Ua loaʻa anei i kou makuahine, ʻanakē, kaikuahine, a i ʻole kekahi lālā o ka ʻohana pili ka maʻi ʻaʻai umauma? Ke hana ʻia kēlā, he mea maʻamau ka manaʻo nui i ka makaʻu a me ka hopohopo, me ka noʻonoʻo ʻana, "E loaʻa pū anei iaʻu?" I ka manawa pinepine, hiki ke hoʻopili ʻia kēia mau ʻano maʻi ʻaʻai i kahi pilikia hoʻoilina. I kēia lā, e kamaʻilio mākou e pili ana i kahi hoʻokolohua kūikawā e nānā ana i kēlā pilikia hoʻoilina. ʻO ia ka hoʻāʻo gene BRCA.
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I ka ʻōlelo maʻalahi, he aha kēia hoʻāʻo BRCA?
ʻAe, e ʻōlelo kākou penei. Loaʻa iā kākou āpau ʻelua ʻano genes i loko o ko kākou kino i kapa ʻia ʻo BRCA1 a me BRCA2 . ʻO kā lākou hana nui ka hoʻoponopono ʻana i ka DNA o nā cell o ko kākou kino a kāohi i nā cell cancer mai ka ulu ʻana ma waho o ke kaohi. Ua like ia me nā kiaʻi ponoʻī o ke kino. ʻO ia ke kumu e kapa ai mākou i kēia mau genes tumor suppressor.
I kēia manawa, e noʻonoʻo, he aha ka mea e hana inā he kīnā, a he mutation paha, i loko o kēia mau genes pale? A laila ua hoʻonāwaliwali ʻia ke kaʻina hana e hoʻōki ai i ka ulu ʻana o nā hunaola kanesa. Hoʻonui nui kēia i ka pilikia o ka maʻi kanesa umauma, ka maʻi kanesa ovarian , a me kekahi mau ʻano maʻi kanesa ʻē aʻe.
ʻO ka mea nui, he mau hoʻololi ʻana kēia mau gene BRCA. ʻO ia hoʻi, hiki ke hoʻoili ʻia mai ka makuahine a i ke keiki. Lawe ka hoʻāʻo BRCA i kahi hāpana o kou koko a nānā e ʻike inā he mutation pilikia kou i loko o nā gene BRCA1 a i ʻole BRCA2.
Pono anei nā kānaka a pau e hana i kēia hoʻāʻo BRCA?
ʻAʻole, ʻaʻole loa. ʻAʻole maʻamau kēia mau kīnā o ka gene BRCA i ka nohona. No laila, ʻaʻole ʻōlelo nā kauka i kēia hoʻāʻo ke ʻole ʻoe he mau kumu pilikia. ʻAʻole kēia he hoʻāʻo no ka hoihoi wale nō.
No laila, he aha ke ʻano o ka poʻe e ʻōlelo aku ai ke kauka i kēia hoʻokolohua? E nānā kākou.
| Kumu pilikia | He wehewehe maʻalahi |
|---|---|
| Ka moʻolelo maʻi kanesa pilikino | Inā ua loaʻa iā ʻoe ka maʻi ʻaʻai umauma, ʻoiai inā ma mua o 50 mau makahiki. A i ʻole inā ua loaʻa iā ʻoe ka maʻi ʻaʻai umauma a me ka maʻi ʻaʻai ovarian. |
| Ka moʻolelo o ka maʻi ʻaʻai ʻohana | Inā ua loaʻa i kekahi a ʻoi aku paha mau lālā o kou ʻohana (e like me kou makuahine, kaikuahine, kaikamahine, ʻanakē) ka maʻi ʻaʻai umauma, ʻoiai inā ua loaʻa i ke kāne ka maʻi ʻaʻai umauma, he kumu ikaika nō hoʻi kēlā. |
| Ua ʻike mua ʻia kahi hemahema BRCA | Inā ua hōʻoia mua ʻia kekahi o kou ʻohana he kīnā gene BRCA. |
| Nā ʻano maʻi ʻē aʻe | Inā ua loaʻa kekahi o kou ʻohana i ka maʻi kanesa e like me ke kanesa ovarian, ke kanesa pancreatic, a i ʻole ke kanesa prostate. |
| Nā maʻi hoʻoilina laha ʻole | Inā he mau maʻi hoʻoilina ʻē aʻe kekahi o kou ʻohana e hoʻonui ai i ka pilikia o ka maʻi kanesa, e like me ka maʻi Cowden a i ʻole ka maʻi Li-Fraumeni. |
ʻO ka mea nui loa, ʻaʻole pono ʻoe e hoʻoholo iā ʻoe iho inā e hana ʻia kēia hoʻokolohua a i ʻole. ʻOi aku ka maikaʻi o ke kūkākūkā ʻana i kēia me kāu kauka a hoʻoholo ma muli o kāna ʻōlelo aʻo.
