Ua ʻike anei ʻoe ua poina i kou makuahine, kou makuakāne, a i ʻole kou ʻelemakule aloha i nā mea? I kekahi manawa, he mea maʻamau ka poina ʻana i nā inoa, nā helu wahi, a i ʻole ka hoʻomanaʻo ʻana i kahi o kou mau aniani i kou wā ʻelemakule. Akā inā e piʻi mālie kēia poina ʻana a ʻaʻole hiki iā ʻoe ke hana i nā hana o kēlā me kēia lā ma kāu iho, he hōʻailona paha ia o ka maʻi Alzheimer. A laila ʻo ka nīnau nui e hiki mai ana i ko mākou manaʻo, 'No ke aha i loaʻa ʻole ai i kahi honua i hoʻomohala ʻia kahi lāʻau lapaʻau no kēia maʻi?' E kamaʻilio hohonu kākou e pili ana i kēia lā.
Pehea i ʻike mua ʻia ai kēia maʻi?
Ua hoʻomaka kēia moʻolelo ma mua o 100 mau makahiki i hala aku nei, i ka makahiki 1901. Ua nānā kekahi kauka Kelemania i kapa ʻia ʻo Alois Alzheimer i ka lolo o kahi wahine i make i ka dementia. Ua ʻike ʻo ia i kahi mea kupanaha loa. Ma waena o nā neurons i loko o ka lolo, ua lilo kekahi ʻano protein i pipili a huikau, e like me nā plaques. Ua kapa ʻia kēia mau mea ma hope he "plaques." Ua ʻike pū ʻo ia ua lilo kekahi ʻano protein i huikau a huikau e like me nā kaula i loko o nā neurons. Ua kapa ʻia kēia mau mea he "tangles."
I ka hala ʻana o ka manawa, ua ʻike nā kānaka ʻepekema ua hana ʻia nā palaki e like me ka ʻeha i kahi protein i kapa ʻia ʻo beta-amyloid . Ua ʻike pū lākou ua hana ʻia nā hiʻohiʻona e like me ke kaula i kahi protein ʻē aʻe i kapa ʻia ʻo tau . I ka hopena, ua kapa ʻia ka maʻi ʻo "Alzheimer's disease" no ka hoʻohanohano ʻana i ke kauka nāna i ʻike.
ʻO ka moʻolelo nui o ka "Amyloid Hypothesis"
No laila, i ka makahiki 1990, ua ulu aʻe kahi manaʻo nui i waena o nā mea noiʻi. ʻO ia hoʻi, ʻo ke kumu nui o kēia maʻi, ʻo ia nā palaki beta-amyloid i hōʻiliʻili ʻia i loko o ka lolo. Ua kapa ʻia kēia manaʻo ʻo "Amyloid Hypothesis." I ka ʻōlelo maʻalahi, ua manaʻo lākou ʻo kēia mau palaki amyloid ke kumu o ka make ʻana o nā hunaola lolo a me ka hāʻule ʻana o ka hoʻomanaʻo.
No laila, no nā makahiki he 30 i hala iho nei , ʻo ka hapa nui o ka noiʻi ʻana i ka maʻi o Alzheimer a me ka hapa nui o nā hana e loaʻa ai kahi lāʻau lapaʻau ua hoʻokumu ʻia ma kēia kuhiakau amyloid.
Akā, ua holomua anei kēia? ʻAʻole maoli. Ua hoʻāʻo ʻia nā haneli o nā lāʻau lapaʻau e wehe i kēia mau palaki amyloid, akā ʻaʻohe mea i hana i kahi ʻokoʻa koʻikoʻi i ke ola o nā maʻi. ʻAʻole i hoʻōki nā lāʻau lapaʻau e hōʻemi ana i ka nui o ka amyloid i loko o ka lolo i ka nalowale o ka hoʻomanaʻo o ka mea maʻi a i ʻole hoʻomaikaʻi i ko lākou ola o kēlā me kēia lā. ʻOiai ka lāʻau lapaʻau i ʻae ʻia nei ʻo `lecanemab` ua kāohi iki wale i ka ʻino o ka maʻi, akā ʻaʻole ia he lāʻau lapaʻau.
Ua paʻa anei kākou ma ke ala hoʻokahi?
