Ðe nèle ʋumenugbagbevi geɖe wɔm le wò ŋutilã mea? Mina míasrɔ̃ nu tso Myeloproliferative Neoplasms (MPN) siawo ŋu!

Èbu nusi adzɔ ne wò ƒumeŋuɖui wɔ ʋumenugbagbevi geɖe akpa le wò ŋutilã me ŋu kpɔa? Aleae myeloproliferative neoplasms, alo MPN kpuie, le. Esia nye ʋumenugbagbeviɣidɔ si mebɔ o, gake wòdea ame ƒe agbe afɔku me, si ate ŋu awu ame ne womekpɔ egbɔ nyuie o. Na míaƒo nu tso eŋu le mɔ bɔbɔe aɖe si gɔme nàte ŋu ase nu.

Nukae nye myeloproliferative neoplasm (MPN) sia?

Kpuie ko la, myeloproliferative neoplasms (MPNs) nye nɔnɔme siwo me wò ƒumeŋuɖui (lãmeka falɛfalɛ aɖe si le wò ƒuwo me) nana ʋumenugbagbevi dzĩwo, ʋumenugbagbevi ɣiwo, alo ʋumenugbagbevi dzĩwo (lãmenugbagbevi siwo kpena ɖe wò ʋu ŋu wòtsia) geɖe wu . Bu eŋu abe dɔwɔƒe si wɔa nu geɖe akpa ene. Esia dzɔna ne nane gblẽ le ʋumenugbagbeviwo wɔwɔ me.

Zi geɖe la , MPN nɔnɔme siawo va nɔa blewu ŋutɔ . Eyata ɖewohĩ dzesi aɖeke madze ame aɖewo ŋu o ƒe geɖe. Esia tae wogayɔa wo be "chronic" alo ɣeyiɣi didi ƒe myeloproliferative neoplasms. Gake le go siwo mebɔ o me la, MPN ƒe nɔnɔme siawo ate ŋu ava zu nusi nu sẽ wu.

Gake mègatsi dzi o, atike nyuiwo li siwo dzi woato aɖu nɔnɔme sia ƒe dzesiwo dzi eye woaxe mɔ ɖe enu be wòagasẽ ɖe edzi o.

MPN ƒomevi kawoe li?

MPN ƒomevi vovovowo li. Ƒomevi ɖesiaɖe kpɔa ŋusẽ ɖe ʋumenugbagbevi ƒomevi si wò ƒumeŋuɖui wɔna wògbɔa eme dzi. Ɣeaɖewoɣi la, ʋumenugbagbevi dzĩwo koe woate ŋu awɔ, evɔ ɣebubuɣiwo la, ʋumenugbagbevi ɣiwo alo ʋumenugbagbevi dzĩwo koe woate ŋu awɔ. Le MPN ƒomevi aɖewo me la, woate ŋu awɔ lãmenugbagbevi siawo ƒe ƒuƒoƒo wòagbɔ eme. Susu bubue nye be lãmenugbagbevi siawo siwo sɔ gbɔ ate ŋu awɔ nu wòato vovo na ʋumenugbagbevi siwo le lãmesẽ me.

Ameka dzie nɔnɔme sia gblẽ nu le wu?

Nu vevi eve siwo kpɔa ŋusẽ ɖe MPN ƒe dzɔdzɔ dzi enye ƒe si nèxɔ kple ŋutsu alo nyɔnu nyenye .

• Ƒe si woxɔ: Togbɔ be MPN ate ŋu adze ame siwo xɔ ƒe vovovowo dzi hã la, ame siwo xɔ ƒe 50, 60, alo esi wu nenema ŋue wòdzena le wu .
• Ŋutsu alo nyɔnu nyenye: Le kpɔɖeŋu me, polycythemia vera, si nye MPN ƒomevi aɖe, bɔ ɖe ŋutsuwo me wu. Ʋumenugbagbeviɣidɔ veviwo bɔ ɖe nyɔnuwo me wu. MPN ƒomevi bubuwo ate ŋu akpɔ ŋusẽ ɖe ŋutsuwo kple nyɔnuwo siaa dzi sɔsɔe.

Aleke MPN kpɔa ŋusẽ ɖe wò ŋutilã dzii?

Dɔléle siawo siwo do ƒome kple ʋu la dzɔna ne wò ƒumeŋuɖui wɔ ʋumenugbagbevi ƒomevi aɖe si sɔ gbɔ wu esi wò ŋutilã hiã. Eyata ŋusẽ si esia kpɔna ɖe wò ŋutilã dzi nɔ te ɖe ʋumenugbagbevi ƒomevi si le wɔwɔm wògbɔ eme dzi . Le kpɔɖeŋu me, MPN ƒomevi ɖeka ate ŋu ana dzidɔ alo ʋusɔgbɔdɔ ƒe afɔkua nadzi ɖe edzi. Ƒomevi bubu ate ŋu ahe ʋusɔgbɔdɔ vɛ.