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Check Availability →He aha kā mākou e aʻo ai mai kahi hoʻokolohua BRCA?
Inā hōʻoia kēia hoʻokolohua he kīnā kou i ka gene BRCA, ʻo ia hoʻi he ʻoi aku ka nui o kou pilikia o ka hoʻomohala ʻana i kekahi mau ʻano maʻi kanesa ma mua o ka maʻamau .
E noʻonoʻo i kēia: ʻO ke kanaka me ka hoʻololi ʻana o ka gene BRCA he ʻeono manawa ka nui o ka pilikia o ka loaʻa ʻana o ka maʻi ʻaʻai umauma i ka makahiki 80 i hoʻohālikelike ʻia me ka heluna kanaka maʻamau. ʻOi aku ka nui o ka hiki ʻana mai o ke kanesa i ka wā ʻōpio a hoʻopilikia i nā umauma ʻelua.
Ma waho aʻe o ke kanesa o ka umauma, hiki i kēia kīnā genetic ke hoʻonui i ka pilikia o kekahi mau ʻano maʻi kanesa ʻē aʻe:
- ʻO ke kanesa ovarian : Pili pū kekahi me ia ʻo ke kanesa o ka ʻōpū fallopian a me ke kanesa peritoneal.
- Ka maʻi ʻaʻai prostate : No nā kāne.
- Ka maʻi ʻaʻai pancreatic
- ʻO ka anemia Fanconi : He maʻi kanesa laha ʻole e hiki ke hana i ka wā kamaliʻi.
He aha ka mea e hana ʻia ma mua, i ka wā, a ma hope o ka hoʻāʻo?
ʻAʻole paʻakikī kēia kaʻina hana e like me kou manaʻo.
Ma mua o ka hoʻāʻo
E kuhikuhi pinepine ʻia ʻoe i kahi kākāʻōlelo genetic . ʻO kēia ka poʻe i loaʻa ka ʻike loea i nā genes, ka hoʻoilina, a me ka pilikia o ka maʻi kanesa. E wehewehe ʻo ia iā ʻoe i kēia mau mea:
- He aha ke ʻano inā he Positive a Negative paha ka hopena o ka hoʻāʻo?
- Pehea ka hopena e pili ai i kou pilikia o ka maʻi kanesa?
- Pehea lā e pili ai kēia hopena i ke koena o kou ʻohana (nā keiki, nā kaikaina)?
I ka wā o ka hoʻāʻo
He mea maʻalahi loa ia. Lawe wale ia i kahi hāpana koko mai kahi aa koko ma kou lima. E like me ka hāʻawi ʻana i ke koko no kahi hoʻāʻo koko maʻamau. ʻOiai paha e ʻeha iki ʻoe i ka wā e hoʻokomo ʻia ai ka nila, ʻaʻole i ʻoi aku ma mua o ʻelima mau minuke ka lōʻihi o ke kaʻina holoʻokoʻa.
Ma hope o ka hoʻāʻo
Hiki ke hala kekahi mau pule no ka hoʻi ʻana mai o nā hopena. Ma hope o ka hoʻi ʻana mai o nā hopena, pono ʻoe e hālāwai hou me kāu kākāʻōlelo genetic. E kōkua ʻo ia iā ʻoe e hoʻomaopopo i nā hopena a kūkākūkā i nā ʻanuʻu e pono ai ʻoe e hana ma hope.
He aha ke ʻano o nā hualoaʻa?
