He aha ka calcitonin? E aʻo maʻalahi kākou e pili ana i ia mea!

Ua lohe paha ʻoe i ka huaʻōlelo calcitonin? Ua lohe paha ʻoe mai ke kauka mai, a ua heluhelu paha ʻoe ma kekahi wahi. He hormone kūikawā kēia i loko o ko kākou kino. Akā hiki ke ʻōlelo ʻia he hormone pohihihi iki ia. E nānā kākou i ke ʻano o kēia calcitonin a me kāna hana i ko kākou kino ma ke ʻano maʻalahi.

He aha ka calcitonin? No hea mai ia?

I ka ʻōlelo maʻalahi, ʻo ka calcitonin kahi hormone i hana ʻia e ko kākou kelepa thyroid. Ua ʻike ʻoe he kelepa liʻiliʻi ke ʻano o ka pepeke ka kelepa thyroid aia ma ke alo o ko kākou ʻāʻī, ma lalo pono o ka ʻili. ʻO kahi ʻano cell kūikawā i loko o ka kelepa thyroid, i kapa ʻia ʻo C-cells a i ʻole nā ​​​​​​cell parafollicular, e hana i kēia hormone calcitonin a hoʻokuʻu iā ia i loko o ko kākou koko.

Akā, ʻo ka mea kupanaha, ʻaʻole maopopo loa i nā kānaka ʻepekema ka hana pololei o kēia hormone, ʻo calcitonin. ʻO ia hoʻi, ʻike mākou i kāna hana, akā ʻaʻole maopopo iā mākou ke kumu o kona loaʻa ʻana. ʻOiai inā he mau ʻano ʻē i nā pae calcitonin, ʻaʻole pinepine lākou e hōʻike i nā hōʻailona nui, a i kekahi manawa ʻaʻohe loa.

I ka wā ma mua, ua hoʻohana nā kauka i nā ʻano synthetic o calcitonin ma ke ʻano he lāʻau lapaʻau no kekahi mau kūlana. No ka laʻana, no ka mālama ʻana i nā kūlana e like me ka maʻi o Paget o ka iwi, a i ʻole hypercalcemia, kahi kūlana i kiʻekiʻe loa ai ka calcium i loko o ke koko. Akā i kēia manawa, me ka hiki ʻana mai o nā lāʻau hou, ʻoi aku hoʻi nā bisphosphonates, ʻaʻole hoʻohana pinepine ʻia ka calcitonin ma ke ʻano he lāʻau lapaʻau.

He aha ka hana a ka calcitonin i ko mākou kino?

ʻO ka hana nui o ka hormone calcitonin, ʻo ia ke hoʻohaʻahaʻa i ka pae o ka calcium i loko o ko kākou koko. E hoʻomanaʻo, e pili ana kēia i ka calcium i loko o ke koko, ʻaʻole i ka calcium i loko o nā iwi. Hana ia i kēia ma nā ʻano ʻelua:

1. Hoʻōki ia i ka hana o nā pūnaewele hoʻomoʻa iwi: Aia kekahi ʻano pūnaewele i kapa ʻia ʻo osteoclasts i loko o ko kākou mau iwi. Hoʻopau kēia mau pūnaewele i ko kākou mau iwi a hoʻohui i ka calcium i ke koko. Hoʻōki ka hormone calcitonin i ka hana o kēia mau osteoclasts no kekahi manawa. Hoʻemi kēia i ka nui o ka calcium i hoʻohui ʻia i ke koko.

2. Hoʻēmi i ka reabsorption o ka calcium mai nā puʻupaʻa i loko o ke koko: Hoʻokuʻu ʻia ka calcium me ka mimi i kānana ʻia e ko mākou mau puʻupaʻa. Eia naʻe, ua reabsorbed ʻia kekahi calcium e nā puʻupaʻa i loko o ke koko. Hoʻēmi ka hormone calcitonin i ka reabsorption o ka calcium mai nā puʻupaʻa i loko o ke koko ma kēia ʻano. Ma muli o kēia, emi ka pae calcium i loko o ke koko.

E noʻonoʻo i kēia ʻano: ua like ka pae calcium i loko o ko kākou koko me ka pae wai i loko o kahi pahu wai. Ua like ʻo Calcitonin me kekahi mea e kōkua ana e hoʻohaʻahaʻa i kēlā pae wai ke piʻi aʻe.

