Ðe wò ŋutilã vuvu kpata ɣeaɖewoɣia? Ate ŋu anye ʋukawo ƒe ʋuʋu!

Ède dzesii kpɔ be wò nuyiwo vuvu zi ɖeka, alo wò ŋkuwo vuvua? Ɣeaɖewoɣi la, wò mo bliboa, wò asiwo kple afɔwo gɔ̃ hã, vuvuna. Enye nusi sɔ be vɔvɔ̃ naɖo ame vie ne nane si le abe esia ene dzɔ. Zi geɖe la, nɔnɔme aɖe si woyɔna be angioedema gbɔe esia tsona. Mina míaƒo nu tso esia ŋu tsitotsito, bɔbɔe ŋutɔ, enyoa?

Nukae nye Angioedema? Mina míase egɔme bɔbɔe!

Kpuie ko la, Angioedema nye lãkusi siwo le míaƒe ŋutigbalẽ te ƒe vuvu, vevietɔ ŋutigbalẽ ƒe akpa si le eme, ŋutigbalẽa ƒe akpa si le eme, alo lãkusi siwo le lãkusi aɖe te. Esia dzɔna abe alesi wowɔa nui ɖe nane ŋu ene. Ðewohĩ èse dɔléle aɖe si woyɔna be urticaria , alo hives ŋu nya kpɔ . Zi geɖe la, ʋukawo me ʋu ƒe sisi kple aɖuɖɔtoewo dzɔna ɖekae, eye nusiwo gbɔ wòtsona la ɖi wo nɔewo ŋutɔ. Le go evea siaa me la, tsi dona tso míaƒe ʋuka suewo me yia lãkusiawo me, si wɔnɛ be teƒeawo vuvu.

Zi geɖe la, ʋukawo me ʋu ƒe sisi dzea egɔme kpata eye wòɖiɖina le ŋkeke ɖeka alo eve megbe. Edzea nuyiwo kple ŋku siwo ƒo xlãe dzi wu . Gake bu eŋu kpɔ, ne ʋuʋudedi sia gblẽ nu le míaƒe yaƒoƒomɔ̃wo ŋu , ate ŋu anye afɔku gã aɖe, eye ate ŋu ade míaƒe agbe afɔku me gɔ̃ hã . Eyata ele be míaɖɔ ŋu ɖo le ema hã ŋu.

Nukawoe nye ʋukawo me ʋu ƒe sisi ƒomevi veviwo?

Angioedema ƒomevi vovovowo li. Lãmesẽhabɔbɔ vovovowo ate ŋu ade wo hatsotso vovovowo me, gake le goawo katã me la, míate ŋu ade dzesi ƒomevi vevi geɖe.

1. Angioedema si nulɔdɔ le ame ŋu vevie

Anɔ eme be esiae nye esi ƒomevi nèse eye nèto eme wu. Edzɔna ne èdo go nane si ŋu wò nulɔdɔ le . Esia ate ŋu anye nane si nèɖu (nuɖuɖu, nunono), atike aɖe si nèno, alo ka asi eŋu (le kpɔɖeŋu me, nane si wotsɔ dzɔdzɔme rababa latex wɔ). Ate ŋu adzɔ hã ne nudzodzoe alo akpɔkplɔ ɖui vɔ.

Acute allergic angioedema dzɔna kabakaba ŋutɔ , zi geɖe le aɖabaƒoƒo ʋɛ aɖewo va ɖo gaƒoƒo ɖeka alo eve me, le esi wòdo go nulɔdɔa vɔ megbe. Zi geɖe la, aɖuɖɔtoewo kpena ɖe vuvu sia ŋu.

2. Angioedema le atike si me nulɔdɔ mele o ƒe dɔwɔwɔ ta

Angioedema sia ƒomevi medzɔna enumake le atike aɖe nono vɔ megbe o. Atikewo ƒe hatsotso vevitɔ si hea dɔléle sia si me nulɔdɔ mele o vɛ enye angiotensin-converting enzyme inhibitors , alo ACE inhibitors alo ACEIs kpuie.Zi geɖe la, wozãa atike siawo tsɔ kekea ʋukawo, tsɔ daa dzidɔ, eye woɖea ʋusɔgbɔdɔ dzi kpɔtɔna. Atike siwo me steroid mele o siwo tsia dɔdzẽ nu (NSAIDs) , abe ibuprofen kple naproxen ene hã ate ŋu ana ʋukawo me ʋu ƒe sisi sia ƒomevi nadze ame dzi.

