Ðe nèle ŋutigbalẽ ƒe abi siwo nu sẽ kpata la me toma? Mina míasrɔ̃ nu tso Pyoderma Gangrenosum ŋu!

Ðe ʋuʋudedi sue aɖe alo teƒe dzĩ aɖe le wò ŋutigbalẽ ŋu si dze egɔme abe ʋuʋudedi sue alo ʋuʋudedi ene eye kasia wòtrɔ zu abi gã aɖe si le veve sem kpɔa? Ate ŋu adzɔ le teƒe siwo wu ɖeka, gake ate ŋu adzɔ le teƒe geɖe le wò ŋutilã hã. Le nyateƒe me la, esia nye nɔnɔme si bia be woalé ŋku ɖe eŋu vie eye ate ŋu asesẽ vie. Egbea míele nu ƒom tso ŋutigbalẽ ƒe dɔléle aɖe si woyɔna be Pyoderma Gangrenosum ŋu, si nye dɔléle si mebɔ o gake wòle vevie ŋutɔ be woanya. Mègatsi dzi o, mina míana wòanɔ bɔbɔe.

Nukae nye Pyoderma Gangrenosum sia?

Kpuie ko la, pyoderma gangrenosum nye ŋutigbalẽ ƒe dɔléle si nɔa anyi didi , si gɔmee nye ŋutigbalẽ ƒe dɔléle si nɔa anyi didi, eye wògbugbɔna yia edzi . Nusi dzɔnae nye be wò ŋutigbalẽ dzea ʋuʋudedi suesuesue siwo ƒe amadede trɔ (ɖewohĩ dzĩ, aŋutiɖiɖi, blɔ, blɔ, alo yibɔ), alo ʋuʋudedi siwo me tsi yɔ fũ (bullae) xɔxɔ gɔme gbã. Nusi me afɔku le wue nye be esiawo ate ŋu alolo kabakaba, aƒo ƒu, eye woazu abi goglo siwo le ʋuʋu ɖi (abi) .

Bu alesi wòanɔ ne nane dze egɔme abe ʋuʋudedi sue aɖe ene eye le ŋkeke ʋɛ aɖewo megbe la, etrɔ zu abi si le veve sem si lolo abe nikel ene ŋu kpɔ? Emae nye nusi dzɔna le afisia. Ðewohĩ abi ɖeka koe axɔ ame aɖewo, gake le nɔnɔme sesẽwo me la, abi geɖe ate ŋu adze ame dzi zi ɖeka. Abi siawo ate ŋu ave ame ŋutɔ .

Vevietɔ la, zi geɖe la, pyoderma gangrenosum do ƒome kple ɖoɖowɔɖi ƒe dɔléle bubuwo , si fia be menye ŋutigbalẽ ƒe kuxi koe wònye o.

Amekae ate ŋu axɔ nusia wu?

Pyoderma gangrenosum ate ŋu adzɔ le ƒe ɖesiaɖe me, gake ƒã ŋutɔ le ɖeviwo me . Ebɔ ɖe nyɔnu siwo xɔ tso ƒe 20 va ɖo ƒe 50. Ate ŋu axɔ pyoderma gangrenosum hã wu ne dɔléle siawo dometɔ aɖe le ŋuwò:

• Rheumatoid arthritis - Esia nye dɔléle si nana ƒunukpeƒewo xɔa abi.
• Ulcerative colitis - Dzoxɔxɔ ƒe nɔnɔme si me abi le le dɔgbo gã la me.
• Crohn ƒe dɔléle - Dzoxɔxɔ ƒe nɔnɔme bubu si dzɔna le nuɖuɖumeŋusẽ me.
• Kansa ƒomevi aɖewo, le kpɔɖeŋu me, ʋumenugbagbeviɣidɔ abe ʋumenugbagbeviɣidɔ alo ʋumenugbagbeviɣidɔ ene.