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No ke aha i hana ai ko kākou thyroid i ka calcitonin?

Hoʻopuka kā mākou ʻōpū thyroid i ka calcitonin ma muli o ka pae o ka calcium i loko o ko mākou koko. Ke piʻi ka pae o ka calcium i loko o ke koko, hoʻopuka ka ʻōpū thyroid i ka nui o ka calcitonin. Pēlā nō, ke emi ka pae o ka calcium i loko o ke koko, emi pū ka nui o ka calcitonin i hana ʻia e ka ʻōpū thyroid. Ua like kēia me kahi kaohi aunoa.

Pehea e nānā ai i nā pae calcitonin? No ke aha i hana ʻia ai kēia hoʻāʻo?

Hiki i kāu kauka ke hana i kahi hoʻāʻo koko e nānā i kāu mau pae calcitonin.

Eia nō naʻe, no ka mea, ʻaʻole i hoʻokumu pinepine nā pae calcitonin maʻamau i nā hōʻailona nui, kauoha pinepine nā kauka i kēia hoʻāʻo no kekahi mau kumu kikoʻī. ʻO kēia mau mea:

• I mea e kōkua ai i ka ʻike ʻana i nā kūlana e like me ke Kanesa Thyroid Medullary (MTC) a i ʻole ka hyperplasia C-cell .
• E nānā i ka holomua o nā lāʻau lapaʻau no ka maʻi kanesa thyroid medullary (MTC).
• Inā loaʻa i kekahi o kou ʻohana kahi maʻi i kapa ʻia ʻo Multiple Endocrine Neoplasia (MEN type 2) .

He aha ka pae calcitonin maʻamau?

Ma keʻano laulā, ʻo nā waiwai maʻamau no ka calcitonin penei:

• No nā kāne: Ma lalo o 25 picograms no ka milliliter (Ma lalo o 25 pg/mL)
• No nā wāhine: Ma lalo o 20 pikograma no ka milliliter (Ma lalo o 20 pg/mL)

Akā, hoʻokahi mea e hoʻomanaʻo ai , ʻo ia ka ʻokoʻa iki o kēia mau waiwai maʻamau mai kēlā me kēia keʻena hoʻokolohua. No laila, pono ʻoe e nānā mau i nā waiwai maʻamau no ka keʻena hoʻokolohua ma kāu hōʻike koko.

Inā loaʻa iā ʻoe kahi hoʻāʻo calcitonin, e wehewehe kāu kauka i nā hopena iā ʻoe a haʻi iā ʻoe inā pono ka hoʻāʻo hou aʻe.

He aha ka mea e hana ai inā piʻi aʻe ka nui o ka calcitonin?

ʻAʻole like me he mea lā he hopena maikaʻi ʻole koʻikoʻi ka loaʻa ʻana o nā pae kiʻekiʻe o ka calcitonin i ko mākou kino. A ʻaʻole ia e hoʻoulu i nā hōʻailona nui. Eia nō naʻe, hiki i nā pae kiʻekiʻe o ka calcitonin ke lilo i hōʻailona o ʻelua mau maʻi kakaikahi loa. He aha lākou?

1. Kanesa Thyroid Medullary (MTC): He ʻano kanesa kakaikahi kēia e kū mai ana i loko o ka ʻōpū thyroid. Hoʻomaka ia i loko o nā pūnaewele C e hana ana i ka calcitonin. ʻO kēia kanesa ke kumu o kēia mau pūnaewele e hana nui i ka calcitonin.

2. Hyperplasia o nā pūnaewele C:ʻAʻole kēia he maʻi kanesa (ʻaʻole he maʻi kanesa). Akā ʻo ka mea e hana ʻia ma kēia, ʻo ia ka ulu ʻana o nā cell-C i kahi ʻano ʻē. Hiki i kēia ʻiʻo i hoʻonui ʻia ke hana i ka nui o ka calcitonin. I kekahi manawa, hiki i kēia ʻano, i kapa ʻia ʻo C-cell hyperplasia, ke lilo i ka maʻi kanesa thyroid medullary (MTC).

Inā loaʻa iā ʻoe nā hōʻailona o kekahi o kēia mau kūlana, hiki i kāu kauka ke ʻōlelo i kahi hoʻāʻo calcitonin.

He aha ka mea e hana ai inā e emi iho ka nui o ka calcitonin?

