Mina míasrɔ̃ nu tso Radiopharmaceuticals ŋu le mɔ bɔbɔe aɖe nu. Esia anɔ vevie na wò ŋutɔ!

Ðewohĩ èvɔ̃na vie ne èse nya "radiopharmaceuticals," alo? Nya "radioactive" nana míeɖoa ŋku nane si me afɔku le dzi enumake, gake ne wozãe nyuie le atikewɔwɔ me la, woate ŋu akpe ɖe ame ŋu ŋutɔ. Eyata egbea, mina míaƒo nu tso nusiwo wonye, ​​alesi wowɔa dɔe, kple alesi wole dedie na wò ŋu.

Nukawoe nye atike siawo siwo wozãna le keklẽŋusẽ me? Mina míase egɔme bɔbɔe!

Kpuie ko la, `(Radiopharmaceuticals)` siawo hã nye atike tɔxɛ aɖe . Gake keklẽŋusẽ sue aɖe le wo ŋu, si fia be keklẽŋusẽ le wo me. Mègatsi dzi o, esia nye keklẽŋusẽ si dzi wokpɔna, si le dedie. Míaƒe ɖɔktawo, si nye atikewɔlawo kple lãmesẽdɔwɔla siwo do ƒome kplii, zãa atike siawo tsɔ doa nɔnɔmetatawo kpɔ le nukliadɔdamɔnu me kple tsɔ daa dɔléle aɖewo, vevietɔ kansa ƒe dɔdzẽwo .

Bu eŋu kpɔ, ne wodi be yewoakpɔe ɖa be nane gblẽ le wò ŋutilã me hã la, ɣeaɖewoɣi ɖɔktawo naa atike vi aɖe wò be nàno alo wodoa atike na wò hafi woawɔ scan na wò? Esia nye nane si le abe ema ene. Ame siwo xɔ hehe etɔxɛe siwo woyɔna be nuklia atikewɔlawoe wɔa atike tɔxɛ siawo hetsɔa wo naa wo . Emegbe , keklẽŋusẽŋutinunyalawo kple keklẽŋusẽŋutinunyalawo (RT) zãa wo tsɔ wɔa nɔnɔmetata siwo wotsɔ dia dɔlélewoe ƒe dodokpɔwo. Ɣeaɖewoɣi la, keklẽŋusẽdɔdalawo hã naa atike siawo abe atike ene.

Nukae wozãna na radiopharmaceutical siawo?

Wozãa atike siawo le akpa eve me koŋ. Na míakpɔ nusiwo wonye ɖa.

1. Radiopharmaceuticals ƒe dɔlélewo didi

Wozãa keklẽŋusẽtikewo zi geɖe le nuklia atikewɔwɔ ƒe nɔnɔmetatawo dodokpɔwo me . Míeyɔa esiawo be "atike siwo wozãna tsɔ dia dɔlékuiwoe." Le United States ɖeɖe dzaa la, wobu akɔnta be wowɔa nukliatike siawo ƒe dodokpɔ miliɔn geɖe ƒe sia ƒe. Eyata àte ŋu akpɔ alesi gbegbe wozãa woe le susu me.

Dodokpɔ siawo ate ŋu akpɔe ɖa be ŋutinu kple lãkusi siwo le wò ŋutilã me le dɔ wɔm nyuie hã . Wowɔa esia ale:

Wona atike sia si me keklẽŋusẽ le ƒe agbɔsɔsɔ sue aɖe ŋutɔ wò be nàno, agbɔ, alo adoe. Woyɔa esiawo ɣeaɖewoɣi be radiotracers . Atike si me keklẽŋusẽ le agbɔsɔsɔme si wona wò magblẽ nu le ŋuwò o. Enye agbɔsɔsɔ sue aɖe ŋutɔ. Atike sia yia teƒe si kuxi aɖe le le wò ŋutilã me eye wòƒoa ƒu. Emegbe, fotoɖemɔ̃ si sea nu gɔme ŋutɔ, abe gamma fotoɖemɔ̃ ene, dea dzesi keklẽ si le wò ŋutilã me eye wòwɔa nɔnɔmetata siwo ɖɔkta ate ŋu akpɔ.

Bu eŋu kpɔ, atike sia le abe ʋɔnudrɔ̃la aɖe si yi ame kukua me ene, le teƒe siwo kuxia le la dim eye wòfia mí be, "Afi siae kuxia le."

