So wunim yare yi a ɛka w’ahurututu ne w’asaabo nyinaa bere koro mu no ho asɛm? Momma yɛnka Goodpasture Syndrome ho asɛm!

So ɛtɔ mmere bi a wofefe a ɛkɔ so daa? So ɛtɔ mmere bi a saa ɔfe no ma mogya kakra ba? Anaasɛ wote nka sɛ worehyia ɔhaw wɔ ahomegye mu, anaasɛ woabrɛ ara kwa na wo nsu so atew? Eyinom betumi ayɛ biribi a anibere wom ho sɛnkyerɛnne. Ɛnnɛ yɛbɛka tebea biako a ɛntaa nsi a ɛte saa ho asɛm, nanso ɛsɛ sɛ wuhu.

Dɛn ne Goodpasture Syndrome?

Sɛ yɛbɛka no tiawa a, Goodpasture Syndrome yɛ yare a ɛntaa nsi nanso ebetumi de nkwa ato asiane mu a nipadua no tumi ko tia nyarewa . "Autoimmune" kyerɛ sɛ yɛn nipadua no ahobammɔ nhyehyɛe, nipadua mu ahoɔden a ɛko tia nyarewa no di mfomso fi ase tow hyɛ yɛn ankasa nkwammoaa ne ntini a ɛte apɔw so.

Wɔ saa yare yi mu no, yɛn nipadua mu tumi a ɛko tia nyarewa no tow hyɛ protein bi a wɔfrɛ no collagen so. Collagen te sɛ ade a wɔde si dan wɔ yɛn nipadua mu. Collagen boa ma yɛn honam ani, ntini, ntini, ntini, ne nnompe yɛ den.

Enti, sɛ wowɔ Goodpasture syndrome, protein ahorow bi a wo nipadua yɛ a, yɛfrɛ no antibodies, kɔ na ɛbata collagen a ɛwɔ w’ahurututu ne w’asaabo mu no ho. Sɛ eyi ba a, ɔfe fi ase wɔ saa mmeae no, na saa ntini no fi ase sɛe nkakrankakra. Sɛ wɔansa eyi a, ebetumi ama asaabo no ayɛ hyew kɛse (glomerulonephritis), na ebetumi ama asaabo no ayɛ adwuma yiye. Wubetumi nso afi ase ayɛ mogya pii afi ahurututu mu (ahurututu mu mogya a ɛtɔ). Mpɛn pii no, nea ɛde owu a yare yi ba titiriw ne mogya a efi ahurututu mu.

Edin foforo a wɔde frɛ eyi ne:

• Yare a ɛko tia glomerular basement membrane (a ɛko tia GBM).
• Goodpasture yareɛ

Eyi abu so dɛn?

Eyi yɛ yare a ɛntaa nsi koraa . Sɛnea nnuruyɛfo kyerɛ no, nnipa 100,000 biara mu biako kosi baanu pɛ na wonya yare yi afe biara. Enti wubetumi asusuw sɛnea ɛho yɛ na no ho.

Dɛn ne sɛnkyerɛnne ahorow no?

Goodpasture syndrome yɛ `(ahurututu-adwene)` tebea. Eyi kyerɛ sɛ ɛka ahurututu ne asaabo no nyinaa bere koro mu. Mpɛn pii no, sɛnkyerɛnne ahorow a edi kan a ɛda adi no fa ahurututu no ho. Eyinom ne:

• Ɔhome a ɛyɛ den (dyspnea): Ɛnyɛ bere a woreforo antweri nko, na mmom bere a woagye w’ahome mpo.
• Koko mu yaw : Koko mu yaw bere a ɔrehome anaa ɔrefefe.
• Ɔfe : Ɔfe a ɛkɔ so daa, ɛtɔ mmere bi a ɛyɛ yaw.
• Dede bi fi koko mu bere a wɔrehome no : Ebetumi ayɛ nnyigyei a ɛyɛ hu, te sɛ nea biribi akɔhyɛ koko no mu.
• Mete nka sɛ mabrɛ paa.`(ɔbrɛ)`: Nkate a ɛma woyɛ mmerɛw araa ma wuntumi nyɛ hwee.
• Mogya a ɛba hwene mu (epistaxis).
• Mogya a wɔfe : Eyi yɛ sɛnkyerɛnne a ɛma nnipa pii suro na ɛhwehwɛ sɛ wɔde wɔn kɔ ayaresabea ntɛm ara.
• Pallor : Wora no dan fitaa esiane mogya a enni mu nti.

