ʻO ke koa liʻiliʻi o ko mākou kino: Nā mea āpau e pili ana iā Erythropoietin!

Ua lohe paha ʻoe i kahi mea i kapa ʻia ʻo 'Erythropoietin' a i ʻole 'EPO'? Malia paha ua kamaʻilio kāu kauka e pili ana i ia mea, a inā he maʻi kou e like me ka anemia, ua kamaʻāina iki paha ka inoa iā ʻoe. He hormone kupaianaha maoli kēia a he mea nui loa i loko o ko kākou kino. I kēia lā, e kamaʻilio mākou e pili ana i ia mea ma ke ʻano maʻalahi e hiki ai iā ʻoe ke hoʻomaopopo.

He aha ka Erythropoietin?

I ka ʻōlelo maʻalahi, ʻo Erythropoietin kahi hormone i hana nui ʻia e kou mau puʻupaʻa. Kāhea pū mākou iā ia he EPO no ka pōkole. ʻO ka hana nui o kēia EPO ke kōkua i ka mālama ʻana i kahi pae olakino o nā hunaola koko ʻulaʻula, ʻo ia hoʻi, nā hunaola koko ʻulaʻula (erythrocytes) . Hana kēia EPO e like me kahi luna e haʻi ana i ka hale hana hunaola koko ʻulaʻula o ko mākou kino e 'hana hou aku!'

I kekahi manawa, hoʻohana nā kauka i kahi ʻano synthetic o ka erythropoietin, ʻoi aku hoʻi no ka mālama ʻana i ka anemia i hoʻokumu ʻia e ka maʻi puʻupaʻa mau loa (CKD) . E noʻonoʻo, no ka mea, ʻaʻole hana pono nā puʻupaʻa o kekahi poʻe, ʻaʻole lākou e hana i ka lawa o kēia hormone EPO. A laila loaʻa iā lākou ka anemia. ʻO ia ka manawa e kōkua ai kēia EPO synthetic.

Eia nō naʻe, hoʻohana hewa kekahi mau mea pāʻani iā ​​ia e hoʻomaikaʻi i kā lākou hana. ʻO ke kumu, hoʻonui ka EPO i ka nui o ka oxygen e hiki aku i ko lākou mau ʻiʻo. ʻAʻole ia he mea maikaʻi iki, no ka mea, hiki iā ia ke hoʻoulu i nā pilikia olakino koʻikoʻi.

Ua ʻike ʻia hoʻi ʻo Erythropoietin e nā inoa ʻē aʻe, e like me erythropoietin, hematopoietin, a me hemopoietin. Eia nō naʻe, ʻo nā inoa i hoʻohana nui ʻia ʻo Erythropoietin lāua ʻo EPO.

He aha ka hana a ka erythropoietin (EPO) i ko mākou kino?

He nīnau koʻikoʻi loa kēia. He hormone nui ʻo EPO e kōkua i ko mākou kino e hana i nā hunaola koko ʻulaʻula . I kēia manawa, no ke aha mākou e pono ai i nā hunaola koko ʻulaʻula? Ke hanu ʻoe, ʻo wai ka mea e lawe i ka oxygen e komo mai ana i loko o kou mau māmā i kēlā me kēia ʻāpana o kou kino, i kēlā me kēia cell? ʻO ia ka hana a nā hunaola koko ʻulaʻula. E noʻonoʻo e like me nā kalaka liʻiliʻi e lawe ana i ka oxygen ma kou kino holoʻokoʻa. Ke haʻi aku nei ʻo EPO i kēia mau kalaka e hana iā lākou.

Ke hiki ka oxygen i ko kākou mau cell, lilo ia i ikehu. He mea nui kēia ikehu no kā kākou hana a pau. A laila, lawe kēia mau cell koko ʻulaʻula i ke kalapona ʻokikene e waiho ana i ko kākou mau cell i nā māmā. Mai laila mai, hoʻokuʻu mākou iā ia.

ʻO ka mea maʻamau e hana ʻia penei: ʻIke nā pūnaewele kūikawā i loko o kou mau puʻupaʻa ua haʻahaʻa ka pae oxygen i loko o kou koko. Ke ʻike lākou i kēlā, hoʻonui lākou i kā lākou hana ʻana o EPO. A laila hele kēia EPO i ka ʻāpana huʻahuʻa o ko mākou mau iwi, ka iwi iwi , a ʻōlelo, 'ʻAe, i kēia manawa e hana i nā hunaola koko ʻulaʻula hou aʻe!'

