Ke ʻike ʻia ʻoe a i ʻole kekahi mea kokoke iā ʻoe me ka maʻi ʻaʻai umauma, ua lohe paha ʻoe i nā kauka e hoʻohana ana i nā huaʻōlelo e like me ' HER2-Positive ' a i ʻole 'HER2-low'. ʻO kēia mau inoa maoli i hoʻohana ʻia e wehewehe i nā ʻano o nā cell cancer. Aia i kēia manawa nā lāʻau lapaʻau hou a holomua e mālama i kēia mau ʻano maʻi kanesa. ʻO kekahi o ia mau lāʻau lapaʻau kūikawā ʻo Enhertu. I kēia lā, e kamaʻilio mākou e pili ana i kēia ma ke ʻano maʻalahi a maʻalahi hoʻi e hoʻomaopopo.
He aha ke ʻano lāʻau lapaʻau ʻo Enhertu? Pehea e hana ai?
I ka ʻōlelo maʻalahi, he lāʻau lapaʻau i kuhikuhi ʻia ʻo Enhertu. I ka pololei, he ʻano lāʻau ia i kapa ʻia ʻo `Antibody-Drug Conjugate (ADC).` ʻOiai ke kani iki nei ka inoa, he mea kupaianaha ke ʻano o kāna hana.
E noʻonoʻo i kēia lāʻau lapaʻau me he missile akamai lā. Ua hana ʻia ia i ʻekolu ʻāpana:
1. ʻĀpana ʻimi i ka pahuhopu (Antibody): Loaʻa i kēia ʻāpana kahi protein kūikawā i kapa ʻia ʻo `HER2` ma luna o ka ʻili o nā hunaola kanesa a hoʻopili iā ia. ʻO ka hana a kēia ʻāpana, ʻo ia ke koho a pale i nā hunaola kanesa wale nō, me ka ʻole o ka hōʻeha ʻana i nā hunaola olakino.
2. Ukana: ʻO kēia ka lāʻau e pepehi i nā hunaola kanesa. I ka pololei, he ʻano chemotherapy ikaika kēia.
3. ʻO ka ʻāpana e hoʻohui i kēia mau mea ʻelua (Linker): Ua hoʻohui ʻia nā ʻāpana ʻelua i ʻōlelo ʻia ma luna e kēia linker.
No laila, ke hāʻawi ʻoe i kēia lāʻau lapaʻau, hele pololei ka ʻāpana antibody o ia mea i nā hunaola kanesa i loaʻa ka protein `HER2`. A laila, komo ka lāʻau lapaʻau i loko o ke hunaola. I loko o ke hunaola, hoʻokuʻu ʻia ka ʻāpana chemo a luku i ke hunaola kanesa. I ka make ʻana o nā hunaola kanesa, emi nā hunaola kanesa a oki i ka ulu ʻana.
ʻO ka pōmaikaʻi nui o kēia ʻano hana, ʻo ia ka hoʻopili pololei ʻana o ka lāʻau i nā hunaola kanesa wale nō, no laila ua hoʻemi nui ʻia ka hōʻino ʻana i nā hunaola olakino.
Pehea e hāʻawi ʻia ai ʻo Enhertu?
He lāʻau lapaʻau ʻo Enhertu i hāʻawi ʻia ma ke kino. ʻO ia hoʻi, ua hāʻawi ʻia i loko o ke kino ma ke ʻano he wai saline (IV infusion). E hāʻawi ʻia kēia lāʻau lapaʻau iā ʻoe e kekahi loea mālama ola ma kahi haukapila, keʻena lapaʻau, a i ʻole ke kikowaena lapaʻau kūikawā.
- Ka lōʻihi: Hāʻawi pinepine ʻia kēia lāʻau i kēlā me kēia 3 pule .
- Ka nui o ka lāʻau lapaʻau: Hoʻoholo ʻia ka nui o ka lāʻau lapaʻau āu e pono ai e kou kaumaha kino. E helu pololei kāu kauka a kuhikuhi iā ia.
