Inā loaʻa kekahi o kou ʻohana, he makuahine aloha paha, he makuakāne, he kupuna wahine a he ʻanakē paha, i ka maʻi Alzheimer, ua ʻike mākou i kona ʻeha. He mea paʻakikī ke hōʻike i ka ʻeha āu e ʻike nei i kou nānā ʻana i kou hoʻomanaʻo e mae mālie ana a nalowale kou hiki ke ʻike iā ʻoe iho. ʻOiai hiki i nā lāʻau lapaʻau o kēia manawa no kēia maʻi ke kāohi i nā hōʻailona i kekahi ʻano, ʻaʻohe lāʻau lapaʻau. Eia naʻe, ʻaʻole e haʻalele ka ʻepekema lapaʻau. I kēia manawa, ke noiʻi nei nā kānaka ʻepekema a puni ka honua i kahi lāʻau pale e hiki ke ho'ōla, kāohi a pale aku i kēia maʻi. No laila e kamaʻilio kākou e pili ana i kēia manaʻolana hou i kēia lā.
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He aha nā lāʻau pale e hiki ke kōkua i ka maʻi o Alzheimer?
ʻO kaʻoiaʻiʻo, ua hōʻike kekahi mau noiʻi he haʻahaʻa iki ka pilikia o ka loaʻa ʻana o ka maʻi Alzheimer i nā pākeke i loaʻa i kekahi mau lāʻau pale no nā maʻi e like me ka moa (no ka laʻana, ka lāʻau pale shingles) a me nā lāʻau pale no nā maʻi e like me ka measles. Akā, ʻaʻole kēia he mau lāʻau pale e kuhikuhi pono ana i ka maʻi Alzheimer.
I ka hoʻomohala ʻana i kahi lāʻau pale kūikawā no ka maʻi Alzheimer, ke nānā nui nei nā kānaka ʻepekema i ʻekolu mau loli nui i ka lolo i hoʻokumu ʻia e ka maʻi. I ka ʻōlelo maʻalahi, aia ʻekolu mau "kuleana" nui i loko o ka lolo o kahi maʻi Alzheimer.
1. Nā hiʻohiʻona protein Tau: Hōʻiliʻili kēia i loko o nā hunaola nerve i loko o ka lolo.
2. Nā pāpaʻi Beta-amyloid: Hōʻiliʻili kēia ma waena o nā hunaola nerve, ʻo ia hoʻi, ma kahi ma waena o nā hunaola ʻelua.
3. Ka mumū i loko o ka lolo: ʻO kēia mau mea ʻelua ke kumu o ka mumū mau, a i ʻole ka mumū, i loko o ka lolo.
ʻO ka pahuhopu o kēlā me kēia lāʻau pale e hana ʻia nei i kēia manawa, ʻo ia ke kāohi i hoʻokahi a ʻoi aku paha o kēia mau mea hana hewa. E nānā kākou i kēlā me kēia ʻano lāʻau pale ma ke kaʻawale.
| ʻAno lāʻau pale a me ka pahuhopu | Ke kaʻina hana a me ka hopena |
|---|---|
| Nā lāʻau pale e pili ana i nā protein Tau | E noʻonoʻo i loko o nā ʻaʻalolo o kou lolo, aia kahi ʻano e like me ka ʻōnaehana kaʻaahi e lawe i nā meaʻai i mua a i hope. ʻO kēia protein i kapa ʻia ʻo 'tau' ka mea e mālama ai i kēlā mau 'ala kaʻaahi' i paʻa. I ka maʻi Alzheimer, lilo kēia mau protein tau i ʻano ʻē, ma kahi o ke ʻano like me nā ala, lilo lākou i hui pū ʻia a lilo i 'pōpō o ke kaula'. A laila pau ka lawe ʻana i loko o nā ʻāpana, a hoʻomaka nā ʻāpana e make. Hoʻāʻo kēia mau lāʻau pale e hoʻōki i kēia huikau. ʻO nā lāʻau pale i kēia manawa ma ke kahua hoʻāʻo ʻo AADvac1 a me ACI-35.030/JACI-35.054 . |
| Nā lāʻau pale i kuhikuhi ʻia i ka beta-amyloid | Ua like kēia me ka 'ʻōpala' a i ʻole nā 'ʻōpala e like me ke kāpili' e hōʻiliʻili ana ma waena o nā hunaola nerve i loko o ka lolo. Hōʻiliʻili kēia mau ʻāpana o kahi protein i kapa ʻia ʻo beta-amyloid a hana i nā waihona i kapa ʻia ʻo 'plaques'. Pale kēia i nā hunaola nerve mai ke kamaʻilio pono ʻana me kekahi i kekahi, ʻo ia hoʻi ua pale ʻia lākou mai ka hoʻouna ʻana i nā 'hōʻailona'. ʻO ka hana a kēia mau lāʻau pale, ʻo ia ka hoʻoulu ʻana i ka ʻōnaehana pale o ke kino e wehe i kēia 'ʻōpala'. No kēia māhele nā lāʻau pale e like me ALZ-101, ABvac40, a me UB-311 . |
