Ke emi mālie nei kou hoʻomanaʻo a me kou neʻe ʻana? E aʻo kākou e pili ana i kēia (Corticobasal Degeneration)!

Ke poina nei ʻoe i kekahi mau mea i kekahi manawa? A i ʻole he paʻakikī iā ʻoe ke hoʻoneʻe i kou mau lima a me kou mau wāwae? Ke ʻōlelo mālie nei ʻoe i kāu mau ʻōlelo ke ʻōlelo ʻoe? Inā ʻike ʻia kēia mau mea e hoʻonui ʻia ana, he mea nui paha iā ʻoe ke makaʻala i kēia kūlana a mākou e kamaʻilio nei i kēia lā i kapa ʻia ʻo `(Corticobasal Degeneration)`. Mai hopohopo, e kamaʻilio maʻalahi kākou e pili ana i kēia.

He aha ka "Corticobasal Degeneration"?

I ka ʻōlelo maʻalahi, ʻo `(Corticobasal Degeneration)` he maʻi neurological e hoʻopilikia ana i ko kākou lolo. Ua kapa pū kekahi poʻe iā ia ʻo `(Corticobasal Syndrome).` ʻO ka mea e hana ʻia ma kēia, ua hōʻino ʻia kekahi mau cell i loko o ko kākou lolo a luku mālie ʻia. E like me kekahi mau lako e hōʻino ana i ka hala ʻana o ka manawa. Ma muli o kēia, hiki i ko kākou hiki ke ʻōlelo, ale i ka meaʻai, hoʻoneʻe i ko kākou kino, a hoʻomanaʻo i nā mea ke emi mālie. ʻO ka mea kaumaha, ʻo ia ka piʻi mālie ʻana o kēia mau hōʻailona (holomua) i ka hala ʻana o ka manawa.

ʻO ka huaʻōlelo "corticobasal" ma ka inoa e pili ana i ʻelua mau ʻāpana o ka lolo i hōʻino nui ʻia e ka maʻi:

• ʻO ka cortex cerebral: ʻO kēia ka papa waho loa o nā ʻiʻo nerve i loko o ko kākou lolo. He mea nui loa kēia ʻāpana no ko kākou hoʻomanaʻo, ke aʻo ʻana, nā neʻe manawaleʻa, a me nā manaʻo.
• ʻO nā ganglia basal: He hōʻiliʻili kēia o nā hunaola aʻalolo i loaʻa i loko o ka lolo. He mea nui ia no ke aʻo ʻana a me nā hana neʻe.

ʻO ke ʻano o ka huaʻōlelo "degeneration" ʻo ia hoʻi "ka hōʻino ʻana" a i ʻole "ka nalowale ʻana o ka hana." No laila, ʻo ka mea e hana ʻia ma kēia maʻi, ʻo ia ka emi mālie ʻana o ka hana o kēia mau ʻāpana ʻelua o ka lolo.

ʻO kēia kūlana, ʻo "Corticobasal Degeneration", hiki ke hoʻopōkole i ke ola o ke kanaka a hoʻoulu i nā pilikia e hoʻoweliweli ai i ke ola. I ka laha ʻana o nā hōʻailona ma ke kino holoʻokoʻa, hiki ke lilo i mea paʻakikī ke hana kūʻokoʻa.

He aha nā hōʻailona o ka `(Corticobasal Degeneration)`?

Hiki ke ʻokoʻa nā hōʻailona o kēia maʻi mai kēlā kanaka a kēia kanaka, akā ʻo nā hiki e hiki ke hoʻopilikia ʻia ma ke ʻano laulā:

• Nā pilikia neʻe (`Apraxia`): ʻO ke ʻano kēia, lilo nā mea e like me ke pihi ʻana i kahi pihi a i ʻole ka paʻa ʻana i kahi puna e ʻai ai i mea paʻakikī. ʻOiai ke hoʻouna nei ka lolo i nā leka i nā lima, ʻaʻole hiki iā lākou ke hana pono.
• Ka hemahema o ka hoʻomanaʻo: Lilo i mea paʻakikī ke hoʻomanaʻo i nā mea hou, a hoʻopoina mālie ʻia nā mea kahiko.
• Ka pilikia o ka ʻike: Loaʻa paha i kekahi poʻe nā pilikia o ka ʻike.
• Nā pilikia ʻōlelo (ʻAphasia): Paʻakikī i ka loaʻa ʻana o nā huaʻōlelo, ke ʻōlelo ʻole ʻana i ka mea āu e makemake ai e ʻōlelo, a i kekahi manawa nalowale loa ka ʻōlelo.
• Paʻakikī ke ale ʻana: Manaʻo paha ʻoe e like me ʻoe e ʻū ana i ka wā e ale ai i ka meaʻai a me ka mea inu.

Ma waho aʻe o kēia, hiki ke ʻike ʻia nā hōʻailona ʻē aʻe e like me kēia:

• ʻO ke kuʻi ʻana o nā ʻiʻo, ka ʻūmiʻi ʻana, ka ʻoʻoleʻa o nā ʻiʻo, a i ʻole ka haʻalulu.
• Paʻakikī ke hana i nā hana liʻiliʻi a palupalu (e like me ke pihi ʻana i kahi pālule, ke kākau ʻana me ka peni).
• ʻO ka maʻi lima malihini: ʻO ka hiki ʻole ke kāohi i kekahi lima a i ʻole wāwae e like me kou makemake (ʻAlien hand syndrome`). E noʻonoʻo e hana ana kekahi o kou mau lima i nā mea āu e makemake ʻole ai e hana, a manaʻo ʻoe ʻaʻole hiki iā ʻoe ke kāohi.
• Ka manaʻo o ka maeʻele ma kekahi ʻaoʻao o ke kino.
• Lohi loa nā neʻe ʻana (`Bradykinesia`) a i ʻole ka hiki ʻole ke hoʻoneʻe i nā lālā (`Akinesia`).
• Ka emi ʻana o ka hana noʻonoʻo, ʻo ia hoʻi, ka emi ʻana o ka naʻauao (Dementia).
• Ka paʻakikī o ka hele wāwae me ke kōkua ʻole.
• Nā loli i ke ʻano a me ke ʻano (nele i ka nānā, huhū koke, apathy).

ʻAʻole like ka hopena o kēia maʻi i nā kānaka a pau. Hoʻomau pinepine ia me ka mālie. I kekahi manawa hoʻomaka nā hōʻailona ma kekahi lima, a laila laha i kekahi lima a me nā wāwae. E hoʻomaka paha ʻoe e manaʻo e like me ʻoe e hele wāwae ana, a laila hiki ʻole iā ʻoe ke hele me ke kōkua ʻole. E hoʻomaka paha ʻoe e ʻōlelo ʻino i kāu mau ʻōlelo i ka wā e ʻōlelo ana, a i ka hala ʻana o ka manawa, ʻaʻole paha ʻoe e hiki ke ʻōlelo i hoʻokahi ʻōlelo koʻikoʻi.

I ka hoʻopilikia ʻana o ka maʻi i nā ʻāpana he nui o ka lolo, e lilo mālie ana nā hōʻailona i mea ʻino. Hana mālie kēia.

I ka manawa hea e hoʻomaka ai nā hōʻailona o ka `(Corticobasal Degeneration)`?

Hoʻomaka pinepine nā hōʻailona ma waena o nā makahiki 50 a me 70. Loaʻa ka hapa nui o ka poʻe i kā lākou mau hōʻailona ma kahi o 64 mau makahiki. ʻOiai hiki ʻole ke hoʻomaka i ka wā mua o 40 mau makahiki, ʻaʻohe hōʻike e pili ana i ka ulu ʻana o ka maʻi i ka wā ʻōpiopio.

He aha nā kumu o ka `(Corticobasal Degeneration)`?