Be nàse nɔnɔme siawo siwo mebɔ o gɔme nyuie wu la, anyo be nàse alesi wowɔa wò ƒumeŋuɖui kple ʋumenugbagbeviwoe gɔme vie. Míaƒe ʋumenugbagbeviɣiwo katã dzea egɔme abe lãmenugbagbeviwo ene le wò ƒumeŋuɖui me. Ƒumeŋuɖui siae nye lãkusi falɛfalɛ si le abe ƒumeŋuɖui ene le wò ƒuwo me. Lãmenugbagbevi siwo dona tso eme ate ŋu azu myeloid stem cells alo lymphoid stem cells.

• Lãmenugbagbevi ɣiwoe nye ʋumenugbagbevi ɣi ƒomevi siwo wɔa avu kple dɔlékuiwo.
• Myeloid stem cells ate ŋu ana ʋumenugbagbevi dzĩwo (siwo tsɔa oxygen yia ŋutilã bliboa me), ʋumenugbagbevi ɣi ƒomevi bubuwo, kple ʋumenugbagbevi dzĩwo (siwo kpena ɖe ame ŋu be ʋu nadzudzɔ ne edzɔ).

Abe lãmenugbagbevi bubuawo katã ene la, lãmenugbagbevi siawo wɔa dɔ le mɔfiame siwo domenyiŋusẽfianuwo na wo nu. Zi geɖe la, lãmenugbagbevi siawo ma hedzina ɖe edzi ne ehiã le wò ƒumeŋuɖui me be woawɔ lãmenugbagbevi yeyewo. Gake ne tɔtrɔ aɖe va le domenyiŋusẽfianu siawo me, si fia be ne domenyiŋusẽfianuawo trɔ la, domenyiŋusẽfianu mawo ɖoa mɔfiame siwo mesɔ o ɖe lãmenugbagbeviwo be woayi edzi anɔ mamam ahanɔ dzidzim ɖe edzi. Mlɔeba la, ʋumenugbagbevi siawo siwo sɔ gbɔ la ƒoa ƒu ɖe ƒumeŋuɖui alo ʋukawo me, si xea mɔ na ʋu ƒe sisi. Ne woxe mɔ ɖe ʋu sia ƒe sisi nu la, lãmesẽkuxi sesẽwo ate ŋu ado mo ɖa.

Nukawoe nye MPN ƒomevi siwo bɔ wu?

MPN ƒomevi etɔ̃e bɔ wu: polycythemia vera, essential thrombocythemia, kple myelofibrosis gbãtɔ.

Polycythemia Vera ƒe ʋumenugbagbeviɣidɔ

Esiae nye MPN ƒomevi si bɔ wu . Edzɔna ne wò ƒumeŋuɖui na ʋumenugbagbevi dzĩwo sɔ gbɔ akpa . Esia wɔnɛ be wò ʋu ƒoa ke eye wòtsia blewu. Amesiwo ŋu polycythemia vera le la le afɔku me be ʋu nate ŋu axe. Ʋumenugbagbeviɣidɔ siawo ate ŋu ana dzidɔ kple ʋusɔgbɔdɔ nadze ame dzi. Ƒã ŋutɔ hafi nɔnɔme sia ate ŋu ava zu ʋumenugbagbeviɣidɔ sesẽ aɖe si woyɔna be ʋumenugbagbeviɣidɔ sesẽ.

Myelofibrosis ƒe dɔléle

Wobua esia be enye MPN ƒomevi si wɔa adã wu . Le myelofibrosis me la, wò ƒumeŋuɖui wɔa lãmenugbagbevi siwo mesɔ o. Lãmenugbagbevi siawo xɔa abi eye wowɔa abi ƒe lãkusi le ƒumeŋuɖui me. Le ɣeyiɣi aɖe megbe la, abi sia yɔa ƒumeŋuɖui me fũ. Emegbe ƒumeŋuɖui megate ŋu wɔa ʋumenugbagbevi dzĩ siwo sɔ be woatsɔ oxygen atsa le ŋutilãa me o. Esia ate ŋu ana ʋusɔgbɔdɔ nadze dziwò. Ʋumenugbagbeviɣidɔ hã le asiwò. Ame aɖewo siwo ŋu myelofibrosis le hã ate ŋu axɔ acute myeloid leukemia (AML).

