Ke hoʻopoina nei anei kou makuahine, kou makuakāne, a i ʻole kekahi āu i ʻike ai? ʻO ka hoʻopoina ʻana i nā mea liʻiliʻi e like me kahi o kāu mau kī a i ʻole ka inoa o kekahi, he hōʻailona mua ia o ka maʻi Alzheimer. ʻOiai ʻaʻohe lāʻau lapaʻau no kēia maʻi koʻikoʻi, ua ʻae piha ʻia kahi lāʻau hou e hiki ke hoʻolohi i ka holomua o ka maʻi e ka US FDA (Food and Drug Administration). He manaʻolana nui kēia no nā maʻi a puni ka honua. No laila, e kamaʻilio hou kākou e pili ana i kēia lāʻau hou, ʻo Leqembi.
He aha kēia lāʻau lapaʻau hou i kapa ʻia ʻo Leqembi?
ʻO ka mea mua e hoʻomaopopo ai, ʻaʻole kēia he lāʻau lapaʻau no ka maʻi Alzheimer. Akā, he kōkua nō ia. Hiki iā ia ke hoʻolohi i ka holomua o ka maʻi. Ua hōʻike ʻia e ka noiʻi hiki iā ia ke hoʻolohi i ka holomua o ka maʻi ma kahi o 27% ma luna o 18 mau mahina.
I kēia manawa, ke noʻonoʻo nei paha ʻoe, 'E hana maoli anei ia i kahi ʻokoʻa?' ʻAe, e hana maoli nō ia. E noʻonoʻo wale, hiki i kekahi e lawe ana i kēia lāʻau lapaʻau ke ola no 5 mau mahina me ka ʻole o ka ʻino ʻana o nā hōʻailona ma mua o kekahi e lawe ʻole ana i ka lāʻau lapaʻau, a hiki iā ia ke hana i kā lākou hana ponoʻī, e hauʻoli me ko lākou ʻohana, e hele e ʻike i kahi moʻopuna puka ... Pehea ka waiwai o kēlā manawa keu e hana ai i nā mea e like me kēia? ʻO ia manawa ka pōmaikaʻi nui loa o kēia lāʻau lapaʻau.
Akā he mea nui e hoʻomanaʻo i kēia: Ua ʻōlelo ʻia ʻo Leqembi no ka poʻe i nā pae mua o ka maʻi Alzheimer , ʻo ia hoʻi ka poʻe e hōʻike ana i ka hemahema iki o ka noʻonoʻo. ʻAʻole ia e hana no kekahi me ka maʻi ʻoi aku ka holomua.
Pehea e hana ai kēia lāʻau lapaʻau?
I mea e hoʻomaopopo ai i kēia, e lawe kākou i kahi laʻana liʻiliʻi. I loko o ka lolo o nā maʻi Alzheimer, ua waiho ʻia kahi protein makemake ʻole ʻia i kapa ʻia ʻo nā plaques amyloid . Ua like ia me ka lepo e paʻa ana i loko o kahi paipu wai a paʻa mālie i loko o ka paipu. Ma muli o ka waiho ʻana o kēia mau protein, ua hoʻopau ʻia ke kamaʻilio ʻana ma waena o nā cell o ka lolo, a hoʻomaka mālie nā cell e make. ʻO ia ke kumu e nalowale ai ka hoʻomanaʻo a loli ke ʻano.
ʻO kēia lāʻau lapaʻau, i kapa ʻia ʻo Leqembi, ke kuhikuhi nei a wehe i nā plaques amyloid i hōʻiliʻili ʻia i loko o ka lolo. No kahi papa o nā lāʻau lapaʻau i kapa ʻia ʻo monoclonal antibodies. Hāʻawi pinepine ʻia kēia lāʻau lapaʻau i ka mea maʻi i ʻelua manawa o ka mahina ma o ka hoʻokomo ʻana o IV.
E nānā kākou i kekahi mau mea nui e pili ana i kēia lāʻau lapaʻau ma kahi papa.
| He hōʻuluʻulu pōkole o Leqembi (lecanemab) | |
|---|---|
| ʻAno lāʻau lapaʻau | He lāʻau lapaʻau ʻano antibody monoclonal. |
| No wai ia mea kūpono? | No nā poʻe wale nō i nā pae mua o ka maʻi Alzheimer, me ka hemahema iki o ka noʻonoʻo. |
| Pōmaikaʻi nui | Ua lohi ka laha ʻana o ka maʻi ma kahi o 27% i loko o 18 mau mahina. |
| Pehea e hāʻawi ai | Hāʻawi ʻia ia ma o kahi aʻa (IV infusion) ʻelua i ka mahina. |
| ʻO ka palena koʻikoʻi loa | ʻAʻole kēia e ho'ōla i ka maʻi. ʻAʻohe ona pono i ka poʻe i loaʻa mua i kahi pae koʻikoʻi o ka maʻi. |
Aia kekahi pilikia i ka hoʻohana ʻana i kēia?
