Ðe kuxi aɖe le wò ʋumenugbagbevi ɣiwo ŋua? Mina míasrɔ̃ nu tso Histiocytosis ŋu le nya bɔbɔewo me!

Ènya be ɣeaɖewoɣi la, lãmenugbagbevi ƒomevi aɖewo siwo le míaƒe ŋutilã me dzea nuwɔwɔ gɔme le mɔ bubu nu viea? Woyɔa nɔnɔme mawo dometɔ ɖeka si mebɔ o be Histiocytosis. Esia aɖi vɔvɔ̃ na wò vie, gake mègatsi dzi o. Mina míaƒo nu tso eŋu bɔbɔe eye míaƒo nu tso eŋu le mɔ si me susu le nu.

Nukae nye Histiocytosis? Ne míagblɔe bɔbɔe la...

Ʋumenugbagbevi ɣi ƒomevi aɖe si woyɔna be histiocytes le wò ŋutilã me. Le ʋumenugbagbevi ɣi mawo dome la, lãmenugbagbevi tɔxɛ aɖe li si woyɔna be histiocytes . Amesiawo le abe míaƒe ŋutilã ƒe dedienɔnɔdzikpɔlawo ene. Woawoe nye amesiwo wɔa avu kple dɔlékui siwo hea dɔléle vɛ siwo woyɔna be dɔlékuiwo - dɔlékuiwo , dɔlékuiwo , kple fungi - eye wokpena ɖe mía ŋu be míaƒe dɔlélenutsiŋutete nanɔ lãmesẽ me.

Ke hã, ɣeaɖewoɣi la, histiocyte lãmenugbagbevi siawo dzea tsitsi gɔme le mɔ si mesɔ o nu, si fia be wozua `` mutant '' . Emegbe, histiocyte lãmenugbagbevi siawo siwo mesɔ o tsina fũu akpa eye woƒoa ƒu ɖe míaƒe ŋutilã ƒe akpa vovovowo. Ne woƒo ƒu wògbɔ eme la, míaƒe dɔlélenutsiŋutete ate ŋu ado go kuxiwo. Nu vevitɔe nye be dɔdzẽ , si fia be nɔnɔme aɖe si le abe vuvu ene , dzɔna le ŋutilãa ƒe lãkusiwo me. Dɔdzẽ sia ate ŋu agblẽ nu le míaƒe ŋutinuwo ŋu ɣeaɖewoɣi.

Histiocyte lãmenugbagbevi siawo siwo mesɔ o ate ŋu aƒo ƒu ɖe wò ʋukawo (siwo woyɔna hã be ʋukawo), ŋutigbalẽ, ƒuwo, lãkusiwo, aklã, dɔgbo, alo wò ŋutilã ƒe teƒe bubu ɖesiaɖe. Ɣeaɖewoɣi la, wò ŋutilã ƒe akpa ɖeka ko dzie wògblẽa nu le. Míeyɔa esia be ‘ɖoɖo ɖeka’ ƒe nɔnɔme. Ɣebubuɣiwo la, ate ŋu agblẽ nu le wò ŋutilã ƒe akpa geɖe ŋu. Míeyɔa esia be ‘nuɖoanyi geɖe’ ƒe nɔnɔme.

Nu vevitɔe nye be histiocytosis menye kansa o . Gake ɣeaɖewoɣi la, ate ŋu awɔ nu abe kansa ene eye wòaɖe dzesi siwo sɔ kple kansa afia. Esia tae wònye nɔnɔme si hiã be woalé ŋku ɖe eŋu etɔxɛe vie. Esi wònye be esia ƒe dzesiwo toa vovo tso ame ɖeka gbɔ yi bubu gbɔ eye nɔnɔmea ƒe sesẽme hã toa vovo ta la, ate ŋu asesẽ ɣeaɖewoɣi be woakpɔ histiocytosis kaba.

Nukawoe nye histiocytosis ƒomevi veviwo?