Alesi wozãa radiopharmaceuticals tsɔ dea dzesi dɔlélea ƒe kpɔɖeŋu aɖewoe nye esi:

• Fluorine-18: Esia nye radiotracer si wozãna zi geɖe le PET scan (Positron Emission Tomography scans) me.
• Technetium 99m: Esiae nye keklẽŋusẽ si wozãna wu le nuklia atikewɔwɔ me. Wozãnɛ tsɔ doa ƒuwo, aklã ƒe dɔwɔwɔ, kple ayiku ƒe dɔwɔwɔ kpɔna.
• Xenon-133: Esia nye atike si me keklẽŋusẽ le si nègbɔna. Wonae be woatsɔ alé ŋku ɖe lãkusi ƒe dɔwɔwɔ ŋu (aklã ƒe dɔwɔwɔ dodokpɔ).
• Rubidium-82: Esia nye atike si wodona na wò to ʋuka me (IV). Wozãnɛ tsɔ léa ŋku ɖe dzitodzito ƒe lãmeka ƒe nɔnɔme ŋu (myocardial imaging).

2. Atikewɔwɔ ƒe Radiotikewo

Azɔ mina míaƒo nu tso alesi wozãa atike siawo tsɔ daa dɔe ŋu. Esiawo to vovo vie tso esiwo wozãna tsɔ dia dɔlélea gbɔ. Atike siwo wozãna tsɔ daa dɔe la doa keklẽŋusẽ si ŋu ŋusẽ le ŋutɔ eye wòwua lãmenugbagbeviwo . Wowɔa esia be woatsɔ awu lãmenugbagbevi siwo mele lãmesẽ me o, vevietɔ kansa lãmenugbagbeviwo .

Atike siawo le abe "bounty hunters" ene. Eyae nye be wokpɔa kansa lãmenugbagbeviwo eye wotsɔa keklẽŋusẽ ƒe atikewɔwɔ naa lãmenugbagbevi mawo tẽ . Esia to vovo na gotagome keklẽŋusẽ ƒe atikewɔwɔ , si zãa mɔ̃ tsɔ ɖoa ​​keklẽŋusẽ ƒe keklẽ siwo tso wò ŋutilã godo ɖa. Gake radiopharmaceutical siawo siwo wozãna tsɔ daa dɔe la wɔa dɔ tẽ to taɖodzinu si woɖo taɖodzinu na me.

Dɔ sia, si nye atike siwo me keklẽŋusẽ le zazã hena atikewɔwɔ, nye nu yeye kura. Numekulawo gale wo zazã yeyewo me dzrom. Woxɔe se be radiopharmaceuticals siwo wozãna tsɔ daa dɔe awɔ akpa vevi aɖe ŋutɔ le kansa dada me le etsɔme.

Nukae nye radiopharmaceuticals siwo wozãna tsɔ daa kansa?

``Radiopharmaceuticals`` ƒomevi geɖewo li siwo ɖɔktawo zãna tsɔ daa kansa. Le kpɔɖeŋu me:

• PLUVICTO® (lutetium Lu 177 vipivotide tetraxetan): Esia nye atike si dzi United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) da asi ɖo. Wozãnɛ tsɔ daa ʋumenugbagbeviɣidɔ (PSMA-positive metastatic castration-resistant prostate cancer - PSMA-positive mCRPC).
• LutatheraTM `(LutatheraTM - Lutetium Lu 177 ƒe lãgbalẽ)`:Esia hã nye atike si dzi FDA da asi ɖo. Wozãnɛ tsɔ daa ahɔhɔ̃mekawo ƒe dɔdzẽ aɖewo (somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors) siwo dzɔna le dɔgbo, dɔgbo, kple dɔgbo me.
• Iodine-131: Esiae nye iodine si me keklẽŋusẽ le ƒe atikewɔwɔmɔnu vevitɔ. Ate ŋu ada lãkusi me dɔdzẽ aɖewo kple Graves ƒe dɔléle aɖewo, si wogayɔna be ʋumenugbagbeviɣidɔ si gbɔ eme.
• Radium-223: Esia wɔa dɔ ŋutɔ le ƒumeŋuɖui siwo dzɔna ne ʋumenugbagbeviɣidɔ kaka (kaka) yi ƒuwo me la dada me. United States ƒe FDA da asi ɖe Radium-223 dichloride (XofigoTM) dzi hena esia wɔwɔ.

Tsɔ kpe ɖe eŋu la, wole atikewɔwɔ me atike ƒomevi bubu geɖe siwo wozãna le keklẽŋusẽ me la dom kpɔ fifia le kansa ƒomevi bubuwo ŋu.

Nukawoe nye radiotike siwo wozãna wu?

Abe alesi míegblɔe va yi ene la, Technetium-99m nye atike si wozãna le keklẽŋusẽ me si ɖɔktawo zãna zi geɖe. Wozãnɛ koŋ tsɔ doa nɔnɔmetatawo kpɔna tsɔ dia dɔlélewoe. Ekpena ɖe ame ŋu be "wòakpɔ" nusiwo gbɔna:

• Aklã me tsidede (ʋu ƒe sisi) le wò lãkusi me.
• Ʋu ƒe sisi le wò ʋukawo me (Vascular perfusion).
• Ƒuwo.
• Dzitodzito me lãkusi.
• Aɖatsi ƒe lãkusiwo.
• Thyroid ƒe lãkusi.

