Ðe nèle ƒunukpeƒewo te ɖe wò ƒunukpeƒewo ŋua? Mina míaƒo nu tso Tumoral Calcinosis ŋu!

Ðe nèsena le ɖokuiwò me ɣeaɖewoɣi be ƒu alo teƒe sesẽ aɖe le ŋutigbalẽa te le ƒunukpeƒe aɖe abe wò abɔta, abɔta, alo klo ene gbɔa? Ðewohĩ mavee ne èzi edzi o, gake ate ŋu alolo vie. Esɔ be nàvɔ̃ vie ne èkpɔ nane si le abe esia ene. Gake menye ƒunukpeƒetetedɔ siawo katãe nye kansa siwo me afɔku le o. Egbea míele nu ƒom tso nɔnɔme aɖe si ɖea dzesi siawo fiana, gake menye kansa o, eye wòbɔ vie gake ele vevie be woanya nu tso eŋu. Emae nye ‘Tumoral Calcinosis’ .

Nukae Nye Tumoral Calcinosis?

Kpuie ko la, dɔdzẽ ƒe calcinosis nye domenyiŋusẽfianu ƒe nɔnɔme . Esia nye ne atike aɖe si woyɔna be phosphate ƒe agbɔsɔsɔ le wò ʋu me sɔ gbɔ akpa. Phosphate nye nu sue aɖe si me elektrikŋusẽ le, alo ion, si me tomenu si nye phosphorus le. Eyata le amesi ŋu tumoral calcinosis le gome la, phosphorus kple calcium siaa ƒoa ƒu ɖe ŋutilãa me, si wɔnɛ be ƒunukpeƒewo dona le ŋutigbalẽa te, vevietɔ ƒo xlã ƒunukpeƒewo.

Phosphorus kple calcium siaa le vevie na míaƒe ŋutilã be wòatu aɖu kple ƒu siwo le lãmesẽ me, siwo sesẽ. Gake ne wokɔ akpa la, tsitsi siwo menye kansa o (siwo me dɔlékui mele o), si fia be womenye afɔku o, gake wodze abe dɔdzẽ ene la, dzea wɔwɔ gɔme le lãkusiawo me. Esiae nye nusi míeyɔna be tumoral calcinosis.

Ðe ŋkɔ bubu aɖe li na esia?

Ẽ, atikewɔwɔ me ŋkɔ bliboa na dɔléle siae nye ‘Hyperphosphatemic Familial Tumoral Calcinosis’ (HFTC) . Ŋkɔ didi aɖe vie, alo? Ðɔkta aɖewo hã yɔnɛ be ‘Teutschlaender dɔléle’. Ema nye be míaɖo ŋku Otto Teutschlaender, Germanytɔ ɖɔkta aɖe si srɔ̃ nu tso dɔléle sia ŋu tso ƒe 1930 va ɖo ƒe 1950-awo me dzi.

Nukae atikewɔŋkɔ didi sia fia?

Ðe míama ŋkɔ sia ɖe akpa vovovowo me ahase egɔmea? Ema anɔ bɔbɔe wu.

• Hyperphosphatemic: Esia fia be phosphate ƒe agbɔsɔsɔ le ʋua me sɔ gbɔ.
• Ƒomea me tɔ: Esia fia be esia nye nɔnɔme si nɔa ƒomewo me eye wònye domenyiŋusẽfianu.
• Tumoral: Wozã nya sia elabena tsitsi siawo siwo le abe dɔdzẽ ene la le abe kansa ƒe dɔdzẽ ene.
• Calcinosis: Esia fia be calcium nɔa wò lãmekawo kple lãmekawo ƒe lãkusiwo me.

Èse gɔmesese si le ŋkɔ didi ma ŋu gɔme fifiaa?

Aleke tututu Tumoral Calcinosis kpɔa ŋusẽ ɖe ŋutilã dzii?

Zi geɖe la, ƒunukpeƒetetedɔ siawo, siwo woyɔna be tumoral calcinosis , dzɔna le ŋutigbalẽa te, le ƒunukpeƒewo gbɔ . Woate ŋu atsi le ƒunukpeƒe siwo wu ɖeka me, gake woate ŋu atsi le ƒunukpeƒe geɖe hã me. Teƒe siwo bɔ wue nye:

• Akɔta ƒe ƒunukpeƒewo
• Abɔtawo
• Abɔtawo
• Gᴐme
• Asibidɛ ƒe ƒunukpeƒewo
• Akɔta ƒe ka si do ƒome kplii
• Aɖu ƒe nuto

Aleke gbegbee nɔnɔme sia bɔe?

