Èsusui kpɔ be ne míaƒe ŋutilã dze dɔ alo xɔ abi la, aʋa gã aɖe dzɔna le ememe be wòada gbe le mía ŋua? Mía ŋutɔwo ƒe aʋakɔ bibi ŋutɔ le mía si be míawɔ avu kple futɔwo abe dɔlékuiwo kple dɔlékui siwo tso míaƒe ŋutilã godo ene. Míeyɔa esia be dɔlélenutsiŋutete. Eyata ele be ame aɖe nanɔ asrafoha sia nu, aɖɔli gbedasiwo, eye wòaɖo wo ɖe afisi tututu futɔwo le. Adzamedɔla mawoe nye cytokines siwo ŋu míele nu ƒom tsoe egbea.
Nuka tututue nye cytokines?
Kpuie ko la, cytokines nye protein suesuesue siwo ɖoa gbedasiwo ɖe lãmenugbagbevi siwo le míaƒe dɔlélenutsiŋutete me dome. Ele abe ‘WhatsApp ƒuƒoƒo’ aɖe si le míaƒe ŋutilã me ene. Ne ŋɔdzinu aɖe abe dɔlékui alo abi ene va ŋutilãa dzi la, dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ɖea gbedasi siawo siwo woyɔna be cytokines ɖe go. Gbedasi siawo gblɔna na dɔlélenutsiŋutete ƒe lãmenugbagbevi bubuwo be, "Kuxi aɖe le afisia, va kaba!", "Futɔ sia ƒomevie wòle be míawɔ avu kplii," kple "Miwɔ asrafo geɖe wu."
Kpɔe ɖa le susu me be dɔlékui aɖe ge ɖe wò ŋutilã me. Ɣemaɣi la, lãmenugbagbevi aɖewo ɖoa cytokine gbedasi siawo ɖa, eye wogblɔna na lãmenugbagbevi bubuwo be woadzra ɖo awɔ avu kple dɔlékuia. Esia fia be ne menye amedɔdɔ sue siawoe o la, anye ne míaƒe dɔlélenutsiŋutete mate ŋu awɔ dɔ nyuie o. Cytokines siawo kpena ɖe mía ŋu be míaƒe dɔlélenutsiŋutete nɔa lãmesẽ me, ne afɔku aɖeke mele eme o gɔ̃ hã.
Ðe cytokine siawo ƒomevi vevi aɖewo lia?
Ẽ, abe alesi ɖoƒe vovovowo le asrafoha me ene la, cytokines ƒomevi vovovowo hã li. Dɔ aɖe koŋ le ƒomevi ɖesiaɖe si. Mina míalé ŋku ɖe ƒomevi vevi aɖewo ŋu.
| Cytokine ƒomevi | Nusi woawɔ bɔbɔe |
|---|---|
| Chemokines ƒe dɔwɔwɔ | Ele abe ‘GPS’ na dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ene. Efiaa mɔ si dzi woato ayi afisi dɔlékuia le la wo. |
| Nusiwo wotsɔ dea dɔlékuiwo nu | Ne dɔlékui aɖe va dze lãmenugbagbevi bubuwo dzi la, eɖoa nuxlɔ̃amedzesi ɖe lãmenugbagbevi bubuwo, gblɔna be, "Do akpoxɔnu si akpɔ ame ta!" Exea mɔ na dɔlékuiwo be woagage ɖe ŋutilãa me o. |
| Interleukins ƒe nyawo | Esiawo ɖɔlia gbedasiwo le dɔlélenutsiŋutete ƒe lãmenugbagbeviwo (ʋumenugbagbevi ɣiwo) dome eye woɖoa dze kple lãmenugbagbevi bubuwo hã. |
| Tumor necrosis factor (TNF) ƒe dɔlélenutsiŋutete . | Ekpena ɖe ame ŋu wòɖua dɔdzẽ dzi le ŋutilãa me eye wònaa dzesi dɔlélenutsiŋutete ƒe lãmenugbagbeviwo hã be woatsrɔ̃ kansa lãmenugbagbeviwo. |
| Nusiwo doa ŋusẽ nutodziɖuɖu (CSF) . | Esiawo naa mɔfiame ʋumenugbagbevi dzĩwo, abe "èzua ʋumenugbagbevi ɣi," "èzua ʋumenugbagbevi dzĩ," eye wotrɔa wo wozua lãmenugbagbevi ƒomevi aɖewo koŋ. |
Tsɔ kpe ɖe eŋu la, wotsɔ ŋkɔ na cytokines aɖewo le lãmenugbagbevi ƒomevi si wɔa wo nu be:
- Lymphokines: Ʋumenugbagbevi ɣi ƒomevi aɖe si woyɔna be lymphocytes ye wɔa wo.
- Monokines: Ʋumenugbagbevi ɣi ƒomevi aɖe si woyɔna be monocytes ye wɔa wo.