Nsɛnkyerɛnne a ɛfa asaabo ho nso betumi ada adi akyiri yi. Nea ɛka ho ne:

• Mogya mu nkwammoaa kɔkɔɔ a ɛwɔ mogya no mu a ɛso tew, kyerɛ sɛ mogya a ɛtɔ kɔ nipadua mu .
• Mogya a ɛwɔ nsu mu (hematuria): Nsu no betumi ayɛ kɔkɔɔ anaa bruu tuntum.
• Nsu a ɛba kakraa bi sen sɛnea ɛtaa ba.
• Mogya mmoroso .
• Akisikuru ne ɔfe : Eyi nso betumi aba bere a aduan ho akɔnnɔ a ɛyera no.

Dɛn na ɛde eyi ba?

Goodpasture syndrome ba bere a nipadua mu nkwammoaa a ɛko tia nyarewa a yɛn nipadua no mu tumi a ɛko tia nyarewa no yɛ no tow hyɛ collagen a ɛwɔ glomerular basement membrane (GBM) a ɛwɔ asaabo no mu no so no. Saa GBM yi yɛ glomeruli, mogya mu nneɛma nketenkete a ɛwɔ yɛn asaabo mu no fã. Saa nnuru a ɛko tia nyarewa yi nso tow hyɛ collagen a ɛwɔ mframa kotoku a ɛwɔ ahurututu no mu no so. Eyi ma ahurututu mu ntini no sɛe, na ɛma mogya tu na ɛma ɛyɛ den sɛ wɔbɛhome.

Wonnya nhuu nea enti a nipadua no mu tumi a ɛko tia nyarewa no tow hyɛ n’ankasa collagen so no ankasa. Ebetumi aba sɛ nneɛma a atwa yɛn ho ahyia ne yɛn awosu mu nkwaadɔm betumi aka tebea no ho. Nhwehwɛmu ahorow ada no adi sɛ nnipa a wɔwɔ yare no ne awosu mu agyiraehyɛde bi a wɔfrɛ no Human Leukocyte Antigen (HLA) DR15 wɔ abusuabɔ a emu yɛ den. Eyi yɛ protein a ɛboa nipadua no mu tumi a ɛko tia nyarewa no ma yehu nsonsonoe a ɛda yɛn ankasa ntini ne nneɛma a ɛyɛ ahɔho ntam.

Ɛtɔ da bi a, saa yareɛ yi tumi pue wɔ ɔyareɛ bi te sɛ atiridiinini anaa atiridiinini akyi. Afei nso, wo:

• Sɛ wonom sigaret a .
• Sɛ wohome nnubɔne te sɛ cocaine a .
• Asiane a ɛwɔ hɔ sɛ wubenya saa yare yi no yɛ kɛse sɛ wode dade mfutuma anaa hydrocarbon nnuru te sɛ methane ne propane di dwuma a.

Hena na eyi reka no kɛse?

Goodpasture syndrome betumi aba wɔ mfe biara mu, nanso ɛtaa ba mmerante ne mmabaa mu, a wɔadi fi mfe du kosi aduasa, na afei ɛsan ba nnipa a wɔadi mfe 60 ne 70 mu.

Ɔkwan bɛn so na wohu yare no?

Sɛ wokɔ oduruyɛfo nkyɛn a, wobebisa wo yare no ho sɛnkyerɛnne na wɔayɛ wo nipadua mu nhwehwɛmu. Nea ɛka ho no, wobetumi ayɛ nhwehwɛmu ahorow a edidi so yi nso de asi Goodpasture syndrome so dua:

• Mogya mu nhwehwɛmu : Eyinom hwɛ wo glomerular filtration rate (eGFR) a wɔasusuw sɛ ɛyɛ adwuma, a ɛkyerɛ sɛnea w’asaabo reyɛ adwuma yiye no.
• Nsu mu nhwehwɛmuNsu mu nhwehwɛmu: Eyi hwɛ sɛ mogya wɔ wo nsu mu anaa protein dodow a ɛkɔ soro (proteinuria).
• Mfoniniyɛ mu nhwehwɛmu : Wɔyɛ koko mu X-ray anaa CT scan de hwɛ sɛ ahurututu mu asɛe anaa.
• Bronchoscopy : Wɔ saa adeyɛ yi mu no, oduruyɛfo de afiri a ɛyɛ tratraa tenten (bronchoscope) a mfoninitwa afiri ne kanea fa wo hwene anaa w’ano abata ho hyɛ mu de hwɛ sɛ w’ahurututu mu asɛe anaa.
• Asaabo mu nhwehwɛmu : Wɔ eyi mu no, woyi ntini ketewaa bi fi asaabo no mu na wɔde afiri a wɔde hwɛ nneɛma nketenkete hwehwɛ mu de hwɛ sɛ asaabo mu yare wɔ hɔ anaa.

