Ke ʻulaʻula nei hoʻi kou maka a poniuniu ma hope o ka inu ʻana i kahi waiʻona liʻiliʻi? E aʻo kākou e pili ana i ka hiki ʻole ke hoʻomanawanui i ka waiʻona!

Ua ʻike anei ʻoe i kekahi poʻe, ʻoiai ma hope o ka inu ʻana i kahi waiʻona liʻiliʻi, loaʻa i kekahi poʻe ka ʻulaʻula o ko lākou helehelena a manaʻo ʻole lākou i ka ʻoluʻolu ʻole? Malia paha ua loaʻa iā ʻoe kēlā mea iā ʻoe pū kekahi. Manaʻo paha ʻoe, 'ʻAuē, ʻaʻole hiki iaʻu ke inu iki'? ʻO ia ke ʻano o ke kūlana a mākou e kamaʻilio ai i kēia lā. Kāhea mākou i kēia ʻo 'Alcohol Intolerance'.

He aha maoli ka hoʻomanawanui ʻole i ka waiʻona?

I ka ʻōlelo maʻalahi, he mea kēia i loaʻa mai nā genes, ʻo ia hoʻi, mai kēlā hanauna a i kēia hanauna. He mea ia a mākou e loaʻa ai mai ko mākou mau mākua, e like me ke kala o ko mākou ʻili a me ke kala o ka lauoho. Ua kapa ʻia hoʻi kēia he maʻi metabolic . I kēia manawa ke noʻonoʻo nei ʻoe i ke ʻano o kēia metabolism, ʻeā? ʻO kēia ke kaʻina hana e hoʻololi ai i nā mea a mākou e ʻai ai a inu ai i ikehu i loko o ko mākou kino, a wāwahi pū a wehe i nā mea pono ʻole. No laila, ʻaʻole hiki i ke kanaka me ka maʻi ʻona ke ʻae pono a hana i ka waiʻona.

E noʻonoʻo e pili ana i ia mea, loaʻa i ko kākou kino nā protein kūikawā e kōkua iā kākou e hoʻoheheʻe i ka meaʻai a wāwahi i nā mea i loko. Kāhea mākou iā lākou he mau enzymes . Hana kēia mau enzymes e like me nā limahana liʻiliʻi. ʻO ka poʻe me ka ʻole o ka waiʻona , he hemahema ko lākou i ka hana o kahi enzyme kūikawā e kōkua ana i ka wāwahi ʻana i ka waiʻona. ʻO ia ke kumu e ʻike ai lākou i nā hōʻailona maikaʻi ʻole e like me ka maka ʻulaʻula (i kapa ʻia hoʻi he 'alcohol flush') a me ka wela wela ma hope o ka inu ʻana i kahi liʻiliʻi o ka waiʻona.

ʻAʻole pono e huikau kēia me ka maʻi ʻaleʻale waiʻona, ʻeā?

He nui ka poʻe e huikau i ka hoʻomanawanui ʻole i ka waiʻona me ka maʻi ʻaleka waiʻona. Akā he ʻelua mau mea ʻokoʻa kēia.

ʻO ka hoʻomanawanui ʻole i ka waiʻona he maʻi genetic, metabolic ʻo ia hoʻi ʻaʻole hiki i kāu ʻōnaehana hoʻoheheʻe ke hana pono i ka waiʻona.

He mea ʻokoʻa ka maʻi ʻaleʻale i ka waiʻona. He pane ia mai ko kākou ʻōnaehana pale kino. E like me kou maʻi ʻaleʻale i ka lepo a i ʻole ka meaʻai, ke pane nei kou kino i kahi mea i loko o ka waiʻona (no ka laʻana, kahi hua i hoʻohana ʻia e hana i ka waiʻona, kahi kemika, a i ʻole kahi mea mālama e like me ka sulfite).

He ʻokoʻa iki nō hoʻi nā hōʻailona. Hiki ke loaʻa ka luaʻi i nā mea ʻelua. Eia nō naʻe, ʻo ka hōʻailona nui o ka hiki ʻole ke inu waiʻona, ʻo ia ka ʻulaʻula o ka ʻili ma ka umauma, ka ʻāʻī, a me ka maka. ʻO ia kaʻu i kamaʻilio ai ma mua, ʻo ka `alcohol flush'.