Dɔ vevitɔ si cytokines wɔna: dɔdzẽ dzi ɖuɖu
Ne ame akpa gãtɔ se nya ‘dɔdzẽ’ la, wosusuna be enye nu gbegblẽ, dɔléle ƒe dzesi. Gake le nyateƒe me la, dɔdzẽ nye dzesi vevi aɖe be míaƒe dɔlélenutsiŋutete le avu wɔm kple futɔwo alo le lãkusi siwo gblẽ la dzram ɖo. Bu eŋu kpɔ be ne ètso wò asibidɛ la, abiã, avuvu, eye wòaxɔ dzo vie, alo? Emae nye nusi dɔdzẽ nye.
Cytokines ye ɖoa gbedasi ɖe dɔlélenutsiŋutete ƒe lãmenugbagbeviwo be, "Kuxi aɖe le afisia, va kaba eye nàda abi sia, nàdzudzɔ dɔlékuiawo ƒe gege ɖe eme!"
Nusiwo gbɔna koŋue cytokines fiana:
- Lãmenugbagbeviwo ƒe dɔwɔwɔ: Afisi woayi kple nusi woawɔ na lãmenugbagbeviwo gbɔgblɔ. Le kpɔɖeŋu me, dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe mɔfiafia yi afisi dɔlékui aɖe le.
- Lãmenugbagbeviwo ƒe vovototodedeameme: Wogblɔna na lãmenugbagbevi si metsi o be "wòazu ʋumenugbagbevi ɣi ƒomevi tɔxɛ aɖe si ate ŋu awɔ avu kple dɔléle sia."
- Lãmenugbagbeviwo ƒe dzidziɖedzi: Dzesi si fia be woawɔ lãmenugbagbevi geɖe, alo lãmenugbagbevi geɖe. Le kpɔɖeŋu me, dzesi sia dona ne ʋumenugbagbevi ɣi geɖe hiã be woatsɔ awɔ avu kple dɔlékui gã aɖe.
Cytokines siwo doa alɔ dɔdzẽ kple esiwo tsia dzodzodzoetsitsi nu
Esia le abe ʋu ƒe duƒuƒu kple brek ene. Wo ame evea siaa le vevie be míate ŋu akpɔ míaƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi pɛpɛpɛ.
- Cytokines siwo doa alɔ dɔdzẽ: Esiawoe nye nusiwo nana wowɔa dɔ kabakaba . Ne dɔlékui aɖe ge ɖe eme la, wohea abi vɛ eye wonaa dɔlélenutsiŋutete ƒe dɔwɔwɔ kabakaba. Ame siawoe naa dzesi be woadze avuwɔwɔa gɔme.
- Cytokines siwo tsia dzodzodzoetsitsi nu: Esiawoe nye brek . Ne woɖu futɔa dzi vɔ la, wotɔa te nusiwo gagblẽna le mía ŋutɔwo ƒe lãkusi siwo le lãmesẽ me ŋu to dɔdzẽ dzi ɖeɖe kpɔtɔ kple nusianu gbugbɔgaɖoanyi me.
Ne dzre nya dze egɔme ko la, ele vevie ŋutɔ hã be woadzudzɔe le ɣeyiɣi nyuitɔ dzi. Ne menye nenema o la, mía ŋutɔwo ƒe lãmenugbagbeviwo ate ŋu agblẽ eye dɔléle sesẽwo ate ŋu adzɔ.
Aleke gbedasiwo ɖɔliɖɔli sia dzɔnae?
Esia nye nuwɔna dodzidzɔname aɖe ŋutɔ. Mina míatsɔe asɔ kple safui kple safui ƒe do.
Cytokine le abe safui ene . Le lãmenugbagbevi si hiã be wòaxɔ gbedasia la ƒe anyime la, safui ƒe do (xɔla) aɖe li si sɔ na safui ma. Ne cytokine (safuia) yi eye wòdo ka kple lãmenugbagbevi ma (safui ƒe do) la, lãmenugbagbevi ma xɔa gbedasia. Emegbe lãmenugbagbevi ma wɔa dɔ le gbedasi ma nu.
Mɔ etɔ̃ li siwo dzi míato aɖo gbedasi siawo ɖa:
1. Autocrine signaling: Lãmenugbagbevi aɖe ɖoa gbedasi ɖe eɖokui.
2. Paracrine signaling: Lãmenugbagbevi aɖe ɖoa gbedasiwo ɖe lãmenugbagbevi siwo te ɖe eŋu.
3. Endocrine signaling: Lãmenugbagbevi aɖe ɖoa gbedasiwo to ʋua me ɖe lãmenugbagbevi siwo le adzɔge tso egbɔ.
Lãmenugbagbevi kawoe wɔa cytokines geɖe wu?
Zi geɖe la, lãmenugbagbevi siwo le míaƒe dɔlélenutsiŋutete me ye wɔa cytokines. Ke hã, menye woawo koe nye lãmenugbagbeviwo o. Lãmenugbagbevi ƒomevi bubu siwo le míaƒe ŋutilã me hã ate ŋu awɔ wo.