Fifia ɖewohĩ èse nusi histiocytosis nye gɔme. Le nyateƒe me la, eƒe ƒomevi siwo wu 100 ye li. Gake ƒomevi vevi etɔ̃ li siwo míekpɔna heƒoa nu tso wo ŋu zi geɖe. Na míalé ŋku ɖe wo ŋu.

1. Langerhans ƒe lãmenugbagbeviwo ƒe histiocytosis (LCH):

• Esiae nye histiocytosis ƒomevi si bɔ wu .
• Nɔnɔme sia dzea ɖevi suewo dzi zi geɖe . Edzea ɖevi miliɔn ɖesiaɖe dometɔ 5 va ɖo 9 dzi.
• Zi geɖe la, esia menye nu sesẽ nenema gbegbe o, eye ateŋu anɔ bɔbɔe abe ``dzesi aɖeke manɔmee'' . Gake ele vevie be míaɖo ŋku edzi be le go aɖewo me la, esia ate ŋu asẽ eye wòate ŋu ade ame ƒe agbe afɔku me gɔ̃ hã.

2. Erdheim-Chester ƒe dɔléle (ECD): .

• Ame tsitsiwo koŋue gblẽa nu le esia ƒomevi ŋu .
• Esia hã nye nɔnɔme si mebɔ kura o .
• Abe LCH ene la, ECD ate ŋu atso esi mesẽ o dzi va ɖo esi nu sẽ eye wòate ŋu ade ame ƒe agbe afɔku me.

3. Rosai-Dorfman ƒe dɔléle (RDD): .

• Abe LCH ene la, RDD dzɔna zi geɖe le ɖeviwo me , gake ate ŋu adzɔ le ame tsitsiwo hã me.
• Esia hã mebɔ kura o. Wokpɔa dɔléle sia le ame akpe alafa eve ɖesiaɖe me lɔƒo.
• Esia ƒe ƒomevi vevitɔe nye ‘klasik RDD’ . Esiae nye esime wò ʋukawo (ʋuʋudedi) vuvu.
• Ƒomevi bubue nye ‘extranodal RDD’ . Le esia me la, ŋutinu bubu siwo menye ʋuka siwo me ʋu sina tona o la gblẽa nu le wo ŋu. Esia fia be histiocyte lãmenugbagbevi siwo sɔ gbɔ ate ŋu aƒo ƒu ɖe ŋutigbalẽ, ƒuwo, alo teƒe bubuwo.

Aleke gbegbee dɔléle sia mebɔ o be Histiocytosis?

Ẽ, abe alesi megblɔe va yi ene la, histiocytosis nye dɔléle si mebɔ ŋutɔŋutɔ o . Le nyateƒe me la, eƒe kansa ƒomevi siwo nu sẽ wu, siwo me kansa le la mede kansa siwo katã wokpɔ le lãkusi falɛfalɛwo kple ʋukawo me ƒe 1% o . Eyata àte ŋu akpɔ alesi gbegbe esia mebɔ o la le susu me.

Nukae nye Histiocytosis ƒe dzesiwo?

Azɔ mina míakpɔ dzesi siwo woɖena fiana le histiocytosis nɔnɔme sia me ɖa. Dzesi siawo ate ŋu ato vovo tso ame ɖeka gbɔ yi bubu gbɔ . Nusitae nye be ŋutinu kple lãkusi siwo me histiocyte lãmenugbagbevi siwo sɔ gbɔ wu la ƒoa ƒu ɖo, abe alesi megblɔe ene, kple alesi gbegbe lãmenugbagbevi mawo gblẽe la kpɔa ŋusẽ ɖe esia dzi.

Dzesi siwo nàte ŋu akpɔ dometɔ aɖewoe nye esi (eye ɖewohĩ bubuwo hã li):