Ma ka ʻaoʻao ʻē aʻe, hiki i kahi maʻi ʻaleʻale waiʻona ke hoʻoulu i nā ʻulaʻula ʻili, ka maneʻo, ka pehu ʻana, a me ka ʻeha nui o ka ʻōpū. ʻOi aku ka ʻeha a me ka ʻoluʻolu ʻole o nā hōʻailona o kahi maʻi ʻaleʻale ma mua o nā mea hiki ʻole ke hoʻomanawanui. I kekahi mau hihia, hiki i kahi maʻi ʻaleʻale waiʻona ke hoʻoweliweli i ke ola inā ʻaʻole mālama ʻia.

No laila, inā ʻike ʻoe i kekahi mau hōʻailona ʻē ma hope o ka inu ʻana i ka waiʻona, e ʻike pono i ke kauka. A laila hiki iā ʻoe ke ʻike pono i ke kumu o ka pilikia.

No laila, ua like anei kēia me ke 'luhi'?

ʻAuē. ʻAʻole manaʻo ka hoʻomanawanui ʻole i ka waiʻona e ʻona koke ʻoe a i ʻole e ʻona me ka waiʻona liʻiliʻi. ʻAʻole ia e hoʻonui i ka nui o ka waiʻona i kou koko. ʻO ka ʻoiaʻiʻo, ua hōʻemi ka nui o ka poʻe me kēia maʻi i kā lākou inu ʻana i ka waiʻona no ka mea ʻaʻole hiki iā lākou ke ʻae i nā hōʻailona maikaʻi ʻole.

ʻO wai ka mea i ʻoi aku ka paʻakikī o ka loaʻa ʻana o kēia maʻi? He aha ke kumu?

ʻOiai he maʻi hoʻoilina kēia e hiki ke hoʻopilikia i kekahi, ʻoi aku ka nui o ka poʻe o ka hanauna Hikina ʻAsia (e like me Kina, Kepanī, a me Kōlea) e loaʻa i ka hiki ʻole ke hoʻomanawanui i ka waiʻona. ʻO kēia no ka mea he ʻoi aku ka maʻamau o ka hoʻololi ʻana o ko lākou mau genes.

ʻAe, e nānā kākou i ke kumu o kēia. Ke inu mākou i ka waiʻona (ʻo ia hoʻi ka ethanol), eia ka mea maʻamau e hana ʻia i loko o ko mākou kino:

1. Hoʻololi kahi enzyme i kapa ʻia ʻo Alcohol Dehydrogenase (ADH) i ka ethanol i loko o kahi mea i kapa ʻia ʻo acetaldehyde . Hiki i kēia acetaldehyde ke hoʻopōʻino i kā mākou mau cell.

2. A laila, hoʻololi kekahi enzyme i kapa ʻia ʻo Aldehyde Dehydrogenase 2 (ALDH2) i kēia acetaldehyde i loko o ka waikawa acetic ʻino ʻole (ʻo ia hoʻi ka vīnega).

I kēia manawa, ʻo ka mea e hana ʻia i kahi kanaka me ka ʻole o ka waiʻona, ʻo ia ka lua o ka enzyme, ʻo ALDH2, he hana ʻole loa a ʻaʻole paha e hana iki. ʻO kēia ma muli o kēlā loli genetic. He aha ka mea e hana ʻia a laila? ʻO kēlā acetaldehyde ʻino, ma kahi o ka hoʻololi ʻia ʻana i ka waikawa acetic , hoʻomaka e hōʻiliʻili i loko o ke koko a me nā ʻiʻo. ʻO ia ke kumu nui o ka ʻike ʻia ʻana o kēlā mau hōʻailona maikaʻi ʻole. Maopopo iā ʻoe?

He aha nā hōʻailona o ka hoʻomanawanui ʻole i ka waiʻona?

