Ua noʻonoʻo paha ʻoe i ka nui o nā mea kupaianaha e hana nei i loko o ko kākou kino? Me ka ʻike ʻole, aia mau ke kaua nui e hana nei i loko o ko kākou kino. Hoʻouka ʻia kēia kaua e ko kākou ʻōnaehana pale. Ua like ia me kahi pūʻali koa e pale ana i ko kākou ʻāina. ʻO ke kuleana o kēia pūʻali koa, ʻo ia ka ʻimi a luku i nā ʻenemi e like me nā maʻi a me nā bacteria e hele mai ana mai waho. Eia naʻe, i kekahi manawa, lilo kēia pūʻali koa i mea hoʻouka kaua iki a hoʻomaka e hoʻouka i nā ʻāpana maikaʻi i loko o ko kākou kino ponoʻī. I nā manawa e like me kēia, pono kekahi e hoʻomalu i kēia pūʻali koa a hāʻawi iā lākou i nā kauoha kūpono, ʻeā? I kēia lā, e kamaʻilio mākou e pili ana i kahi ʻano kūikawā o ke kelepona e hana ana i kēlā hana koʻikoʻi loa. ʻO ia nā Regulatory T cells, a i ʻole Tregs no ka pōkole.
I ka ʻōlelo maʻalahi, he aha kēia mau pūnaewele Regulatory T (Tregs)?
E noʻonoʻo i kāu ʻōnaehana pale ma ke ʻano he pūʻali koa ikaika loa. Aia nā ʻano koa like ʻole i loko o kēia pūʻali koa. I waena o lākou, ua like nā pūnaewele Regulatory T me nā luna kiʻekiʻe, a i ʻole nā mākaʻi, i loko o kēia pūʻali koa. ʻO kā lākou hana nui ka kaohi ʻana i nā pūnaewele ʻē aʻe (nā koa) o ka ʻōnaehana pale mai ka lilo ʻana i mea hana nui a hoʻonāukiuki paha.
He ʻano koko keʻokeʻo kēia i loko o ko kākou kino. Ke nānā mau nei lākou i ka hana o ka ʻōnaehana pale. Inā ma kekahi wahi e pane nui ana ka ʻōnaehana pale, ʻo ia hoʻi inā e hoʻāʻo ana e hoʻouka i kā kākou mau pūnaewele ponoʻī, e komo kēia mau pūnaewele Tregs a hoʻōki i kēlā kaʻina hana. Ua like lākou me ka ʻōlelo ʻana, "ʻAe, ʻae, ua lawa kēlā. ʻO ia kekahi o kā kākou iho, mai hoʻouka."
Me ka ʻole o kēia mau Tregs, nalowale ko mākou ʻōnaehana pale kino a hoʻomaka e hōʻino i ko mākou kino ponoʻī. ʻO kēia ka mea a mākou e kapa nei he maʻi autoimmune .
I ka ʻōlelo maʻalahi, he ʻano cell koʻikoʻi ʻo Tregs e mālama ana i ke kaulike o kā mākou ʻōnaehana pale, e koho ana ma waena o ka pono a me ka hewa a me ka hoʻopakele ʻana iā lākou.
No laila, he aha kēia mau 'antigens'?
Ua ʻōlelo mākou he pūʻali koa ka ʻōnaehana pale. No laila, ʻo wai ka mea e kaua aku ai kēia pūʻali koa? Ke kaua nei lākou i nā antigens . ʻO nā antigens nā ʻenemi o ka ʻōnaehana pale. Hiki i kēia mau mea ke lilo i mea ʻino i ko mākou kino, nā mea ʻē. Ke komo kēia ʻenemi i loko o ke kino, ʻike kā mākou ʻōnaehana pale iā ia a hana i nā protein i kapa ʻia he antibodies e hakakā iā ia.
ʻEkolu mau ʻano nui o kēia mau antigens. E nānā kākou i ke ʻano o lākou.
| ʻAno antigen | He wehewehe wale nō |
|---|---|
| Nā antigens haole | He mau ʻenemi kēia e komo mai i loko o ko kākou kino mai waho mai. Eia kekahi laʻana, nā bacteria, nā virus, nā parasites, a me nā kemika ʻawahia. |
| Nā antigen ponoʻī | Hoʻopuka ʻia kēia mau mea i loko o ko kākou kino, ma luna o ko kākou mau pūnaewele ponoʻī a me nā ʻiʻo. ʻAʻole hoʻouka pinepine kā kākou ʻōnaehana pale iā lākou. No ka laʻana, aia nā antigens ma nā pūnaewele koko i loko o ko kākou koko. |
| Nā Antigens (Neoantigens) ma nā pūnaewele kanesa | Hoʻopuka ʻia kēia mau mea e nā hunaola kanesa. He mau antigens hou kēia i hoʻololi ʻia mai nā 'antigens ponoʻī' i loaʻa i loko o kā mākou mau hunaola ponoʻī. |
ʻO ka hiki kupaianaha o nā pūnaewele Treg ke koho pololei i kahi o kēia mau antigens e hoʻouka a ʻo wai e waiho ʻole ʻia .