Thrombocythemia Vevietɔ

Essential thrombocythemia nye nɔnɔme si me wò ƒumeŋuɖui wɔa ʋumenugbagbevi dzĩwo fũ akpa.Nuwɔwɔ. Zi geɖe la, ne ʋuka aɖe gbã la, ʋumenugbagbevi dzĩwo ƒoa ƒu wɔa ʋuka si me ʋu sina tona eye ʋu si le dodom la nu tsona. Gake le nɔnɔme sia me la, wowɔa ʋumenugbagbevi dzĩwo le ƒumeŋuɖui me le susu aɖeke manɔmee. Ʋumenugbagbevi dzĩ siawo siwo sɔ gbɔ wu ate ŋu ana ʋu natsi eye dzidɔ kple ʋusɔgbɔdɔ ƒe afɔkua nadzi ɖe edzi. Abe MPN bubuwo ene la, dzesiawo dona vivivi. Wokpɔa dɔléle sia le ame akpa gãtɔ ŋu ne ʋudodokpɔ edziedzi ɖee fia be ʋumenugbagbevi dzĩwo sɔ gbɔ. Le ame aɖewo gome la, nɔnɔmea ate ŋu ava zu ʋumenugbagbeviɣidɔ.

Ðe MPN ƒomevi bubuwo lia?

Ẽ, MPN ƒomevi bubu geɖewo li. Wo dometɔ aɖewoe nye:

• Chronic eosinophilic leukemia (CEL): Esia nye nɔnɔme si me ʋumenugbagbevi ɣi ƒomevi aɖe si woyɔna be eosinophil ƒe dzidziɖedzi fũ akpa le. Zi geɖe la, edzɔna le aɖuɖɔtoe me. Ƒã hafi ate ŋu ava zu ʋumenugbagbeviɣidɔ sesẽ (AML). Wogayɔa esia be hypereosinophilic syndrome.
• Chronic myelogenous leukemia (CML): Esia nye ʋumenugbagbevi ɣi ƒomevi aɖe si woyɔna be granulocytes si wɔa dɔ wògbɔa eme. Lãmenugbagbevi siawo ƒoa ƒu eye wònana wòsesẽna na ƒumeŋuɖui be wòawɔ ʋumenugbagbevi bubu siwo hiã.
• Chronic neutrophilic leukemia (CNL): Le esia me la, wowɔa ʋumenugbagbevi ɣi ƒomevi aɖe si woyɔna be neutrophils wògbɔa eme.
• Myeloproliferative neoplasm, unclassifiable (MPN-U): Esia nye MPN ƒomevi aɖe si mesɔ ɖe hatsotso bubuawo dometɔ aɖeke me o. Ate ŋu ana ʋumenugbagbevi vovovowo abe ʋumenugbagbevi ɣiwo, ʋumenugbagbevi dzĩwo, alo ʋumenugbagbevi dzĩwo ene nadzi ɖe edzi akpa.

Nukae nye MPN ƒe dzesiwo?

Le gɔmedzedzea me la, ɖewohĩ màkpɔ dzesi aɖeke o . Ne nɔnɔmea le sesẽm ɖe edzi la, àte ŋu ade dzesi dzesi siwo fia be dɔgbo vuvu (splenomegaly). Aɖuɖɔtoea le wò miame le wò akɔta te. Ate ŋu ase le eɖokui me be yeƒe lãme yɔ fũ, yeƒe lãme sẽ, eye yeƒe dzi mefa o. Togbɔ be dɔgbo ƒe vuvu sia bɔ ɖe MPN ƒomevi geɖe me hã la, mebɔ nenema le ʋumenugbagbeviɣidɔ veviwo me o.

Dzesi bubuwo toa vovo le MPN ƒe ƒomevi nu .

Ʋumenugbagbeviɣidɔ si nɔa anyi didi (CEL) .

• Dzesi si bɔ wue nye ŋutigbalẽ ƒe ʋuʋu .
• Ðewohĩ ɖeɖi te ŋuwò eye asrã le ŋuwò.
• Dzesi bubuwo nɔ te ɖe wò ŋutilã ƒe akpa siwo wò eosinophil ƒe agbɔsɔsɔ si sɔ gbɔ gblẽ nu le dzi.

Ʋumenugbagbeviɣidɔ si nɔa anyi didi (CML) kple ʋumenugbagbeviɣidɔ si nɔa anyi didi (CNL) .