3. Ʋukawo me ʋu ƒe sisi si womenya nusi gbɔ wòtso o (Idiopathic angioedema) .

Nya " idiopathic" gɔmee nye "si womenya nusi gbɔ wòtso o." Eyata esesẽ be woake ɖe nusi koŋ gbɔ ʋuka me ʋu ƒe sisi sia ƒomevi tsona ŋu. Zi geɖe la, vuvua dzɔna le mo, abɔwo, akɔta, kple afɔwo dzi. Dɔlélenutsiŋutete ƒe kuxiwo kple nuteɖeamedzi ate ŋu anɔ ame aɖewo hã ŋu.

4. Domenyinu ƒe ʋukawo me ʋu ƒe sisi (HAE) .

Esia nye domenyiŋusẽfianu ƒe ʋukawo ƒe ʋuʋu , si wogayɔna kpuie be HAE . Esia nye nusi nèxɔna tso dziwòlawo gbɔ to wò domenyiŋusẽfianu dzi. Ðeviwo ate ŋu anyie dome ne dzila ɖeka koe domenyiŋusẽfianua le gɔ̃ hã, alo ne dɔlélea le wo ŋu gɔ̃ hã. Ame aɖewo hã ate ŋu axɔ ʋukawo ƒe ʋuʋu sia ƒomevi le domenyiŋusẽfianu ƒe tɔtrɔ siwo dzɔna le wo ɖokui si ta. Wobu akɔnta be domenyiŋusẽfianu ƒe ʋuka me ʋu ƒe sisi (HAE) sia ƒomevi ate ŋu anɔ ame 1 le 50,000 ɖesiaɖe me. Esia ƒomevi vevi etɔ̃e li, eye wo dometɔ ɖesiaɖe do ƒome le mɔ aɖe nu kple C1 protein kple/alo C1 esterase inhibitor ƒe agbɔsɔsɔ le míaƒe ʋu me.

5. C1 mɔxenu ƒe anyimanɔmanɔ ƒe angioedema si woxɔ

Esia hã hea ʋukawo ƒe ʋuʋu vɛ, gake menye domenyiŋusẽfianue wònye o. Nusiwo woxɔ fia be womedzi wò kple gbɔdzɔgbɔdzɔa o, gake èva xɔe le wò tsitsime. Abe ƒomevi bubuwo ene la, ʋukawo ƒe ʋuʋu sia ƒomevi ate ŋu agblẽ nu le wò lãkusi, alo yaƒoƒomɔ̃ ŋu, eye ate ŋu ana nàgbɔdzɔ. Ne dɔléle aɖe abe B-cell lymphoma ene le ŋuwò la, woyɔa dɔléle sia be Acquired C1 inhibitor deficiency.

6. Ʋukawo ƒe ʋuʋu si tso ʋuʋudedi gbɔ (Vibratory angioedema) .

Le nɔnɔme sia me la, ʋuʋudedi si yia edzi gbɔe vuvua tsona. Le kpɔɖeŋu me, esia ate ŋu adzɔ ne èdo dzokeke, le du ƒum, le du ƒum, le asi sisim na wò sesĩe, alo le nu bubu mawo tɔgbe wɔm. Vibratory angioedema nye dɔléle si mebɔ o si woyɔna be chronic inducible urticaria ƒomevi bubu . Le eme la, atɔ dona le gotagome nusiwo doa ŋusẽ ame abe vuvɔ, dzoxɔxɔ, tsi, nyaƒoɖeamenu, alo ʋuʋudedi ene ta. Welt siwo le ʋuʋum la nɔa anyi ɖaa eye wonɔa anyi abe kwasiɖa ade ene.

Amekae ate ŋu axɔ ʋukawo me ʋu ƒe sisi wu?

Le nyateƒe me la, amesiame ate ŋu axɔ ʋukawo ƒe ʋuʋu. Wobu akɔnta be Amerikatɔwo ƒe 20% va ɖo 25% akpɔ ʋukawo me ʋu ƒe sisi kple/alo ʋuka me ʋu ƒe sisi zi ɖeka ya teti le woƒe agbenɔɣi. Eyata nɔnɔme sia bɔ ɖe Sri Lanka hã.

Nukawoe nye ʋukawo me ʋu ƒe sisi ƒe dzesiwo? Aleke nèwɔna dea dzesi woe?