• Ŋutilã me ʋuʋudedi : Woate ŋu akpɔ esiawo vevietɔ le vidzĩ suewo ƒe ta ƒe teƒe siwo fu le (míeyɔa wo be ‘cradle cap’ ) alo le aŋekotokua ƒe teƒe.
• Asrã .
• Ðeɖiteameŋu, ɖeɖiteameŋu .
• Taɖuame.
• Kɔdzi alo gbɔgbɔtsixetsixe .
• Kpekpeme dzi ɖeɖe kpɔtɔ si womeɖe o .
• Ƒu ƒe vevesese .
• Lãmetsiŋusẽ si vuvu (esiae vuvu fia).
• Nukpɔkpɔ ƒe tɔtrɔ alo ŋku siwo le ʋuʋum .
• Aɖuɖɔɖɔɖɔ enuenu kple tsikɔwuame fũu akpa .
• Ŋutilã ƒe ʋuʋudedi (ate ŋu adze le ŋkume gɔ̃ hã).
• Esesẽna be susu nanɔ nu ŋu alo aɖo ŋku nuwo dzi .
• Kuxi siwo le dadasɔ kple nuwɔwɔ aduadu me .

Aleke dzesiawo dzɔnae? Le afisi histiocytes la ƒoa ƒu ɖo nu!

Dzesi siawo nɔ te ɖe afisi histiocyte lãmenugbagbeviwo ƒoa ƒu ɖo le ŋutilãa me dzi. Teƒe vevi siwo woƒoa ƒu ɖo la toa vovo le histiocytosis ƒomevi nu.

Teƒe siwo woate ŋu akpɔ ŋusẽ ɖo le Langerhans cell histiocytosis (LCH) me:

• Ƒu
• Ŋutigbalẽ
• Lãmetsiŋusẽ ƒe ʋukawo (ʋuʋudedi) .
• Aklã
• Aɖuɖɔtoe
• Nu
• Dzitodzito
• Central nervous system (si nye ahɔhɔ̃ kple aklã) .

Nuto siwo me Erdheim-Chester dɔléle (ECD) ate ŋu adze le:

• Ƒu didiwo (vevietɔ le afɔwo me) .
• Ŋkuwo
• Titina lãmekawo ƒe dɔwɔwɔ
• Dzitodzito
• Dzi
• Ʋukawo
• Ayikuwo
• Ŋutinu siwo le ƒodo ƒe megbe (míeyɔa wo be ‘retroperitoneum’ ) .

Nuto siwo me Rosai-Dorfman dɔléle (RDD) ate ŋu adze le:

• Lãmetsiŋusẽ ƒe ʋukawo (vevietɔ le kɔ me, gake ate ŋu adzɔ le teƒe bubuwo hã) .
• Ŋutigbalẽ
• Lãmetsi falɛfalɛwo
• Yagbɔgbɔ ƒe mɔ̃ si le etame
• Ƒu
• Retroperitoneum (ŋutilã siwo le ƒodo ƒe megbe) .
• Ŋkuwo

Nukae hea Histiocytosis vɛ?

Dzɔdzɔmeŋutinunyalawo menya nusi tututu hea histiocytosis vɛ haɖe o , gake wokpɔe be ɖewohĩ edo ƒome kple domenyiŋusẽfianu ƒe tɔtrɔ .

Kpuie ko la, domenyiŋusẽfianu, alo mɔfiame aɖewo le lãmenugbagbevi ɖesiaɖe si le míaƒe ŋutilã me. Mɔfiame siawoe afia ale si wòle be lãmenugbagbevi mawo nawɔ nui. Eyata ne tɔtrɔwo va le mɔfiame siawo, siwo woyɔna be domenyiŋusẽfianu ƒe tɔtrɔ, me la, lãmenugbagbeviawo tea nuwɔna si mesɔ o. Le kpɔɖeŋu me, domenyiŋusẽfianu ƒe tɔtrɔ ate ŋu ana lãmenugbagbevi si le abe histiocyte ene nasrɔ̃ eɖokui eye wòadze kaka gɔme le mɔ si dzi womate ŋu aɖu o nu.

De dzesi domenyiŋusẽfianu ƒe tɔtrɔ siawo na numekulawo te ŋu to atike yeyewo vɛ na histiocytosis. Dɔdamɔnu siawo wɔa dɔ to mɔxexe ɖe lãmenugbagbeviwo ƒe tɔtrɔ gbegblẽ siwo nana histiocyte lãmenugbagbeviwo tsina le wo ɖokui si womate ŋu aɖu o nu.