• Ƒu ƒe vevesese
• Zã me fifia
• Asrã kple ɖeɖiteameŋu
• Nuveviwɔame bɔbɔe
• Nuɖuɖudzroame ƒe vɔvɔ kple lolo dzi ɖeɖe kpɔtɔ

Ʋumenugbagbeviɣidɔ vevi aɖe

• Nuveviwɔame bɔbɔe
• Ʋu si dona le ŋɔti, nu, alo aɖuwo me le susu aɖeke manɔmee
• Ʋu si dona le dɔgboa alo dɔgbo me
• Ʋu le aɖuɖɔ me

Polycythemia vera ƒe ʋumenugbagbeviɣidɔ

• Taɖuame
• Taɖuame
• Ðeɖiteameŋu
• Nukpɔkpɔ si me mekɔ o alo nukpɔkpɔ eve

Myelofibrosis gbãtɔ

• Ʋusɔgbɔdɔ ƒe dzesiwo (ɖeɖiteameŋu, gbɔdzɔgbɔdzɔ, gbɔgbɔtsixetsixe) ate ŋu adze.
• Nu bubu siwo le eme:
• Ŋutilã si ƒe ŋutigbalẽ le ɣie
• Zã me fifia
• Asrã
• Ŋutilã si le ʋuʋum
• Nuɖuɖu fũ alo sese le eɖokui me be yeɖi ƒo kaba le nuɖuɖu vɔ megbe (nuɖuɖu kaba) .
• Kpekpeme dzi ɖeɖe kpɔtɔ
• Ƒu ƒe vevesese

Nukae hea MPN vɛ?

MPN ƒe nɔnɔmewo katã nye domenyiŋusẽfianu ƒe dɔléle siwo woxɔ . Esia fia be womenyi wo dome tso dziwòlawo gbɔ o. Wodzɔna ne domenyiŋusẽfianu siwo kpɔa lãmenugbagbeviwo ƒe tsitsi dzi la ƒe tɔtrɔ alo tɔtrɔwo va, si wɔnɛ be ʋumenugbagbeviwo tsina le mɔ si mesɔ o nu.

Atikewɔwɔ ŋuti numekulawo ke ɖe nu siwo gbɔna ŋu tso domenyiŋusẽfianu ƒe tɔtrɔ siwo hea MPN vɛ ŋu:

• Janus kinase (JAK) ƒe tɔtrɔ: Zi geɖe la, domenyiŋusẽfianu si woyɔna be Janus kinase 2 (JAK2) ƒe tɔtrɔ gbɔe nɔnɔmewo abe polycythemia vera, primary myelofibrosis, kple essential thrombocythemia ene tsona. Dzɔdzɔmeŋusẽ ƒe tɔtrɔ sia ate ŋu ana lãmenugbagbeviwo namã le mɔ si dzi womate ŋu aɖu o nu.
• MPL domenyiŋusẽfianu alo CALR domenyiŋusẽfianu ƒe tɔtrɔ: Zi geɖe la, ame siwo ŋu ʋumenugbagbeviɣidɔ veviwo kple myelofibrosis gbãtɔ le la trɔna le woƒe MPL domenyiŋusẽfianu alo CALR domenyiŋusẽfianu me.
• Dzɔdzɔmeŋusẽ ƒe vodadawo: Vodada aɖe koŋ le amesiwo ŋu ʋumenugbagbeviɣidɔ si nɔa anyi didi (CML) le la ŋu le woƒe domenyiŋusẽfianu (si nye wɔwɔme si me domenyiŋusẽfianuwo le) me. Le CML me la, domenyiŋusẽfianu ɖeka ƒe akpa aɖe trɔna kple domenyiŋusẽfianu bubu, eye wòwɔa "Philadelphia domenyiŋusẽfianu."

Togbɔ be nusiwo ŋu woke ɖo siawo meɖe nusi tututu hea domenyiŋusẽfianu ƒe tɔtrɔ vɛ me o hã la, wokpena ɖe ɖɔktawo ŋu be woanya dɔlélewo eye woato atikewɔmɔnu siwo aɖo taɖodzinu na domenyiŋusẽfianu ƒe tɔtrɔ siawo vɛ.

Nukawoe nye afɔku siwo le MPN me?

Dɔlélea ƒe ƒome ŋutinya (togbɔ be dɔléle siawo nye dɔléle siwo woxɔ hã la, ƒome aɖewo ate ŋu aɖee afia be dɔlélea dze ame ŋu), ƒexɔxɔ, kple ŋutsu alo nyɔnu nyenye ate ŋu ana MPN xɔxɔ ƒe afɔkua nadzi ɖe edzi.