ʻO ke kumu nui o kēia, ʻo ia ka haki mālie ʻana o nā ʻiʻo a me nā hunaola o ka lolo a make. ʻO ka hapa nui o ka manawa, hoʻomaka kēia hōʻino ma nā wahi a mākou i kamaʻilio mua ai i kapa ʻia ʻo ka cerebral cortex a me ka basal ganglia. I ka holomua ʻana o ka maʻi, hiki iā ia ke hoʻopilikia i nā ʻāpana ʻē aʻe o ka lolo.

Manaʻo nā kānaka noiʻi he protein i kapa ʻia ʻo "Tau" ke komo nei i kēia maʻi. Loaʻa pinepine kēia protein i loko o nā hunaola lolo. Akā i loko o kēia maʻi, hui pū kēia protein a hana i nā hui. Ua kapa ʻia kēia mau hui ʻo "neurofibrillar tangles." ʻO kēia mau hui ke kumu o ka palaho a make ʻana o nā hunaola lolo. ʻO ka hopena, loaʻa nā pilikia me ka neʻe ʻana, ka ʻōlelo ʻana, a me ka hoʻomanaʻo.

ʻAʻole i ʻike ʻia ke kumu kikoʻī o ka hui pū ʻana o ka protein Tau. Ua ʻike ʻia he nui ka poʻe me ka Corticobasal Degeneration he ʻano genetic (mutation) i kapa ʻia ʻo ka H1 haplotype ma ka chromosome 17. Hiki i kēia ʻano genetic ke hana i ka protein Tau i ka nui a hui pū, a i ʻole he hui methyl paha i hoʻopili ʻia i ka gene Tau, e hoʻopilikia ana i kāna hana.

Akā, ua ʻike nā kānaka noiʻi ʻaʻole kēia gene wale nō ke kumu o kēia. No ka mea, he nui ka poʻe o ka heluna kanaka i loaʻa kēia gene, ʻaʻole lākou e loaʻa nā hōʻailona o ka "Corticobasal Degeneration." No laila, ke hana ʻia nei ka noiʻi e ʻike i ke kumu pololei o kēia ʻano.

He ʻano hoʻoilina anei ka `(Corticobasal Degeneration)`?

ʻAʻole maopopo i nā loea lapaʻau ke kumu e loaʻa ai i kekahi poʻe ka Corticobasal Degeneration. He mea kākaʻikahi loa i nā lālā o ka ʻohana hoʻokahi ke loaʻa i ka maʻi. ʻO ia hoʻi , he paʻakikī ke ʻōlelo he maʻi hoʻoilina ia.

He aha nā pilikia e hiki mai ana?

I ka holomua ʻana o ka maʻi, ua piʻi ka pilikia o ka loaʻa ʻana o nā pilikia olakino e like me:

• Nā maʻi bacteria
• Nā ʻūpā koko a me nā embolisms pulmonary
• Nā ulia kino (e like me ka hāʻule ʻana)
• Pneumonia
• Sepsis (kahi maʻi koʻikoʻi i hoʻokumu ʻia e nā germs e komo ana i ke koko)

Pehea e ʻike ai nā kauka i kēia maʻi? (`Diagnosis`)

ʻO ke ʻano ʻē o ka ʻike ʻana i ka `(Corticobasal Degeneration)` ʻo ia ka hiki ke hōʻoia paʻa ʻia ma ka nānā ʻana i ka lolo ma hope o ka make ʻana. A laila wale nō e hiki ai i ke kauka a i ʻole ka pathologist ke hoʻoholo pololei i ka nui o ka degeneration o ka lolo.

Eia nō naʻe, i kou wā e ola ana, hiki i kāu kauka ke kapa i kēia ʻano "Corticobasal Syndrome" ma muli o kāu mau hōʻailona.

No ka hana ʻana i kahi hōʻailona, ​​e hana mua kāu kauka i kahi hoʻokolokolo kino. E nānā pono lākou i kāu mau hōʻailona.