Eia nō naʻe, inā ʻike nā pūnaewele i loko o nā puʻupaʻa ua lawa ka oxygen i loko o ke koko, hoʻemi lākou i ka hana ʻana o EPO. Ua like kēia me kahi ʻōnaehana lako-i-ke koi. Hoʻopuka lākou i nā mea hou aʻe ke pono ke kino, a hana lākou i ka mea liʻiliʻi ke emi ka pono.

ʻAʻole anei he mea kupanaha ke ʻano o kēia mau mea i loko o ko kākou kino? Ua hoʻolālā maikaʻi ʻia nā mea a pau!

Hiki i kekahi mau kūlana olakino ke hoʻopilikia i ka nui o ka EPO i hana ʻia e nā puʻupaʻa. Hiki i kēia ke hana i ka nui o ka EPO e hana ʻia, a i ʻole ʻaʻole lawa. Hiki i kēia mau mea ʻelua ke hana i kahi kaulike ʻole i nā pae o nā cell koko ʻulaʻula.

He aha ka mea e hana ai inā piʻi aʻe ka pae o ka erythropoietin (EPO)?

Inā piʻi nui nā pae EPO me ke kumu ʻole, ʻo ia hoʻi, inā hoʻonui ke kino i ka EPO me ka ʻole o ka pono maoli, piʻi pū ka helu o nā hunaola koko ʻulaʻula. Kāhea mākou i kēia polycythemia . I ka ʻōlelo maʻalahi, nui loa nā hunaola koko ʻulaʻula i loko o ke koko. He pilikia nō hoʻi kēia, no ka mea, mānoanoa ke koko a hiki ke hana ʻia nā ʻūpā koko.

No ke aha e piʻi ai nā pae erythropoietin (EPO)?

Aia kekahi mau kumu e kiʻekiʻe loa ai nā pae EPO:

• Ke noho nei i kahi ʻano me nā pae oxygen haʻahaʻa no ka manawa lōʻihi: E noʻonoʻo, inā hoʻomau ke kanaka i ka puhipaka, haʻahaʻa ka nui o ka oxygen e hiki aku i ko lākou kino. A laila manaʻo nā puʻupaʻa, 'Auē, ʻaʻole lawa ka oxygen, pono mākou e hana i nā ʻulaʻula hou aʻe,' a hana lākou i ka EPO hou aʻe. Pēlā nō, inā noho ke kanaka ma kahi kiʻekiʻe loa e like me Nuwara Eliya no ka manawa lōʻihi, hiki ke piʻi aʻe ka pae EPO ma muli o ka pae oxygen haʻahaʻa i ka lewa ma laila. Akā he mea maʻamau no ka piʻi ʻana o ka EPO ma kēia kiʻekiʻe, he hoʻololi ia o ke kino.
• ʻAʻole i hoʻokumu ʻia ka anemia e ka maʻi puʻupaʻa: I kekahi manawa, ʻaʻole i hoʻokumu ʻia ka anemia e ka pilikia puʻupaʻa. Akā no ka mea he kakaikahi loa nā hunaola koko ʻulaʻula a i ʻole ʻaʻole hana pono nā hunaola koko ʻulaʻula, ʻike nā puʻupaʻa ʻaʻole lākou e loaʻa ana i ka oxygen lawa. ʻOiai i kēlā manawa, hana lākou i ka EPO hou aʻe e kōkua i ka hana ʻana i nā hunaola koko ʻulaʻula. He pane maʻamau kēia o ke kino.
• Kekahi ʻano o nā puʻupuʻu: ʻOiai he mea kakaikahi loa, hiki i kekahi ʻano o nā puʻupuʻu ke hoʻokuʻu i nā puʻupaʻa i ka nui o ka EPO.

He aha ka mea e hana ai inā e emi ana nā pae erythropoietin (EPO)?

ʻO ke kumu nui o nā pae EPO haʻahaʻa, ʻo ia ka maʻi puʻupaʻa mau loa (CKD) . E like me ka mea i ʻōlelo ʻia ma mua, ke hōʻino ʻia nā puʻupaʻa, ʻaʻole hiki iā lākou ke hana pono i ka EPO. ʻO kēia ka hopena i nā pae EPO haʻahaʻa. ʻO kēia kūlana, CKD, a me nā pae EPO haʻahaʻa e alakaʻi i ka anemia. ʻO ke ʻano kēia e hiki iā ʻoe ke luhi, mae, a pilikia ka hanu ʻana.