Atike bubu siwo wozãna zi geɖe le keklẽŋusẽ me dometɔ aɖewoe nye:

• 18F Fluorodeoxyglucose `(18F Fluorodeoxyglucose - FDG)`
• Gallium-68 NYAWO ƑE ƑOMEDODO
• Gallium-68 PSMA `(Gallium-68 PSMA)`
• 18F PSMA `(18F PSMA)`
• Iodine 123 `(Iodine 123)`

Eyata ɖe radiopharmaceutical siawo le dedie ŋutɔŋutɔa?

Esia nye nyabiase si le ame geɖe si. Ne wozã radiotikewo eye wokpɔ wo dzi nyuie la, womele dedie o. Wò keklẽŋusẽŋutinunyala kple/alo keklẽŋusẽdɔdala awɔ dɔ kple nuklia atikewɔla aɖe akpɔ egbɔ be keklẽŋusẽtike agbɔsɔsɔme si wona wò la sɔ eye wòle dedie . Eyata naneke meli si ŋu woatsi dzi ɖo o.

Abe atikewo katã ene la, keklẽŋusẽdɔdamɔnu ate ŋu ahe nugbegblẽ aɖewo vɛ . Gake zi geɖe la, atike la ƒe viɖewo lolona wu afɔku siwo le eme. Wò ɖɔkta aɖe nugbegblẽ le ame ŋu siawo siwo ate ŋu ado tso eme la me na wò hafi nàdze atikewɔwɔ gɔme.

Togbɔ be wozãa radiopharmaceuticals ƒe bla nanewoe nye sia le nuklia-atikewɔwɔ ƒe nɔnɔmetatawo ɖeɖe me hã la, nyitsɔ laa koe wodze wo zazã gɔme tsɔ daa kansa. Numekulawo gale nu srɔ̃m tso alesi atike siawo siwo me keklẽŋusẽ le la tɔa ŋku kansa lãmenugbagbeviwo hewua woe ŋu. Ne èdi be yeanya nu tso atike siwo wozãna le keklẽŋusẽ me ƒe dodokpɔ siwo wowɔna le atikewɔnyawo me hena kansa dada ŋu la, ke ƒo nu kple wò ɖɔkta. Edzɔa dzi na wo be yewoakpe ɖe ŋuwò.

Mlɔeba la, nu vevitɔ kekeake siwo dzi wòle be nàɖo ŋkui

Enyo, eyata, le nusiwo ŋu míeƒo nu tsoe nu la, nu vevi siawoe wòle be nàɖo ŋkui:

• Atike siwo wotsɔa keklẽŋusẽ wɔe nye atike tɔxɛ aɖe si kpɔa keklẽŋusẽ ƒe dɔwɔwɔ dzi .
• Wozãa esiawo koŋ tsɔ doa nɔnɔmetatawo kpɔna tsɔ dia dɔlélewoe (e.g. PET scans, bone scans) kple tsɔ daa dɔléle aɖewo, vevietɔ kansa .
• Le dɔlélewo didi me la, esiawo wɔa dɔ abe ``Radiotracers'' ene, "fiaa asi" ŋutilã ƒe akpa siwo kuxiwo le.
• Le atikewɔwɔ me la, esiawo kpena ɖe ame ŋu wòɖoa taɖodzinu na kansa lãmenugbagbeviwo hetsrɔ̃a wo .
• Atike siawo mele dedie ne wona wo le atikewɔla ƒe dzikpɔkpɔ nyuie te . Abe alesi wòle le atikewo katã gome ene la, nu suesuesuewo ate ŋu ado tso eme, gake zi geɖe la, viɖeawo sɔa gbɔ wu wo.
• Dɔ sia, vevietɔ le kansa dada me, gakpɔtɔ le tɔtrɔm , eye woate ŋu akpɔ mɔ na ŋgɔyiyi geɖe le etsɔme.

Eyata, ɣebubuɣi si nàse ``(Radiopharmaceutical)'' ŋu nya la, èse nusi wònye kple nusi wozãnɛ na gɔme nyuie wu azɔ, alo? Ne nya bubu aɖewo gale asiwò la, mègahe ɖe megbe ɣesiaɣi le wò ɖɔkta biabia me o.

` Radiopharmaceuticals, Nuklia Atikewɔwɔ, Kansa Dada, Scan, Kekeli ƒe Dɔdamɔnu, Dɔlélewo Didi