Atikeŋutinunyalawo meka ɖe edzi be ame neni tututue ŋu dɔdzẽ ƒe calcinosis sia le o. Because it's a very rare condition , ebɔ wu le amesiwo tso Afrika kple Titina Ɣedzeƒe gome. Ate ŋu agblẽ nu le ŋutsuwo kple nyɔnuwo siaa ŋu.

Nukawoe nye Tumoral Calcinosis ƒomevi veviwo?

Esia ƒomevi si bɔ wue nye Hyperphosphatemic Familial Tumoral Calcinosis, si ŋu míeƒo nu tsoe va yi. Tsɔ kpe ɖe eŋu la, ƒomevi bubu siwo mebɔ o hã li:

• Hyperphosphatemia-hyperostosis syndrome (HHS): Esia nye nɔnɔme si nana ƒuwo tsina fũu akpa eye ƒu ƒe abi siwo menye kansa o la dona.
• Normophosphatemic tumoral calcinosis: Wokpɔa esia ƒomevi zi geɖe le amesiwo ƒe ayiku mewɔa dɔ nyuie o ŋu. Ate ŋu ahe nɔnɔme aɖe si woyɔna be hyperparathyroidism, si nye parathyroid gland si wɔa dɔ fũu akpa vɛ.

Nukae hea Tumoral Calcinosis vɛ?

Tumor calcinosis nye lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔléle si ƒe dome wonyi . Ame siwo ŋu dɔléle sia le ƒe akpa etɔ̃lia lɔƒo ƒe domenyiŋusẽfianu ƒe tɔtrɔ, alo tɔtrɔ, le woƒe FGF23 domenyiŋusẽfianu me. FGF23 domenyiŋusẽfianu kpena ɖe míaƒe ƒu ƒe lãmenugbagbeviwo ŋu wowɔa protein si woyɔna be fibroblast growth factor (FGF) 23. Nɔnɔme sia le ame aɖewo hã ŋu le tɔtrɔ siwo va le GALNT3 kple KL domenyiŋusẽfianuwo me ta. Domenyiŋusẽfianu siawo kpɔa FGF23 ƒe wɔwɔ dzi. Ame siwo ŋu nomophosphatemic tumor calcinosis le la ƒe domenyiŋusẽfianu trɔ le SAMD9 domenyiŋusẽfianu me.

Zi geɖe la, protein `FGF23` gblɔa phosphate agbɔsɔsɔme si míaƒe ayikuwo gbugbɔ xɔ tso ʋua me. Gake ne domenyiŋusẽfianu ƒe tɔtrɔ aɖe va la, nuwɔna sia metoa mɔ ɖeka o. Emegbe ayikuawo gaxɔa phosphate geɖe wu alesi wòle be woaxɔe. Zi geɖe la, ayikuawo ɖea phosphate si sɔ gbɔ ɖe aɖuɖɔ me. Gake le dɔdzẽ ƒe calcinosis me la, phosphate sia blana ɖe calcium ŋu eye wòwɔa dɔdzẽ le lãkusi falɛfalɛawo me.

Amekawoe le afɔku me be woaxɔ dɔléle sia?

Tumorous calcinosis nye dɔléle si tsoa autosomal recessive dɔlélea gbɔ . Esia gɔmesese sesẽ vie, gake ne míagblɔe bɔbɔe la, hafi dɔlélea nadze ŋuwò la, ele be nànyi domenyiŋusẽfianu ƒe tɔtrɔ la ƒe dome tso dziwòla evea siaa gbɔ. Dziwòlawo ate ŋu anye nugbagbevi si trɔna la tsɔlawo, gake ɖewohĩ dɔlélea mele wo ŋu o.

Ne dzila evea siaa nye ʋutsɔlawo la, mɔnukpɔkpɔ siwo gbɔna la asu wo viwo dometɔ ɖesiaɖe si:

• Mɔnukpɔkpɔ li be domenyiŋusẽfianu si trɔ la manɔ ame 1 le 4 ɖesiaɖe me o (afɔku aɖeke mele eme be dɔlélea nadze ame dzi o).
• Mɔnukpɔkpɔ li be ame 1 le 4 ɖesiaɖe me naxɔ dɔdzẽ ƒe calcinosis.
• Mɔnukpɔkpɔ li be ame 1 le 2 ɖesiaɖe me nanye amesi tsɔa dɔlélea si mexɔa dɔlélea o.

Nukae nye Tumoral Calcinosis ƒe dzesiwo?