Angioedema ƒe dzesi veviwoe nye:

• Mo ƒe vuvu alo fu , vevietɔ le ŋkuwo kple nu ŋu, siwo dome nuyiwo kple aɖe hã le. Kpɔe ɖa le susu me be èfɔ le ŋdi me eye kasia wò nuyiwo vuvu ale gbegbe be wòawɔ na wò abe ɖe wòsesẽ be nàƒo nu ene.
• Ne wò dɔgbowo xɔ abi la, àte ŋu akpɔ nuɖuɖumeŋusẽ ƒe kuxiwo . Esia lɔ dɔgbo ƒe veve, aɖuɖɔtoe, ʋuʋudedi, kple ʋuʋudedi ɖe eme.
• Asiwo, afɔwo, alo vidzinuwo ƒe akpa siwo vuvu.
• Ʋu ƒe sisi ƒe tɔtrɔ ate ŋu ahe nuwo abe taɖuame alo alɔ̃madɔmadɔ ene vɛ .
• Nu, ŋɔti, alo yaƒoƒomɔ̃wo ƒe vuvu ate ŋu ana gbɔgbɔ kple nuƒoƒo nasesẽ. Esiae nye nusi me afɔku le wu. Ne nane si le abe esia ene dzɔ la, ke atikewɔwɔ kpatae. Ele be nàyi kɔdzi enumake!

Vevietɔ wu: Ne wò ŋɔti vuvu eye nèse le ɖokuiwò me be gbɔgbɔ le sesẽm na ye la, ke menye fefenyae wònye o. Di atikewɔlawo ƒe aɖaŋuɖoɖo enumake.

Nukatae ʋukawo me ʋu ƒe sisi dzɔna? Nukawoe gbɔ wòtsona?

Nusiwo hea ʋuka me ʋu ƒe sisi vɛ la toa vovo le ʋuka me ʋu ƒe sisi ƒomevi si le ŋuwò nu. Gake nusi gbɔ wòtsona wue nye nulɔdɔwo . Nulɔdɔ ƒomevi geɖe li siwo ate ŋu ahe dɔlélea vɛ:

• Nuɖuɖu ƒe nulɔdɔ: Notsi, azi, nukuwo abe aŋɔ ene, kple ƒumelã siwo le abe lãgbalẽ ene koŋue hea esia vɛ.
• Atikewo ƒe nulɔdɔwo: Dɔlékuiwutikewo abe penicillin kple sulfa atikewo, nonsteroidal anti-inflammatory drugs (NSAIDs), kple vovototodeamememɔ̃ siwo wozãna le nɔnɔmetatawo dodokpɔ aɖewo me ate ŋu ahe esia vɛ. Nulɔdɔ siawo ƒomevi ate ŋu ahe aɖuɖɔtoe vɛ.
• Aɖi: Aɖi si nudzodzoewo ɖuna, eye ƒã hafi lãwo abe brown recluse spider ene dona.
• Dzɔdzɔme rababa latex: Latex nye nusi wozãna tsɔ wɔa nuwo abe asigɛ, balloon, kɔndɔm, kple atikewɔwɔ ƒe ka ene. Ðewohĩ wò ɖɔkta bia wò be latex ƒe nulɔdɔ le ŋuwò hã.

Nu bubu siwo gbɔ wòtsonae nye kuxi siwo dona tso domenyiŋusẽfianu me kple emegbe le C1 mɔxenu protein ŋu, atikewo ƒe dɔwɔwɔ si dzɔna si me ʋuʋudedi alo ʋuʋudedi manɔmee (esiawo menye nusiwo ŋu womelɔ̃a nu le o siwo bɔ o), kple ʋuʋudedi ƒe ʋuʋu.

Ðe Angioedema xɔa ame mea?

Ao, menye nenema kura o.Màte ŋu axɔ ʋuka me ʋu ƒe sisi tso ame bubu gbɔ o, eye màte ŋu akakae ɖe ame bubu hã gbɔ o. Menye dɔléle si xɔa ame me o.

Aleke nàwɔ anya ʋuka me ʋu ƒe sisi? Nukae ɖɔktawo dia?

Ate ŋu asesẽ be nànya ʋukawo me ʋu ƒe sisi ƒomevi si tututu le ŋuwò. Wò ɖɔkta ado wò kpɔ le ŋutilã me gbã, gake zi geɖe la, abi la dzena bɔbɔe. Emegbe woabia nya ʋɛ aɖewo wò:

• Ɣekaɣie vuvua dze egɔme?
• Ðe nèɖu nu, no nu, no, alo ka asi nane si nèsusu be ɖewohĩ eya gbɔe wòtso be wòwɔ nu ɖe ​​ame ŋua?
• Atike kple kpeɖeŋutɔ kawoe nèle nom fifia?
• Ðe nuwɔna sia tɔgbe dzɔ kpɔ?
• Ðe wò ƒomea me tɔ bubu aɖe hã vuvu alea?

