So wo duruyɛfo akyerɛw Glasdegib (Daurismo) ama wo anaa obi a ɔwɔ w’abusua mu ama kokoram bi a wɔfrɛ no Acute Myelogenous Leukemia? Ɛyɛ aduru a tumi wom yiye a edin a ɛyɛ den wom. Enti, eyi yɛ ɔkwan a ɛyɛ mmerɛw na ɛyɛ adamfofa su a yɛbɛfa so aka saa aduru yi ho asɛm, sɛnea wɔde di dwuma, ne nea ɛsɛ sɛ yɛhwɛ yiye titiriw wɔ ho.
Aduru bɛn na Glasdegib yɛ?
Sɛ yɛbɛka no tiawa a, Glasdegib yɛ aduru a ɛde n’ani si kokoram nkwammoaa so na esiw wɔn nyin ano. Kokoram nkwammoaa a ɛwɔ yɛn nipadua mu no hia protein soronko na ama anyin. Nea aduru yi yɛ ne sɛ egyae saa protein ahorow no dwumadi. Saa kwan yi so no, sɛ kokoram nkwammoaa ntumi nnyin a, yenya mmoa kɛse de siw kokoram ano.
Wɔde saa aduru yi sa mogya mu kokoram bi a wɔfrɛ no acute myelogenous leukemia titiriw. Ɛtɔ da bi a, wo duruyɛfoɔ nso bɛtumi akyerɛw saa aduru yi ama tebea foforɔ. Wo duruyɛfo bɛkyerɛkyerɛ eyi mu akyerɛ wo kɔ akyiri.
Nneɛma a ɛho hia sen biara a ɛsɛ sɛ woka kyerɛ wo duruyɛfo ansa na woanom saa aduru yi
Esiane sɛ Glasdegib yɛ aduru a ano yɛ den yiye nti, ɛho hia yiye sɛ wobɛbɔ wo duruyɛfo amanneɛ wɔ aduruyɛ mu tebea foforo biara a wowɔ ho. Sɛ wowɔ tebea horow a ɛwɔ ase ha no bi a, ka ho asɛm kyerɛ wo duruyɛfo ansa na woafi aduru no ase.
- Sɛ wowɔ komayare a.
- Sɛ woadi kan anya koma a ɛbɔ a ɛnteɛ a.
- Sɛ wowɔ abakɔsɛm a ɛkyerɛ sɛ wowɔ nyarewa biara a ɛfa ntini ho a.
- Sɛ wowɔ asaabo mu yare a.
- Sɛ wowɔ mmerɛbo mu yare a.
- Sɛ electrolytes dodow a ɛwɔ mogya no mu (e.g. potassium, magnesium) sua dodo anaasɛ ɛkɔ soro dodo a.
- Sɛ wo ho ayɛ wo hyew wɔ Glasdegib, nnuru afoforo, nnuan, nnuru a wɔde yɛ nneɛma, anaa nneɛma a wɔde siesie nneɛma ho a.
- Sɛ woanyinsɛn, anaasɛ woreyɛ nhyehyɛe sɛ wobɛnyinsɛn nnansa yi ara a.
- Sɛ woyɛ ɛna a ɔma nufu a.
Saa nsɛm yi a wode besie wo duruyɛfo no betumi de w’akwahosan ato asiane mu a ɛho nhia, enti nsuro sɛ wobɛka biribiara ho asɛm pefee.
Ɔkwan bɛn so na wɔde aduru no bedi dwuma yiye?
Ɛho hia yiye sɛ wobɛnom aduru no sɛnea oduruyɛfo no akyerɛ no pɛpɛɛpɛ, wɔ dodow a ɛfata mu, wɔ bere a ɛfata mu.
- Fa nsu kuruwa mene saa tablet yi nyinaa. Mmu, nbubu, anaa nwe tablet no.
- Wubetumi de eyi aka aduan ho anaasɛ wunhia. Nanso nea ɛho hia sen biara ne sɛ wobɛfa no ɔkwan koro so da biara da.Sɛ nhwɛso no, sɛ wufi ase nom bere a woadidi awie a, fa no da biara da bere a woadidi awie no. Sɛ wufi ase nom ansa na woadi a, fa no da biara ansa na woadi.