Numekulawo kpɔ kadodo hã le MPN kple aɖi kple keklẽŋusẽ aɖewo ƒe amedzidzedze dome . Numekuku aɖewo ɖee fia be amesiwo ŋu keklẽŋusẽ kple aɖi aɖewo abe benzene ene sɔ gbɔ ɖo la le afɔku me be woaxɔ MPN, abe polycythemia vera, primary myelofibrosis, kple chronic myelogenous leukemia ene.

Aleke wowɔna dea dzesi MPN?

Wò ɖɔkta abia wò dzesiwo kple wò lãmesẽ ŋutinya. Emegbe, woawɔ ŋutilãmedɔdada atsɔ akpɔe ɖa be MPN ƒe dzesiwo le wo ŋu hã. Woado wò ʋu kple ƒumeŋuɖui akpɔ be dɔlélea le ŋuwò.

• Ʋu ƒe xexlẽme bliboa (CBC):Esia dzidzea wò ʋumenugbagbevi ƒomeviwo katã ƒe agbɔsɔsɔ. Le ʋumenugbagbeviɣidɔ veviwo me la, woléa ŋku ɖe ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ ŋu. Le polycythemia vera me la, woléa ŋku ɖe hemoglobin (protein si le ʋumenugbagbevi dzĩwo me), kpakple ʋumenugbagbevi ɣiwo kple ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ ŋu.
• Ʋumenugbagbeviɣidɔ (PBS): Dodokpɔ sia ate ŋu adi ʋumenugbagbeviwo ƒe nɔnɔme siwo mesɔ o, si ate ŋu ana woakpɔ kpeɖodzi tso atikewɔwɔ me nɔnɔme aɖe ŋu.
• Ʋu ƒe lãmenugbagbeviwo ƒe dodokpɔ: Esiawo ate ŋu adzidze atike vovovowo (abe protein, enzyme, kple sukli ene) ƒe agbɔsɔsɔ le wò ʋu me. Xexlẽdzesi siawo ate ŋu ana nàkpɔ alesi wò ŋutinuwo le dɔ wɔme, si ate ŋu ana ɖikeke nanɔ MPN ŋu.
• Ƒumeŋuɖui ƒe lãmenugbagbeviwo ɖeɖe: Wò ɖɔkta ate ŋu awɔ ƒumeŋuɖui ƒe ʋuʋu alo ƒumeŋuɖui ƒe ʋuʋu. Esia bia be nàɖe wò ƒumeŋuɖui aɖe ahadoe kpɔ be ʋumenugbagbeviwo le eme hã. Emegbe atikeŋutinunyalawo léa ŋku ɖe ʋumenugbagbeviwo kple lãmenugbagbeviwo ŋu le nusuekpɔmɔ̃ me be yewoakpɔ vovototo siwo le lãmenugbagbevi siwo sɔ kple esiwo mesɔ o dome. Woadi lãmenugbagbevi ɖesiaɖe si mesɔ o hã. Woadi domenyiŋusẽfianu ƒe tɔtrɔ kple domenyiŋusẽfianu bubu siwo mesɔ o siwo ate ŋu afia MPN ƒomevi aɖe hã.
• Domenyiŋusẽfianu dodokpɔ: Ðɔktawo ate ŋu adzro wò ʋumenugbagbeviwo me akpɔe ɖa be tɔtrɔ aɖewo le domenyiŋusẽfianu siwo kpɔa ŋusẽ ɖe ʋumenugbagbeviɣidɔ dzi hã.

Ðe woate ŋu ada MPN keŋkeŋa? Nukawoe nye atikewɔmɔnuawo?

Atike ɖeka kolia si li fifia na dɔléle siawoe nye allogeneic stem cell transplantation . Nublanuitɔe la, ame geɖe mate ŋu awɔ lãmenugbagbeviwo ƒe lãmenugbagbeviwo dodo na ame sia o elabena enye dɔ sesẽ aɖe si bia ame ƒe ŋutilã.

Wò ɖɔkta aŋlɔ atike siwo woatsɔ akpɔ wò nɔnɔmea gbɔ, aɖe wò ʋumenugbagbeviɣiwo dzi akpɔtɔ, aɖe dzesiwo dzi akpɔtɔ, eye wòaxe mɔ ɖe kuxiwo nu. Dɔdamɔnu aɖewo ate ŋu ana dɔlélea nu natso gɔ̃ hã. MPN ƒe atikewɔwɔwo toa vovo le eƒe ƒomevi nu:

• Chronic eosinophilic leukemia (CEL): Wò ɖɔkta ate ŋu azã atikewɔmɔnu, corticosteroids, alo dɔlélenutsiŋutete ƒe dɔdamɔnu atsɔ aɖe wò eosinophil ƒe agbɔsɔsɔ dzi akpɔtɔ.
• Chronic myelogenous leukemia (CML): Atike si wozãna wue nye atikewɔwɔ si woɖo taɖodzinu na, si xea mɔ na lãmenugbagbeviwo ƒe dzidziɖedzi le mɔ si dzi womate ŋu aɖu o nu. Dɔdamɔnu bubuwoe nye atikewɔmɔnu, dɔlélenutsiŋutete ƒe dɔdamɔnu, keklẽŋusẽdɔdamɔnu, kple lãmenugbagbeviwo dodo na ame.
• Chronic neutrophilic leukemia (CNL): Atikewɔwɔ ate ŋu anye atikewɔmɔnu, dɔlélenutsiŋutete ƒe dɔdamɔnu, kple lãmenugbagbeviwo dodo na ame.
• Ʋumenugbagbeviɣidɔ veviwo:Ne dzesi aɖeke mele ŋuwò o la, wò ɖɔkta ate ŋu atso nya me be yealé ŋku ɖe wò nɔnɔmea ŋu nyuie tsɔ wu be yeaŋlɔ atike na wò. Ne dzesiwo le ŋuwò la, ahiã be nàno atike si ana lãmenugbagbeviwo nagadzi ɖe edzi le mɔ si dzi womate ŋu aɖu o nu. Ðewohĩ ahiã hã be nàno atikewo be woaɖe ʋu ƒe sisi ƒe afɔkua dzi akpɔtɔ alo be wò ƒumeŋuɖui nagawɔ ʋumenugbagbevi dzĩwo fũ akpa o.
• Polycythemia vera: Phlebotomy ye nye atike si wozãna wu na polycythemia vera. Le dɔ sia wɔwɔ me la, wò ɖɔkta aɖe ʋu sue aɖe ɖa edziedzi (abe ʋudodo ene) be wòaɖe wò ʋu ƒe agbɔsɔsɔ dzi akpɔtɔ eye wòaɖe ʋumenugbagbevi dzĩ siwo sɔ gbɔ ɖe eme la ɖa. Ne dzesiwo le ŋuwò la, woate ŋu ana atike si woɖo taɖodzinu na wò be lãmenugbagbeviwo nagadzi ɖe edzi le mɔ si dzi womate ŋu aɖu o nu. Woate ŋu ana atike siwo ɖea ʋu ƒe sisi ƒe afɔkua dzi kpɔtɔna (abe aspirin ene) alo atike siwo ɖea ʋumenugbagbevi dzĩwo ƒe xexlẽme dzi kpɔtɔna hã wò.
• Myelofibrosis gbãtɔ: Ne dzesi aɖeke mele ŋuwò o la, wò ɖɔkta ate ŋu atso nya me be yealé ŋku ɖe wò nɔnɔmea ŋu nyuie. Mɔnu alo atike vovovowo li siwo woate ŋu azã atsɔ ada ʋusɔgbɔdɔ. Le kpɔɖeŋu me, ne wò ƒumeŋuɖui mele ʋumenugbagbevi dzĩwo wɔm wòsɔ gbɔ o la, ahiã be woado ʋu na wò. Ðewohĩ ahiã hã be nàno atike siwo doa ŋusẽ ƒumeŋuɖui be wòawɔ ʋumenugbagbevi geɖe. Dɔdamɔnu bubuwoe nye atikewɔwɔ si woɖo taɖodzinu na, atikewɔmɔnu, dɔlélenutsiŋutete ƒe dɔdamɔnu, keklẽŋusẽdɔdamɔnu, kple lãmenugbagbeviwo dodo na ame.

Ɣeyiɣi didi kae amesi ŋu MPN le ate ŋu anɔ agbe?

Esia toa vovo ŋutɔ tso ame ɖeka gbɔ yi bubu gbɔ . Nu geɖe kpɔa ŋusẽ ɖe esia dzi, siwo dometɔ aɖewoe nye MPN ƒe ƒomevi, alesi wokpɔa dɔlélea kabae, kple alesi nèwɔa nu ɖe ​​atikewɔwɔ ŋu nyuie. Ne wolé ŋku ɖe ame geɖe ŋu nyuie hewɔ atike na wo la, wonɔa agbe ƒe geɖe . Nyagblɔɖi ɖeka aɖeke meli alo nusi wokpɔ mɔ be ado tso eme na nɔnɔme siawo o. Le goawo katã me la, ame akpa gãtɔ siwo ŋu wokpɔ MPN le la gakpɔtɔ le agbe le ƒe atɔ̃ megbe.