Wogblɔ be edzɔna le ame abe akpe alafa ɖeka ɖesiaɖe me ene le United States . Ema fia be mebɔ nenema gbegbe o.

Aleke esia kpɔa ŋusẽ ɖe ŋutilãa dzii? Nukawoe nye dzesiawo?

Pyoderma gangrenosum naa ʋuʋudedi suesuesue siwo ƒe amadede trɔna kple abi, si fia be wò ŋutigbalẽ vuvu eye wòbiãna. Aɖuɖɔtoe siawo ate ŋu adze le ŋutilãa ƒe akpa sia akpa, gake zi geɖe la, wokpɔa wo le afɔwo, afɔkpodziwo, kple afɔwo (afɔ siwo le ete) dzi .

Aɖuɖɔtoe siawo ate ŋu agbã kaba, atrɔ azu abi gã siwo le veve sem, eye woakaka.Dzesi vevitɔwoe nye:

• Aɖuɖɔ suesuesue siwo ƒe amadede trɔ (dzẽ, aŋutiɖiɖi, blɔ, blɔ, alo yibɔ) siwo me ʋuʋudedi yɔ fũ. Esiawo lolona kabakaba .
• Abi siwo le ʋuʋu ɖi (ulcers) dona. Wokɔ abi siawo ƒe goawo ɖe dzi eye wokpɔa wo nyuie .
• Ʋuʋudedi kple vevesese sesẽ si ƒo xlã abi la.
• Ame aɖewo ate ŋu axɔ asrã .
• Ƒunukpeƒewo ƒe vevesese hã ate ŋu adzɔ.

Abi siawo te ŋu lolo ŋutɔ eye wogoglo ɣeaɖewoɣi , eye vevesesea ate ŋu anye nusi womate ŋu ado dzi atsɔ o.

Numekuku aɖewo ɖee fia be amesiwo ŋu pyoderma gangrenosum le ƒe 70% ateŋu akpɔ dɔléle bubu siwo wu ɖeka (comorbidities) le ɣeyiɣi ɖeka me. Ne wotsɔ pyoderma gangrenosum kpe ɖe nɔnɔme bubuwo ŋu la, wogblɔna be ku ƒe afɔkua ate ŋu adzi ɖe edzi va ɖo 30%. Eyata esia menye nusi woabu nu tsɛe o.

Ðe esia nye dɔléle si dɔlélenutsiŋutete ŋutɔ hena vɛa?

Ẽ, woxɔe se be pyoderma gangrenosum nye dɔléle si dɔlélenutsiŋutete ŋutɔ hena vɛ . Kpuie ko la, wò ŋutilã ŋutɔ ƒe ametakpɔnu, si nye dɔlélenutsiŋutete, dzea wò ŋutɔ wò ŋutigbalẽ me lãmenugbagbeviwo dzi. Le ame aɖewo gome la, pyoderma gangrenosum nu yina ne woda dɔléle bubu siwo míeyɔ ɖe etame la.

Nukatae pyoderma gangrenosum va dona?

Atikeŋutinunyalawo menya nusi tututu gbɔ wòtso haɖe o , gake dɔléle bubuwo le amesiwo ŋu pyoderma gangrenosum le ƒe afã kple edzivɔ ŋu (abe ƒunukpeƒetetedɔ, ʋumenugbagbeviɣidɔ, kple Crohn ƒe dɔléle ene), abe alesi míegblɔe va yi ene.

Tsɔ kpe ɖe eŋu la, pyoderma gangrenosum ate ŋu adzɔ le ŋutigbalẽ ƒe abixɔxɔ, aŋɔsisi, alo amekoko megbe hã (pathergy) . Kpɔe ɖa le susu me be wò asi vuvu vie, alo amekoko sue aɖe le ŋuwò, eye afisiae dɔléle sia ate ŋu adze egɔme tsoe. Ɣeaɖewoɣi la, abi siawo hã dona ƒo xlã stoma teƒe aɖe le amekoko vɔ megbe. Woyɔa esia be peristomal pyoderma gangrenosum.