Aleke nèwɔna dea dzesi histiocytosis?

Ne èsusu be histiocytosis le ye ŋu la, wò ɖɔkta awɔ ŋutilãmedɔdada gbã eye wòabia wò atikewɔwɔ ŋutinya. Emegbe, woatso nya me le dodokpɔ siwo woawɔ ŋu le wò dzesiwo kple ŋutinu siwo wosusu be histiocyte siwo sɔ gbɔ la gblẽ nu le wo ŋu la nu.

Dodokpɔ aɖewo siwo nàte ŋu awɔe nye esi:

• Nɔnɔmetatawo ɖeɖe ƒe ɖoɖowo :
• Wò ɖɔkta ate ŋu adɔ be woawɔ dɔ tɔxɛ aɖe si woyɔna be FDG PET/CT scan . Esia ate ŋu ade dzesi nuwo abe dɔdzẽ ene le ŋutilã bliboa me.
• Tsɔ kpe ɖe eŋu la , dodokpɔwo abe CT scan, MRI scan, ƒu ƒe fotoɖeɖe, ultrasound scan, X-ray, alo echocardiogram (dzi ƒe fotoɖeɖe) ate ŋu ahiã.

• Nudokpɔƒe ƒe dodokpɔwo :
• Wò ɖɔkta ado tsi siwo woɖe tso eme, abe wò ʋu alo aɖuɖɔ ene, akpɔ be histiocytosis ƒe dzesiwo li hã.
• Woléa ŋku ɖe wò ʋumenugbagbeviɣiwo ŋu. Wodia lãmetsiŋusẽ alo protein tɔxɛ aɖewo siwo fia alesi wò ŋutinuwo le dɔ wɔm hã. Ne ŋutinu aɖe mele dɔ wɔm nyuie o la, ate ŋu afia be histiocytes sɔ gbɔ akpa le ŋutinu ma me.

• Biopsy dodokpɔ `(Biopsy)` : .
• Nusi esia wɔnae nye be ɖɔktaa xɔa lãkusi aɖe hedoa wo kpɔ le nusuekpɔmɔ̃ me be yeakpɔe ɖa be histiocytosis le ŋuwò hã.
• Edia domenyiŋusẽfianu ƒe tɔtrɔ tɔxɛ siwo do ƒome kple histiocytosis hã.
• Ɣeaɖewoɣi la, ne womate ŋu awɔ biopsy o la, woate ŋu ado domenyiŋusẽfianu si le wò ʋu me kpɔ. Woyɔa esia be ‘liquid biopsy’ .

Nukawoe nye Histiocytosis ƒe atikewo?

Histiocytosis dada nɔ te ɖe nu geɖe dzi . Etɔxɛe:

• Aleke gbegbe wò dzesiawo nu sẽe .
• Eɖanye abi ɖeka alo geɖe le ŋuwò o (esiawo nye teƒe siwo lãmeka siwo mesɔ o le).
• Afikae `abi` siawo le le ŋutilãa dzi ?
• Eɖanye kansa nye ƒunukpeƒetetedɔ siawo alo menyee o .

Ðɔktawo nɔa te ɖe nu siawo dzi tsoa nya me le atikewɔwɔ ŋu. Atikewɔwɔ ƒe mɔnu aɖewoe nye esi:

• Kpɔ nyuie eye nàlala : Ne wò histiocytosis mesẽ o eye dzesi gã aɖeke mele ŋuwò o la, ɖeko wò ɖɔkta agblɔ na wò be nàlé ŋku ɖe wò nɔnɔmea ŋu.
• Amekoko: Ne histiocyte lãmenugbagbeviwo ƒo ƒu ɖe ŋutilã ƒe akpa ɖeka ko la, woate ŋu awɔ dɔ na ame aɖe atsɔ aɖe akpa ma ɖa.
• Kekeli ƒe atikewɔwɔ : Esia bia be woazã mɔ̃ aɖe atsɔ akplɔ keklẽŋusẽ ƒe keklẽ siwo ŋu ŋusẽ geɖe le ayi abiawo gbɔ. Kekeli siawo wua lãmenugbagbevi siwo mesɔ o eye wowɔa dɔdzẽwo ƒe tsitsi blewu. Ɣeaɖewoɣi la, keklẽŋusẽdɔdamɔnu hã ate ŋu akpe ɖe ame ŋu be woaɖe dzesiawo dzi akpɔtɔ.
• Chemotherapy (si woyɔna hã be ‘chemo’) : Esia bia be nàɖo atikewo ɖe wò ʋukawo me be woatsrɔ̃ histiocyte cells siwo sɔ gbɔ wu siwo kaka ɖe wò ŋutilã katã me. Ne histiocyte lãmenugbagbeviwo kaka ɖe wò ŋutilã katã me ko hafi ɖɔktawo kafua ‘chemo’.
• Corticosteroids : Atikewo abe prednisone ene dze le hatsotso sia me. Esiawo ate ŋu aɖe dɔdzẽ (vuvu) si kpena ɖe histiocytosis ŋu dzi akpɔtɔ. Woate ŋu ana atike siawo ɖeɖeko alo woatsɔ wo akpe ɖe atikewɔmɔnu bubuwo abe atikewɔmɔnu ene ŋu.
• Dɔlélenutsiŋutete ƒe atikewɔwɔ : Esia wɔa dɔ to ŋusẽdodo wò ŋutɔ wò dɔlélenutsiŋutete me, si kpena ɖe eŋu wòdea dzesi lãmenugbagbevi siwo gblẽa nu le ame ŋu, abe histiocytes siwo mesɔ o ene, hetsrɔ̃a wo.
• Atikewɔwɔ si woɖo taɖodzinu na : Esia nye atikewɔwɔ tɔxɛ aɖe. Wozãa atikewɔwɔ sia na histiocytosis nɔnɔme siwo do ƒome kple domenyiŋusẽfianu ƒe tɔtrɔ aɖewo.

Ðe woate ŋu ada Histiocytosis keŋkeŋa?

Esesẽ be woagblɔ be ‘ɛ̃’ alo ‘ao’ na esia, elabena enɔ te ɖe nɔnɔmea dzi. Ame geɖe siwo ŋu histiocytosis le la yia nusi woyɔna be ‘dɔléle si nɔa anyi didi’ me. Eyae nye be wodzona dɔlélea ƒe dzesi alo dzesi aɖeke manɔmee.

Woate ŋu ada histiocytosis ƒomevi aɖewo, vevietɔ ne histiocytosis la le teƒe ɖeka ko le ŋutilãa me, keŋkeŋ ne amekoko . Wò ɖɔkta ana nàva srã wò kpɔ be yeagakpɔe ɖa be egadzɔ ake hã.

Gake ne womate ŋu ada histiocytosis ƒomevi si le ŋuwò keŋkeŋ o la, wò ɖɔkta aɖo aɖaŋu na wò be nàwɔ atikewɔmɔnu si ate ŋu akpe ɖe ŋuwò nàkpɔ dɔlélea gbɔ.

Nukae nye nɔnɔme sia ƒe ŋgɔdonya?

Wò nɔnɔmea ƒe ŋgɔdonya nɔ te ɖe nu geɖe dzi. Le ame aɖewo gome la, histiocytosis nyona ɖe edzi le eɖokui si atike aɖeke mawɔmawɔe . Le kpɔɖeŋu me, amesiwo ŋu RDD le dometɔ siwo ade 40% ƒe lãme sẽna ne womewɔ atike na wo o. Azɔ hã, ne LCH gblẽ nu le ŋutilã ƒe akpa ɖeka ko ŋu (míeyɔnɛ be ‘localized LCH’) , zi geɖe la, enyona ɖe edzi le eɖokui si.

Gake, le go bubuwo me la, histiocytosis bia be woawɔ atike na ame vevie ahalé ŋku ɖe eŋu nyuie, le ɖeviwo kple ame tsitsiwo siaa gome.Le nɔnɔme siwo nu sẽ wu me la, histiocytosis ate ŋu agblẽ nu le ŋutinuwo ŋu eye wòate ŋu ade ame ƒe agbe afɔku me gɔ̃ hã .

