Yala ji bɛ bɔ aw fari la nin cogo la wa? An ka kuma Syndrome de fuite capillaire kan!

Yala aw delila ka Syndrome de fuite capillaire ko mɛn wa? Tɔgɔ bɛ se ka kɛ ko a ka gɛlɛn dɔɔnin. Nka n’an b’a fɔ cogo nɔgɔman na, o ye bana ye min na joli yɔrɔ jilama min bɛ wele ko joli-sira-funu, o bɛ bɔ an farikolo joli-sira-funu misɛnninw na, minnu bɛ wele ko kapilɛriw. O ji bɛ don an farikolo yɔrɔw la, an farikolo yɔrɔw la, an farikolo yɔrɔw la ani an farikolo yɔrɔw la. O bɛ se ka kɛ bana jugumanba ye, o la a nafa ka bon ka a dɔn.

Nin min bɛ wele ko kapilɛri bɔli syndrome, o ye mun ye?

O bɛ ɲɛ, an ka ɲɛfɔli kɛ dɔɔnin. Miiri k’a filɛ, jibolisiraw sigicogo dɔ bɛ i fari la. O pipew ye an ka joli siraw ye. Pipe misɛnnin minnu bɛ o la, olu ka fin kosɛbɛ, olu bɛ wele ko kapilɛriw. Olu ye tubabukanw ye minnu fɛ oksizɛni ni balofɛnw bɛ taa an farikolo yɔrɔ bɛɛ la. O la, `(Capillaire Leak Syndrome)` la, joli yɔrɔ jilama, n’o ye joli-sira-funu ye , o bɛ bɔ ka bɔ o joli-sira-funu misɛnnin ninnu fɛ. A bɛ i n’a fɔ ji bɛ bɔ jibɔyɔrɔ la.

O jibɔ in bɛ kɛ sababu ye ka ji dalajɛ farikolo yɔrɔ caman na. Misali la, o ji in bɛ se ka bɔ farikolo yɔrɔw la, farikolo yɔrɔw la, farikolo yɔrɔ suguya caman na, walima yɔrɔw la (farikolo yɔrɔw) farikolo yɔrɔw bɛ yɔrɔ minnu na.

Nin `(Capillary Leak Syndrome)` in waatiw bɛ se ka kɛ siɲɛ caman san kɔnɔ, walima siɲɛ kelen dɔrɔn a si kɔnɔ. Nka ni a ma furakɛ joona, aw ka tansiyɔn bɛ se ka jigin yɔrɔnin kelen, o bɛ na ni farikolo yɔrɔw dɛsɛli ye ani tuma dɔw la hali saya. O la sa, nin tɛ fɛn ye min ka kan ka ta nɔgɔya la.

Fura banbali tɛ o la fɔlɔ. Nka, a nafa ka bon ka taa dɔgɔtɔrɔso la joona walasa ka bana taamasiɲɛw kunbɛn. Tuma dɔw la, a bɛ se ka kɛ ka binkanni nataw bali ni aw bɛ to ka furaw ta walima ni aw ye saline pikiri kɛ.

Yala nin suguya dɔw bɛ yen wa? U tɛ kelen ye cogo di?

Ɔwɔ, `(Syndrome de fuite capillaire)` suguya belebele fila bɛ yen. An k’a lajɛ u ye min ye.

• Sistɛmu ka ɲɛgɛnɛsiralabanaw : A bɛ fɔ fana ko ``Primary Capillary Leak Syndrome'' walima ``Clarkson ka bana'', o ye bana ye min kɔnɔ binkanniw bɛ kɛ siɲɛ caman , hali mɔgɔ kɛnɛman na.
• Kapilari filanan : O ye waati ye ni binkanni bɛ kɛ siɲɛ kelen ka a sababu kɛ bana, cogoya walima fura wɛrɛ ye.

N’an y’a fɔ cogo nɔgɔman na, kelen ye fɛn ye min bɛ se ka kɛ tuma bɛɛ, tɔ kelen ye fɛn ye min bɛ kɛ waati dɔɔnin kɔnɔ kun wɛrɛ kosɔn.

Jɔn de ka teli ka nin bana in sɔrɔ?