E like me kaʻu i ʻōlelo ai ma mua, ʻo ka hōʻailona nui a maopopo loa, ʻo ia ka ʻulaʻula a me ka wela ma ka maka, ka ʻāʻī, a me ka umauma. Ua kapa ʻia hoʻi kēia ʻo 'alcohol flushing syndrome'. Hiki ke hana kēia ma hope o ka inu ʻana i kahi waiʻona liʻiliʻi.

Ma waho aʻe o kēlā, hiki iā ʻoe ke ʻike i nā ʻano hana ʻē aʻe e like me:

• Ka luaʻi a me ka luaʻi
• Puʻuwai wikiwiki (i kapa ʻia hoʻi ʻo 'tachycardia') a i ʻole ka manaʻo o kou puʻuwai e kuʻi ana ('heart palpitations')
• Ke koko haʻahaʻa (hypotension)
• Manaʻo luhi me kahi ʻeha poʻo ʻoi (e like me ka hangover)
• Paʻa ihu
• Ka maʻi pākī
• Inā loaʻa iā ʻoe ka hānō, hiki ke hoʻonui ʻia ka ʻino.

ʻAʻole like kēia mau hōʻailona no nā kānaka a pau. Loaʻa paha i kekahi hoʻokahi a ʻelua paha, aʻo kekahi he nui paha.

Pehea e ʻike ai nā kauka i kēia?

E nīnau ke kauka iā ʻoe e pili ana i nā hōʻailona āu e ʻike ai a me nā hopena āu e ʻike ai ke inu ʻoe i ka waiʻona. ʻO ia ka hana mua.

Eia kekahi, i kekahi manawa hiki ke hana ʻia kahi hoʻāʻo i kapa ʻia he hoʻāʻo patch ethanol . He hoʻāʻo maʻalahi loa kēia.

• Hoʻokomo ke kauka i kahi kulu o ka ethanol ma kahi ʻāpana gauze liʻiliʻi a kau iā ia i kou lima.
• ʻEhiku minuke i koe.
• A laila e wehe i ka ʻāpana gauze a nānā e ʻike inā he ʻulaʻula, maneʻo, a pehu paha kēlā ʻāpana o kou lima.

Hiki i kēia ke hāʻawi iā ʻoe i kekahi manaʻo o ke kūlana.

Aia kekahi lāʻau lapaʻau no kēia? Hiki ke ho'ōla ʻia?

ʻO kaʻoiaʻiʻo, ʻaʻohe ala e ho'ōla loa ai no ka mea he genetic ia. ʻO ia hoʻi, loaʻa iā mākou mai ko mākou mau mākua mai. No laila, ʻaʻole hiki ke ho'ōla ʻia.

Akā, mai hopohopo. Hiki i kāu kauka ke kōkua iā ʻoe e hoʻokele i kēia mau hōʻailona maikaʻi ʻole.

ʻO ka mea nui, ʻo ia ke pale ʻana a i ʻole ka palena ʻana i ka inu ʻana i ka waiʻona. ʻO ia ke ala maikaʻi loa a maʻalahi hoʻi e pale aku ai i nā hōʻailona. Hiki iā ʻoe ke koho i nā mea inu ʻē aʻe ʻaʻohe waiʻona.

Aia kekahi mau mea nui ʻē aʻe e pono ʻoe e makaʻala:

• E hōʻalo i ka hoʻohana ʻana i ka paka a i ʻole ka ʻike ʻana i ka uahi o kahi cigarette: Hiki i ka puhipaka ke hoʻonui i nā pae o ka acetaldehyde i loko o ke kino, kahi e hoʻonui ai i ka pilikia o ka maʻi kanesa.
• E hōʻalo i ka inu ʻona i ka wā e lawe ana i kekahi mau lāʻau lapaʻau: ʻO ka inu ʻana i ka waiʻona me kekahi mau lāʻau lapaʻau e hiki ke hoʻonui i kou mau hōʻailona.
• E makaʻala i ka hoʻohana ʻana i nā antacids a i ʻole antihistamines e hōʻemi i nā hōʻailona: Hoʻopau wale kēia mau lāʻau i nā hōʻailona. Hiki iā ʻoe ke hoʻowalewale ʻia e inu hou aku i ka waiʻona no ka mea ʻaʻole ʻoe e ʻike i kekahi ʻeha. ʻO ka hana ʻana pēlā e hoʻonui wale i ka pilikia.

