Ðe gbɔgbɔ sesẽna na wò hã abe asrã enea? Le ɣeyiɣi mawo me la, ɖewohĩ ɖɔktaa gblɔ na wò be nàzã yagbɔgbɔ. Beta-agonists nye atike tɔxɛ aɖe si le gbɔgbɔtsixetsixe mawo me si nana míaƒe gbɔgbɔ nɔa bɔbɔe. Togbɔ be ŋkɔ sia sesẽ vie hã la, esiawo ƒe dɔwɔwɔ le bɔbɔe ŋutɔ. Mina míaƒo nu tso esia ŋu tsitotsito vie, bɔbɔe ŋutɔ.
Kpuie ko la, nukae nye beta-agonist?
Bu lãmenugbagbevi siwo le míaƒe ŋutilã me ŋu be ‘switches’ alo ‘buttons’ suesuesuewo le wo si. Le atikewɔwɔ me la, míeyɔa nusiawo be xɔla. Atike sia ƒomevi si woyɔna be beta-agonist la ʋua ‘switch’ siawo siwo woyɔna be beta-receptors le míaƒe lãkusiwo kple ŋutinu bubuwo me.
Ne woʋu ʋuƒo sia la, lãmeka siwo ƒo xlã yaƒoƒomɔ̃ siwo le lãkusiwo me la ɖea dzi ɖi. Esia ʋua yaƒoƒomɔ̃ siwo xaxa eye wònana míegbɔa ya bɔbɔe. Esia tae wogayɔa atike siawo be ‘bronchodilators’. Tsɔ kpe ɖe eŋu la, wokpena ɖe ame ŋu be dzia ƒe tsotso dzina ɖe edzi eye dzia ƒe dɔwɔwɔ dzina ɖe edzi vaseɖe afi aɖe.
Ðe beta-agonists ƒomevi vevi aɖewo lia?
Ẽ, woma atike siawo hã ɖe hatsotso gã etɔ̃ me, le beta-xɔla ƒomevi siwo le míaƒe ŋutilã me nu.
- Beta-1 agonists: Esiawo kpɔa ŋusẽ ɖe dɔlékui siwo xɔa dɔlékuiwo dzi le míaƒe dzi me koŋ . Atike sia ƒomevi nana dzia ƒoa kabakaba eye wòkpena ɖe eŋu wòtsɔa ŋusẽ geɖe kɔa ʋu. Esia tae ɖɔktawo zãa wo le dzidɔ kple nɔnɔme kpata aɖewo me ɖo.
- Beta-2 agonists: Esiae nye ƒomevi si wozãna wu. Atike siawo, vevietɔ esiwo wonana to yagbɔgbɔmɔ̃ dzi, wɔa dɔ to kadodo kple lãmenugbagbevi siwo le lãkusi me tẽ me , si naa lãmeka siwo le yaƒoƒomɔ̃wo me la ɖea dzi ɖi eye wònana wònɔa bɔbɔe be woagbɔ ya. Wole vevie ŋutɔ le nɔnɔmewo abe asrã kple COPD (Chronic Obstructive Pulmonary Disease) ene dada me.
- Beta-3 agonists: Esiawo nye atike yeye aɖe ŋutɔ. Atike siwo wozãna fifia le hatsotso sia me koŋ wɔa dɔ to lãmeka siwo le tsinyegoea me ƒe ɖiɖiɖeme me , si wɔnɛ be mehiã be woatsi aɖuɖɔ enuenu o. Esia fia be wozãa wo tsɔ daa dɔléle aɖe si woyɔna be tsinyegoe si wɔa dɔ fũu akpa.
Beta-2 agonists ƒomevi aɖewo hã li.
Ẽ, beta-2 ƒomevi sia si wonana ɖe gbɔgbɔtsixetsixe ta hã ma ɖe akpa eve me. Ele vevie ŋutɔ be nànya esia.
| Atike ƒomevi | Nuɖᴐɖᴐ |
|---|---|
| Beta-Agonist siwo wɔa dɔ Kpuie (SABA) . | Woyɔa esiawo be "xɔname ƒe gbɔgbɔtsixetsixe." Wozãa wo ne asrãdɔa nu sẽ zi ɖeka alo ne gbɔgbɔ sesẽ na wò. Wowɔa dɔ le aɖabaƒoƒo ʋɛ aɖewo ko me eye wonaa gbɔdzɔe kaba. |
| Beta-Agonist siwo wɔa dɔ ɣeyiɣi didi (LABA) . | Esiawo menye gbɔdzɔe xɔxɔ kaba o. Wozãa wo gbesiagbe, le ɣeyiɣi siwo sɔ me, be woatsɔ aɖu dzesiwo dzi eye woaxe mɔ ɖe gbɔgbɔtsixetsixe nu. Woƒe ŋusẽkpɔɖeamedzi nɔa anyi gaƒoƒo geɖe. Zi geɖe la, wonaa wo kpena ɖe steroid (corticosteroid) atike ŋu. |
Aleke atike sia wɔa dɔ le ŋutilãa me?
Mɔ nyuitɔ si dzi míato ase esia gɔmee nye be míabu míaƒe ŋutilã ƒe "avuwɔwɔ alo sisi" ƒe ŋuɖoɖo ŋu. Tsɔe be esusɔ vie nàdze ŋgɔ afɔku kpata aɖe. Le ɣeyiɣi ma me la, wò ŋutilã dzrana ɖo be yeawɔ avu alo asi.