Nɔnɔme sia nana ƒunukpeƒetetedɔ siwo ƒe lolome le vovovo la dzɔna le ƒunukpeƒe ɖeka alo esi wu nenema gbɔ. Zi geɖe la , ƒunukpeƒetetedɔ siawo dzena le ɖevime alo ƒewuiwo me . Ke hã, woate ŋu atsi le vidzĩwo kple ame tsitsiwo hã me. Ɣeaɖewoɣi la, ƒunukpeƒetetedɔ ʋɛ aɖewo koe dona le ame ƒe agbemeŋkekewo katã me. Alo, ƒunukpeƒetetedɔ geɖe ate ŋu ado zi ɖeka.

Ðewohĩ dzesi siwo le abe esiawo ene anɔ ŋuwò:

• Esesẽna be woaʋuʋu ƒunukpeƒe si ŋu dɔlélea le alo abɔbɔ nyuie.
• Kpe sesẽ siwo me vevesese mele o (ƒuƒoƒo aɖewo ate ŋu ase veve vie ne woka asi wo ŋu).
• Lãmetsiŋusẽ ƒe vevesese.

Aleke wokpɔa Tumoral Calcinosis ƒe dɔlélea?

Ƒumeŋutinunyala nye ɖɔkta si bi ɖe ƒu kple ƒunukpeƒewo ƒe kuxiwo me. Ado wò kpɔ ahabia wò dzesiwo. Emegbe ate ŋu awɔ X-ray siwo gbɔna la dometɔ ɖeka alo esi wu nenema atsɔ adi dɔdzẽ siawo kple ƒu ƒe kuxi bubuwo:

• X-ray dodokpɔ `(X-ray)`
• CT-dɔdamɔnu
• MRI ƒe fotoɖeɖe `(MRI)`

Nɔnɔme bubu kawoe ɖea dzesi siwo sɔ kple Tumoral Calcinosis fiana?

Esia le vevie ŋutɔ. Elabena ele vevie be woakpɔ dɔlélea nyuie . Nusitae nye be nɔnɔme bubuwo li siwo ɖea dzesi mawo tɔgbe fiana, gake wosẽna wu. Nɔnɔme siawo dometɔ aɖewoe nye:

• Lãmetsi falɛfalɛ siwo me dɔlékui aɖeke mele o kple lãmeka falɛfalɛ siwo me dɔlékui vɔ̃ɖiwo le
• Calcific myonecrosis (si nye dɔdzẽ si me calcium si le afɔ ƒe lãmekawo me) .
• Calcific tendonitis (calcium ƒe ƒuƒoƒo kple lãkusidɔ) .
• Calcinosis circumscripta (calcium si nɔa ŋutigbalẽ kple asiwo kple afɔ ƒe lãkusiwo me) .
• Calcinosis si nye ayiku (ayiku) ƒe dɔmawɔmawɔ nyuie atraɖii (calcium ƒe agbɔsɔsɔ le amesiwo le ʋumenugbagbeviɣidɔ me) .
• Calcinosis universalis (calcium dze siwo le ŋutigbalẽ, lãkusiwo, lãkusiwo, kple lãmekawo me) .
• Lãmetsi siwo doa ka kple wo nɔewo ƒe dɔlélewo
• Gout
• Myositis ossificans (lãmeka si trɔna zua ƒu) .
• Osteosarcoma kple sarcoma (ƒumeŋuɖui) .
• Synovial chondromatosis (ƒunukpeƒetetedɔ siwo le ƒunukpeƒewo) .

Kpɔ? Togbɔ be dzesiawo ɖi wo nɔewo hã la, nusi gbɔ wòtso ate ŋu ato vovo kura. Esia tae wòle vevie be nànya nusi tututu le edzi yim ɖo.

Nukawoe nye atikewɔwɔ siwo menye amekoko o?

Wò ɖɔkta ate ŋu aɖe phosphate ƒe agbɔsɔsɔ si le wò ʋu me dzi akpɔtɔ.Woate ŋu aŋlɔ atike siwo blaa phosphate na ame. Ne wotsɔ atike siawo siwo blaa phosphate tsaka kple atike aɖe si woyɔna be acetazolamide (si wozãna zi geɖe na asrãdɔ kple ŋkudɔ) la, woate ŋu axe mɔ na ŋutilãa ƒe ŋutete be wòaxɔ phosphorus. Ðewohĩ ahiã hã be nàɖu nuɖuɖu si me phosphorus mesɔ gbɔ ɖo o .

Nukae nye nuɖuɖu si me phosphorus mesɔ gbɔ ɖo o?