He mea nui: ʻOiai hiki i nā antacids a i ʻole antihistamines ke hōʻoluʻolu i nā hōʻailona no kekahi manawa, ʻaʻole lākou e ho'ōla i ka maʻi ʻona ʻole. ʻAʻole hoʻi lākou e hōʻemi i ka pōʻino i ke kino.

He aha ka mea e hiki mai ana inā e hoʻomau wau i ka inu ʻona ma kēia ʻano?

Inā hoʻomau ka hoʻohana ʻana o ke kanaka me kēia maʻi i ka waiʻona, ʻaʻole wale nō e loaʻa kēlā mau hōʻailona maikaʻi ʻole, akā e piʻi pū ka pilikia o ka loaʻa ʻana o nā maʻi koʻikoʻi ʻē aʻe.

ʻOi aku ka nui o ka pilikia o ka poʻe me ka ʻona ʻole i ka waiʻona no kēia mau mea inā e hoʻomau lākou i ka inu ʻona:

• Ka maʻi ʻaʻai waha a me ka ʻāʻī(`Ka Maʻi ʻAʻai Poʻo a me ka ʻĀʻī`)
• Maʻi ate (no ka laʻana, cirrhosis)
• ʻO ka maʻi Alzheimer i hoʻomaka hope ʻia

No laila, ʻaʻole maikaʻi i ke kino ke inu i ka waiʻona ʻoiai inā ʻike ʻoe he maʻi kou.

No laila, he aha nā mea e pono ai kākou e hoʻomanaʻo mai kēia mau mea a pau?

ʻAe, e hōʻuluʻulu kākou i nā mea a mākou i kamaʻilio ai e kōkua iā ʻoe e hoʻomanaʻo i kekahi o nā mea nui loa.

He maʻi hoʻoilina ka hiki ʻole ke ʻona i ka waiʻona. ʻO ia hoʻi, ua hoʻoilina ʻoe mai kou mau mākua mai. ʻAʻole hiki ke ho'ōla ʻia, akā hiki ke mālama ʻia nā hōʻailona.

ʻO ka mea nui, ʻo ia ke pale aku i ka waiʻona i ka hiki. Inā ʻoe e hana pēlā, e pakele ʻoe i kēlā mau hōʻailona maikaʻi ʻole a hiki iā ʻoe ke ola i kahi ola olakino a hana.

Manaʻo paha ʻoe, 'Auē, he mea paʻakikī loa ka inu ʻole ʻana i kahi kīʻaha waina a i ʻole ka pia i kēlā me kēia manawa.' Akā ʻo ka ʻoiaʻiʻo, ʻo ka noho mamao ʻana mai ka waiʻona hiki ke kōkua iā ʻoe e pale aku i kēlā mau helehelena ʻulaʻula, nā ʻeha kino, a me nā pilikia ʻōpū. ʻAʻole wale ia, hiki nō hoʻi ke kōkua iā ʻoe e pale aku i nā maʻi koʻikoʻi e like me ke kanesa.

Inā ʻaʻohe ou ʻona i ka waiʻona, akā ʻaʻole hiki iā ʻoe ke kāohi i kāu inu ʻana i ka waiʻona me ka ʻeha a me ka ʻoluʻolu ʻole, e kamaʻilio pono me ke kauka. Aia nā lawelawe e hiki ke kōkua me nā maʻi hoʻohana waiʻona.

E hoʻomanaʻo, ʻo kou olakino ka mea waiwai nui loa!

ʻAʻole hiki ke hoʻomanawanui i ka waiʻona, ka waiʻona, ka holoi ʻana i ka waiʻona, ALDH2, nā maʻi hoʻoilina, ka hoʻohana ʻino ʻana i ka waiʻona, nā enzymes