ʻEkolu ʻano hopena e hiki mai ana. E kamaʻilio maopopo kākou e pili ana iā lākou pākahi.
| ʻAno hopena | He aha kēlā manaʻo? |
|---|---|
| 1. Maikaʻi ka hopena. | |
| Manaʻo | ʻO ke ʻano kēia he mutation kou i loko o kāu gene BRCA1 a i ʻole BRCA2 e hoʻonui ai i kou pilikia o ka maʻi kanesa. Eia naʻe, ʻaʻole kēia manaʻo he maʻi kanesa kou a e loaʻa maoli nō paha iā ʻoe. ʻO ia hoʻi, ʻoi aku ka kiʻekiʻe o kou pilikia. |
| He aha ka mea e hana ai ma hope? | I kēia manawa hiki iā ʻoe ke hana i nā hana e hōʻemi ai i kou pilikia. Ma hope o ke kūkākūkā ʻana i kēia me kāu kauka, hiki iā ʻoe ke noʻonoʻo i nā mea e like me:
|
| 2. ʻAʻole maikaʻi ka hopena. | |
| Manaʻo | ʻO ia hoʻi, ʻaʻohe ou kīnā gene BRCA i loko o kou kino. ʻO ia hoʻi, ʻaʻole e hoʻoilina kāu mau keiki i kahi kīnā gene BRCA mai iā ʻoe. |
| Akā... | ʻAʻole kēia e hōʻoiaʻiʻo ʻaʻole loa ʻoe e loaʻa i ka maʻi kanesa. ʻO ia hoʻi, ua like kou pilikia me ko kekahi o ka heluna kanaka. Eia nō naʻe, inā he moʻolelo ʻohana ikaika kou no ka maʻi kanesa, loaʻa paha iā ʻoe kahi hoʻololi ʻano gene ʻē aʻe e hoʻonui ai i kou pilikia no ka maʻi kanesa. E kamaʻilio me kāu kākāʻōlelo genetic e pili ana i kēia. |
| 3. ʻAʻole maopopo ka hopena (Uncertain / VUS) | |
| Manaʻo | He mea paʻakikī iki kēia. ʻO ke ʻano kēia aia kahi loli (variant) i loko o kāu gene BRCA, akā ʻaʻole maopopo i nā kānaka ʻepekema inā he mea ʻino ka loli, e hoʻonui ana i ka pilikia o ka maʻi kanesa, a i ʻole he loli maʻamau, ʻino ʻole. Ua kapa ʻia kēia he Variant of Unknown Significance (VUS). |
| He aha ka mea e hana ai ma hope? | Mai hopohopo i kēia manawa. E wehewehe hou aku kāu kākā'ōlelo genetic i kēia iā ʻoe. Pono paha ʻoe e hoʻāʻo ʻia nā lālā ʻē aʻe o ka ʻohana a i ʻole e hoʻomaopopo ʻia i ka wā e hiki mai ana inā loaʻa ka ʻike hou. I kēia manawa, ʻo kēia ʻano hopena ka mea maʻamau i manaʻo ʻia he hopena maikaʻi ʻole. |
Leka Lawe-Home
- ʻO ka hoʻāʻo BRCA kahi hoʻāʻo genetic kūikawā e nānā ana i ka pilikia hoʻoilina no ka umauma, ka ovarian, a me nā ʻano maʻi ʻē aʻe.
- ʻAʻole kēia he hoʻokolohua e pono ai nā kānaka a pau. Paipai wale nā kauka iā ia no ka poʻe me kekahi mau kumu pilikia, e like me ka mōʻaukala ʻohana o ka maʻi kanesa.
- ʻAʻole manaʻo ka hopena maikaʻi he maʻi kanesa kou. ʻO ia hoʻi, ʻoi aku ke kiʻekiʻe o kou pilikia a hiki iā ʻoe ke hana i nā hana e hoʻokele ai i kēlā pilikia.
- He mea nui loa e kūkākūkā i kēia me ke kauka a me ke kākā'ōlelo genetic ma mua a ma hope o ka loaʻa ʻana o nā hualoaʻa.
- He mana ka ʻike. ʻO ka ʻike i kou mau pilikia he mea nui ia i ka pale ʻana i kou olakino a me ke olakino o kou ʻohana i ka wā e hiki mai ana.
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