He aha nā ʻano nui o Tregs?
ʻOiai he nui nā ʻano like ʻole o kēia mau pūnaewele Treg, ua hoʻokaʻawale nā mea noiʻi iā lākou i ʻelua mau pūʻulu nui, a he ʻelua mau hana ko kēlā me kēia.
| ʻAno Treg | Hana nui |
|---|---|
| iTregs (Tregs i hoʻoulu ʻia) | ʻO kā lākou mau pahuhopu nui he mau antigens haole a me nā cell cancer (neoantigens). Hoʻomaka lākou i kā lākou hana me nā hōʻailona mai nā protein liʻiliʻi i kapa ʻia ʻo cytokines . |
| nTregs (Nā Tregs Kūlohelohe) | ʻO kā lākou pahuhopu nui nā antigens ponoʻī o ko mākou kino ponoʻī (self-antigens). ʻO ia hoʻi, ʻo kā lākou hana ke kāohi i ka mumū autoimmune. |
He aha ka lawelawe a nā pūnaewele Regulatory T e hāʻawi maoli ai i ko mākou kino?
Ua ʻike mākou i kēia manawa ʻo Tregs nā haku o ka ʻōnaehana pale. Hāʻawi lākou iā mākou i nā lawelawe waiwai nui. E nānā kākou i ko lākou ʻano:
- Kāohi i ka pane ʻana o ka pale ʻana: Ke alakaʻi nei ia i ka ʻōnaehana pale e hoʻouka wale i ka nui e pono ai o nā ʻenemi haole a me nā hunaola maʻi ʻaʻai, ma ka pahuhopu pololei.
- Ke pale ʻana i ko kākou kino: ʻO ka mea nui loa, ʻo ia ke hoʻōki i ka hoʻouka ʻana i ko kākou mau hunaola olakino ponoʻī. Ua kapa ʻia kēia e nā kauka he 'hoʻomanawanui ponoʻī' . ʻO ia hoʻi, ke aʻo aku nei mākou i ko mākou kino e ʻae i kāna mau mea ponoʻī. Penei mākou e hiki ai ke pale aku iā mākou iho mai ka ulu ʻana o nā maʻi autoimmune.
- Hoʻomalu i ka mumū: Kōkua ia i ka kaohi ʻana i ka mumū a me ka pehu pono ʻole i loko o ke kino a pale i ka hōʻino ʻana o nā ʻiʻo.
- Kōkua i nā hoʻoili kino: Ke loaʻa i kekahi kahi hoʻoili kino hou (e like me ka puʻupaʻa a puʻuwai paha), ʻike ko mākou kino iā ia he mea ʻē a hoʻāʻo e hōʻole iā ia. Hoʻomālielie nā pūnaewele Tregs i ka ʻōnaehana pale a kōkua iā ia e ʻae i ke kino hou.
Ma hea mai kēia mau pūnaewele kupaianaha?
Hoʻopuka ʻia kēia mau Treg e ka thymus gland i loko o ko kākou kino. He gland kēia i lohe ʻole ʻia e ka poʻe he nui. Aia ia ma ke alo o ko kākou umauma, ma waena o nā māmā ʻelua, ma hope o ka iwi umauma (sternum).
Hoʻopuka ka ʻōpū thymus i kahi hormone i kapa ʻia ʻo thymosin. Kōkua kēia hormone i nā pūnaewele Tregs e ulu. Ke hele nā kelepona koko keʻokeʻo (ʻo ia hoʻi nā lymphocytes ) i hana ʻia i loko o ko kākou iwi iwi ma o ka ʻōpū thymus, lilo lākou i mau pūnaewele T. Ke oʻo kēia mau pūnaewele T, hele lākou i nā lymph nodes a hoʻomākaukau no ka hana.
ʻO ka mea kupaianaha maoli, ʻo ka thymus gland wale nō ka mea e hana ai i nā pūnaewele T a hiki i ko kākou wā makua. Ma hope o kēlā, emi mālie ka gland a pani ʻia e ka momona.
He mea pono anei ʻo Tregs no nā kūlana ʻē aʻe?
ʻAe, ʻoiaʻiʻo nō! ʻO kēia kekahi o nā kumuhana wela loa i ka lāʻau lapaʻau i kēia manawa. Ke hoʻāʻo nei nā kānaka noiʻi e ʻike inā hiki ke hoʻohana ʻia kēia mau cell Tregs e mālama i nā maʻi like ʻole. ʻOi aku hoʻi nā maʻi allergies, ke kanesa, a me nā maʻi autoimmune.