Ma muli o kēia mau hopena i kūleʻa ʻole, nui nā mea noiʻi e nīnau nei, "Ke hele nei anei mākou i ke ala hewa?" ʻO ka ʻoiaʻiʻo, ʻaʻole hiki i ka ʻepekema ke hana i kahi ʻokoʻa nui i ka manawa hoʻokahi. Ua like ia me kahi moku nui, ʻaʻole hiki ke hoʻohuli ʻia i ka manawa hoʻokahi. Hoʻopaʻa haʻawina nā mea noiʻi i ke kumuhana like no nā makahiki, a laila hana hou i ka noiʻi ma ke kumuhana like. A laila, kūkulu ʻia kahi hui nui o ka poʻe a me ka ʻike a puni ka manaʻo like. Ke hele ʻoe e hana me kahi manaʻo hou, ua nele nā ʻano hana a me ka ʻike pili. No laila, i ke ʻano o Alzheimer, ua holo kēia moku nui i ke ala o "amyloid." No laila, ua liʻiliʻi loa ka nānā ʻana i nā kumu ʻē aʻe, e like me ka mumū, nā maʻi like ʻole, a i ʻole nā maʻi autoimmune.
Akā, ʻaʻole hewa loa kēia moʻolelo amyloid. Aia paha ka pilikia i ka lāʻau lapaʻau. A i ʻole, hewa paha ka manawa o ka lāʻau lapaʻau. Pono paha e hoʻomaka ʻia kēia mau lāʻau lapaʻau i nā makahiki ma mua o ka ʻike ʻia ʻana o nā hōʻailona.
Aia kekahi pilikia ʻē aʻe. A hiki i kahi o ʻumi makahiki i hala aku nei, ʻaʻohe ala e hōʻoia 100% i ka maʻi Alzheimer i ka wā e ola ana kekahi, koe wale nō ma ka nānā ʻana i ko lākou lolo ma hope o ko lākou make ʻana. No laila, ʻaʻole i loaʻa i kekahi o ka poʻe i komo i nā haʻawina kahiko ka maʻi Alzheimer. No laila, ua hewa ka ʻikepili mai kēlā mau haʻawina, ʻeā?
Akā i kēia manawa ua ʻokoʻa ke kūlana. Me ka ʻenehana hou, ʻoiai nā scan PET a me nā hoʻāʻo wai cerebrospinal, hiki ke ʻike i ke alo o nā protein amyloid a me tau i loko o ka lolo o ke kanaka ola.
ʻO ka 'Traffic Jam' i loko o ka lolo a me ka noiʻi hou
I kēia manawa, ma kahi o ka noʻonoʻo wale ʻana e pili ana i ka wehe ʻana i kēlā mau palaki, ke hoʻomaka nei nā mea noiʻi e nānā i ke kumu o ka pilikia, me ka nīnau ʻana, "No ke aha e hana ʻia ai kēia mau palaki?" Me he mea lā ʻaʻole hiki iā ʻoe ke hoʻoponopono i ka pilikia me ka ʻike ʻole i kahi o ia mea. I kēia manawa, aia kekahi mau manaʻo hou e pili ana i kēia. E nānā kākou i ke ʻano o lākou.
| Ke Alakaʻi Noiʻi Hou | Ma nā huaʻōlelo maʻalahi ... |
|---|---|
| Pilikia Pae Kelepona | Aia kahi 'paʻa kaʻa' i loko o ka ʻōnaehana e hoʻoneʻe ana i nā protein a puni i loko o nā hunaola lolo. ʻO kēia ke kumu o ka hōʻiliʻili ʻana o nā protein amyloid a me tau. Ke ʻimi nei nā kānaka noiʻi i nā ala e hoʻopau ai i kēia 'paʻa'. |
| Maʻi autoimmune | Wahi a kēia kumumanaʻo, ʻo ka amyloid kekahi ʻāpana o ka ʻōnaehana pale o ka lolo. Eia naʻe, ma muli o kekahi hewa, hele hewa kēia ʻōnaehana a hoʻouka i nā hunaola lolo olakino ma kahi o ke kaua ʻana i nā maʻi. |
| Nā maʻi a me ka mumū | Aia kekahi mau hōʻike e hiki i ka mumū i loko o ka lolo i hoʻokumu ʻia e kekahi mau maʻi viral, e like me ka herpes, ke kumu o ka maʻi o Alzheimer. |
| Maʻi Metabolic | Kapa kekahi poʻe i kēia he "maʻi diabetes o ka lolo" a i ʻole "Maʻi Diabetes Type 3." I kēia, ʻaʻole pane pono nā hunaola o ka lolo i ka insulin (ke kūʻē ʻana o ka insulin), e hoʻoulu ai i ka mumū a me nā pōʻino ʻē aʻe. |
No laila, ʻaʻohe mea hiki iā kākou ke hana? E kamaʻilio kākou e pili ana i ka pale ʻana.