- Mma nnnyae nnuru a wobɛnom mpofirim da a wunnya wo duruyɛfo afotu.
- Sɛ wode saa aduru yi rema mmofra a, wo ne mmofra oduruyɛfo nka ho asɛm na fa di dwuma sɛnea n’akwankyerɛ nkutoo kyerɛ.
- Sɛ wonom nnuru pii wɔ akwanhyia mu a: Sɛ wususuw sɛ woanom nnuru pii a, frɛ National Poisons Information Center a ɛwɔ Colombo National Hospital , ntɛm ara , anaa kɔ Emergency Treatment Unit (ETU) a ɛbɛn wo no nkyɛn.
Sɛ wopa dose bi a, dɛn na woyɛ?
Sɛ wo werɛ fi sɛ wobɛnom dose bi a, fa no bere a woakae ara pɛ. Nanso, sɛ ennu nnɔnhwerew 12 kosi wo dodow a edi hɔ a wobɛnom no so a, twa dodow a woayera no so na fa dodow a edi hɔ no wɔ bere a woahyɛ da ayɛ no mu. Mfa nnuru abien prɛko pɛ da.
Dɛn ne nneɛma a ɛko tia sɛ wɔmfa saa aduru yi nni dwuma?
Glasdegib tumi ne nnuru afoforo di nkitaho, enti ɛho hia sɛ woka nnuru a worenom nyinaa kyerɛ wo duruyɛfo.
Mfa nnuru yi nka Glasdegib ho:
- Cisapride na ɔkyerɛwee
- dronedarone a wɔde di dwuma
- fluconazole a wɔde di dwuma
- pimozide a wɔde yɛ aduru
- posaconazole a wɔde di dwuma
- saquinavir a wɔde di dwuma
- thioridazine a wɔde ma
Saa nnuru yi nso betumi ne Glasdegib adi nkitaho:
- Nnuru a wɔde ko tia HIV anaa AIDS
- Nnuru bi a wɔde sa fungal yare (e.g. itraconazole, ketoconazole) .
- Nnuru bi a ekum ɔyare mmoawa (e.g. clarithromycin) .
- Nnuru bi a wɔde sa akisikuru (e.g. carbamazepine, phenytoin) .
- Nnuru afoforo a ɛma koma bɔ ntɛmntɛm (ɛma QT ntam kwan kyɛ) .
- Nnuru a wɔde di dwuma wɔ amanne kwan so te sɛ St. John’s Wort
- Grapefruit nsu a wɔde yɛ
Saa list yi nwie pɛyɛ. Enti ma wo duruyɛfo no nkyerɛw nnuru, vitamin, nhabannuru, ne nnuru a wɔde ka aduan ho a wonom nyinaa ho kyerɛwtohɔ a edi mũ. Mma wo werɛ mmfi sɛ wobɛka akyerɛ wɔn sɛ wonom sigaret anaa wonom nsa a.
Nneɛma a ɛsɛ sɛ wohwɛ yiye wɔ ho titiriw bere a worenom Glasdegib no
- Mogya mu nhwehwɛmu: Ɛyɛ ahyɛde sɛ wobɛyɛ mogya mu nhwehwɛmu (mogya adwuma) sɛnea wo duruyɛfo akyerɛ wo bere a worenom aduru yi.
- Nyinsɛn: Ɛsɛ sɛ mmea kwati sɛ wobenyinsɛn bere a wɔrenom aduru yi ne anyɛ yiye koraa no nnafua 30 bere a wɔagyae aduru no akyi . Ɛsɛ sɛ mmarima nso kwati sɛ wɔbɛwo abofra bere a wɔrenom aduru yi ne anyɛ yiye koraa no nnafua 30 bere a wɔagyae aduru no akyi . Saa aduru yi betumi apira akokoaa a ɔhyɛ yafunu mu kɛse.
- Nufu a wɔde ma: Bere a wɔrenom aduru no ne anyɛ yiye koraa no nnafua 30 bere a wɔagyae no.Kwati sɛ wobɛma akokoaa no nufu.
- Nkwaboaa ne mogya a wɔde ma: Kwati sɛ wode mmadwoa anaa mogya bɛma bere a worenom aduru no ne anyɛ yiye koraa no nnafua 30 bere a woagyae no.