ʻAe. E like me nā lāʻau lapaʻau āpau, loaʻa i kēia kekahi mau pilikia a me nā hopena ʻaoʻao. ʻO kaʻoiaʻiʻo, ua hoʻopuka ka FDA i kahi "ʻōlelo aʻo pahu ʻeleʻele" no kēia lāʻau lapaʻau, ʻo ia ka pae kiʻekiʻe loa o ka ʻōlelo aʻo palekana . ʻO ke kumu o ia mea he kūlana i kapa ʻia ʻo ARIA.
He aha ka ARIA?
ʻO ARIA ka pōkole no nā Amyloid-Related Imaging Abnormalities. I ka pōkole, hiki i kēia lāʻau lapaʻau ke hoʻoulu i kekahi poʻe e hoʻomohala i ka pehu ʻana o ka lolo a i ʻole ke kahe koko liʻiliʻi (microbleeds) . ʻOiai ʻaʻole koʻikoʻi kēia mau mea, hiki i kekahi manawa ke hoʻoweliweli i ke ola.
- ʻO ka gene APOE4: ʻO ka poʻe me ʻelua kope o ka hoʻololi ʻana o ka gene APOE4 e ʻoi aku ka nui o ka pilikia o ka hoʻomohala ʻana i kēia kūlana ARIA ma mua o nā poʻe ʻē aʻe.
- Nā Mea Hoʻomāmā Koko: ʻO kekahi mea nui loa, ʻo ia ka ʻōlelo aʻo ikaika a nā kauka e kūʻē i ka hoʻohana ʻana i kēia lāʻau lapaʻau no kekahi e lawe ana i nā mea hoʻomāmā koko. No ka mea, inā ʻoe e hana pēlā, nui ka manawa e lilo ai ke koko liʻiliʻi i koko nui e hoʻoweliweli ai i ke ola (macro-bleed). I kekahi manawa hiki i kēia ke alakaʻi i nā hopu ʻana, ka hoʻokipa ʻia ʻana i ka haukapila, a i ʻole ka make.
No laila, ma mua o ka hoʻomaka ʻana i kēia lāʻau lapaʻau, he mea nui e kūkākūkā pono i kēia mau pilikia a pau me kāu kauka, e hana i nā hoʻokolohua e pono ai, a e hōʻoia inā kūpono kēia iā ʻoe.
No laila he aha kaʻu e hana ai?
Inā ʻo ʻoe, ka mea heluhelu o kēia ʻatikala, he kānalua iki paha ʻoe a i ʻole kekahi mea kokoke iā ʻoe i nā hōʻailona mua o ka maʻi Alzheimer, ʻo ka mea maikaʻi loa e hana ai, ʻo ia ke ʻike koke i ke kauka a loaʻa kahi hōʻailona pololei.
No ka mea, e like me kā mākou i kūkākūkā ai ma mua, he pono wale nā lāʻau lapaʻau e like me Leqembi i nā pae mua o ka maʻi. Inā hoʻopaneʻe ʻoe, e nalowale paha ʻoe i ka manawa kūpono no ka mālama ʻana. Eia kekahi, hiki ke pipiʻi nā lāʻau lapaʻau hou e like me kēia. No laila he manaʻo maikaʻi e kamaʻilio me kāu kauka e pili ana i kēlā ma mua o ka hoʻomaka ʻana i ka mālama ʻana.
Manaʻo nā loea i ka wā e hiki mai ana, e loaʻa nā lāʻau lapaʻau e hiki ke ʻike a pale i nā maʻi ma mua o ka hōʻike ʻana o nā kānaka i kekahi mau hōʻailona. E like me kā mākou hiki ke ʻike a mālama i ka maʻi ʻaʻai umauma a me ke kanesa prostate i ka wā mua, e hiki iā mākou i kekahi lā ke ʻike a pale i ka maʻi Alzheimer i ka wā mua. A hiki i kēlā manawa, hāʻawi nā lāʻau lapaʻau e like me Leqembi i ka manaʻolana nui no mākou a pau.
Leka Lawe-Home
- ʻAʻole ʻo Leqembi he lāʻau lapaʻau no ka maʻi Alzheimer. Hoʻolohi wale ia i ka holomua o ka maʻi i kona mau wā mua.
- Hana kēia lāʻau lapaʻau ma ka wehe ʻana i nā plaques amyloid ʻino e hōʻiliʻili ana i loko o ka lolo.
- Aia kahi pilikia o nā hopena ʻaoʻao koʻikoʻi e like me ka pehu ʻana o ka lolo a i ʻole nā koko koko liʻiliʻi (ARIA), no laila he mea nui e kūkākūkā i nā pilikia āpau me ke kauka.
- ʻAʻole kūpono kēia lāʻau lapaʻau no ka poʻe e lawe ana i nā lāʻau hoʻokahe koko a i ʻole ka poʻe me nā maʻi koʻikoʻi.
- Inā ʻoe a i ʻole kekahi mea kokoke iā ʻoe e loaʻa nei i nā pilikia hoʻomanaʻo, e ʻimi koke i ke kōkua lapaʻau. He mea nui ka ʻike mua ʻana no ka mālama ʻana.
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