Ðe vitamin B12 mesɔ gbɔ na wò oa? Kpɔe ɖa to Methylmalonic Acid (MMA) dodokpɔ sia dzi!

Egbea míele nu ƒom tso dodokpɔ aɖe si ƒe ŋkɔ le atikewɔwɔ me vie, gake wòle vevie ŋutɔ na míaƒe ŋutilã ƒe lãmesẽ ŋu. Enye Methylmalonic Acid ( MMA ) dodokpɔ, alo abe alesi míeyɔnɛ kpuie ene. Ðewohĩ mèse ŋkɔ sia kpɔ o. Gake bu eŋu kpɔ, MMA dodokpɔ sia ɖea vi ŋutɔ le enyanya me ne vitamin B12 (ŋkɔ bubu na vitamin B12 enye cobalamin) le wò ŋutilã me, alo nenye be wò ŋutilã ate ŋu axɔe nyuie. Eyata, mina míaƒo nu tso esia ŋu tsitotsito vie, alo?

Nukae nye MMA dodokpɔ sia?

Kpuie ko la, methylmalonic acid (MMA) dodokpɔ nye mɔ si dzi nàto anya ne vitamin B12 ƒe vevesese le ŋuwò . Wò ɖɔkta aɖe wò ʋu alo aɖuɖɔ eye wòalé ŋku ɖe methylmalonic acid (MMA) ƒe agbɔsɔsɔ ŋu.

Bu eŋu ale. Ne vitamin B12 ƒe agbɔsɔsɔ si le míaƒe lãme mede o, alo ne míexɔ B12 si míeɖuna nyuie o la, míaƒe ŋutilã dzea atike aɖe si woyɔna be MMA wɔwɔ gɔme. Ne míagblɔe tututu la, MMA nye vitamin B12 ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe akpa aɖe. Ne B12 le sue la, nuwɔna sia medzɔna nyuie o, eyata MMA tua eɖokui ɖo. Eyata, ne wò MMA ƒe agbɔsɔsɔme sɔ gbɔ la, efia be kuxi aɖe ate ŋu anɔ B12 ŋu.

Nukatae nèdi be yeawɔ MMA dodokpɔ?

Fifia ɖewohĩ ànɔ eŋu bum be, "Nukatae mele MMA dodokpɔ sia wɔm?" Susu ʋɛ aɖewo ate ŋu anɔ anyi:

• Ne vitamin B12 ƒe anyimanɔmanɔ ƒe dzesiwo le ŋuwò la:
• Ðe nèsena le ɖokuiwò me ɣesiaɣi be ɖeɖi te ye ŋu eye agbe mele ye ŋu oa ?
• Ðe nuɖuɖumeŋusẽ ƒe kuxi aɖewo, abe aɖuɖɔtoe alo dɔgbo ƒe veve enea?
• Ðe wò abɔwo kple afɔwo le ʋuʋum alo le ʋuʋuma ?
• Ðe nuɖuɖu dzroa wòa?

Ne dzesi siawo le ŋuwò la, wò ɖɔkta ate ŋu aɖo aɖaŋu na wò be nàwɔ MMA dodokpɔ, elabena esiawo ate ŋu anye dzesi siwo fia be B12 mele ŋuwò o.

• Be woado vidzĩ yeyewo kpɔ: Ɣeaɖewoɣi la, wowɔa MMA dodokpɔ na vidzĩ le edzidzi vɔ megbe teti be woatsɔ akpɔe ɖa be domenyiŋusẽfianu ƒe nɔnɔme aɖe si mebɔ o si woyɔna be methylmalonic acidemia alo methylmalonic aciduria . Zi geɖe la, wowɔa esia abe aɖuɖɔ me MMA dodokpɔ ene tsɔ léa ŋku ɖe nɔnɔmea ŋu.

Ele vevie be woanya vitamin B12 ƒe anyimanɔmanɔ nyuie, elabena ate ŋu anye lãmesẽkuxi sesẽ geɖe siwo ate ŋu agblẽ nu le lãmekawo ŋu ƒe dzesi . Kpɔɖeŋu aɖewoe nye ʋusɔgbɔdɔ si gblẽa nu le ame ŋu (ʋusɔgbɔdɔ ƒomevi aɖe si tsoa ŋutetemanɔamesi be wòaxɔ B12 gbɔ) kple ahɔhɔ̃mekawo ƒe dɔléle si do ƒome kple suklidɔ .