- Awo: Ebia aduru yi bɛka sɛnea wubetumi awo mma. Sɛ wowɔ eyi ho dadwen bi a, wo ne wo duruyɛfo nkasa.
Nsunsuanso bɔne a ebetumi aba esiane nnuru nti
Te sɛ aduru biara no, Glasdegib betumi anya nkɛntɛnso bɔne. Ebinom hwehwɛ sɛ wɔde wɔn adwene si so ntɛm, bere a afoforo nso abu so.
| Nsunsuanso bɔne | Nkyerɛmu |
|---|---|
| Nneɛma a ɛsɛ sɛ wobɔ wo duruyɛfo anaa Emergency Department (ETU) amanneɛ ntɛm ara | |
| Nneɛma a ɛma obi ho yɛ no hyew | Wora mu akisikuru, ɛyaw, anim, ano anaa tɛkrɛma a ɛho ahonhon. |
| Ɔhome a ɛyɛ den | Ɔhome a ɛyɛ den. |
| Nsɛnkyerɛnne a ɛkyerɛ sɛ obi anya ɔyare mmoawa | Atiridiinini, awɔw, menewam yaw, ano a ɛyɛ yaw. |
| Ntini mu yaw | Ntini mu yaw a emu yɛ den a wontumi nkyerɛkyerɛ mu. |
| Mogya a ɛtɔ a ɛnyɛ ne kwan so | Nsu a ɛyɛ tuntum anaa mogya wom; biribi a ɛte sɛ kɔfe a wɔayam a wɔfe; nsensanee kɔkɔɔ a ɛwɔ honam ani; mogya a ɛtɔ fi hwene, anom, anaa aniwa mu; honam ani akisikuru a ɛyɛ soronko. |
| Nsakrae a ɛba koma a ɛbɔ mu | Koko mu yaw, adwenemhaw, koma a ɛbɔ ntɛmntɛm anaasɛ ɛnteɛ, te nka sɛ watɔ piti, ɔtotɔ piti. |
| Ɔbrɛ a ɛyɛ soronko | Sɛ wote nka sɛ woayɛ mmerɛw kɛse, woayɛ mmerɛw anaasɛ woabrɛ. |
| Sɛ ɛkɔ so anaasɛ ɛhaw wo a, ka kyerɛ wo duruyɛfo. | |
| Nsakrae a ɛba wɔ dɛ mu | Aduan dɛ sesa. |
| Ayamtim | Ɛyɛ den sɛ wobɛfa nsu mu. |
| Abofono | Sɛ wote nka sɛ wobɛfe. |
| Rehono | Asen, anan, anaa nsa a ɛho ahonhon. |
| Ɔbrɛ a ɛba obiara so | Ɔbrɛ kakra a wɔte nka. |
Sɛ wunya sɛnkyerɛnne foforo biara a ɛyɛ soronko a wɔanka ho asɛm wɔ saa nsɛm yi mu a, yɛsrɛ sɛ ka ho asɛm nso kyerɛ wo duruyɛfo.
Nkrasɛm a Wɔde Kɔ Fie
- Bere nyinaa fa Glasdegib sɛnea wo duruyɛfo akyerɛ wo no pɛpɛɛpɛ, wɔ bere a ɛfata mu, ne dodow a ɛfata mu.
- Ansa na wubefi aduru no ase no, ka nnuru, vitamin, nnuru a wonom, ne ayaresa tebea biara a wowɔ nyinaa kyerɛ wo duruyɛfo.
- Kwati nyinsɛn, nufu a wobɛma, mogya a wode bɛma, ne mmadwoa a wode bɛma bere a worenom saa aduru yi ne nnafua 30 bere a woagyae no. Eyi fa mmea ne mmarima nyinaa ho.
- Sɛ nsunsuanso bɔne a emu yɛ den (sɛ nhwɛso no, ɛyɛ den sɛ wobɛhome, mogya a ɛtɔ soronko, wo koko mu yaw) ba a, kɔ oduruyɛfo nkyɛn ntɛm ara anaa kɔ Dwumadibea a Ɛhwɛ Ntɛmntɛm (ETU) nkyɛn.
- Wɔakyerɛw saa aduru yi ama wo nkutoo. Mfa biribiara nnkyɛ nkyerɛ afoforo.
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