Dɔlélenutsiŋutete ƒe lãmenugbagbeviwo
- Macrophages ƒe lãmenugbagbevi gãwo
- Dendritic lãmenugbagbeviwo
- Lãmetsiŋusẽ ƒe lãmenugbagbeviwo
- Monocytes ƒe lãmenugbagbevi siwo woyɔna be monocytes
- Neutrophils ƒe dɔwɔwɔ
- Basophils ƒe lãwo
- Eosinophils ƒe lãwo
- Mast cells ƒe lãmenugbagbeviwo
Lãmenugbagbevi bubuwo
- Endothelial cells (lãmenugbagbevi siwo le ʋukawo ƒe eme) .
- Lãmenugbagbevi siwo le lãkusi me nye lãmenugbagbevi siwo tsyɔa míaƒe ŋutinuwo ƒe anyime.
- Lãmenugbagbevi siwo le kadodoŋusẽ me (Fibroblasts, Stromal cells) .
- Lãmenugbagbevi siwo ƒo xlã lãmekawo (Schwann cells) .
Nukae dzɔna ne cytokine ƒe dadasɔ bu?
Togbɔ be cytokines le vevie na míaƒe lãmesẽ abe nu bubu ɖesiaɖe ene hã la, wo zazã fũ akpa menyo o. Ɣeaɖewoɣi la, le dɔlékui aɖe alo atikewɔwɔ aɖewo ta la, dɔlélenutsiŋutetea doa ŋusẽ akpa eye wòdzea cytokines gbogbo aɖewo wɔwɔ gɔme si dzi womate ŋu aɖu o.
Míeyɔa nɔnɔme sia be Cytokine Release Syndrome (CRS) alo cytokine ahom . Ðeko wòle abe ɖe mía ŋutɔwo ƒe dɔlélenutsiŋutete ƒe dɔmawɔmawɔ nyuie, menye míaƒe futɔwo ɖeɖeko dzie wòdzena o, ke edzea mía ŋutɔwo ƒe lãmenugbagbevi siwo le lãmesẽ me hã dzi. Esia ate ŋu ahe abi si gbɔ eme, lãmekawo ƒe gbegblẽ, kple dɔléle vovovowo vɛ.
Dɔléle siwo ate ŋu atso cytokines siwo sɔ gbɔ gbɔ gbɔ:
- Dɔlélenutsiŋutete ƒe dɔlélewo: Le esia me la, dɔlélenutsiŋutete dzea eya ŋutɔ ƒe lãmenugbagbevi siwo le lãmesẽ me dzi vodadatɔe.
- Lãmetsiŋusẽ ƒe dɔmawɔmawɔ nyuie: Kuxi siwo le alesi nuɖuɖu trɔna wòzua ŋusẽ ŋu.
- Kansa.
- Sepsis: Esia nye dɔléle sesẽ aɖe ŋutɔ. Dzoxɔxɔ sesẽ le ŋutilãa me nana ʋu si sina yia ŋutinu veviwo me dzi ɖena kpɔtɔna. Esia nye atikewɔwɔ kpata eye ate ŋu awu ame ne womewɔ atike nɛ o.
Ne ɖikeke aɖe le ŋuwò le nɔnɔme sia ŋu la, ele vevie ŋutɔ be nàkpɔ wò ɖɔkta enumake aɖaɖo aɖaŋu na wò .
Cytokine ƒe ƒuƒoƒo ƒe dodokpɔ
Ðɔktawo ate ŋu anya ne cytokines sɔ gbɔ akpa alo ʋɛ akpa le wò ŋutilã me. Woyɔa ʋudodokpɔa be cytokine panel . Edzidzea cytokines siwo le wò ʋu me siwo kpɔa gome le dɔdzẽ me ƒe agbɔsɔsɔ. Wò ɖɔkta ate ŋu anɔ te ɖe nusiwo do tso eme dzi aŋlɔ atike siwo woatsɔ axe mɔ ɖe dɔdzẽ nu ne èsɔ gbɔ akpa.
Gbedasi si Wotsɔ Yi Aƒeme
- Cytokines nye atikewo ƒe dɔla siwo le vevie na kadodo le míaƒe dɔlélenutsiŋutete me.
- Esiawo wɔa dɔ tsɔ wɔa avu kple ŋɔdzidoname siwo le ŋutilãa ŋu, be woahe ‘dɔdzẽ’ vɛ, eye woadzudzɔe ne avuwɔwɔa wu enu ko.
- Cytokines ƒe dadasɔ nyuie le vevie na lãmesẽ nyui. Wo dometɔ geɖe alo ʋɛ akpa ate ŋu ahe dɔléle vɛ.
- ‘Cytokine storm’ nye nɔnɔme sesẽ aɖe si dɔlélenutsiŋutete ƒe dɔwɔwɔ fũ akpa hena vɛ.
- Ne dzimaɖitsitsi alo dzesi aɖewo le ŋuwò ku ɖe wò dɔlélenutsiŋutete ŋu la, di aɖaŋuɖoɖo tso atikewɔla bibi aɖe gbɔ ɣesiaɣi.
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