Ne tumoral calcinosis le ŋuwò la, wò ɖɔkta ate ŋu aɖo aɖaŋu na wò be nàɖu nuɖuɖu si me phosphorus mesɔ gbɔ ɖo o. Phosphorus le lã, tɔmelã, kple nyinotsi me le dzɔdzɔme nu. Wotsɔa phosphorus dea nuɖuɖu bubu aɖewo hã me abe nusi wotsɔ dzraa nuɖuɖu ɖo alo nusi naa nu vivina ene.

Dze agbagba nàɖe nuɖuɖu kple nunono siwo me phosphorus sɔ gbɔ ɖo, abe:

• Beer, colas, iced tea kple tsokolet nonowo.
• Tsokolet kple caramel ƒomeviwo.
• Notsi me nuɖuɖuwo (notsi, cheese, ice cream, yogurt siwo menye Helatɔwo tɔ o, mɔli siwo me kreme le).
• Ƒumelãwo abe ƒumelãwo kple sardines ene, kple ŋutinuwo abe nyilã kple koklolã ƒe aklã ene.
• Lã siwo ŋu wotrɔ asi le (hot dogs, ŋdɔnuɖuɖu lã, bacon, soseti).
• Nusiwo wowɔ tso oat bran me.

Anyo wu be nàƒo nu kple wò ɖɔkta alo nuɖuɖuŋutinunyala tso esia ŋu hena nyatakaka bubuwo.

Nukawoe nye amekoko ƒe dɔdamɔnuawo?

Ðewohĩ ahiã be woawɔ dɔ na wò be woaɖe dɔdzẽ siwo lolo akpa be woate ŋu awɔ dɔ nyuie la ɖa. Gake anɔ eme be dɔdzẽ siawo agatsi ake wu . Wò ɖɔkta ate ŋu axɔ lãkusi si woɖe la hã eye wòawɔ dɔ na wò be wòaɖo kpe dɔlélea dzi.

Nukawoe nye kuxi siwo ate ŋu ado tso Tumoral Calcinosis me?

Ƒã ŋutɔ hafi nɔnɔme sia ate ŋu agblẽ nu le wò ʋukawo alo ahɔhɔ̃ ŋu, si ana lãmesẽkuxi sesẽwo abe dzidɔ kple ʋusɔgbɔdɔ ene xɔxɔ ƒe afɔkua nadzi ɖe edzi.

Tsɔ kpe ɖe eŋu la, nɔnɔme sia ate ŋu ahe nusiwo gbɔna hã vɛ:

• Ŋku ƒe kpeƒekpeƒewo alo angioid streaks (red streaks) le ŋku ƒe ŋkume ƒe ŋkume.
• Aɖuŋutinunya ƒe kuxiwo.
• Ƒu ƒe tsitsi fũ akpa (hyperostosis).
• Dzo legbe siwo le wò afɔwo alo abɔwo me (diaphysis) me.

Ðe woate ŋu axe mɔ ɖe Tumoral Calcinosis nua?

Ne domenyiŋusẽfianu ƒe tɔtrɔ si hea dɔdzẽ ƒe calcinosis vɛ le mia kple wò zɔhɛa siaa ŋu la, àte ŋu aƒo nu kple domenyiŋusẽfianu ŋuti aɖaŋuɖola aɖe tso mɔ siwo dzi nàto aɖe afɔku si le viwòwo ƒe domenyinyi ƒe domenyinyi me dzi akpɔtɔ ŋu. Ame aɖewo tiaa dɔdamɔnu aɖe si woyɔna be Preimplantation Genetic Diagnosis (PGD) . Esia bia be woade dzesi fugboe siwo me tɔtrɔa mele o. Emegbe wò ɖɔkta zãa mɔnu aɖe si woyɔna be In Vitro Fertilization (IVF) tsɔ tsɔa fugboe siwo le lãmesẽ me la yia nyɔnua ƒe vidzidziŋusẽ me. Ne viwòa wɔ dɔ sia la, domenyiŋusẽfianu ƒe tɔtrɔ si hea dɔlélea vɛ la dome manyi o.

Nukae nye mɔkpɔkpɔ na amesi ŋu Tumoral Calcinosis le?

Ame akpa gãtɔ siwo ŋu tumoral calcinosis le la nɔa agbe bliboe, si me wowɔa dɔ le . Ƒã hafi nɔnɔmea hea lãmesẽkuxi sesẽwo vɛ. Gake ahiã be nàyi ɖɔkta gbɔ edziedzi akpɔe ɖa be dɔlélea gadze egɔme hã.

Ɣekaɣie wòle be makpɔ ɖɔkta?