Nukatae nàlé ŋku ɖe MMA ŋu tsɔ wu be nàlé ŋku ɖe B12 ƒe dzidzenuwo ŋu tẽ?

Nyabiase nyui aɖee nye esia. Ðewohĩ àsusu be ne èlé ŋku ɖe B12 ƒe agbɔsɔsɔ si le ʋua me ŋu ko akpɔ kuxia gbɔ. Gake viɖe tɔxɛ aɖewo le B12 ƒe dzidzenu kple MMA ƒe dzidzenu siaa me dzodzro me. Ne ɖɔktaa lé ŋku ɖe MMA ƒe agbɔsɔsɔme ŋu la , enaa nyatakaka geɖe wu eye wònaa woate ŋu akpɔ dɔlélea nyuie wu .

Bu eŋu ale. B12 ƒe agbɔsɔsɔ si le wò ʋu me ate ŋu asɔ ne èdoe kpɔ. Gake ɖewohĩ wò ŋutilã mate ŋu azã B12 la nyuie o. Woyɔa esia be nugbagbewo ƒe dɔwɔwɔ si mebɔ o . Ðo ŋku edzi be MMA dzɔna ne B12 ƒe agbɔsɔsɔ le sue. Eyata ne wò ʋu me B12 ƒe agbɔsɔsɔ sɔ hã la, ne wò MMA ƒe agbɔsɔsɔ sɔ gbɔ la, ate ŋu ana wò ɖɔkta be wò ŋutilã mele B12 zãm nyuie o, eye be nane gblẽ. Azɔ hã, MMA ƒe agbɔsɔsɔ si sɔ ate ŋu akpe ɖe ame ŋu wòanya lãmesẽkuxi aɖewo ahada wo kaba .

Aleke woawɔ MMA dodokpɔae?

Be nàwɔ MMA dodokpɔ la, zi geɖe la, wò ɖɔkta abia tso asiwò be nàɖe ʋu (ʋuɖeɖe) alo aɖuɖɔtoe (aɖuɖɔ dodokpɔ).

• Woate ŋu axɔ ʋu le dodokpɔxɔ, kɔdzi, alo ɖɔkta ƒe dɔwɔƒe.
• If it’s a urine sample , woate ŋu abia tso asiwò be nàxɔe le aƒeme atsɔe ayi dodokpɔxɔ me, alo woate ŋu abia tso asiwò be nàtsɔe ana le ɖɔkta ƒe dɔwɔƒe.

Woléa ŋku ɖe MMA ƒe agbɔsɔsɔ si le kpɔɖeŋu sia me ŋu le dɔlélewo ŋuti nudokpɔƒe, si nye teƒe si wodoa ŋutilã me tsiwo kple lãkusiwo kpɔna le.

Ɣeaɖewoɣi la, wò ɖɔkta ate ŋu abia hã be woado homocysteine ​​kpɔ . Emegbe, wotua dɔlélea didi ɖe nyatakaka ma kple MMA ƒe nyatakaka siaa dzi.

Aleke nèdzrana ɖo ɖe dodokpɔ sia ŋu?

Dzadzraɖo ƒe ɖoɖoa ate ŋu ato vovo vie le alesi wole wò MMA dodokpɔa wɔm kple ʋu alo aɖuɖɔ ta. Eyata bia wò ɖɔkta ɣesiaɣi ne mɔfiame tɔxɛ aɖewo li.

• Zi geɖe la, ne ʋudodokpɔe , woabia tso asiwò be nàtsi nu adɔ , si fia be mègaɖu nu alo ano naneke o, gaƒoƒo ʋɛ aɖewo hafi dodokpɔa nadze egɔme.
• Ne wole aɖuɖɔtoe xɔm gaƒoƒo 24 la , woate ŋu abia tso asiwò be nàdzudzɔ nuɖuɖu kple atike aɖewo nono ŋkeke si do ŋgɔ na dodokpɔa.

Nukae dzɔna le dodokpɔa wɔɣi?

Esia hã toa vovo le kpɔɖeŋu si nèdi be yeana nu.