``Systemic Capillary Leak Syndrome'' ye bana ye min man ca kosɛbɛ.A fɔra ko nin bana in bɛ mɔgɔ 500 bɔ diɲɛ kɔnɔ. A ka teli ka kɛ cɛmancɛlamɔgɔw de la. A ka dɔgɔ kosɛbɛ denmisɛnni fitiniw na. Nka, i n’a fɔ nin bana in bɛ mɔgɔ minnu na, tuma dɔw la, u bɛ sɛgɛsɛgɛ cogo jugu la ko bana wɛrɛ bɛ u la, o la, nin bana in bɛ mɔgɔ minnu na, olu hakɛ yɛrɛ bɛ se ka caya kosɛbɛ.

Nka, Syndrome de fusion capillaire secondaire bɛ se ka kɛ mɔgɔ si hakɛ bɛɛ la. Banakisɛ dɔw, furakɛli cogoyaw ani fura dɔw bɛ se ka kɛ sababu ye.

Mun bɛ kɛ farikolo la ni o kɛra? (Etape saba) .

Fɛn min bɛ kɛ an farikolo la nin `(Capillaire leak Syndrome)` binkanni in senfɛ, o bɛ se ka tila yɔrɔ saba ye. An k’a lajɛ u ye min ye.

Dakun fɔlɔ : Sani bana taamasiɲɛw ka bɔ kɛnɛ kan (Faase prodromal) .

O ye waati ye tile kelen walima tile fila ka kɔn binkanni ɲɛ. O waati kɔnɔ, aw bɛ se ka taamasiɲɛ dɔw daminɛ.

• A bɛ kɛ i n’a fɔ a sɛgɛnnen don
• Ji minnɔgɔ bɛ caya
• Fɛnw i n’a fɔ farikolo girinya barikama, olu bɛ se ka kɛ.

Dakun filanan : Leak walima resuscitation phase

O waati de la binkanni bɛ kɛ tiɲɛ na. Min bɛ kɛ, o ye ko ji ni albumin (poroteyini suguya dɔ bɛ joli la) bɛ bɔ aw ka joli siraw la ka taa aw farikolo yɔrɔw ni ɲɔgɔn cɛ yɔrɔw la. O bɛ dɔ bɔ joli la min bɛ oksizɛni ta. Aw ka tansiyɔn bɛ jigin, ani joli kuru bilenmanw bɛ ɲɔgɔn dalajɛ, o bɛ aw joli kɛ ka caya. O ji bɔli bɛ kɛ sababu ye ka joli hakɛ dɔgɔya, o min bɛ wele ko joli bɔli dɔgɔyali .

Dakun sabanan : Binkanni kɔfɛ `(Post-leak phase walima recruitment phase)`

Nin ye waati ye binkanni in bannen kɔfɛ. Min bɛ kɛ, o ye ko aw ka joli-sira-funu bɛ daminɛ ka ji ni albumin minɛ ka bɔ farikolo yɔrɔw la tuguni. Nka o waati kɔnɔ, aw farikolo bɛ se ka ji caman dalajɛ (ji caya kojugu) . O de kosɔn, aw fari bɛ se ka sugunɛ caman bɔ (polyuria) ani aw fogonfogonw bɛ se ka fa ji la (fogonfogon la sɔgɔsɔgɔninjɛ).

Miiri k’a filɛ, a bɛ i n’a fɔ ɛponji min bɛ ji minɛ. Fɔlɔ, ji bɛ bɔ fari la, o kɔ, ni a y’a minɛ kokura joona kojugu, a bɛ a minɛ ka tɛmɛ a ka kan ka min minɛ.

Mun de bɛ o kɛ?

An ka a lajɛ sisan fɛn min bɛ se ka nin `(Syndrome de fuite capillaire)` in lase mɔgɔ ma.

`(Syndrome de fuite capillaire systémique)` sababuw

Ni an bɛ se ka tiɲɛ fɔ, hali bi, bana min bɛ wele ko Système Capillaire Leak Syndrome, o sababu tigitigi ma dɔn. Sɛgɛsɛgɛlikɛlaw dalen b’a la ko a bɛ se ka kɛ an farikolo tangalanw ka jaabi ye bana walima banakisɛ dɔw la.