Tsɔ kpe ɖe nya siawo biabia ŋu la, wò ɖɔkta ate ŋu abia be woado ʋu kpɔ alo ado ŋutigbalẽ akpɔ be nulɔdɔ le ŋuwò hã , alo be woado ʋu kpɔ be ʋukawo me ʋu ƒe sisi si do ƒome kple C1 inhibitor protein la hã.

Nukawoe nye Angioedema ƒe atikewo?

Angioedema ƒe atikewɔwɔ toa vovo le ƒomevi si le ŋuwò nu.

• Le nulɔdɔ sesẽwo gome la, wò ɖɔkta ate ŋu ado epinephrine si woate ŋu ado na wò si nàte ŋu adzra ɖo ɖe ŋuwò ɣesiaɣi. Ele be nàdo atike sia ɖokuiwò ne èƒo ka na 911 (ƒe 1990 le Sri Lanka) le nɔnɔme kpata aɖe me.
• Le ʋuka siwo me nulɔdɔ le ƒe ʋuʋu gome la , wò ɖɔkta ate ŋu aŋlɔ atike siwo wua ʋumenugbagbeviɣidɔ alo steroid na wò . Woate ŋu ano esiawo abe atikekuiwo ene, abe tsi ene (nono), alo woado wo ɖe ʋuka me.
• Ne atike si me nulɔdɔ mele o le ŋuwò la, wò ɖɔkta akpɔ atike si sɔ ɖe atike si le vuvua hem la teƒe. Mègadzudzɔ wò atikewo nono wò ɖɔkta ƒe aɖaŋuɖoɖo manɔmee gbeɖe o.

Aƒeme atikewo dometɔ aɖewoe nye tsikpe sisi ɖe eŋu be wòaɖe abi dzi akpɔtɔ, tsilele fafɛ, kple avɔ fafɛ si me tsi le sisi ɖe teƒe si vuvu la ŋu. Esiawo ate ŋu awɔ dɔ nyuie na nuyiwo ƒe vuvu le teƒe ɖeka, nuyiwo katã ƒe vuvu, alo ŋku siwo fu.

Ne domenyiŋusẽfianu, idiopathic, alo acquired C1 inhibitor deficiency angioedema , le ŋuwò la, anɔ eme be woaɖo wò ɖe eŋutinunyala bibi aɖe gbɔ. Atike siwo wozãna tsɔ daa domenyiŋusẽfianu ƒe ʋukawo ƒe ʋuʋu (HAE) alo xea mɔ na wo dometɔ aɖewoe nye:

• C1 esterase mɔxenu (si wogbugbɔ ƒo ƒu) (Ruconest®) .
• C1 mɔxenu (amegbetɔ) (Berinert®, Cinryze®, Haegarda®) .
• Ecallantide (Kalbitor®) ƒe dɔlékuiwutike .
• Icatibant (Firazyr®) ƒe atike .
• Lanadelumab (Takhzyro®) ƒe dɔlékuiwutike .
• Berotralstat (Orladeyo®) ƒe lãmesẽnyawo gbɔ kpɔkpɔ.

Ðe mɔ aɖewo li siwo dzi woato axe mɔ ɖe ʋukawo ƒe ʋuʋu nua?

Ẽ, mɔ aɖewo li.

• Ne ʋuka me ʋu ƒe sisi si do ƒome kple nulɔdɔ le ŋuwò la, àte ŋu axe mɔ ɖe enu ne èƒo asa na nuɖuɖu, atikewo, alo nu bubu siwo (nu siwo ʋãa ame) siwo nana nulɔdɔa dzɔna.
• Ne ʋuka siwo me nulɔdɔ mele o dze dziwò esime nèle ACEI atikewo (ACE inhibitors) zãm la, ele be nàƒo nu kple wò ɖɔkta tso tɔtrɔ ɖe atike bubu ŋu ŋu.

Nukae amesi ŋu angioedema le ate ŋu akpɔ mɔ na?

Angioedema ƒe dɔléle akpa gãtɔ menɔa anyi didi o . Zi geɖe la, wotsoa nya me le wo ɖokui si. Gake le dɔléle sesẽwo me la, ehiã be woawɔ atike na ame be yaƒoƒomɔ̃a nanɔ ʋuʋu ɖi.

Ðe Angioedema ate ŋu awu amea? Ðe esia nye afɔkua?

