Nea ɛsɛ sɛ wuhu fa aduru a aba foforo a wɔde siw srade ano (PCSK9 Inhibitors) ho .

So wo nso worepere wɔ srade a ɛwɔ mogya mu ho ? Ebia worenom aduru a wo duruyɛfo akyerɛw ama wo no, woredi w’aduan so , na woreyɛ apɔw-mu-teɛteɛ. Nanso ɛda so ara yɛ den sɛ wobɛtew wo srade dodow so, ɛnte saa? Ɛtɔ mmere bi a, ɛmfa ho mmɔden biara a wobɛbɔ no, srade bɔne a ɛwɔ wo nipadua mu no betumi akɔ so ayɛ kɛse. Wɔ asɛm yi mu no, yɛrebɛka nnubɔne kuw foforo koraa a ebetumi aboa nnipa a wɔte saa ho asɛm.

Sɛ yɛbɛka no tiawa a, dɛn ne saa PCSK9 Inhibitors yi?

Ebia eyi bɛyɛ te sɛ edin a ɛyɛ den, nanso ɛyɛ adwuma tiawa koraa. PCSK9 inhibitors yɛ nnuru kuw bi a ɛtew mogya mu srade so. Ne titiriw no, wɔde wɔn ani si LDL (Low-Density Lipoprotein) srade , a ɛyɛ “srade bɔne” a epira yɛn nipadua no so. Nnipa binom srade dɔɔso wɔ wɔn nkwa nna nyinaa mu. Wɔ saa nkurɔfo no fam no, saa aduru yi betumi aboa kɛse.

Okay, afei momma yɛnhwɛ nea edin `PCSK9` no kyerɛ. `PCSK9` yɛ protein soronko bi a yɛn mmerɛbo no yɛ. Saa protein yi din ne `proprotein convertase subtilisin/kexin type 9`. Nea ɛyɛ ne sɛ ɛhwɛ nneɛma a wɔfrɛ no `LDL receptors` so wɔ yɛn nipadua mu. Aduruyɛ mu nhwehwɛmu ahorow ada no adi sɛ sɛ obi nipadua fi awosu mu yɛ `PCSK9` protein pii a, ɛda adi sɛ saa onipa no benya srade pii .

Henanom na wohia saa aduru yi?

Eyi yɛ asɛmmisa a ɛho hia paa. Efisɛ wɔmfa saa aduru yi mma obiara a srade dɔɔso wom. Mpɛn pii no tebea atitiriw abien na ɛwɔ hɔ a wo duruyɛfo betumi akyerɛw saa `PCSK9 inhibitor` aduru yi:

1. Sɛ nnuru afoforo ntumi nsiw srade so: Sɛ wode nnuru afoforo a ɛtew srade so te sɛ `(statins),` redi dwuma dedaw nanso wo srade dodow da so ara dɔɔso a, wubetumi abu saa aduru yi sɛ anammɔn a edi hɔ.

2. Wɔ awosu mu tebea horow bi mu: Nnipa binom wɔ awosu mu tebea bi a wonya fi awo mu a srade dɔɔso wom. Wɔfrɛ eyi ``abusua mu srade a ɛboro so`` wɔ aduruyɛ ho nyansahu mu.Saa aduru yi nso boa nnipa a wɔwɔ saa tebea yi kɛse.

Ɔkwan bɛn so na saa aduru yi yɛ adwuma wɔ nipadua no mu?

Sɛ yɛbɛte eyi ase a, momma yɛmfa nhwɛso ketewaa bi.

Fa no sɛ wo nipadua wɔ “nsa a ɛkyere srade.” Yɛfrɛ eyinom “LDL agyefo.” Saa “nneɛma a wogye” yi dodow no ara wɔ yɛn mmerɛbo mu nkwammoaa no ani. Saa “nsa” yi kyere srade bɔne a ɛsensɛn mogya no mu (LDL srade) no na ɛde kɔ mmerɛbo no mu. Afei mmerɛbo no bubu saa srade no mu na eyi fi nipadua no mu. Eyi yɛ adeyɛ a ɛyɛ daa.

Nanso ɔbɔnefo ketewaa bi wɔ ha. Ɛno ne `(PCSK9)` protein a yɛadi kan aka ho asɛm no. Saa `PCSK9` protein yi yɛ adwuma te sɛ `scissors`. Nea ɛyɛ ne sɛ ɛsɛe saa nsa a ɛkyere srade no, kyerɛ sɛ, `LDL receptors`, na ɛtew wɔn dwumadi so. Sɛ `PCSK9` protein no kɔ soro wɔ nipadua no mu a, `nsa` dodow a ɛkyere srade no so tew. Afei srade bɔne a ɛwɔ mogya no mu no, mmerɛbo no ntumi nyi mfi hɔ na ɛboaboa ano wɔ mogya no mu.