• Ʋudodokpɔ: Ènɔa zikpui dzi hedoa alɔ ɖeka ɖe enu. Emegbe la, ʋukaŋutinunyala, si nye amesi wona hehee be wòaɖe ʋu, tsɔa aŋe dea ʋuka aɖe si le wò alɔnu si te ɖe wò abɔta ŋu me eye wòɖea ʋu sue aɖe. Ne woɖe aŋea ɖa la, woabia tso asiwò be nàtsɔ gaze aɖe alé teƒea ɖe teƒea. Emegbe, woblaa aŋe sue aɖe ɖe eŋu. Mègatsi dzi o, àse veve vie, gake adzo kaba.

• Gaƒoƒo 24 ƒe aɖuɖɔ dodokpɔ: ȃoa wò aɖuɖɔ nu ƒu le gaƒoƒo 24 me le aŋetu tɔxɛ aɖe si le dzadzɛ me. Wò ɖɔkta alo dɔnɔdzikpɔla afia alesi tututu nàwɔ esia wò. Ne ɣeyiɣia wu enu la, ele be nàtsɔ aŋetu la ayi dodokpɔxɔa me.

• Aɖuɖɔtoe si woɖena edziedzi (aɖuɖɔtoe me dzodzro): Esia bia be nàƒo aɖuɖɔ sue aɖe nu ƒu ɖe kplu dzadzɛ aɖe me, le aƒeme alo le wò ɖɔkta ƒe dɔwɔƒe. Woafia alesi nàwɔ esiae wò.

• Vidzĩ yeyewo ƒe dodokpɔ nye dodokpɔ si me lãmesẽdɔwɔla tsɔa aŋe ɖe ʋu ʋɛ aɖewo tso teƒe sue aɖe si le viwòa ƒe afɔkpodzi dzi. Zi geɖe la, wowɔa esia le kɔdzi, le ŋkeke ɖeka alo eve me tso esime wodzii.

Nukae dzɔna le dodokpɔa megbe?

Ne wowɔ ʋudodokpɔ alo aɖuɖɔ dodokpɔ vɔ la, naneke tɔxɛ aɖeke megali nàte ŋu awɔ o. Nudokpɔƒea ado kpɔɖeŋua kpɔ eye wòaɖo nyatakakaa ɖe wò ɖɔkta. Ate ŋu adze le wò elektrɔnik atikewɔwɔ ŋuti nuŋlɔɖiwo hã me.

Ðe afɔku aɖewo le dodokpɔ sia mea?

Abe alesi wòle le ʋudodokpɔ ɖesiaɖe gome ene la, afɔku sue aɖe koe li be dɔlékuiwo xɔxɔ le afisi wodo aŋea ɖo, gake ebɔbɔ ŋutɔ.

Afɔku siwo le aɖuɖɔ dodokpɔ me enye be ɖewohĩ womaƒo kpɔɖeŋua nu ƒu nyuie o (vevietɔ ne wole aɖuɖɔtoe xɔm gaƒoƒo 24) eye be kpɔɖeŋua ate ŋu aƒo ɖi – le kpɔɖeŋu me, ne nane abe dɔlékui siwo tso aɖuɖɔ me ge ɖe aɖuɖɔa me ene – si ateŋu ahe emetsonu siwo mesɔ o vɛ le nyatakakaa me.

Aleke MMA ƒe seƒe le mama dedie nu le?

MMA ƒe agbɔsɔsɔ si sɔ le ʋu kple aɖuɖɔ siaa me ate ŋu ato vovo vie tso dodokpɔxɔ ɖesiaɖe me.

• MMA ƒe agbɔsɔsɔ si sɔ le ʋumenugbagbevi dzĩ me nye 0.40 μmol/L (micromole le lita ɖeka me) , woŋlɔnɛ ɣeaɖewoɣi be umol/L alo mcmol/L, eye ele be wòaɖiɖi wu agbɔsɔsɔ ma.
• MMA ƒe agbɔsɔsɔ le aɖuɖɔ me ate ŋu asɔ, ne esɔ gbɔ abe 4.0 mmol/mol crt (millimole le creatinine mole ɖeka me) gɔ̃ hã . Le afisia la, crt fia atike aɖe si woyɔna be creatinine.