| Nā lāʻau pale e pili ana i ka mumū o ka lolo | I loko o ka lolo olakino, aia nā pūnaewele kūikawā i kapa ʻia ʻo microglia. Ua like lākou me ka 'hui hoʻomaʻemaʻe' o ka lolo. ʻO kā lākou hana ka wehe ʻana i nā ʻōpala a me nā mea ʻawahia i makemake ʻole ʻia. Akā i ka maʻi Alzheimer, hele hewa kēia mau limahana. Ma kahi o ka wehe ʻana i nā ʻōpala, hana lākou i nā kemika ʻino e hoʻoulu ai i ka mumū mau i loko o ka lolo. Hōʻino pū kēia i nā pūnaewele nerve olakino. Hoʻāʻo kēia mau lāʻau pale e hoʻihoʻi i kēia 'ʻōnaehana hoʻomaʻemaʻe haumia'. ʻO GV1001 a me Protollin ʻelua o kēia mau lāʻau pale hoʻokolohua. |
No laila, i ka manawa hea e loaʻa ai iā mākou ka lāʻau pale no Alzheimer?
ʻO kēia ka nīnau nui loa ma ka noʻonoʻo o nā kānaka a pau. ʻO ka ʻoiaʻiʻo, e lōʻihi ana kēia. ʻO kēia mau lāʻau pale a pau a mākou i kamaʻilio ai, aia nō lākou i loko o ke kahua hoʻokolohua lapaʻau. ʻO ia hoʻi, ke hoʻāʻo ʻia nei lākou e ʻike inā palekana lākou e hāʻawi i nā kānaka a pehea ko lākou pono.
ʻO ka mea nui loa, inā e holomua kēia noiʻi, hiki ke pale ʻia a mālama ʻia paha ka maʻi Alzheimer i nā pae mua o ka wā e hiki mai ana.
Wahi a ka ʻike o kēia manawa, ma waena o nā lāʻau pale i ʻōlelo ʻia ma luna, ʻo GV1001Ua holomua iki ka lāʻau pale ma nā hoʻokolohua lapaʻau, akā ʻaʻole kēia nā hopena hope loa.
He aha kā kākou e hana ai a hiki i kēlā manawa?
He mea maikaʻi ke loaʻa ka manaʻolana no kēia lāʻau pale hou. Akā a hiki i kēlā manawa, inā ʻoe a i ʻole kekahi o kou ʻohana e ʻeha nei i kēia maʻi, ʻo ka mea maikaʻi loa e hana ai, ʻo ia ke hahai i ka lāʻau i ʻōlelo ʻia e kāu kauka i kēia manawa.
Ua hōʻike ʻia nā lāʻau lapaʻau o kēia manawa, e like me Aducanumab lāua ʻo Lecanemab, e hoʻolohi i ka holomua o ka maʻi i kekahi ʻano inā ʻike mua ʻia. No laila, he mea nui e hoʻomau i ka launa pū ʻana me kāu kauka a hahai i kāna mau kuhikuhi.
Inā makemake ʻoe e komo i kahi hoʻokolohua lapaʻau e like me kēia, hiki iā ʻoe ke kamaʻilio me kāu kauka e pili ana i ia mea. E hiki iā ia ke hāʻawi iā ʻoe i ke alakaʻi pololei no ka loaʻa ʻana o kahi manawa kūpono nou a inā kūpono ʻoe no ia mea.
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- ʻO ka maʻi Alzheimer kahi maʻi i hoʻokumu ʻia e nā loli paʻakikī i ka lolo (nā tangles protein tau, nā waihona beta-amyloid, ka mumū).
- Ke hana nui nei nā kānaka ʻepekema e hoʻomohala i nā lāʻau pale e hiki ke kuhikuhi i kēia mau loli a pale, ho'ōla, a kaohi paha i ka maʻi.
- ʻOiai aia nō kēia mau lāʻau pale i ke kahua noiʻi, e lōʻihi ana ka manawa e loaʻa ai iā lākou ma nā wahi āpau.
- ʻO ka mea maikaʻi loa e hana ai i kēia manawa, ʻo ia ka hoʻomau ʻana i ka lāʻau i ʻōlelo ʻia e kāu kauka a hahai i kāna mau kuhikuhi.
- Ke hoʻomohala pono ʻia kahi lāʻau pale i ka wā e hiki mai ana, e hoʻomaopopo kāu hui lapaʻau iā ʻoe e pili ana i ia mea.
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