Ke lohe ʻoe i kēia mau mea a pau, manaʻo paha ʻoe, 'ʻAuē, ʻaʻohe mea hiki iā ʻoe ke hana e pili ana i ia mea.' Akā, mai manaʻo pēlā. ʻO ka nūhou maikaʻi, he lōʻihi ka manawa e ulu ai ka maʻi o Alzheimer, ma kahi o 20 a 30 mau makahiki. ʻO ia hoʻi, he nui ko kākou manawa e hoʻōki ai a hoʻolohi paha i ka holomua o ka maʻi.
ʻOiai aia kahi mana hoʻoilina, aia kekahi mau mea pilikia hiki ke hoʻololi ʻia e hiki ke hoʻopilikia i ka ulu ʻana o ka maʻi Alzheimer. Eia kēia mau mea:
- Momona
- Maʻi diabetes
- Maʻi cardiovascular
- Kolesterol kiʻekiʻe
- Ke koko kiʻekiʻe
- Poho lohe
- Kaumaha a me ka mehameha
ʻO ia hoʻi, ʻo ke kāohi ʻana i kou koko, ka cholesterol, a me nā pae kō , ka mālama ʻana i ke kaumaha olakino, ka hoʻoikaika kino, a me ka ʻai ʻana i ka meaʻai kaulike nā mea maikaʻi loa hiki iā ʻoe ke hana e hōʻemi i kou pilikia o ka maʻi Alzheimer. I kekahi manawa, ʻoiai kekahi mea maʻalahi e like me ka hoʻohana ʻana i kahi mea kōkua lohe no kahi pilikia lohe hiki ke hana i kahi ʻokoʻa nui.
ʻO ka pōmaikaʻi nui o kēia mau mea, ʻo ia ka emi ʻana o ka pilikia, emi ke kumukūʻai, a ʻoi aku ka maikaʻi no ko kākou olakino holoʻokoʻa. Pehea ka nui o ka waiwai o ka hoʻololi ʻana i ko kākou nohona ma mua o ka hoʻolilo ʻana i nā haneli haneli kālā i ka makahiki ma kahi lāʻau lapaʻau hou?
I ka wā e hiki mai ana, ʻo ka mālama ʻana iā Alzheimer, e like me ka mālama ʻana i ka maʻi kanesa, e pili ana paha i ka hui pū ʻana o kekahi mau ʻano hana like ʻole a me nā lāʻau lapaʻau, kahi "cocktail," ma mua o hoʻokahi lāʻau lapaʻau. Eia naʻe, ʻo ka manaʻolana nui loa i ke kaua ʻana i kēia maʻi, ʻo ia ka nīnau ʻana o nā kānaka ʻepekema i ko lākou mau manaʻoʻiʻo kahiko a loaʻa nā ala hou.
Leka Lawe-Home
- He maʻi paʻakikī loa ka maʻi ʻo Alzheimer. ʻAʻole ia i kaupalena ʻia i ka hōʻiliʻili ʻana o nā plaques amyloid i loko o ka lolo.
- No laila, ʻaʻole hiki ke ho'ōla ʻia kēia maʻi me hoʻokahi "pila kilokilo" i ka wā e hiki mai ana.
- Ke nānā nei nā kānaka noiʻi i nā ʻano like ʻole e like me nā pilikia autoimmune, nā maʻi, a me nā maʻi metabolic.
- ʻO ka mea nui loa: Hiki iā ʻoe ke hōʻemi i kou pilikia. He mea nui e kaohi i kou koko, ka maʻi diabetes, ka cholesterol, ka hoʻoikaika kino, a me ka ʻai ʻana i ka meaʻai olakino.
- Inā he mau hopohopo a makaʻu paha kāu e pili ana i kou hoʻomanaʻo a i ʻole ka hoʻomanaʻo ʻana o kahi mea aloha, mai hoʻokaʻulua i ke kamaʻilio ʻana me kāu kauka e pili ana i ia mea. ʻO ka wikiwiki o kou kamaʻilio ʻana e pili ana i ia mea, ʻoi aku ka maikaʻi.
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