Kpɔ ɖɔkta ne dzesi siawo le ŋuwò:

• Ʋuʋu ƒe didime si dzi ɖe kpɔtɔ le ƒunukpeƒe.
• Ƒunukpeƒeveame, ƒu ƒe vevesese, alo lãmekawo ƒe vevesese.
• Dɔdzẽ alo ƒunukpeƒetetedɔ ƒe dzedzeme le ŋutigbalẽa te.

Nukae wòle be mabia nye ɖɔkta?

Àte ŋu abia ɖɔktaa nya siawo abe esiawo ene:

• Nukatae dɔdzẽ ƒe calcinosis va dze dzinye?
• Nukae nye atikewɔwɔ nyuitɔ kekeake nam?
• Ðe wòhiã be woawɔ dɔ nam?
• Nuɖuɖu kawo ƒomevie wòle be maɖe dzi akpɔtɔ?
• Ðe wòle be matsi dzi ɖe kuxi siwo ado mo ɖa ŋua?
• Ðe wòle be woado domenyiŋusẽfianu ƒe dodokpɔ na nye ƒomea me tɔ mamlɛawoa?

Ðe Tumoral Calcinosis ate ŋu anye Kansa?

Togbɔ be nya "tumoral" le ŋkɔa me hã la, dɔdzẽ siwo dona le tumoral calcinosis ta la menye kansa ŋutɔŋutɔ o . Afɔku aɖeke mele eme be dɔdzẽ siawo nazu dɔlékui vɔ̃ɖiwo o. Eyata mègatsi dzi ɖe eŋu o.

Enye nyateƒe be dɔdzẽ siwo le ŋutigbalẽa te le dɔdzẽ ƒe calcinosis ta ate ŋu ana ame ƒe dzi nadze eme vie eye wòado vɔvɔ̃ na ame. Gake le ame akpa gãtɔ gome la, dɔdzẽ siawo mehea kuxi gã aɖeke vɛ o. Atikewo ate ŋu aɖe phosphorus ƒe agbɔsɔsɔ si le ʋua me dzi akpɔtɔ. Wò ɖɔkta ate ŋu aɖo aɖaŋu na wò hã be nàkpɔ nuɖuɖuŋutinunyala aɖe be wòakpe ɖe ŋuwò nàɖu nuɖuɖu si me phosphorus mesɔ gbɔ ɖo o. Ne vevesese le wò ƒunukpeƒewo, ƒuwo, alo lãmekawo me si na be màte ŋu azɔ o la, gblɔe na wò ɖɔkta. Togbɔ be woate ŋu aɖe dɔdzẽwo ɖa to amekoko me hã la, nenɔ susu me na wò be woate ŋu atrɔ ava.

Gbedasi si Woatsɔ Ayi Aƒee (Nu Siwo Dzi Nàɖo Ŋku) .

Enyo, eyata mina míagbugbɔ aƒo nu tso nya vevi siwo me míedzro egbea ku ɖe Tumoral Calcinosis ŋu la ŋu:

• Esia nye nɔnɔme si mebɔ o, si tso domenyiŋusẽfianu me. Phosphate ƒe agbɔsɔsɔ si dzi ɖe edzi le ʋua me nana wowɔa ɖeka kple calcium tsɔ wɔa ƒunukpeƒewo le ƒunukpeƒewo gbɔ.
• Menye kansae dɔdzẽ siawo nye o .
• Zi geɖe la, nusiawo mevea ame o, gake woate ŋu ado kplamatse ƒunukpeƒewo ƒe ʋuʋu.
• Dɔdamɔnua dometɔ aɖewoe nye atike siwo ɖea phosphate dzi kpɔtɔna, nuɖuɖu si me phosphorus mesɔ gbɔ ɖo o, kple ne ehiã la, amekoko.
• Ne èkpɔ ƒunukpeƒetetedɔ abe esia ene la, mègatsi dzodzodzoe eye nàdi atikewɔlawo ƒe aɖaŋuɖoɖo o. Dɔlélea didi nyuie le vevie ŋutɔ.
• Ame geɖe nɔa agbe si sɔ, si me wowɔa dɔ le kple nɔnɔme sia.

Eyata ne dzesi siawo le wò alo ame aɖe si nènya ŋu la, anyo wu be nàyi ɖɔkta gbɔ aɖaɖo aɖaŋu na wò.

` Tumorous calcinosis, ƒunukpeƒetetedɔ, phosphate, calcium, domenyiŋusẽfianu ƒe dɔlélewo, ŋutigbalẽ me nodules, ƒumedɔlélewo