Ðe esia xɔa ame mea?

Ao, Pyoderma gangrenosum mexɔa ame o . Womate ŋu akaka tso ame ɖeka me ayi ame bubu gbɔ to ŋutigbalẽ kple ŋutigbalẽ ƒe kadodo me o. Esia nye nusi ŋu ame geɖe tsi dzi ɖo, eyata ele vevie be míana nya sia me nakɔ.

Aleke ɖɔktawo wɔna dea dzesi esia?

Ne míagblɔe tututu la, dɔléle si nye pyoderma gangrenosum didi ate ŋu asesẽ vie . Dodokpɔ aɖeke meli si ŋu kakaɖedzi le si ate ŋu aɖo kpe edzi be nɔnɔmeae o. Eyata zi geɖe la, ɖɔktawo wɔa dodokpɔwo tsɔ ɖea nɔnɔme bubu siwo ate ŋu ahe ŋutigbalẽ ƒe kuxi mawo tɔgbe vɛ la ɖa . Eyae nye be wokpɔa egbɔ gbã be nɔnɔme bubu siwo ƒe dzesiwo sɔ kple wo nɔewo mele wo me o. Le kpɔɖeŋu me:

• Dɔlékui vovovowo.
• Ŋutilã me kansawo.
• Ʋukawo ƒe dɔdzẽ le ŋutigbalẽa me.
• Lupus ƒe dɔléle.
• Nɔnɔme aɖe si woyɔna be Sweet syndrome.

Dodokpɔ siwo woawɔ na esia ate ŋu anye:

• Ʋudodokpɔwo.
• Ŋutilã sue aɖe tsɔtsɔ be woadoe kpɔ (Biopsy).
• Ƒumeŋuɖui ƒe kpɔɖeŋuwo ɖeɖe - vevietɔ ne wosusu be nuwo abe ʋumenugbagbeviɣidɔ ene.
• Proctoscopy ƒe dɔwɔwɔ.
• Colonoscopy - ne wosusu be nɔnɔmewo abe Crohn ƒe dɔléle ene li.

Ne wowɔ dodokpɔ siawo katã vɔ eye woɖe asi le nu bubu ɖesiaɖe ŋu vɔ ko hafi ɖɔktaa ƒo nya ta be pyoderma gangrenosum ye.

Nukawoe nye atikewɔmɔnuawo?

Atikewɔwɔmɔnu vovovowo li na pyoderma gangrenosum. Ele vevie be woakpɔ dɔlélea kaba ahadae be woaxe mɔ ɖe abi xɔxɔ nu .

Dɔléle siwo bɔ, siwo mesẽ boo o la dada

Ne abiawo mesẽ akpa o la, ɖɔkta ate ŋu aŋlɔ atike siwo wotsɔna ƒoa abi alo ami siwo wotsɔna ƒoa abie. Esiawo dometɔ aɖewoe nye:

• Corticosteroids: Esiawo nye atike siwo ɖea dɔdzẽ dzi kpɔtɔna. Woate ŋu atsɔ wo asisi ɖe abi ŋu abe atike ene alo ano wo abe atikekui ene. Kpɔɖeŋuwo: cortisone, prednisone. Gake nusiawo ate ŋu agblẽ nu le ame ŋu abe nuɖuɖu ƒe dzodzro ƒe dzidziɖedzi, lolo, seselelãme ƒe tɔtrɔ, aklãdɔ, kple alɔ̃madɔmadɔ ene.
• Atike siwo me steroid mele o (NSAIDs): Esiawo nye vevesesenutsitikewo. Kpɔɖeŋuwo: aspirin, ibuprofen. Esiawo ate ŋu ana gas , ʋuʋudedi, dɔgbo nase veve, aɖuɖɔtoe, ʋuʋudedi, aɖuɖɔtoe, kple dɔmeɖui.
• Silver sulfadiazine skin cream: Le nyateƒe me la, esia nye dɔlékuiwutike si wotsɔna ƒoa dzoe be wòaxe mɔ ɖe dɔlékuiwo xɔxɔ nu. Wozãnɛ ɣeaɖewoɣi na nɔnɔme sia hã. Ate ŋu ana ame naɖu dzi, axɔ dzo, axɔ vuvɔ, ŋutigbalẽ naxɔ abi, eye wòase veve ɖe ɣe ƒe keklẽ nu.