Ma muli o nā maʻi he nui he mau hōʻailona like, hiki i kāu kauka ke hana i nā ʻano hoʻokolohua like ʻole e hoʻoholo ai i ke kumu pololei. Hiki i kēia mau mea ke komo pū me:

• Nā hoʻāʻo koko
• Nā hoʻāʻo kiʻi lolo (`Nā scan kiʻi`) - no ka laʻana `(MRI)` a i ʻole `(CT scan`)
• Ka hoʻāʻo ʻana o Neuropsychological e loiloi i ka hana o ka lolo a me ka hoʻomanaʻo

Eia kekahi, hiki i ke kauka ke kauoha i nā scan lāʻau lapaʻau nukelea e like me `(FDG-PET (Fluorodeoxyglucose Positron Emission Tomography))` a me `(DAT (Dopamine Transporter))`. I kekahi manawa, hiki i ka `skin biopsy` ke kōkua i ka hōʻoia ʻana.

He aha nā lāʻau lapaʻau no ka `(Corticobasal Degeneration)`?

Hiki i kāu kauka ke kuhikuhi i nā lāʻau lapaʻau like ʻole e kāohi i nā hōʻailona like ʻole o kēia maʻi.

E hoʻomanaʻo, ʻaʻohe lāʻau lapaʻau no kēia maʻi a i ʻole he lāʻau lapaʻau e hoʻōki i ka holomua o nā hōʻailona. Eia nō naʻe, aia nā mea e hiki ke kōkua i ka hōʻemi ʻana i ka ʻoluʻolu ʻole i hoʻokumu ʻia e nā hōʻailona.

ʻO nā lāʻau lapaʻau no nā hōʻailona pili i ka ʻiʻo e hiki ke komo pū me:

• Nā neʻe lohi a i ʻole ka ʻoʻoleʻa o nā ʻiʻo: `(Levodopa)`
• No nā ʻūmiʻi ʻiʻo: Clonazepam (Benzodiazepines)
• No ka paʻakikī o nā ʻiʻo a i ʻole ka kaohi ʻana i ka neʻe ʻana: `(Botulinum toxin)` (Nā inikini Botox)
• No ka ʻoʻoleʻa o nā ʻiʻo: `(Cyclobenzaprine)`, `(Levetiracetam)` a i ʻole `(Baclofen)`

No nā pilikia hoʻomanaʻo, hiki i kāu kauka ke kuhikuhi i kekahi o kēia mau ʻano lāʻau i kapa ʻia ʻo "Cholinesterase inhibitors":

• ʻO Donepezil
• ʻO Rivastigmine
• `(Galantamine)`

ʻAʻole hana like kekahi mau lāʻau lapaʻau no nā hōʻailona o kēlā me kēia kanaka, no laila e hoʻāʻo paha kāu kauka i nā ʻano like ʻole e ʻike i ka mea e hana maikaʻi loa iā ʻoe.

Eia kekahi, e like me nā lāʻau lapaʻau āpau, aia nā hopena ʻaoʻao. E kamaʻilio kāu kauka me ʻoe e pili ana i kēia. E nānā mau lākou iā ʻoe e hōʻoia i ka hana pono ʻana o ka lāʻau lapaʻau a inā he mau pilikia. Inā loaʻa iā ʻoe kekahi mau hopena ʻaoʻao, pono ʻoe e haʻi koke i kāu kauka.

ʻO ka mea nui loa, ʻaʻohe lāʻau lapaʻau i kēia manawa e hoʻōki i ka holomua o kēia mau hōʻailona a i ʻole e ho'ōla loa i ka maʻi.

Pehea e mālama ai i nā hōʻailona?