Le ame aɖewo gome la, allergic angioedema ateŋu ahe nɔnɔme aɖe si woyɔna be anaphylaxis - yaƒoƒomɔ̃wo kple lãkusiwo ƒe vuvu sesẽ vɛ. Esia ate ŋu ade ame ƒe agbe afɔku me . Ðɔktawo ɖo aɖaŋu na amesiwo ŋu dɔléle sia le be woatsɔ epinephrine si wodona ɖe lãme na ame (EpiPen®, Auvi-Q®, Adrenaclick® kple atike bubuwo) ɖe asi atsɔ ada nulɔdɔ sesẽwo.

Nuka kee wòɖatso o, ʋukawo ƒe ʋuʋu si gblẽa nu le yaƒoƒomɔ̃a ŋu nyea atikewɔwɔ kpata ɣesiaɣi. Eyata ehiã be woawɔ atike nɛ enumake. Ɣeaɖewoɣi la, amekoko si woyɔna be tracheostomy (si nana yaƒoƒomɔ̃a ʋuna) ate ŋu ahiã be wòakpe ɖe gbɔgbɔ ŋu.

Ne ʋukawo me ʋu ƒe sisi le ŋunye la, aleke mawɔ akpɔ ɖokuinye dzi?

Ne ʋukawo me ʋu ƒe sisi le ŋuwò la, ele be nàƒo asa na nusiwo hea nulɔdɔ vɛ . Ne wò ɖɔkta ŋlɔ atikewo na wò be wòaxe mɔ ɖe dɔléle bubuwo nu la, no wo abe alesi wogblɔe ene pɛpɛpɛ. Ne wogblɔ na wò be nàtsɔ epinephrine si wodona ɖe lãme na ame ɖe asi la , kpɔ egbɔ be ele ye gbɔ ɣesiaɣi. Fia wò ƒometɔwo kple xɔlɔ̃wo alesi woazãe.

Ɣekaɣie wòle be makpɔ ɖɔkta?

Ne nulɔdɔ sesẽ aɖe le ŋuwò eye vuvu gblẽ nu le wò yaƒoƒomɔ̃wo ŋu la, ƒo ka na 1990 (amergency ambulance service) enumake.

Le nɔnɔme siwo mesẽ boo o me la, ne ʋukawo ƒe ʋuʋu yi edzi le dɔ lém la, yi ɖɔkta gbɔ. Woate ŋu adzro mɔxexeɖedɔlélea nu ƒe mɔnuwo me. Atike bubu siwo woate ŋu azãe nye atike siwo wozãna tsɔ wua ʋumenugbagbeviɣidɔ kple steroid siwo woano. Idiopathic, edada sesẽÐɔkta aɖewo zã dɔlékuiwutike si nye monoclonal antibody si woyɔna be Omalizumab (Xolair®) tsɔ da ʋukawo ƒe ʋuʋu (idiopathic angioedema) ta.

Mlɔeba la, nu vevitɔ kekeake siwo dzi wòle be woaɖo ŋkui

Ne wò ŋkuwo, nuyiwo, alo asiwo se le wo ɖokui me be yevuvu la, ate ŋu anye ŋutigbalẽ ƒe dɔwɔwɔ si woyɔna be angioedema. Esia ate ŋu adzɔ wu ne nulɔdɔwo le fu ɖem na wò. Wɔ nuŋlɔɖi tso ɣeyiɣi si me nusia dzɔna kple ɣeyiɣi siwo me wòdzɔna ŋu, eye nàsrɔ̃ alesi nàƒo asa na nusiwo ŋu wò nulɔdɔ le. Ne ènya be ame bubuwo hã le wò ƒomea me kpɔ nuwɔna siawo la, gblɔe na wò ɖɔkta. Ate ŋu aɖo aɖaŋu be nàwɔ dodokpɔwo atsɔ akpɔe ɖa be nɔnɔmea le zɔzɔm le wò ƒomea me hã. Ne ʋuka siwo me ʋu sina tona le lãme na wò le nulɔdɔ ta la, ele vevie ŋutɔ be nàna epinephrine si woate ŋu ado na wò la nanɔ gbɔwò, elabena ne wò yaƒoƒomɔ̃wo vuvu la, ate ŋu ana nàdzudzɔ gbɔgbɔ. Mègatsi dzodzodzoe o, gake nunya le eme be nànya esia eye nàwɔ afɔɖeɖe siwo hiã.

` Angioedema, vuvu, nulɔdɔwo, ŋutigbalẽdɔlélewo, beléle kpata, epinephrine, urticaria