So wobetumi asa Goodpasture yare no?

Yiw, sɛ wohu yare no yiye na wofi ayaresa ase ntɛm a, wobetumi asa eyi.

Ɔkwan bɛn so na wɔsa?

Goodpasture syndrome no ayaresa gu ahorow gyina sɛnea tebea no mu yɛ den so. Sɛ tebea no mu nyɛ den dodo a, nnuruyɛfo betumi akyerɛw nnuru te sɛ:

• Corticosteroids : Sɛ nhwɛso no, nnuru te sɛ prednisone. Eyinom boa ma mogya a ɛtɔ wɔ ahurututu mu no gyae.
• Nnuru a ɛma nipadua no tumi ko tia nyarewa : Nnuru te sɛ cyclophosphamide. Eyinom ma wo nipadua mu tumi a ɛko tia nyarewa no ntumi ntow nhyɛ n’ankasa ntini so.
• Nnuru a ɛma mogya mmoroso so tew (aduru a ɛko tia mogya mmoroso): Eyinom boa ma wɔhwɛ mogya mmoroso so na ɛtew asaabo a ɛsɛe no so.

Nea ɛka ho no, nnuruyɛfo nso de aduru bi a wɔfrɛ no plasmapheresis di dwuma. Nea ɛka eyi ho ne sɛ wubegye mogya afi ntini bi a ɛwɔ wo nsa mu mu afa ade mu, na atew mogya no fã a ɛyɛ nsu a wɔfrɛ no plasma no afi mogya mu nkwammoaa no ho. Nnuru a epira a ɛko tia GBM no wɔ plasma yi mu. Afei woyi plasma no, na wɔsan de mogya a efi obi a ɔwɔ apɔwmuden mu ka wo mogya nkwammoaa mu na wɔsan de ma wo. Sɛ yɛbɛka no tiawa a, eyi nnuru a epira a ɛko tia nyarewa no fi wo nipadua mu.

Bere tenten ahe na egye na obi ho atɔ no wɔ ayaresa akyi?

Ɛho behia sɛ wonom nnuru a ɛma nipadua no tumi ko tia nyarewa bɛyɛ asram 6 kosi 12. Mpɛn pii no, ebia ɛsɛ sɛ woyɛ plasmapheresis da biara da adapɛn pii.

Dɛn na ɛbɛba akyi?

Sɛ wɔansa Goodpasture yare no yare a, ebetumi ama mogya atɔ ahurututu mu a ɛde ne nkwa to asiane mu na asaabo no ayɛ adwuma yiye. Nanso, sɛ wohu yare no ntɛm na wofi ase sa yare a, mpɛn pii no nea efi mu ba no ye. Wo nipadua no yɛ saa antibodies a epira no bere tiaa bi pɛ – efi adapɛn kakraa bi kosi bɛyɛ mfe abien. Nneɛma a ɛsan ba bio anaasɛ ɛsan ba bio no ntaa mma koraa.

Eyi mu ɔhaw a emu yɛ den sen biara ne asaabo a entumi nyɛ adwuma yiye. Sɛ ɛba saa a, ɛho hia sɛ wɔde dialysis sa yare na ama wɔatumi ayi mogya no mu.Ɛho hia sɛ wɔde asaabo foforo ma.

Dɛn na mewɔ ka fa me nkwa nna ho?

Nnipa a wɔwɔ Goodpasture syndrome no mu bɛyɛ 80% wɔ mfeɛ anum nkwa nna yɛ 80%. Ɛno ne sɛ wohu yare no ntɛm na wɔsa no yiye a.

So wobetumi asiw eyi ano?

Ebia ɛrentumi nyɛ yiye sɛ wobesiw ano koraa. Nanso, wubetumi atew asiane a ɛwɔ hɔ no so denam nneɛma bi a wobɛkwati so:

• Hydrocarbons, a ɛkyerɛ nneɛma te sɛ methane, propane, pɛtro, kerosene, ne tar.
• Dade a wɔde yɛ mfutuma.
• Cocaine a wɔde di dwuma.
• Nneɛma a wɔde yɛ ti nhwi kɔla.