I ka wā e noho ana me nā hōʻailona o ka "Corticobasal Syndrome," hiki i nā lāʻau lapaʻau ma lalo nei ke kōkua i ka mālama ʻana iā lākou:

• Hoʻōla hana: Hiki i kēia ke kōkua iā ʻoe e aʻo i nā ala hou e hana ai i nā hana o kēlā me kēia lā a mālama i kou kūʻokoʻa no ka lōʻihi o ka hiki. Inā pono, hiki iā ʻoe ke aʻo pehea e hoʻohana ai i nā mea hana neʻe kōkua.
• Hoʻōla kino: Kōkua kēia i ka mālama ʻana i ka neʻe ʻana o ke kino a hōʻemi i ka ʻoluʻolu ʻole i hoʻokumu ʻia e nā hōʻailona pili i nā ʻiʻo. Hiki i ka hoʻoikaika kino ke kōkua i ka hoʻoikaika ʻana i nā ʻiʻo a mālama i ka palupalu.
• Hoʻōla ʻōlelo: Kōkua kēia i nā pilikia o ka ʻōlelo a me ke ale ʻana. Hiki iā ia ke kōkua me nā mea e like me ke ʻano o ka hōʻike ʻana i nā manaʻo, pehea e haʻi ai i nā huaʻōlelo, a pehea e ale ai i ka meaʻai me ka palekana.

E hana pū kāu kauka me ʻoe e ʻimi i nā hoʻolālā hoʻokele maikaʻi loa no kāu mau hōʻailona. Hiki ke ʻokoʻa kēia mau hoʻolālā mai kēlā kanaka a kēia kanaka, a pono paha e hoʻololi ʻia i ka loli ʻana o kou kūlana i ka hala ʻana o ka manawa.

Āhea ʻoe e ʻike ai i ke kauka?

Inā loaʻa iā ʻoe a i ʻole kekahi mea aloha kekahi o kēia mau hōʻailona o ka `(Corticobasal Degeneration)`, e ʻike koke i ke kauka:

• Inā pilikia ʻoe i ka hele ʻana a i ʻole ka kaohi ʻana i kou mau lālā.
• Inā ʻoe e ʻike nei i nā pilikia hoʻomanaʻo a i ʻole nā ​​​​hōʻailona o ka dementia.
• Inā pilikia ʻoe i ka ʻōlelo ʻana, ka moni ʻana, a i ʻole ka hanu ʻana.
• Inā he mau haʻalulu.

He aha ka wānana no ka `(Corticobasal Degeneration)`?

ʻO kaʻoiaʻiʻo, ʻaʻole maikaʻi loa ka manaʻolana no ka Corticobasal Degeneration. He maʻi holomua ia, ʻo ia hoʻi, e ʻoi aku ka ʻino o nā hōʻailona i ka hala ʻana o ka manawa.Akā, hana pinepine kēia me ka lohi, i nā makahiki. E hāʻawi kāu kauka iā ʻoe i nā lāʻau lapaʻau e kōkua iā ʻoe e hoʻomanawanui a hoʻokele i kāu mau hōʻailona. ʻOiai hiki i kēia mau lāʻau lapaʻau ke hōʻemi i ke koʻikoʻi o kāu mau hōʻailona, ​​​​ʻaʻole hiki iā lākou ke pale aku iā lākou mai ka ʻino ʻana. Ke ʻino aʻe kāu mau hōʻailona, ​​​​hiki ke lilo i mea paʻakikī ke hoʻokele iā lākou ma kāu iho.

Ma muli o ka holomua mālie o kēia maʻi, loaʻa iā ʻoe ka manawa e hoʻolālā ai no kou wā e hiki mai ana. ʻAʻole pono ʻoe e hana koke i kēia mau mea ke loaʻa iā ʻoe kahi hōʻailona. Pono ʻoe e hoʻokaʻawale i ka manawa e noʻonoʻo ai i ka mea maikaʻi loa iā ʻoe. Pono ʻoe e hana pū me kāu mau kauka a me nā poʻe āu e hilinaʻi nei e hoʻonohonoho i kāu mau makemake a me ke ʻano o ka mālama āu e pono ai.

He aha ke ola o kekahi me ka `(Corticobasal Degeneration)`?

Ma ka awelika, ola ka hapa nui o ka poʻe ma kahi o ʻeono a ʻewalu mau makahiki ma hope o ka ʻike ʻia ʻana o nā hōʻailona mua o ka Corticobasal Degeneration. Eia naʻe, ʻaʻole like kēia no nā kānaka a pau, a ola kekahi poʻe no ka lōʻihi. ʻAʻole paha e kūpono kou kūlana i nā helu helu, no laila ʻo ke kanaka maikaʻi loa e kamaʻilio e pili ana i kēia ʻo kāu kauka.