Le ɣeyiɣi sia me la, dzesiwo tsoa ahɔhɔ̃a me, eye wokekea yamɔ siwo le lãkusiwo me ɖe enu be woaxɔ ɔksidzin geɖe, eye wònana dzi ƒe tsotso kabakaba be wòaɖo ʋu ma si me oxygen sɔ gbɔ ɖo ɖe lãmekawo me kabakaba wu.
Nu ma tututue beta-agonist atikewo wɔna le mɔ si wowɔ kple asi nu. Woʋua ‘switches’ (receptors) siwo sɔ eye wonaa ŋutilãa wɔa nu abe ɖe wòdze ŋgɔ nɔnɔme kpata aɖe ene. Esia tae lãmeka siwo le lãkusiwo me la ɖea dzi ɖi, si wɔnɛ be gbɔgbɔ nɔa bɔbɔe.
Nukawoe nye beta-agonist atike siwo wozãna wu?
Beta-agonist atike ƒomevi vovovowo li siwo ɖɔktawo ŋlɔna na ame. Kpɔɖeŋu aɖewoe nye esi:
| Atikewo ƒe hatsotso | Kpɔɖeŋuwo (atike vɔ̃ɖiwo ƒe ŋkɔwo) . |
|---|---|
| Beta-2 si wɔa dɔ kpuie (SABA) . | Salbutamol / Albuterol, Nusiwo wotsɔna ƒoa ƒui |
| Beta-2 (LABA) si wɔa dɔ ɣeyiɣi didi . | Formoterol, Salmeterol, Indakaterol ƒe dɔléle |
| Beta-1 ƒe atike si nye beta-1 | Dobutamine, Norepinephrine ƒe atike |
| Beta-3 ƒe atike si nye beta-3 | Mirabegron ƒe ŋkɔ |
Ðe atike sia ƒe nugbegblẽ le ame ŋu aɖewoa?
Abe atike ɖesiaɖe ene la, beta-agonists ate ŋu ahe nugbegblẽ le ame aɖewo ŋu. Gake ne wozãe abe atike ene la, atike la yia lãkusiwo me tẽ, eyata zi geɖe la, eƒe nugbegblẽ le ame ŋu mesẽna boo o. Gake ame aɖewo ate ŋu akpɔe be:
- Dzi ƒe tsotso kabakaba (Tachycardia) .
- Dzi ƒe tsotso si mesɔ o (Arrhythmia) .
- Ʋuʋudedi
- Dzitsitsi
- Taɖuame
- Lãmetsiwo ƒe ʋuʋu
- Fifia ƒe ʋuʋu
Nu vevitɔe nye be ne èkpɔ nugbegblẽ le ame ŋu siawo dometɔ aɖe, alo ne èse nane si mebɔ o le atikeawo zazã vɔ megbe la, ƒo nu kple wò ɖɔkta enumake. Ðewohĩ ate ŋu atrɔ asi le atikeawo ƒe agbɔsɔsɔme ŋu alo aŋlɔ atike bubu na wò.
Ɣekaɣie wòle be nàkpɔ ɖɔkta?
Nɔnɔme geɖewo li siwo me wòle vevie ŋutɔ be nàkpɔ wò ɖɔkta.
- Ne èkpɔ nugbegblẽ siwo medzea ŋuwò o, siwo mèle mɔ kpɔm na o la .
- Ne èse le ɖokuiwò me be yeƒe atike mele dɔ wɔm nyuie abe tsã ene o (le kpɔɖeŋu me, ele be nàzã wò yagbɔgbɔmɔ̃a wu tsã be gbɔdzɔe nasu asiwò).
- Ne èse le ɖokuiwò me be yeƒe dzesiwo le gbegblẽm ɖe edzi eye màte ŋu aɖu wo dzi o .
Le go sia me la, wò ɖɔkta ate ŋu ato wò atikewɔwɔ ƒe ɖoɖoa me eye wòana egbɔkpɔnu si me nàvo le wu eye wòawɔ dɔ nyuie wu la wò.Mègadzudzɔ wò atikewo nono alo atrɔ atikeawo ƒe agbɔsɔsɔme gbeɖe atikewɔlawo ƒe aɖaŋuɖoɖo manɔmee o. Ne èkpɔ nugbegblẽ sesẽ aɖe la, yi kɔdzi ƒe Dɔwɔƒe si Kpɔa Nudzɔdzɔ Kpatawo Gbɔ (ETU) si te ɖe ŋuwò enumake.
Gbedasi si Wotsɔ Yi Aƒeme
- Beta-agonists nye atike ƒomevi aɖe si nana gbɔgbɔ nɔa bɔbɔe, eye wozãnɛ koŋ na gbɔgbɔmedɔlélewo abe asrã kple COPD ene.
- Wole ƒomevi vevi eve: ɣeyiɣi kpui aɖe (SABA) si naa gbɔdzɔe kabakaba le nɔnɔme kpatawo me, kple ɣeyiɣi didi (LABA) si naa dɔlélea dzi ɖuɖu ɣeyiɣi didi.
- Zã atike sia ɣesiaɣi abe alesi wò ɖɔkta gblɔe ene pɛpɛpɛ, eye nàzãe le agbɔsɔsɔ si nèŋlɔ nɛ me ko .
- Kpɔ nyuie le nugbegblẽ le ame ŋu abe dzi ƒe tsotso kabakaba kple asiwo ƒe ʋuʋu ene ŋu. Ne èse veve aɖe la, na wò ɖɔkta nanya enumake.
- Ne èse le ɖokuiwò me be yeƒe atikewɔwɔ mele dɔ wɔm nyuie o alo yeƒe dzesiwo le sesẽm ɖe edzi la, mègawɔ atike na ɖokuiwò eye nàdi atikewɔlawo ƒe aɖaŋuɖoɖo o.
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