Agbetsitsi ƒe agbɔsɔsɔme na MPN ƒomevi tɔxɛwoe nye esiawo:

• Chronic myelogenous leukemia (CML): Agbetsitsi ƒe agbɔsɔsɔ si do ƒome kple CML dzi ɖe edzi ŋutɔ le atikewɔwɔ yeye siwo woɖo taɖodzinu na ƒe dzidzedzekpɔkpɔ ta. Ƒe atɔ̃ ƒe agbetsitsi ƒe agbɔsɔsɔme na CML nye 90%.
• Chronic neutrophilic leukemia (CNL) kple polycythemia vera: Ne wokpɔ dɔlélea gbɔ nyuie la, ame akpa gãtɔ nɔa agbe abe ƒe 20 ene le mamã dedie nu le dɔlélea kpɔkpɔ vɔ megbe.
• Ʋumenugbagbeviɣidɔ vevi: Ame geɖe nɔa agbe ƒe geɖe ne wozã atike siwo xea mɔ na kuxi siwo ate ŋu ade woƒe agbe afɔku me abe ʋu ƒe sisi ene.
• Myelofibrosis gbãtɔ: Ame akpa gãtɔ siwo ŋu myelofibrosis gbãtɔ le la nɔa agbe ƒe atɔ̃ va ɖo ewo le dɔlélea kpɔkpɔ vɔ megbe.

Ne dɔléle sia le ŋuwò la, bia wò ɖɔkta tso wò ŋgɔdonya ŋu. Woawoe nya nusiwo katã kpɔa ŋusẽ ɖe nyagblɔɖi dzi. Eye vevietɔ wu la, wonya wò, wò ƒexɔxɔ, kple wò lãmesẽ bliboa, kpakple afɔku siwo kpɔa ŋusẽ ɖe ŋgɔdonya dzi.

Ðe dɔléle siawo wua amea?

Esiawo menye dɔléle siwo wua ame le wo ɖokui si o , gake MPN ƒomevi aɖewo ate ŋu ahe kuxi siwo ate ŋu ade ame ƒe agbe afɔku me abe dzidɔ kple ʋusɔgbɔdɔ ene vɛ.

Nya kawoe wòle be mabia nye ɖɔkta?

MPN nye dɔléle sesẽ aɖe. Atikewɔwɔmɔnu geɖe li, eye ɣeaɖewoɣi la, eƒe nugbegblẽ le ame ŋu. Azɔ hã, kuxi geɖe li siwo ate ŋu ado mo ɖa le wò nɔnɔmea nu. Ele vevie be nànya dzesi siwo wòle be nànya. Ƒo nu kple wò ɖɔkta be wòase dɔléle si wokpɔ le ŋuwò gɔme eye nàtso nya me le atikewɔwɔ ŋu.

Nya aɖewo siwo nàte ŋu abia:

• Nukae nye atikewɔwɔ ƒe taɖodzinu (be woaɖe dɔlélea dzi akpɔtɔ, aɖe dzesiwo dzi akpɔtɔ, axe mɔ ɖe kuxiwo nu, kple bubuawo)?
• Nukawoe nye nye atikewɔwɔ ƒe tiatia?
• Nukawoe ate ŋu ado tso atikewɔwɔ me?
• Ɣeyiɣi didi kae wòahiã be woawɔ atike nam le nye dɔlélea ta?
• Zi nenie wòahiã be woawɔ dodokpɔwo (nɔnɔmetatawo alo ʋu ƒe dɔwɔwɔ) nam be woalé ŋku ɖe nye nɔnɔmea ŋu?
• Dzesi kawoe akpe ɖe ŋunye manya ne nye nɔnɔmea le nyonyom ɖe edzi alo le gbegblẽm ɖe edzi?
• Dzesi kawoe xlɔ̃a num tso kuxi aɖe ŋu?
• Kuxi kawoe hiã be woawɔ atike na wo kpata?
• Nukae nye nusi wokpɔ mɔ be woagblɔ ɖi na nye nɔnɔmea?
• Agbenɔnɔ ƒe tɔtrɔ kawoe nèkafu be matsɔ akpɔ nye nɔnɔmea kple atikewɔwɔ ƒe nugbegblẽ le ame ŋu gbɔ?