- Palena manawa:Inā pane maikaʻi kāu maʻi ʻaʻai i kēia lāʻau lapaʻau, e aʻo aku kāu kauka iā ʻoe e hoʻomau i kēia lāʻau lapaʻau no ka lōʻihi e hiki ai. Eia nō naʻe, inā loaʻa iā ʻoe kekahi mau hopena ʻaoʻao, pono paha ʻoe e hoʻololi i ka nui o ka lāʻau lapaʻau, e hoʻōki i ka lāʻau lapaʻau no kekahi manawa, a i ʻole e hoʻōki loa. E kūkākūkā kāu kauka i kēia mau mea āpau me ʻoe a hoʻoholo.
Pehea ka maikaʻi o ka lāʻau Enhertu?
Ua loaʻa nā hopena maikaʻi loa i ʻelua mau hoʻokolohua lapaʻau e noiʻi ana i ka pono o ka lāʻau Enhertu.
1. Hoʻohālikelike ʻana o Enhertu lāua ʻo Kadcyla (hoʻāʻo DESTINY-Breast03)
Ma kēia hoʻokolohua, ua hoʻohālikelike ʻia ʻo Enhertu me Kadcyla (ado-trastuzumab emtansine), kekahi lāʻau lapaʻau ʻē aʻe e kuhikuhi ana i ka ``HER2.'' Ua hōʻike ʻia nā hopena ma ka papa ma lalo nei.
| Wahi hoʻohālikelike | Lapaʻau Enhertu | Ka lāʻau lapaʻau ʻo Kadcyla |
|---|---|---|
| Ola Holomua ʻole (ʻO kēia ka manawa e pono ai no ka hapalua o nā maʻi e hoʻi hou mai ko lākou kanesa a i ʻole e laha ʻole) | 28.8 mahina | 6.8 mahina |
| Pakeneka o nā maʻi i hoʻolaha ʻole i ka maʻi ma hope o 12 mau mahina | 75.2% | 33.9% |
| Pakeneka o nā maʻi i hoʻolaha ʻole i ka maʻi ma hope o 24 mau mahina | 53.7% | 26.4% |
2. Hoʻohālikelike ʻana o Enhertu a me ka chemotherapy (hoʻokolohua DESTINY-Breast04)
Ua hoʻohālikelike kēia hoʻokolohua iā Enhertu me ka chemotherapy maʻamau.
| Wahi hoʻohālikelike | Lapaʻau Enhertu | Lapaʻau chemotherapy |
|---|---|---|
| Ola Holomua ʻole | 9.9 mahina | 5.1 mau mahina |
| Ola holoʻokoʻa (ʻO kēia ka manawa i ola ai ka hapalua o nā maʻi i loaʻa ka lāʻau lapaʻau) | 23.4 mahina | 16.8 mahina |
Hōʻike kēia ʻikepili he ʻoi aku ka maikaʻi o ka lāʻau lapaʻau ʻo Enhertu ma mua o kekahi o nā lāʻau lapaʻau o kēia manawa.
Pehea e nānā ai i koʻu ho'ōla hou ʻana?
Hoʻomaka ka hana a Enhertu ke loaʻa iā ʻoe kāu mahele mua. E hana kāu kauka i nā hoʻokolohua like ʻole e ʻike ai pehea e pane ai kou kino i ka lāʻau lapaʻau.
- Nā scan: Hana pinepine ʻia kahi scan ma kahi o 6 mau pule ma hope o ka hoʻomaka ʻana o ka lāʻau lapaʻau e nānā i ka holomua o ke kanesa. Hiki ke hana ʻia kēia ma mua a ma hope paha.
- Nā hoʻāʻo koko: Hana ʻia nā hoʻāʻo koko maʻamau e nānā i kāu mau keʻokeʻo koko, neutrophil, a me ka helu platelet. E kōkua kēia i ka hoʻoholo ʻana inā hiki iā ʻoe ke hoʻomau palekana i ka lawe ʻana i ka lāʻau. Inā loaʻa iā ʻoe nā hopena ʻaoʻao, e like me ke kuni ʻana, hiki iā ʻoe ke hana i nā hoʻāʻo kūikawā ʻē aʻe e nānā iā lākou.
Nā hopena ʻaoʻao a pehea e mālama ai iā lākou?
He mea maʻamau nā hopena ʻaoʻao me nā lāʻau lapaʻau maʻi kanesa. He ʻoiaʻiʻo nō hoʻi kēia no Enhertu. ʻO ka mea nui loa, ʻo ia ke haʻi aku i kāu kauka e pili ana i nā hopena ʻaoʻao āu e ʻike ai. Na ia e hoʻoholo inā he koʻikoʻi lākou a haʻi iā ʻoe i ka mea e hana ai e pili ana iā lākou.