Sesẽnuwɔwɔ viea?

Ne abi la nu sẽ wu la, ɖɔkta ate ŋu aŋlɔ atike siwo le abe esiawo ene:

• Atike siwo tsia dɔlélenutsiŋutete nu: Esiawo wɔa dɔ to wò dɔlélenutsiŋutete ƒe ŋutete be wòagblẽ nu le eya ŋutɔ ƒe ŋutilã ŋu dzi ɖeɖe kpɔtɔ me. Kpɔɖeŋuwo: mycophenolate, cyclosporine.
• Dɔlékuiwutikewo: Esiawo nye atike yeye ƒomeviwo. Wowɔa dɔ to protein tɔxɛ siwo le ŋutilãa me siwo hea dɔdzẽ vɛ la ŋudɔwɔwɔ me. Kpɔɖeŋuwo: infliximab, adalimumab, ustekinumab.
• Hyperbaric oxygen therapy: Esia bia be woana oxygen 100% le xɔ tɔxɛ aɖe me. Wogblɔ be enaa ŋutilã ƒe lãkusiwo ƒe dɔyɔyɔ kabakaba.

Na míasrɔ̃ nu tso amekoko hã ŋu.

Le go aɖewo me la, amekoko be woaɖe lãkusi kukua ɖa le abi la ŋu (ɖe abi la ɖeɖeɖa) ate ŋu aɖe vi. Gake afɔkuwo hã le esia me .Esi ŋutigbalẽ ƒe gbegblẽ (pathergy) ate ŋu ana pyoderma gangrenosum ƒe dzesiwo nagblẽ ɖe edzi ta la, ele be nàwɔ esia kple ŋuɖɔɖɔɖo gã aɖe eye le wò ɖɔkta ƒe didi nu.

Ɣeaɖewoɣi la, woate ŋu awɔ ŋutigbalẽ ƒe ʋuʋu . Esia fia be woɖea ŋutigbalẽ tso ŋutilã ƒe akpa aɖe si le lãmesẽ me eye wodonɛ ɖe teƒe si abi le.

Nukae wòle be nànya abe amesi ŋu dɔléle sia le ene?

Ne pyoderma gangrenosum le ŋuwò la, nuveviwɔame ƒomevi ɖesiaɖe si le wò ŋutigbalẽ ŋu – lãɖeɖe, ƒoƒo, abi – ate ŋu ana wò dzesiwo nagagblẽ ɖe edzi . Eyata ele be nàɖɔ ŋu ɖo alesi nàte ŋui. Tsɔe be èle dɔ wɔm le abɔ me alo le nuɖaƒe, eye ƒoƒo sue aɖe gɔ̃ hã ate ŋu ava zu kuxi gã aɖe.

Azɔ hã, abiwo ƒe dzadzɛnyenye le vevie be woaxe mɔ ɖe dɔlékuiwo xɔxɔ nu .

• Klɔ abiawo nyuie kple tsi dzadzɛ si le sisim kple adzalẽ.
• Emegbe, tsɔ aŋe si meléna ɖe nu ŋu o tsyɔ abi la dzi nyuie. Esia ana ɖiƒoƒo kple dɔlékuiwo nagage ɖe eme o.
• Wò ŋutigbalẽŋutinunyala ana nyatakaka bubuwo wò tso alesi nàwɔ ana abi la nakɔ kple alesi nàbla abie ŋu. Wɔ ɖe mɔfiame mawo dzi nyuie.
• Ne wotsɔ ami aɖe na wò la, klɔ abi la, tsɔ amia sisi ɖe eŋu, eye emegbe nàblae.