Mɛyɛ dɛn ahwɛ me ho?

Sɛ wowɔ Goodpasture syndrome a, ɛyɛ papa sɛ wobɛyɛ saa nneɛma yi:

• Gyae sigaretnom koraa. Kwati sɛ wobɛkɔ mmeae a nnipa afoforo nom sigaret (i.e. kwati sɛ wobɛda `wusiw a ɛto so abien` mu).
• Anyɛ yiye koraa no, fa wo ho hyɛ apɔw-mu-teɛteɛ mu simma 30 da biara.
• Bɔ mmɔden sɛ wobɛtew adwennwen so .

Bere bɛn na ɛsɛ sɛ mekɔ oduruyɛfo nkyɛn?

Sɛ wofe mogya, ɛyɛ den ma wo sɛ wobɛhome, wo ho so atew, anaasɛ wowɔ sɛnkyerɛnne afoforo a yɛabobɔ din wɔ atifi hɔ no bi a, kɔ oduruyɛfo nkyɛn ntɛm ara. Sɛ wuhu ntɛm a, ɛma hokwan a wowɔ sɛ wo ho bɛtɔ wo no yɛ kɛse. Sɛ wɔansa a, ebetumi ama asaabo asɛe daa na ahurututu mu haw a edi awu mpo aba.

Nsɛm bɛn na ɛsɛ sɛ wubisa oduruyɛfo no?

Sɛ wokɔ oduruyɛfo nkyɛn a, wubetumi abisa nsɛm yi:

• Mɛyɛ dɛn ahu sɛ mewɔ Goodpasture Syndrome anaa?
• Me tebea no mu yɛ den dɛn?
• Ayaresa ahorow bɛn na wokamfo kyerɛ?
• Dɛn na metumi ayɛ de ahwɛ m’asaabo so?
• So ɛsɛ sɛ mekɔ nephrologist anaa ahurututu ho oduruyɛfo nkyɛn?
• So wubetumi aka kuw bi a wɔboa a wɔboa nnipa a wɔwɔ yare yi ho asɛm akyerɛ me?

Dɛn ne nneɛma atitiriw abiɛsa (Triad) a ɛwɔ Goodpasture syndrome mu?

Wɔ aduruyɛ mu no, ``triad'' kyerɛ sɛnkyerɛnne atitiriw abiɛsa a ɛkyerɛkyerɛ aduruyɛ tebea bi mu. Goodpasture Syndrome ho sɛnkyerɛnne atitiriw abiɛsa ne:

• Mogya a ɛtɔ fi ahurututu mu.
• Asaabo mu ɔfe a ɛkɔ soro ntɛmntɛm.
• Saa nnuru a ɛko tia nyarewa a wɔfrɛ no ``anti-GBM antibodies'' a ɛwɔ nipadua no mu.

Sɛ obi nya saa yare yi a, ebetumi ahaw wo na wayɛ ankonam ankasa, titiriw esiane sɛ wonnya nnim nea ɛde ba ankasa nti. Ebetumi asiw wo da biara da dwumadi ahorow kwan, na sɛ wode dade powder, pɛtro, anaa tar yɛ adwuma a, ebia ebehia mpo sɛ wosakra adwuma.

Awiei koraa no, nea ɛsɛ sɛ yɛkae

Enti, Goodpasture Syndrome yɛ biribi a ɛsɛ sɛ wusuro, nanso sɛ wuhu sɛnkyerɛnne ahorow no ntɛm, kɔ oduruyɛfo nkyɛn ntɛm, na wufi ase sa yare a, wubetumi anya nea eye paa. Hwɛ nsakrae a ɛba wo nipadua mu no yiye. Sɛ wote nka sɛ biribi yɛ nwonwa a, ɛho hia sɛ wohwehwɛ aduruyɛ mu afotu a wommu no sɛ biribi ketewaa bi. Ɛnyɛ wo nko ara, na nnuruyɛfo betumi aboa wo.

` Goodpasture syndrome, Anti-GBM yare, ahurututu mu mogyatɔw, asaabo mu yare, autoimmune nyarewa, ɔhome a ɛyɛ den, mogya a ɛwɔ nsu mu