Eyata ele be nàlé ŋku ɖe nufiame ƒe didime si wona le wò nyatakakaa me ŋu godoo.

Ɣeyiɣi didi kae wòxɔna hafi akɔntabubua va ɖoa?

Ate ŋu axɔ tso ŋkeke ɖeka va ɖo kwasiɖa ɖeka alo eve hafi nyatakakaa natrɔ tso MMA dodokpɔ me. Etoa vovo le dodokpɔxɔa nu. Àte ŋu abia wò ɖɔkta ɣekaɣie nàte ŋu akpɔ mɔ na nyatakakaa.

Nukae dzɔna ne MMA ƒe ɖoƒea lolo akpa?

Ne wò MMA nyatakaka ɖee fia be wò agbɔsɔsɔme sɔ gbɔ la, ate ŋu ahiã be woado wò kpɔ alo awɔ atike na wò be vitamin B12 ƒe anyimanɔmanɔ le ŋuwò. Anɔ eme be wò ɖɔkta atsɔ wò MMA ƒe nyatakaka asɔ kple dodokpɔ bubuwo me tsonu, abe wò B12 ƒe nyatakaka kple ɖewohĩ wò homocysteine ​​ƒe nyatakaka ene, be wòatso nya me.

• Ne MMA sɔ gbɔ ɖe vidzĩ si wodzi yeyee me la, ate ŋu axɔ methylmalonic acidemia.Ate ŋu anɔ anyi. Anɔ eme be ɖɔktaa aɖe gbe be woagawɔ dodokpɔ bubuwo atsɔ aɖo kpe dɔlélea dzi. Dɔléle sia dada dometɔ aɖewoe nye vitamin siwo wotsɔ kpena ɖe ame ŋu, nuɖuɖu si me protein mesɔ gbɔ ɖo o, kple nuɖuɖu siwo me amino acid aɖewo le dzi ɖeɖe kpɔtɔ .

Ke ne B12 sɔ gake MMA sɔ gbɔ ɖe?

Le kpɔɖeŋu me, wò B12 ƒe agbɔsɔsɔme sɔ, gake wò MMA ƒe agbɔsɔsɔme sɔ gbɔ. Togbɔ be ele alea hã la, àte ŋu akpɔ B12 ƒe gbɔdzɔgbɔdzɔ kokoko – vevietɔ ne dzesiwo le ŋuwò. Ate ŋu anye nusi mehiã o kaba alo nusi gbɔdzɔ vie . Esia mefia kokoko be àva gblẽ ɖe edzi o. Wò ɖɔkta atso nya me nenye be èhiã atikewɔwɔ alo mèhiãe o.

Ɣekaɣie wòle be makpɔ ɖɔkta?

Ne vitamin B12 ƒe anyimanɔmanɔ ƒe dzesiwo le ŋuwò, alo ne nya aɖe le asiwò ku ɖe wò dodokpɔa me tsonu ŋu la, kpɔ egbɔ be yeyi ɖɔkta gbɔ. Mègavɔ̃ o, ɖɔkta aɖe nu sia nu me na wò.

Mlɔeba la, nu siwo dzi wòle be woaɖo ŋkui

Èkpɔa, ɣeaɖewoɣi la, dodokpɔ si wowɔ le míaƒe ŋutilã ƒe akpa aɖe ate ŋu ana míanya alesi akpa bubu le dɔ wɔm. MMA dodokpɔ sia le nenema. MMA ƒe agbɔsɔsɔ si dzi ɖe edzi ate ŋu ana wò ɖɔkta be wò B12 ƒe agbɔsɔsɔ le ʋɛ, alo be wò ŋutilã mele exɔm nyuie o.

Esia ate ŋu anye nyatakaka vevi aɖe ŋutɔ, vevietɔ be míade dzesi nɔnɔme siwo gblẽa nu le míaƒe lãmekawo ŋu eye míadze atikewɔwɔ gɔme kaba.

Eyata, ne nyabiase alo dzimaɖitsitsi aɖe le asiwò ku ɖe MMA dodokpɔ sia alo eƒe nyatakaka ŋu la, mègahe ɖe megbe le nuƒoƒo na wò ɖɔkta tso eŋu o. Ana numeɖeɖe siwo katã nèhiã la wò. Nɔ lãmesẽ me!

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