Aleke malé be na ɖokuinye? (Nu vevi aɖewo na wò)

MPN nɔnɔ ate ŋu atɔtɔ ame vie ɣeaɖewoɣi. Ðewohĩ èle edzi dzem nyuie eye mèle kuxi aɖeke sem o, gake àbia ɖokuiwò be ɖe nane li mate ŋu awɔ atsɔ axe mɔ ɖe dzesiawo nu hã. Ne èle atike wɔm la, àte ŋu ahiã kpekpeɖeŋu le atikewɔwɔ ƒe nugbegblẽ le ame ŋu kple dzesiawo gbɔ kpɔkpɔ me. Ke hã, ahiã be nànɔ agbe kple dɔléle sia ƒe geɖe. Aɖaŋuɖoɖo aɖewo siwo ate ŋu akpe ɖe ŋuwòe nye esi:

• Se wò lãmesẽnyawo gɔme: MPN ƒe dzesi geɖe sɔ kple nɔnɔme bubu siwo mesẽ boo o. Dzesi aɖewo hã ate ŋu anye atikewɔwɔ me kuxi sesẽwo ƒe dzesiwo. Ate ŋu asesẽ be nàde dzesi vovototoa, eye àte ŋu ase le ɖokuiwò me be kpeɖodzi vevi aɖewo to ye ŋu. Bia wò ɖɔkta be wòaɖe alesi nɔnɔme sia ate ŋu akpɔ ŋusẽ ɖe dziwòe me. Nusi nàkpɔ mɔ na nyanya ate ŋu akpe ɖe ŋuwò nàka ɖe wò nɔnɔmea dzi geɖe wu.
• Dzra wò nuteɖeamedzi dzi: Agbenɔnɔ kple dɔléle si nɔa anyi eteƒe nadidi ate ŋu anye nuteɖeamedzi. Ne èle dzi tsim ɖe wò nɔnɔmea ŋu la, ƒo nu tso eŋu na wò ɖɔkta. Woate ŋu aɖe nu si woate ŋu awɔ atsɔ akpe ɖe ŋuwò fifia kple nu si woate ŋu awɔ atsɔ akpe ɖe ŋuwò le etsɔme la me.
• Ƒo nuɖuɖu si da sɔ si naa lãmesẽ:Nuɖuɖu nyuie ate ŋu akpe ɖe ŋuwò nàkpɔ wò nɔnɔmea gbɔ. Ƒo nu kple nuɖuɖuŋutinunyala ne èhiã kpekpeɖeŋu be nàtu nuɖuɖu nyui ɖo.
• De kame vie: Kamedede nye mɔ nyui aɖe si dzi nàto aɖu nuteɖeamedzi dzi.
• Di kpekpeɖeŋu: MPN nye dɔléle si mebɔ o. Kpekpeɖeŋunahawo ate ŋu anye mɔ nyui aɖe si dzi nàto aɖo kadodo kple ame siwo nya nusi me tom nèle la ahaƒo nu kple wo.

Ðo ŋku edzi be ne nɔnɔme sia tɔgbe le ŋuwò gɔ̃ hã la, àte ŋu anɔ agbe nyui ne ènya nu tso atikewɔlawo ƒe aɖaŋuɖoɖowo ŋu hewɔ ɖe wo dzi.

Ɣekaɣie wòle be makpɔ ɖɔkta?

Ne MPN le ŋuwò gake dzesi aɖeke mele ŋuwò o, alo nède dzesi tɔtrɔwo le wò ŋutilã me si fia be dzesiwo dze le ŋuwò la, yi wò ɖɔkta gbɔ enumake.

Le nyateƒe me la, MPN nye nya ɣaɣla vie. Numekulawo nya be MPN do ƒome kple ʋumenugbagbeviɣidɔ si mesɔ o. Wonya hã be domenyiŋusẽfianu ƒe dɔlélewoe yewonye, ​​gake womenya nusi tututu ʋãa domenyiŋusẽfianu ƒe tɔtrɔ siwo hea MPN vɛ haɖe o . Esi wònye be dɔléle siawo nye esiwo mebɔ o ta la, ame geɖe menya alesi wòle be woanɔ agbe kple MPN o. Gake ɖɔktawo kple numekulawo le nu geɖe srɔ̃m tso MPN ŋu, vevietɔ tso mɔ nyuitɔ siwo dzi woato akpɔ dzesiwo gbɔ eye woaɖe atikewɔwɔ me kuxi sesẽwo ƒe afɔkua dzi akpɔtɔ ŋu. Eyata, mègana mɔkpɔkpɔ gbeɖe o .

` Myeloproliferative neoplasm, MPN, ʋumenugbagbeviɣidɔ, ƒumeŋuɖui, ʋumenugbagbevi dzĩwo, ʋumenugbagbevi ɣiwo, ʋumenugbagbevi dzĩwo, dzesiwo, atikewɔwɔ