No ke aha e emi ai nā pae erythropoietin (EPO)?

ʻOiai ʻo ke kumu nui ʻo CKD, aia kekahi kumu ʻē aʻe. ʻO ia ke ʻano i kapa ʻia ʻo Polycythemia Vera . He ʻano maʻi ʻaʻai kēia e kū mai ana i loko o ke koko. Ma muli o kahi hoʻololi genetic, hana ka iwi iwi i nā hunaola koko ʻulaʻula he nui loa. A laila manaʻo nā puʻupaʻa, 'Auē, he nui loa nā hunaola koko ʻulaʻula i loko o ke koko, ʻaʻole pono mākou e hana hou i ka EPO.' No laila hoʻemi lākou i ka hana ʻana o EPO. ʻO ia kekahi kumu o ka EPO haʻahaʻa.

He aha nā lāʻau lapaʻau e hiki ke hana inā haʻahaʻa nā pae EPO?

Inā haʻahaʻa nā pae EPO, mālama ʻia ma ka mālama ʻana i ke kumu kumu . ʻO ia hoʻi, inā he maʻi puʻupaʻa, mālama ʻia, inā he kumu ʻē aʻe, mālama ʻia.

Eia nō naʻe, ʻo ka lāʻau lapaʻau nui no ka anemia i hoʻokumu ʻia e nā pae EPO haʻahaʻa ʻo ia ka erythropoietin recombinant . Ua kapa ʻia kēia mau mea he erythropoietin-stimulating agents (ESAs) . He mau mana synthetic kēia o ka hormone EPO i hana ʻia i loko o kahi lab. Hoʻopili nā kauka i ka gene EPO a hāʻawi iā ʻoe ma ke ʻano he injection. A laila komo ia i loko o kou kino a hoʻoulu i kou iwi iwi e hoʻomaka e hana i nā hunaola koko ʻulaʻula hou aʻe.

ʻO ke kumu nui o kēia lāʻau lapaʻau, ʻo ia ka mālama ʻana i ka anemia i hoʻokumu ʻia e ka hāʻule mau ʻana o nā puʻupaʻa. Hāʻawi ʻia nō hoʻi i nā poʻe me kekahi mau ʻano maʻi kanesa kakaʻikahi.

Akā hiki i kēia mau ESA ke hana i kekahi mau hopena ʻaoʻao:

• Ke koko kiʻekiʻe
• kuni
• Pōʻino
• Ka luaʻi
• ʻEha ma kahi i hoʻokomo ʻia

No laila, he mea nui loa ka lawe ʻana i kēia lāʻau lapaʻau ma ke ʻano kikoʻī, e like me ka ʻōlelo a ke kauka.

Pehea e ana ʻia ai nā pae erythropoietin (EPO)?

Hiki i kāu kauka ke ana i kāu mau pae EPO me kahi hoʻāʻo koko maʻalahi. Hiki i kēia hoʻāʻo koko ke ʻike i nā loli i loko o kāu mau hunaola koko e hoʻopilikia ana i ka hoʻokuʻu ʻia ʻana o EPO. Hiki i kēia ke kōkua i ka hoʻoholo ʻana inā he polycythemia kou, anemia, a i ʻole nā ​​​​maʻi ʻē aʻe o ka iwi.

E koho ke kauka a kahu maʻi paha i kahi aa koko ma kou lima a hoʻomaʻemaʻe i ka ʻili ma laila me kahi mea e like me ka iodine a i ʻole ka isopropyl alcohol. A laila, e lawe kahi nila lahilahi loa (he nila 21 gauge - ma kahi o ka liʻiliʻi ma mua o ka piko o ke apo pepeiao) i kahi hāpana koko liʻiliʻi mai kou aa koko. E hoʻouna ʻia ka hāpana koko i kahi keʻena hoʻokolohua no ka nānā ʻana.

Ke loaʻa nā hopena o ka lab, e kamaʻilio kāu kauka me ʻoe e pili ana iā lākou a e pane i nā nīnau āu e loaʻa ai. E hoʻomanaʻo, ʻoiai inā aia kāu mau pae EPO i loko o ka pae maʻamau, pono paha ʻoe i nā lāʻau ʻē aʻe. Na kāu kauka ia e hoʻoholo.