ʻAʻole like ka hopena nui o nā pae haʻahaʻa o ka calcitonin i ko mākou kino. ʻOiai ka poʻe i wehe loa ʻia ko lākou thyroid, a no laila he mau pae calcitonin i ʻike ʻole ʻia, ʻaʻole lākou e ʻike i kekahi mau hōʻailona e pili ana i ko lākou mau pae calcium koko. ʻO kēia ka mea kupanaha e pili ana i kēia hormone.

He aha ka ʻokoʻa ma waena o ka Parathyroid Hormone a me Calcitonin?

Kōkua ka Parathyroid Hormone (PTH) a me Calcitonin i ka hoʻokele ʻana i ka pae o ka calcium i loko o ko kākou koko. Eia nō naʻe, aia ka ʻokoʻa i ke ʻano o kā lākou hana a me ka nui o ko lākou hopena i ko kākou pae calcium.

• Hoʻonui ka hormone parathyroid (PTH) i ka pae o ka calcium i loko o ko kākou koko. Kōkua pū ka PTH i ka hoʻomalu ʻana i ka pae o ka phosphorus i loko o ko kākou koko a me nā iwi. Hoʻāla pū ia i ka huaora D.
• Hoʻemi ʻo Calcitonin i ka nui o ka calcium i loko o ko kākou koko.

Eia nō naʻe, manaʻoʻiʻo nā kānaka ʻepekema he ʻoi aku ka nui o ka hana a ka hormone parathyroid (PTH) ma mua o ka calcitonin i ka kaohi ʻana i ka pae o ka calcium i loko o ko kākou koko. ʻO ke kumu nui kēia no ka mea hiki i nā pae PTH kūpono ʻole ke alakaʻi i nā kūlana koʻikoʻi e like me ka hypercalcemia (calcium koko kiʻekiʻe) a i ʻole hypocalcemia (calcium koko haʻahaʻa). Eia naʻe, ʻaʻohe hopena koʻikoʻi o nā pae calcitonin kūpono ʻole i ke kino.

He like anei nā mea like o ka calcitonin a me ka calcitriol?

ʻAʻole, ʻelua mau mea like ʻole ka calcitonin a me ka calcitriol. ʻOiai ʻo nā hormones ʻelua e hoʻopilikia i nā pae calcium, he ʻokoʻa kā lāua mau hana.

• ʻO Calcitriol kekahi inoa ʻē aʻe no ka huaora D ikaika. Hoʻonui ia i ka pae o ka calcium i loko o ke koko. Pehea e hana ai i kēlā? Hoʻonui ia i ka nui o ka calcium e hiki ke komo i loko o ko kākou mau ʻōpū mai nā meaʻai a kākou e ʻai ai. A laila komo kēlā calcium i loko o ke koko. Pale pū ʻo Calcitriol i nā puʻupaʻa mai ka nalowale ʻana o ka calcium. Hoʻoulu ka hormone Parathyroid (PTH) i ka enzyme e hoʻololi i ka huaora D i calcitriol.
• Hana ʻo Calcitonin ma ka hoʻemi ʻana i nā pae calcium i loko o ke koko.

No laila, ʻo ka mea hope loa, nā mea e pono ai mākou e hoʻomanaʻo (Leka Lawe-Home)

He hormone ʻano ʻē a pohihihi hoʻi ʻo Calcitonin.

• Inā haʻahaʻa a kiʻekiʻe paha ka pae, ʻaʻole paha e hoʻoulu i nā hopena maikaʻi ʻole a i ʻole nā ​​​​hōʻailona.
• Eia nō naʻe, hiki i nā pae calcitonin kiʻekiʻe ke hōʻailona o kahi kūlana e like me ka medullary thyroid cancer (MTC) a i ʻole C-cell hyperplasia.
• Inā loaʻa iā ʻoe nā hōʻailona o kēia mau kūlana, a inā he mau nīnau kāu e pili ana i kou pilikia o ka loaʻa ʻana o lākou, e kamaʻilio me kāu kauka. Aia lākou ma laila e kōkua iā ʻoe. Mai hopohopo, ʻo ka mea nui loa, ʻo ia ka maopopo e pili ana i nā mea āpau.

Ua maopopo iaʻu? Lana koʻu manaʻo he mea pono kēia ʻike iā ʻoe.

ʻO Calcitonin, Calcitonin, Thyroid, Hormone, Calcium, Calcium Koko, Kanesa Thyroid Medullary