He aha nā kūlana ʻē aʻe i loaʻa nā hōʻailona like?

Hiki ke like kekahi o nā hōʻailona o ka `(Corticobasal Degeneration)` me nā hōʻailona o nā maʻi ʻē aʻe, e like me:

• Ka maʻi ʻaʻai lolo (ʻAʻai ʻaʻai lolo / puʻupuʻu lolo)
• `(Dementia Frontotemporal)`
• ka maʻi o Alzheimer
• `(Ka emi ʻana o ka ʻōnaehana he nui)`
• ka maʻi o Parkinson
• `(Paluhia supranuclear holomua)`
• Hahau

No laila, he mea nui loa ke ʻike koke aku i ke kauka inā loaʻa iā ʻoe kekahi mau hōʻailona, ​​​​​​no ka mea, hiki i ka mālama mua ʻana ke hoʻōla i ke ola, ʻoiai i nā hihia e like me ka maʻi lolo.

Hiki ke paʻakikī ke hoʻokele i nā manaʻo e hele mai me kahi hōʻailona e like me `(Corticobasal Degeneration)`. Hiki iā ʻoe ke makaʻu a hopohopo e pili ana i ka wā e hiki mai ana. I ka ulu ʻana o nā hōʻailona i nā makahiki, e noʻonoʻo paha ʻoe pehea e hoʻohana pono ai i kēlā me kēia manawa. Hiki ke paʻakikī ke lawelawe i kēia mau mea āpau i ka manawa hoʻokahi. Makemake paha ʻoe e kamaʻilio me kahi loea olakino noʻonoʻo no ke kākoʻo i kēia manawa paʻakikī.

E hoʻomanaʻo, ʻaʻole ʻoe hoʻokahi i kēia mau mea a pau. Inā makemake ʻoe i ke kōkua, mai kānalua e hoʻokaʻaʻike aku i kāu hui lapaʻau.

ʻO ka mea hope loa, nā mea e hoʻomanaʻo ai

ʻAe, eia kekahi mau mea a mākou i kamaʻilio ai e pili ana i ka `(Corticobasal Degeneration)` aʻu e manaʻo nei he mea nui iā ʻoe:

• He kūlana kēia e hoʻopilikia ai i ka lolo a piʻi mālie nā hōʻailona i ka hala ʻana o ka manawa.
• ʻAʻole i loaʻa ke kumu kikoʻī o kēia, akā ua manaʻo ʻia he pili ia i kahi protein i kapa ʻia ʻo `(Tau)`.
• ʻAʻohe lāʻau lapaʻau i kēia manawa e ho'ōla loa ai i ka maʻi.
• Eia nō naʻe, aia nā lāʻau lapaʻau e mālama i nā hōʻailona a maʻalahi ke ola.(E like me ka lāʻau lapaʻau, ka hoʻōla kino, ka hoʻōla hana, ka hoʻōla ʻōlelo).
• He mea nui e ʻimi koke i ke kōkua lapaʻau.
• E hoʻolālā no ka wā e hiki mai ana a e loaʻa ke kākoʻo āu e pono ai.
• ʻAʻole ʻoe hoʻokahi. He mea nui loa hoʻi e noho ikaika ka noʻonoʻo. E kiʻi i ke kōkua mai nā kauka, ka ʻohana, a me nā hoaaloha.

Manaʻolana wau he mea kōkua kēia ʻike iā ʻoe. Inā he mau nīnau kāu, mai kānalua e kamaʻilio me kāu kauka.

ʻO ka Degeneration Corticobasal, nā maʻi lolo, nā maʻi Neurological, nā maʻi neʻe, ka hemahema o ka hoʻomanaʻo, nā maʻi ʻōlelo, Tau Protein, CBS, Atrophy lolo, Apraxia, Aphasia, Dementia