He aha ka pae maʻamau o ka erythropoietin (EPO)?

Ana nā kauka i ka EPO ma nā milliunits no ka milliliter (mU/mL) . Hiki i ka pae EPO o ke kanaka olakino ke piʻi mai 4 a 26 mU/mL.

Akā, nou kēia mau waiwai:

• Makahiki
• Kāne/Wahine
• Kūlana olakino holoʻokoʻa

Hiki ke ʻokoʻa ma muli o kekahi mau kumu, e like me: No laila, ʻo kāu kauka wale nō ke hiki ke wehewehe pololei i kāu mau hopena a haʻi iā ʻoe inā aia lākou i loko o kahi pae olakino a i ʻole ma waho. No laila, mai hana i kāu hōʻailona ponoʻī ma muli o ka mea i loaʻa ma ka Pūnaewele.

Hiki ke hoʻonui i nā pae erythropoietin (EPO) ma ke ʻano kūlohelohe?

Inā loaʻa iā ʻoe ka maʻi puʻupaʻa mau loa (CKD) a i ʻole ka anemia me nā pae EPO haʻahaʻa, hiki i kekahi mau hoʻololi i ka ʻai a me ke ʻano o ka nohona ke kōkua i ka hoʻonui iki ʻana i kāu mau pae EPO. Eia nō naʻe, pono e hana ʻia kēia mau mea me ka ʻōlelo aʻoaʻo lapaʻau a ʻaʻole ma ke ʻano he pani no ka lāʻau lapaʻau.

• Hoʻoikaika Kino: Hōʻike ka noiʻi ke hoʻoikaika kino mau ʻoe, ma ka ikaika kūpono, hoʻohana kou kino i ka oxygen hou aku. A laila haʻi aku kou lolo i kou kino e 'hana i ka EPO hou aku.' ʻO nā mea e like me ke kaʻa paikikala, ka holo wikiwiki ʻana, a me ka ʻauʻau ʻana he mau laʻana maikaʻi ia o kēia ʻano hoʻoikaika kino.
• Hao meaʻai: ʻO ka hao kahi ʻāpana nui o ka hemoglobin i loko o ko kākou mau hunaola koko ʻulaʻula. ʻO kēia hemoglobin ka mea e lawe ai i ka oxygen. Ke kamaʻilio mākou e pili ana i nā meaʻai waiwai i ka hao, ʻo ia hoʻi ka ʻiʻo ʻulaʻula, nā yolks hua manu, nā legumes, a me nā mea kanu ʻōmaʻomaʻo e like me ka spinach i loaʻa iā mākou ma ko mākou kauhale. Loaʻa pū ka hao i ka tofu, nā cereals i hoʻonui ʻia i ka hao, ka palaoa, a me ka berena.

Ma waho aʻe o kēia mau mea, ʻo nā mea e like me ka ʻai ʻana i ka meaʻai kaulike, ka inu ʻana i ka wai lawa, a me ka pale ʻana i ka puhipaka he mea maikaʻi nō hoʻi ia no kou olakino holoʻokoʻa, a ma ke ʻano ʻē aʻe, kāu mau pae EPO.

ʻO ka mea hope loa, nā mea e pono ai ʻoe e hoʻomanaʻo

He hormone koʻikoʻi loa ka Erythropoietin (EPO) e haʻi ana i ko kākou iwi ʻiʻo e 'hana i nā hunaola koko ʻulaʻula hou aʻe'.

I kekahi manawa, hana ko mākou kino i nā hunaola koko ʻulaʻula he nui loa, a ʻaʻole lawa paha. Hiki i kēia mau mea ʻelua ke hoʻopilikia i ke olakino. Hiki i kāu kauka ke nānā i ka nui o ka EPO i loko o kou koko me kahi hoʻāʻo koko a, inā pono, e kuhikuhi i ka lāʻau kūpono. No laila, inā loaʻa iā ʻoe nā hōʻailona o ka anemia (luhi, mae, pōkole o ka hanu), a inā he pilikia kou i nā puʻupaʻa, e ʻimi pono i ka ʻōlelo aʻoaʻo lapaʻau. E kōkua lākou iā ʻoe ma ke ala kūpono. E noho olakino!

ʻErythropoietin , EPO, nā hunaola koko ʻulaʻula, anemia, nā puʻupaʻa, nā hormones, ka iwi ʻiʻo