`(Syndrome de fuite capillaire secondaire)` sababuw

Kun damadɔ bɛ o la. a sababu ka teli ka kɛ bana ye min bɛ wele ko sepsis . O kɔrɔ ye ko gɛlɛya min bɛ mɔgɔ ka ɲɛnamaya bila farati la, min bɛ sɔrɔ banakisɛ dɔ fɛ. Ka fara o kan, sababu wɛrɛw bɛ yen:

• Bana minnu bɛ sɔrɔ farikolo tangalanw fɛ:Min bɛ kɛ o la, o ye ko an yɛrɛ ka farikolo tangalanw bɛ bin an yɛrɛ ka farikolokisɛ kɛnɛmanw kan.
• Danfaralan : Gɛlɛya min bɛ se ka sɔrɔ jolidɛsɛ suguya dɔw furakɛli senfɛ (jolidɛsɛ jugumanba walima jolidɛsɛ jugumanba).
• Engraftment syndrome : Gɛlɛya min bɛ se ka sɔrɔ kolotugudaw cili kɔfɛ.
• Hémophagocytique lymphohistiocytose : Bana min bɛ se ka mɔgɔ ka ɲɛnamaya bila farati la, o bɛ sɔrɔ farikolo tangalanw ka baara caya kojugu fɛ.
• Ovari hyperstimulation syndrome (Ovari hyperstimulation syndrome): Gɛlɛya min bɛ se ka sɔrɔ bangekɔlɔsi furakɛli senfɛ.
• Risini baga bɛ mɔgɔ la.
• Sa ka kinni.
• Farikolo jolilabanaw (viral hemorrhagic fevers): O ye banakisɛw ye minnu bɛ sɔrɔ banakisɛw fɛ.

Fura dɔw, i n’a fɔ kansɛribana fura minnu bɛ wele ko jemcitabine (gemcitabine - Gemzar®) ani tagraxofusp (tagraxofusp - Elzonris®) , olu fana bɛ se ka o lase mɔgɔ ma (Secondary Capillary Leak Syndrome).

Taamasiɲɛ jumɛnw bɛ sɔrɔ ka kɔn bana in daminɛ ɲɛ?

A ka ca a la, tile kelen walima tile fila sani ``Capillaire Leak Syndrome'' ka binkanni ka kɛ, o kɔrɔ ye ko ``prodromal phase'' waati, aw bɛ se ka taamasiɲɛw sɔrɔ i n'a fɔ:

• Kɔnɔdimi walima farikolodimi (mialgie).
• Sɛgɛn kojugu walima fanga dɔgɔyali.
• Kunkolodimi .
• Ji minnɔgɔ bɛ caya.
• Dimi, dimi.
• Fɔɔnɔnege.
• Farikolo girinya bɛ caya yɔrɔnin kelen.
• Banakisɛbana taamasiɲɛw walima ninakilidegun sanfɛla.

Ni nin taamasiɲɛ suguw bɛ aw la, aw kana a ta nɔgɔya la, k’a fɔ ko: “O, n’a sɔrɔla farigan dɔrɔn de don,” kɛrɛnkɛrɛnnenya la ni aw ye o ɲɔgɔn sɔrɔ ka kɔrɔ.

Ni bana dɔ bɛ aw la, taamasiɲɛ jumɛnw bɛ sɔrɔ aw la?

`(Capillaire Leak Syndrome)` binkanni waati, o kɔrɔ ye ko `(fura walima lakununni waati)` waati, a taamasiɲɛw bɛ se ka ɲɔgɔn ta mɔgɔ ni mɔgɔ cɛ. Nka, ninnu ye taamasiɲɛw ye minnu ka teli ka ye, minnu bɛ se ka ye:

• Farikolo fununi, kɛrɛnkɛrɛnnenya la farikolo yɔrɔw (edema périphérique).
• Kɔnɔboli.
• Tansiyɔn jiginni (tansiyɔn jiginni).
• Joli kuruli (hypercoagulability) - O bɛ se ka sɔrɔ joli kuru bilenmanw hakɛ caya fɛ (hematocrit) walima joli kuru finmanw hakɛ caya fɛ (leukocytose).