Manaʻo lākou ma ka hoʻonui ʻana i ka helu o kēia mau cell Tregs i loko o ke kino, e hiki ai ke kāohi i ka hana makemake ʻole o ka ʻōnaehana pale. Ma o kēia, e hiki ai ke kāohi a hoʻōla paha i nā maʻi ma hope aku i ka wā e hiki mai ana.
- Lupus
- Sclerosis lehulehu (MS)
- ʻO ka maʻi thyroid
- ʻAno 1 diabetes
- ʻO ka ʻāʻī rheumatoid
- ʻO ka maʻi ulcerative colitis
He aha kā mākou e hana ai e mālama i ke olakino o kā mākou mau cell Tregs?
Aia i loko o ko kākou mau lima ke mālama ʻana i kēia mau hunaola makamae e hoʻomau i ke kaulike o ko kākou ʻōnaehana pale. ʻAʻole pono kākou e hana i kekahi mea kūikawā e hana ai i kēlā. ʻO ka mea nui loa, ʻo ia ka hahai ʻana i kahi nohona maʻalahi a olakino hoʻi.
- E kāohi i kāu inu ʻona: Inā inu ʻoe i ka waiʻona, e hana pēlā me ke akahele.
- E ʻai i ka meaʻai momona: E ʻai i nā mea kanu, nā huaʻai, a me nā greens.
- Hoʻoikaika kino mau: E hana ma ka liʻiliʻi he 30 mau minuke o ka hoʻoikaika kino ikaika i ka lā.
- E hiamoe pono: He mea nui ka hiamoe maikaʻi no 7-8 mau hola i ka lā.
- E mālama i ke kaumaha olakino: ʻO ka mālama ʻana i ke kaumaha olakino no kou kiʻekiʻe e kōkua i ka pale ʻana iā ʻoe mai nā maʻi he nui.
- E hoʻokele i ke kaumaha: E mālama i ka maikaʻi o ka noʻonoʻo ma o nā hana e like me ka yoga a me ka noʻonoʻo ʻana.
- E pale i ka puhipaka: Inā ʻoe e puhipaka, e haʻalele i kēia lā.
- E lāʻau pale i ka manawa kūpono: ʻO ka loaʻa ʻana o nā lāʻau pale e pono ai e hoʻoikaika i ka ʻōnaehana pale.
- E holoi pinepine i kou mau lima: ʻO ke ala maikaʻi loa e pale aku ai i nā germs, ʻo ia ka holoi pinepine ʻana i kou mau lima.
Hiki iaʻu ke noi i kaʻu kauka no ka lāʻau Tregs?
He nīnau kēia a ka poʻe he nui. I kēia manawa, ʻaʻole loaʻa nā lāʻau lapaʻau e hoʻohana ana i nā cell Treg ma nā haukapila maʻamau a i ʻole nā keʻena lapaʻau. Aia nō kēia mau lāʻau lapaʻau i ke kahua noiʻi (nā hoʻokolohua lapaʻau).
Ke hoʻomau nei nā kānaka noiʻi i ka noʻonoʻo ʻana pehea e hoʻonui ai i nā pūnaewele Treg i loko o ke kino me ka palekana a me ka maikaʻi. Eia kekahi o nā ʻano hana a lākou e aʻo nei:
- Nā ʻano lāʻau lapaʻau
- Nā lāʻau pale
- Hoʻōla kelepona: Ke hoʻololi nei i nā pūnaewele Treg ma waho o ke kino a hoʻokomo hou iā lākou i loko o ke kino
- Hoʻoili ʻōpala
No laila, e lilo paha kēia i mau lāʻau lapaʻau waiwai nui loa e hiki iā mākou ke kakali i mua i ka wā e hiki mai ana.
Leka Lawe-Home
- Ua like nā pūnaewele T hoʻoponopono (Tregs) me nā "kiaʻi" a i ʻole "mākaʻi" o kā mākou ʻōnaehana pale.
- ʻO kā lākou hana nui ka pale ʻana i ka ʻōnaehana pale mai ka lilo ʻana i mea hana nui a me ka hoʻouka ʻana i ko mākou kino ponoʻī (maʻi autoimmune).
- Hoʻokaʻawale lākou ma waena o nā ʻenemi o waho a me nā hunaola o ko mākou kino ponoʻī, e hāʻawi ana i nā kauoha kikoʻī i ka ʻōnaehana pale.
- Ma ka hahai ʻana i kahi nohona olakino, hiki iā mākou ke mālama i ka hana o kēia mau pūnaewele Tregs.
- ʻOiai ke kau nei nā lāʻau lapaʻau e hoʻohana ana i nā pūnaewele Treg i ke kahua noiʻi, nui ka manaʻolana e kōkua lākou i ka ho'ōla ʻana i nā maʻi he nui i ka wā e hiki mai ana.
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