Le abi sesẽwo gome la, wò ɖɔkta ate ŋu aɖo aɖaŋu na wò be nàbla atike si nye hydrocolloid . Esiawo kpɔa abi la ta be wòagatutu abi kple dɔlékuiwo o. Wo "aƒo" ɖe ŋutigbalẽa me le ŋkeke eve va ɖo etɔ̃ me.

Ɣeyiɣi didi kae wòxɔna hafi wòhayana?

Pyoderma gangrenosum nye dɔléle aɖe si dada sesẽ . Ne woda abiawo nyuie gɔ̃ hã la, ate ŋu axɔ kwasiɖa geɖe, ɣeaɖewoɣi ɣleti geɖe hafi woahaya. Eya ta, ehiã be nàgbɔ dzi ɖi.

Ðe woate ŋu axe mɔ ɖe esia nua?

Esi womenya nusi tututu gbɔ wòtso o ta la, esesẽ be woagblɔ alesi woawɔ axe mɔ ɖe enu kple kakaɖedzi . Gake ne afɔkuwo abe ʋumenugbagbeviɣidɔ alo dɔgbo ƒe dɔléle si naa dɔdzẽ ene le ŋuwò, eye ŋutigbalẽ me kuxi yeye ɖesiaɖe va dze ŋuwò (vevietɔ abi siwo tsina kabakaba) , gblɔe na wò ɖɔkta enumake . Bia wò ɖɔkta be wòaɖo wò ɖe ŋutigbalẽŋutinunyala alo eŋutinunyala bibi bubu si si nuteƒekpɔkpɔ le le pyoderma gangrenosum ŋu gbɔ.

Ɣekaɣie wòle be makpɔ ɖɔkta?

Ele be nàkpɔ ɖɔkta godoo le nɔnɔme siawo me:

• Ne dɔgbo ƒe dɔléle, ƒunukpeƒetetedɔ, alo ʋumenugbagbeviɣidɔ aɖe le ŋuwò eye ʋuʋudedi alo abi siwo lolona kabakaba .
• Ne wò abi dze abe dɔlékui le eŋu ene (dzẽ, aŋutiɖiɖi, ɣi alo ɣi, vuvu, alo vevesese).
• Ne dzesi yeyewo va dze ŋuwò la .
• Ne èkpɔ nugbegblẽ sesẽwo le atikeawo nono vɔ megbe.

Nya vevi siwo wòle be nàbia wò ɖɔkta

Ne èyi ɖɔkta gbɔ la, ele vevie ŋutɔ be nàbia nya siawo:

• Aleke tututu nègblɔ be pyoderma gangrenosum le ŋunye?
• Ne pyoderma gangrenosum mele ŋunye o la, ŋutigbalẽdɔ bubu kae ate ŋu anye?
• Dodokpɔ ka ƒomevie nèle mɔ kpɔm be yeawɔ?
• Atike alo atikewɔwɔ ka ƒomevie nèkafu?
• Àte ŋu ana kreme aɖem be matsɔ asisi ɖe eŋu alo atike aɖem be mano?
• Nukae nye atike kple atikewɔwɔ siawo ƒe nugbegblẽ le ame ŋu ƒe xexlẽdzesi bliboa?
• Nukae wòle be mawɔ be nye dɔlélea ƒe dzesiwo dzi naɖe akpɔtɔ?
• Ðe wòle be makpɔ ŋutigbalẽŋutinunyala, amekola, dɔgboŋutinunyala, dɔlélenutsiŋuteteŋutinunyala, alo dɔdala bibi bubua?

Ele vevie ŋutɔ be nàbia nya siawo eye nàse wò nɔnɔmea gɔme nyuie.

