛn mogya mu no so. Nanso, nsonsonoe no gyina sɛnea wɔyɛ adwuma ne sɛnea ɛka yɛn calcium dodow no so.

• Parathyroid hormone (PTH) ma calcium dodow a ɛwɔ yɛn mogya mu no yɛ kɛse. PTH nso boa ma yɛhwɛ phosphorus dodow a ɛwɔ yɛn mogya ne yɛn nnompe mu no so. Ɛsan nso ma vitamin D yɛ adwuma.
• Calcitonin ma calcium dodow a ɛwɔ yɛn mogya mu no so tew.

Nanso, nyansahufo gye di sɛ parathyroid hormone (PTH) di dwuma kɛse sen calcitonin wɔ calcium dodow a ɛwɔ yɛn mogya mu a ɛhwɛ so no mu. Eyi te saa titiriw efisɛ PTH dodow a ɛnteɛ betumi de tebea horow a emu yɛ den te sɛ hypercalcemia (mogya mu calcium a ɛdɔɔso) anaa hypocalcemia (mogya mu calcium a ɛba fam) aba. Nanso, calcitonin dodow a ɛnteɛ no nnya nipadua no so nkɛntɛnso kɛse.

So calcitonin ne calcitriol yɛ ade koro?

Dabi, calcitonin ne calcitriol yɛ nneɛma abien a ɛsono emu biara. Ɛwom sɛ hormone abien no nyinaa nya calcium dodow so nkɛntɛnso de, nanso ɛsono dwumadi ahorow.

• Calcitriol yɛ din foforo a wɔde frɛ vitamin D a ɛyɛ adwuma.Ɛma calcium dodow a ɛwɔ mogya mu no kɔ soro. Ɛyɛ dɛn na ɛyɛ saa? Ɛma calcium dodow a ebetumi akɔ yɛn dwensɔtwaa mu afi nnuan a yedi mu no yɛ kɛse. Afei saa calcium no hyɛn mogya no mu. Calcitriol nso mma asaabo no ntumi nhwere calcium. Parathyroid hormone (PTH) kanyan enzyme a ɛdannan vitamin D ma ɛbɛyɛ calcitriol no.
• Calcitonin yɛ adwuma denam calcium dodow a ɛwɔ mogya no mu a ɛtew so.

Enti, awiei koraa no, nneɛma a ɛsɛ sɛ yɛkae (Take-Home Message) .

Calcitonin yɛ hormone a ɛyɛ nwonwa na ɛyɛ ahintasɛm kakra.

• Sɛ́ ebia dodow no sua anaasɛ ɛkɔ soro no, ɛnyɛ nea ɛda adi sɛ ɛde nkɛntɛnso bɔne anaa sɛnkyerɛnne atitiriw biara bɛba.
• Nanso, calcitonin dodow a ɛkɔ soro no betumi ayɛ tebea bi te sɛ medullary thyroid cancer (MTC) anaa C-cell hyperplasia ho sɛnkyerɛnne.
• Sɛ wowɔ saa tebea horow yi ho sɛnkyerɛnne, anaasɛ wowɔ nsɛmmisa bi fa asiane a ɛwɔ hɔ sɛ wubenya bi ho a, hwɛ hu sɛ wo ne wo duruyɛfo bɛkasa. Wɔwɔ hɔ sɛ wɔbɛboa wo. Mma wo ho nnyɛ wo hu, ade a ɛho hia sen biara ne sɛ wobɛma biribiara mu ada hɔ.

Ate aseɛ? Mewɔ anidaso sɛ saa nsɛm yi ho bɛba wo mfaso.

` Calcitonin, Calcitonin, Ntini mu Ntini, Hormone, Calcium, Mogya mu Calcium, Medullary Thyroid Kokoram