Dɔgɔtɔrɔw b’o dɔn cogo di?

Dɔgɔtɔrɔ bɛna Capillaire Leak Syndrome sɛgɛsɛgɛ ni a ye i ka furakɛli tariku ɲininka ani ka farikolo sɛgɛsɛgɛli kɛ. U bɛna a lajɛ ni aw ka tansiyɔn dɔgɔyara.

Ani fana, sani aw ka a jira ko nin ye Capillaire Leak Syndrome ye, bana wɛrɛw ka kan ka ban. U bɛ se ka joli sɛgɛsɛgɛli caman kɛ walasa ka o kɛ:

• Aw bɛ a lajɛ ni hematocrite (joli kuru bilenman hakɛ min bɛ joli la) ka ca.
• Aw bɛ a lajɛ ni ɛmoɲini hakɛ ka ca (poroteyini min bɛ sɔrɔ joli kuru bilenmanw na).
• Aw bɛ a lajɛ ni farikolojɔli dumuniw ka dɔgɔn joli la (hypoalbuminemia).

Ka fara o kan, joli sɛgɛsɛgɛli bɛ se ka kɛ walasa ka farikolo tangalan farikolojɔli dumuni dɔ lajɛ min bɛ wele ko ``monoclonal gammopathy, walima M protein'' joli la. ``Capillaire Leak Syndrome'' bɛ mɔgɔ minnu na, o ``(M proteine)'' bɛ se ka kɛ u joli la.

A bɛ furakɛ cogo di? Yala a bɛ se ka furakɛ wa?

A ka c’a la, fura banbali tɛ yen min bɛ wele ko « Syndrome de vitesse capillaire ». Dɔgɔtɔrɔw b’a ɲini ka bana taamasiɲɛw kunbɛn ani ka gɛlɛyaw bali.

``Capillaire Leak Syndrome'' binkanni waati la, dɔgɔtɔrɔw b'a ɲini ka tansiyɔn kunbɛn ani ka joli bolicogo ɲuman sabati farikolo yɔrɔw la. U b’a ɲini fana ka funu damatɛmɛni ni ji dalajɛli bali. U bɛ se ka baara kɛ ni ninnu ye:

• Glucocorticoïdes : Olu ye furakisɛ suguya dɔ ye min bɛ dɛmɛ ka ji bɔli dɔgɔya ka bɔ joli siraw la.
• Ji minnu bɛ don joli la: Fɛn minnu bɛ kɛ i n’a fɔ saline, olu bɛ di walasa ka joli bɔli caya farikolo yɔrɔw la i n’a fɔ sugunɛ.

A ka ca a la, aw bɛna a ɲini ka taa dɔgɔtɔrɔso la binkanni kɔfɛ. Furakɛli waati, dɔgɔtɔrɔ bɛna to ka degun kɔlɔsi aw jolisiraw ni joli siraw la walasa ka a dɔn ko ji caman tɛ aw fari la, o bɛ se ka kɛ sababu ye ka gɛlɛya wɛrɛw lase aw ma, i n’a fɔ fogonfogon la kirinni ani dusukun tantanni barikama.

Kapilari bɔli kɔfɛ, o min bɛ wele ko joli bɔli kɔfɛ walima mɔgɔ ɲinini waati, dɔgɔtɔrɔ bɛ se ka sugunɛbilenni fura (fura min bɛ kɛ sababu ye ka sugunɛ caman bɔ) di aw ma walasa ka ji wɛrɛ hakɛ dɔgɔya aw fari la.

Yala Système capillaire leak Syndrome (SCLS) bɛ se ka bali ka segin a kan wa?

Aw tɛ se ka Système Capillaire Leak Syndrome bali ka sɔrɔ a daminɛ na. Nka, ni binkanni kɛra i la dɔrɔn, i b’a dɔn ko bana in bɛ i la.