Vovototo kae le Pyoderma Gangrenosum kple Ecthyma Gangrenosum dome?

Ŋkɔ eve siawo ɖi wo nɔewo vie, eyata woate ŋu atɔtɔ wo.

Ecthyma gangrenosum nye ŋutigbalẽdɔléle si mebɔ o si Pseudomonas bacteraemia, si nye dɔlékui si bɔ ɖe tsi kple anyigba me, hena vɛ. Ate ŋu ana ŋutigbalẽ naxɔ abi eye lãmeka siwo ƒo xlãe hã naku. Edzea amesiwo ƒe dɔlélenutsiŋutete gbɔdzɔ dzi wu .

Pyoderma gangrenosum hã nana ŋutigbalẽa xɔa abi. Womenya nusi tututu gbɔ wòtso o. Wosusu be enye dɔléle si tsoa dɔlélenutsiŋutete gbɔ. Gake menye nɔnɔme si gblẽa nu le amesiwo ƒe dɔlélenutsiŋutete gbɔdzɔ koŋ ŋu o .

Ðe pyoderma gangrenosum ƒe abi ƒomevi vovovowo lia?

Ẽ, pyoderma gangrenosum ƒe abi ƒomevi vevi ene li:

• Classic pyoderma gangrenosum: Esiae nye ƒomevi si bɔ wu. Zi geɖe la, abi siwo le veve sem la dona ɖe afɔawo dzi.
• Atypical alo bullous pyoderma gangrenosum: Esia ƒomevi dzena abe ʋuʋudedi siwo me tsi yɔ fũ ene. Zi geɖe la, wokpɔnɛ le asiwo dzi. Ebɔ ɖe amesiwo ŋu ʋumenugbagbeviɣidɔ le me wu.
• Pustular pyoderma gangrenosum: Edzena abe ʋuʋudedi suesuesue siwo yɔ fũ kple ʋuʋudedi (pustules) le asiwo kple afɔwo ŋu ene. Esia bɔ ɖe amesiwo ŋu dɔgbo ƒe dɔléle si naa dɔdzẽ le ŋu wu.
• Vegetative pyoderma gangrenosum: Zi geɖe la, abi sia ƒomevi mevea ame o.

Mlɔeba la, nu siwo dzi wòle be woaɖo ŋkui

Pyoderma gangrenosum nye dɔléle si dzea egɔme abe ʋuʋudedi suesuesuewo ene le ŋutigbalẽa dzi eye ate ŋu atrɔ kabakaba azu abi gãwo. Ate ŋu asesẽ be woakpɔ dɔlélea ahadae , eyata ehiã be mia kple wò ɖɔkta siaa miagbɔ dzi ɖi.

Ðo ŋku edzi be ele vevie ŋutɔ be nàkpɔ nyuie le nuveviwɔame ɖesiaɖe si axɔ wò ŋutigbalẽ ŋu, elabena esia ate ŋu ana nàxɔ abi yeyewo.

Ne pyoderma gangrenosum nu sẽ eye dɔléle bubu siwo kpe ɖe eŋu le ŋuwò la, ate ŋu ahe vevesese sesẽ, abi, kple kuxi siwo ate ŋu ade wò agbe afɔku me gɔ̃ hã vɛ. Eyata ne dɔléle aɖe si dɔlékuiwo ƒe dɔlélenutsiŋutete wɔna le ŋuwò eye ŋutigbalẽ ƒe abi siwo le tsitsim kabakaba la le fu ɖem na wò la, yi atikewɔƒe enumake. Ne èkpɔe kaba eye nèdae la, ate ŋu akpe ɖe ŋuwò nàhaya. Mègatsi dzodzodzoe o , gake kpɔ nyuie.

` Pyoderma Gangrenosum, Ŋutilãmedɔlélewo, Abiwo, Abi, Dɔlélenutsiŋutete, Ŋutilãŋutinunya, Dɔléle Siwo Nɔa Anyi Didi