I mea e pale ai i nā hopena ʻaoʻao maʻamau e like me ka luaʻi ʻana a me ka nausea, hiki i kāu kauka ke kuhikuhi i nā lāʻau lapaʻau ʻē aʻe e lawe ma mua o ka hāʻawi ʻana iā ʻoe i ka lāʻau. He mea nui loa ia e hahai pololei i kēlā mau kuhikuhi.
Eia kekahi, hiki iā ʻoe ke hana i nā mea maʻalahi e like me kēia e kōkua ai i ka kaohi ʻana i ka nausea, ka luaʻi ʻana, a me ka maʻi diarrhea:
- E ʻai i nā meaʻai palaka me ka ʻaila a me ka chili liʻiliʻi.
- Ma kahi o ʻekolu mau pāʻina nui, e ʻai i kekahi mau pāʻina liʻiliʻi i ka lā.
Ma muli o ke koʻikoʻi o kekahi mau hopena ʻaoʻao, hiki i kāu kauka ke hoʻoholo e hōʻemi i ka nui o kāu lāʻau lapaʻau, e hoʻōki i ka lāʻau no kekahi manawa, a i ʻole e hoʻōki loa. Mai hopohopo no ia mea. No kou palekana wale nō ia.
Aia kekahi mau ʻōlelo aʻo kūikawā e pono iaʻu e ʻike?
ʻAe. He ʻōlelo aʻo pahu ʻeleʻele koʻikoʻi ko Enhertu. ʻO kēia ka ʻōlelo aʻo kiʻekiʻe loa i hoʻopuka ʻia e ka FDA (US Food and Drug Administration).
1. Ka pōʻino i ke keiki i hānau ʻole ʻia: Pono ʻoe e pale loa i ka hāpai ʻana i ka wā e lawe ana i kēia lāʻau lapaʻau. Hiki i kēia ke hōʻeha nui i kahi pēpē i hānau ʻole ʻia. Inā ʻoe a i ʻole kāu hoa e hoʻolālā ana e hāpai, e hōʻoia e haʻi i kāu kauka . E aʻo aku kāu kauka iā ʻoe i nā ʻano hana hoʻomalu hānau kūpono e hoʻohana ai i ka wā o ka mālama ʻana.
2. Ka hōʻino ʻana o ka māmā: Hiki i kēia lāʻau lapaʻau ke hana i kahi maʻi māmā koʻikoʻi i kapa ʻia ʻo 'Interstitial Lung Disease (ILD).' No laila, e nānā kāu kauka iā ʻoe no kēia ma ke kaʻina o ka lāʻau. Inā ʻike ʻoe i nā hōʻailona e like me ke kuni a me ka paʻakikī o ka hanu ʻana, e hoʻomaopopo koke i kāu kauka.
Ma muli o kēia mau kumu, he mea nui loa e mālama mau i ka launa pū ʻana me ke kauka a hahai pololei i kāna mau kuhikuhi.
Leka Lawe-Home
- He lāʻau lapaʻau holomua ʻo Enhertu e kuhikuhi ana i ka protein HER2 i ka maʻi ʻaʻai umauma a pepehi wale i nā hunaola kanesa.
- He lāʻau lapaʻau kēia i hāʻawi ʻia ma o kahi aʻa koko (IV) i kēlā me kēia 3 pule.
- Ua hōʻoia nā hoʻokolohua lapaʻau ua ʻoi aku ka maikaʻi o kēia lāʻau lapaʻau ma mua o nā lāʻau lapaʻau ʻē aʻe e hoʻohana ʻia nei.
- Hiki ke loaʻa nā hopena ʻaoʻao e like me ka nausea a me ka luaʻi i ka wā o ka mālama ʻana, a aia nā ala e hoʻokele ai iā lākou. E hoʻomaopopo koke i kāu kauka e pili ana i kekahi ʻeha.
- ʻO ka lawe ʻana i kēia lāʻau lapaʻau i ka wā hāpai hiki ke hōʻeha nui i ka pēpē i hānau ʻole ʻia, a aia kahi pilikia o nā hopena ʻaoʻao koʻikoʻi e hoʻopilikia ai i nā māmā. E kamaʻilio me kāu kauka e pili ana i kēia me ka wehe.
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