Afei ebia wobɛte nea `PCSK9 inhibitor` aduru no yɛ ase. Sɛ yɛbɛka no pɛpɛɛpɛ a, saa aduru yi siw `PCSK9` protein a ɛyɛ adwuma te sɛ scissor no ano. Ɛno kyerɛ sɛ, sɛ wɔnom saa aduru yi a, `PCSK9` protein no ntumi nsɛe saa nsa a ɛkyere srade (LDL receptors) no.

Dɛn na ɛba saa bere no?

• LDL agyefo a wɔyɛ adwuma kɛse wɔ hɔ.
• Saa ‘nsa’ a ɛyɛ nnam yi kyere srade bɔne a ɛwɔ mogya no mu no pii na ɛde kɔ mmerɛbo no mu.
• Mmɛn no yi saa srade no fi nipadua no mu.

Nea efi mu ba awiei koraa ne srade bɔne a ɛwɔ wo mogya mu no so tew kɛse.

Aduru yi tu mpɔn dɛn? Na dɛn ne ahorow no?

PCSK9 inhibitors yɛ nnuru kuw bi a wɔada no adi sɛ etu mpɔn kɛse ma nnipa binom. Nhwehwɛmu ahorow bi ada no adi sɛ saa nnuru yi betumi atew srade bɔne (LDL cholesterol) dodow so akodu 70% na ebetumi nso atew asiane a ɛwɔ hɔ sɛ obi benya komayare no so bɛyɛ nkyem abiɛsa mu biako.

`PCSK9 inhibitors` ahodoɔ mmienu na ɛwɔ hɔ a mprempren wɔtaa de di dwuma wɔ Sri Lanka ne wiase nyinaa:

• `Alirocumab` (ahyɛnsode din: Praluent®)
• `Evolocumab` (ahyɛnsode din: Repatha®) .

Woyɛ dɛn nom aduru no?

Eyi nyɛ aduru a ɛsɛ sɛ wɔnom da biara da. `PCSK9 inhibitors` na wɔde ma sɛ injection.Mpɛn pii no, ɛho behia sɛ wonya saa aduru yi adapɛn kakraa biara anaa asram kakraa biara, sɛnea wo duruyɛfo no kyerɛ no.

Bere a worenom saa aduru yi no, wo duruyɛfo no bɛyɛ mogya mu nhwehwɛmu daa de ahwɛ sɛnea aduru no reyɛ adwuma yiye. Ɛtɔ da bi a, wobetumi de saa aduru yi nkutoo ama, na mmere foforo nso wobetumi de aka aduru bi a worenom dedaw te sɛ statin ho.

Dɛn ne mfaso horow ne nea ebetumi afi mu aba?

Te sɛ aduru biara no, saa aduru yi betumi anya mfaso ne nsunsuanso nketenkete. Nanso, nnipa dodow no ara nnya nsunsuanso bɔne a anibere wom.

So aduru no nkutoo dɔɔso? Dabi, eyi yɛ nhyehyɛe kɛse bi fã.

Eyi ho hia paa. Sɛ́ ebia wonom PCSK9 inhibitor anaa aduru foforo a ɛtew srade so no, ɛyɛ w’ayaresa nhyehyɛe nyinaa fã biako pɛ. Nneɛma foforo pii wɔ hɔ a wubetumi ayɛ de abɔ wo koma akwahosan ho ban, a womfa wo ho nto nnuru nkutoo so.

• Aduan pa: Di ngo, asikre, ne nkyene pii, na di nhabannuru, nnuaba, nhabannuru, ne nnuan a ahoɔdennuru pii wom pii.
• Apɔw-mu-teɛteɛ: Fa wo ho hyɛ apɔw-mu-teɛteɛ a ɛma koma nya ahoɔden, te sɛ nantew a emu yɛ den, mmirikatu, anaa sakre so, anyɛ yiye koraa no nna kakraa bi dapɛn biara.
• Adwennwen ano aduru: W’adwene a wode bɛdwo denam nneɛma te sɛ adwennwen ne yoga so.
• Da pa: Anyɛ yiye koraa no, nna nnɔnhwerew 7-8 anadwo biara.
• Kwati sigaretnom: Sɛ wonom sigaret a, gyae koraa.

Wubenya nea eye sen biara bere a wode asetra mu nsakrae yi ka nnuru ho no.

PCSK9 inhibitors, srade, srade, LDL srade, komayare, ɔyare a ɛma obi hwe ase, abusua mu srade a ɛboro so, statin, Alirocumab, Evolocumab