Eyata anyo wu be nàbia wò ɖɔkta tso nyagblɔɖi si ku ɖe dɔléle si wokpɔ le ŋuwò koŋ ŋu.

Ðe woate ŋu axe mɔ ɖe Histiocytosis nua? Aleke woate ŋu aɖe afɔkua dzi akpɔtɔ?

Le nyateƒe me la, mɔ aɖeke meli si dzi nàto axe mɔ ɖe histiocytosis nu o, gake atikewɔwɔ ate ŋu akpe ɖe ŋuwò nàkpɔ wò dzesiwo gbɔ.

Gake nu ɖeka aɖe li. Atamanono dzudzɔ ate ŋu aɖe afɔku si le LCH (Langerhans cell histiocytosis), si nye lãkusi me dɔdzẽ, xɔxɔ me dzi akpɔtɔ. Asiɖeɖe le atamanono ŋu alo atamanono manɔmee hã ate ŋu ana wò alesi nàwɔ nu ɖe ​​atikewɔwɔ ŋu nanyo ɖe edzi. Ne èhiã kpekpeɖeŋu be nàdzudzɔ atamanono la, bia wò ɖɔkta tso atamanono dzudzɔ ƒe ɖoɖo siwo wowɔna tsɔ ɖoa ​​ame gbɔe ŋu.

Nya kawoe wòle be mabia nye ɖɔkta?

Ne wokpɔ histiocytosis le ŋuwò la, esɔ be nyabiase geɖe nanɔ susu me na wò. Ele vevie be nàƒo nu tso nusiawo katã ŋu na wò ɖɔkta eye nàse wò nɔnɔmea gɔme nyuie. Nyabiase aɖewo siwo nàte ŋu abiae nye esi:

• Histiocytosis ƒomevi ka ƒomevie le ŋunye?
• Ðe mahiã be woawɔ atike na ma?
• Atikewɔwɔmɔnu kawoe nèkafu?
• Nu gbegblẽ kawoe woate ŋu akpɔ mɔ na le atikewɔwɔ me?
• Nukawoe ate ŋu ado tso atikewɔwɔ me?
• Ðe woate ŋu ada nye nɔnɔmea keŋkeŋa?

Gbedasi Mamlɛtɔ si Wotsɔ Yi Aƒeme

Kpuie ko la, histiocytosis nye ŋkɔ si wotsɔ na ʋumenugbagbeviɣidɔ siwo mebɔ o ƒe ƒuƒoƒo aɖe si tsoa histiocytes, si nye ʋumenugbagbevi ɣi ƒomevi aɖe, ƒe dzidziɖedzi fũ akpa le lãmenugbagbeviwo me gbɔ. Esiawo dometɔ aɖewo ate ŋu anɔ bɔbɔe ŋutɔ, womahe dzesi aɖeke vɛ o, gake bubuwo ya nu sẽ ale gbegbe be woate ŋu ade ame ƒe agbe afɔku me .

Amesiame si ŋu histiocytosis le la ƒe histiocytes sɔ gbɔ ɖe woƒe lãkusiwo me, si wɔnɛ be dɔdzẽ (vuvu) dona. Gake dɔlélea ƒe dzesiwo, atikewɔwɔwo, kple emetsonuwo ate ŋu ato vovo ŋutɔ, le amesiwo ŋu histiocytosis ƒomevi ɖeka le gɔ̃ hã dome .

Wò ɖɔktae nye ame nyuitɔ kekeake si ase wò dɔlélea kple nɔnɔme tɔxɛ siwo ƒo xlãe gɔme. Eyata be nàse wò dɔlélea didi kple atikewɔwɔ ƒe ɖoɖoa gɔme bliboe la, mègavɔ̃ be yeabia nya gbeɖe o. Ðo dze kple wò ɖɔkta tso nusianu si le susu me na wò ŋu.

` Histiocytosis, Ʋumenugbagbevi ɣiwo, Histiocytes, Dɔlélenutsiŋutete, LCH, ECD, RDD, Dzesiwo, Atikewɔwɔ