Nka, ni aw bɛ to ka furaw ta walima ka saline pikiri kɛ, o bɛ se ka dɛmɛ don ka binkanni nataw bali ani ka dɔ bɔ u juguya la. O furakɛli ninnu bɛ se ka kɛ ninnu ye:

• Kalo o kalo farikolo tangalan (IVIG) tali jolisira fɛ .
• Sɔgɔsɔgɔninjɛ fura minnu bɛ ta da la, i n’a fɔ teyofilini (theophylline - Elixophyllin®), terbutaline (terbutaline - Brethine®), ani montelukast (montelukast - Singulair®) .
• Aw bɛ dɔ bɔ funu naStɛroyidiw (Stéroïdes).

Mɔgɔ minnu bɛ balo ni nin bana in ye, olu ka siniɲɛsigi ye mun ye? `(Laɲini)`

A ka ca a la, farikolojidɛsɛ furakɛli bɛ se ka furakɛ ni banakunbɛn furakɛli ye. Furakɛli ka teli ka ɲɛ ni bana in sɛgɛsɛgɛra joona ani ni gɛlɛyaw ka dɔgɔn. Gɛlɛya juguman minnu bɛ se ka sɔrɔ ni kapilɛri bɔli ye, olu dɔw ye:

• Sindrom de compartiment : Tansiyɔn bɛ caya farikolo kɔnɔ ani joli bɔli bɛ dɔgɔya.
• Ji minnu bɛ dalajɛ dusukun ni fogonfogon lamini na (dusukun tantanni, dusukun tantanni, ani ɲɛgɛnɛsira bɔli).
• Dusukun tantanni.
• Sugunɛbilenni.
• Neuropathie (Sɔgɔsɔgɔninjɛ furakɛli).
• Fogonfogon la sɔgɔsɔgɔninjɛ.
• Rabdomyolyse : Sugunɛbilenni ka a sababu kɛ farikolo tiɲɛni ye.
• Kuru bɔ.

Ninnu bɛ se ka kɛ siranfɛn ye, nka i n’a fɔ a fɔra cogo min na ka tɛmɛ, furakɛli teliya ni furakɛli ɲuman nafa ka bon kosɛbɛ.

Tuma jumɛn na ne ka kan ka taa dɔgɔtɔrɔso la?

Ni aw hakili la ko aw bɛ ka bana dɔ sɔrɔ min tɔgɔ ye ko Capillaire Leak Syndrome, aw bɛ taa dɔgɔtɔrɔso la o yɔrɔnin bɛɛ. U bɛ se ka dɛmɛ don ka aw ka bana taamasiɲɛw kunbɛn ani ka lafiya di aw ma.

Aw ye aw hakili to a la ko hali ni nin ye bana ye min man teli ka sɔrɔ, a nafa ka bon ka a taamasiɲɛw dɔn ani ka dɔgɔtɔrɔ ka ladilikan ɲini joona ni siga bɛ aw la.

Take-Home cikan

O bɛ ɲɛ, o la sa, an ye kuma nafama minnu kan, an ka segin olu kan:

• O ye ni joli yɔrɔ jilama (plasma) bɛ bɔ joli sira misɛnninw na (capillaire) an fari la.
• O bɛ se ka kɛ siɲɛ kelen walima siɲɛ caman.
• Ni a ma furakɛ, gɛlɛya jugumanbaw bɛ se ka sɔrɔ, o la, a nafa ka bon ka taa dɔgɔtɔrɔso la joona.
• Hali ni fura banbali tɛ yen, fura dɔw bɛ yen minnu bɛ se ka bana taamasiɲɛw kunbɛn ani ka binkanni nataw bali.
• Ni aw bɛ sigasiga nin taamasiɲɛ ninnu dɔ la kelen na, aw bɛ taa dɔgɔtɔrɔso la joona. Ni aw ye bana in sɛgɛsɛgɛ joona ani ka furakɛli daminɛ, aw ka kɛnɛya sɔrɔli bɛ se ka kɛ.

O la, n jigi b’a kan ko nin kunnafoni in nafa ka bon aw bolo. Aw ka to kɛnɛya la!

` Kapilɛri bɔli, joli-sira-funu, Tansiyɔn dɔgɔyali, Clarkson ka bana, Ɲɛgɛnɛsiraw, Ji bɔli farikolo la